Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy

Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosu...
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Autor*in:	Lam, Lok-Ka [verfasserIn] Chan, Thomas Sau Yan Hwang, Yu-Yan Mak, Lung-Yi Seto, Wai-Kay Kwong, Yok-Lam Yuen, Man-Fung

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	HBV reactivation Ibrutinib B cell depletion Occult hepatitis B Case report

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Virology journal - London : BioMed Central, 2004, 20(2023), 1 vom: 01. Aug.
Übergeordnetes Werk:	volume:20 ; year:2023 ; number:1 ; day:01 ; month:08

Links:	Volltext

DOI / URN:	10.1186/s12985-023-02140-w

Katalog-ID:	SPR052610071

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245	1	0	\|a Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
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520			\|a Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib.
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650		4	\|a Case report \|7 (dpeaa)DE-He213
700	1		\|a Chan, Thomas Sau Yan \|4 aut
700	1		\|a Hwang, Yu-Yan \|4 aut
700	1		\|a Mak, Lung-Yi \|4 aut
700	1		\|a Seto, Wai-Kay \|4 aut
700	1		\|a Kwong, Yok-Lam \|4 aut
700	1		\|a Yuen, Man-Fung \|4 aut
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allfields	10.1186/s12985-023-02140-w doi (DE-627)SPR052610071 (SPR)s12985-023-02140-w-e DE-627 ger DE-627 rakwb eng Lam, Lok-Ka verfasserin aut Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Chan, Thomas Sau Yan aut Hwang, Yu-Yan aut Mak, Lung-Yi aut Seto, Wai-Kay aut Kwong, Yok-Lam aut Yuen, Man-Fung aut Enthalten in Virology journal London : BioMed Central, 2004 20(2023), 1 vom: 01. Aug. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:20 year:2023 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12985-023-02140-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 01 08
spelling	10.1186/s12985-023-02140-w doi (DE-627)SPR052610071 (SPR)s12985-023-02140-w-e DE-627 ger DE-627 rakwb eng Lam, Lok-Ka verfasserin aut Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Chan, Thomas Sau Yan aut Hwang, Yu-Yan aut Mak, Lung-Yi aut Seto, Wai-Kay aut Kwong, Yok-Lam aut Yuen, Man-Fung aut Enthalten in Virology journal London : BioMed Central, 2004 20(2023), 1 vom: 01. Aug. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:20 year:2023 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12985-023-02140-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 01 08
allfields_unstemmed	10.1186/s12985-023-02140-w doi (DE-627)SPR052610071 (SPR)s12985-023-02140-w-e DE-627 ger DE-627 rakwb eng Lam, Lok-Ka verfasserin aut Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Chan, Thomas Sau Yan aut Hwang, Yu-Yan aut Mak, Lung-Yi aut Seto, Wai-Kay aut Kwong, Yok-Lam aut Yuen, Man-Fung aut Enthalten in Virology journal London : BioMed Central, 2004 20(2023), 1 vom: 01. Aug. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:20 year:2023 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12985-023-02140-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 01 08
allfieldsGer	10.1186/s12985-023-02140-w doi (DE-627)SPR052610071 (SPR)s12985-023-02140-w-e DE-627 ger DE-627 rakwb eng Lam, Lok-Ka verfasserin aut Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Chan, Thomas Sau Yan aut Hwang, Yu-Yan aut Mak, Lung-Yi aut Seto, Wai-Kay aut Kwong, Yok-Lam aut Yuen, Man-Fung aut Enthalten in Virology journal London : BioMed Central, 2004 20(2023), 1 vom: 01. Aug. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:20 year:2023 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12985-023-02140-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 01 08
allfieldsSound	10.1186/s12985-023-02140-w doi (DE-627)SPR052610071 (SPR)s12985-023-02140-w-e DE-627 ger DE-627 rakwb eng Lam, Lok-Ka verfasserin aut Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213 Chan, Thomas Sau Yan aut Hwang, Yu-Yan aut Mak, Lung-Yi aut Seto, Wai-Kay aut Kwong, Yok-Lam aut Yuen, Man-Fung aut Enthalten in Virology journal London : BioMed Central, 2004 20(2023), 1 vom: 01. Aug. (DE-627)394165004 (DE-600)2160640-7 1743-422X nnns volume:20 year:2023 number:1 day:01 month:08 https://dx.doi.org/10.1186/s12985-023-02140-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2023 1 01 08
language	English
source	Enthalten in Virology journal 20(2023), 1 vom: 01. Aug. volume:20 year:2023 number:1 day:01 month:08
sourceStr	Enthalten in Virology journal 20(2023), 1 vom: 01. Aug. volume:20 year:2023 number:1 day:01 month:08
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	HBV reactivation Ibrutinib B cell depletion Occult hepatitis B Case report
isfreeaccess_bool	true
container_title	Virology journal
authorswithroles_txt_mv	Lam, Lok-Ka @@aut@@ Chan, Thomas Sau Yan @@aut@@ Hwang, Yu-Yan @@aut@@ Mak, Lung-Yi @@aut@@ Seto, Wai-Kay @@aut@@ Kwong, Yok-Lam @@aut@@ Yuen, Man-Fung @@aut@@
publishDateDaySort_date	2023-08-01T00:00:00Z
hierarchy_top_id	394165004
id	SPR052610071
language_de	englisch
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author	Lam, Lok-Ka
spellingShingle	Lam, Lok-Ka misc HBV reactivation misc Ibrutinib misc B cell depletion misc Occult hepatitis B misc Case report Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
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topic_title	Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy HBV reactivation (dpeaa)DE-He213 Ibrutinib (dpeaa)DE-He213 B cell depletion (dpeaa)DE-He213 Occult hepatitis B (dpeaa)DE-He213 Case report (dpeaa)DE-He213
topic	misc HBV reactivation misc Ibrutinib misc B cell depletion misc Occult hepatitis B misc Case report
topic_unstemmed	misc HBV reactivation misc Ibrutinib misc B cell depletion misc Occult hepatitis B misc Case report
topic_browse	misc HBV reactivation misc Ibrutinib misc B cell depletion misc Occult hepatitis B misc Case report
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title	Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
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title_full	Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
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author_browse	Lam, Lok-Ka Chan, Thomas Sau Yan Hwang, Yu-Yan Mak, Lung-Yi Seto, Wai-Kay Kwong, Yok-Lam Yuen, Man-Fung
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author-letter	Lam, Lok-Ka
doi_str_mv	10.1186/s12985-023-02140-w
title_sort	hepatitis b virus reactivation in seronegative occult hepatitis b patient receiving ibrutinib therapy
title_auth	Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
abstract	Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. © The Author(s) 2023
abstractGer	Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. © The Author(s) 2023
abstract_unstemmed	Background Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients with chronic HBV infection or prior HBV exposure undergoing cytotoxic or immunosuppressive chemotherapy for hematologic malignancies. This phenomenon has been frequently reported with rituximab. However, published data on the risk of HBV reactivation induced by ibrutinib are scarce. Cases of HBV reactivation in hematologic patients receiving ibrutinib therapy have recently been described, but limited only to overt hepatitis B patients or seropositive occult hepatitis B patients. Case presentation We report the first case of HBV reactivation during ibrutinib treatment in an asymptomatic 82-year-old woman with seronegative occult hepatitis B patient (i.e., negative for HBsAg, anti-HBc and anti-HBs). Four months after ibrutinib treatment, her liver function test (LFT) was deranged, with seroconversion to HBsAg positivity. Serum hepatitis B virus DNA was quantified to be 1.92 × $ 10^{8} $ IU/ml. Antiviral treatment was initiated, and viral load was gradually suppressed with improvement in LFT. Conclusions Our case illustrated that in populations with a high incidence of HBV exposure, systematic screening for HBV exposure is essential prior to ibrutinib treatment, followed by serial monitoring of serologic and molecular markers of hepatitis B. There is a need for an international consensus to support the recommendation of antiviral prophylaxis against HBV reactivation in patients using ibrutinib. © The Author(s) 2023
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container_issue	1
title_short	Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
url	https://dx.doi.org/10.1186/s12985-023-02140-w
remote_bool	true
author2	Chan, Thomas Sau Yan Hwang, Yu-Yan Mak, Lung-Yi Seto, Wai-Kay Kwong, Yok-Lam Yuen, Man-Fung
author2Str	Chan, Thomas Sau Yan Hwang, Yu-Yan Mak, Lung-Yi Seto, Wai-Kay Kwong, Yok-Lam Yuen, Man-Fung
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up_date	2024-07-03T13:29:11.358Z
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Hepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy

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