Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection

Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, eff...
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Autor*in:	Jiang, Yuxing [verfasserIn] Rong, Hongtao Wang, Yifan Liu, Shange Xu, Peng Luo, Zhen Guo, Lamei Zhu, Tao Rong, Hongpan Wang, Dingsheng Zhang, Jiatao Yi, Yu Wang, Hao

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	single-atom catalysis spinal cord injury reactive oxygen and nitrogen species anti-inflammation neuroprotection

Anmerkung:	© Tsinghua University Press 2023

Übergeordnetes Werk:	Enthalten in: Nano research - [S.l.] : Tsinghua Press, 2008, 16(2023), 7 vom: 13. März, Seite 9752-9759
Übergeordnetes Werk:	volume:16 ; year:2023 ; number:7 ; day:13 ; month:03 ; pages:9752-9759

Links:	Volltext

DOI / URN:	10.1007/s12274-023-5588-z

Katalog-ID:	SPR052628302

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520			\|a Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model.
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912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
912			\|a GBV_ILN_170
912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
912			\|a GBV_ILN_370
912			\|a GBV_ILN_602
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912			\|a GBV_ILN_2038
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912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
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912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
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912			\|a GBV_ILN_2057
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912			\|a GBV_ILN_2064
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912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
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allfields	10.1007/s12274-023-5588-z doi (DE-627)SPR052628302 (SPR)s12274-023-5588-z-e DE-627 ger DE-627 rakwb eng Jiang, Yuxing verfasserin aut Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213 Rong, Hongtao aut Wang, Yifan aut Liu, Shange aut Xu, Peng aut Luo, Zhen aut Guo, Lamei aut Zhu, Tao aut Rong, Hongpan aut Wang, Dingsheng aut Zhang, Jiatao aut Yi, Yu aut Wang, Hao aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 16(2023), 7 vom: 13. März, Seite 9752-9759 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759 https://dx.doi.org/10.1007/s12274-023-5588-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 13 03 9752-9759
spelling	10.1007/s12274-023-5588-z doi (DE-627)SPR052628302 (SPR)s12274-023-5588-z-e DE-627 ger DE-627 rakwb eng Jiang, Yuxing verfasserin aut Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213 Rong, Hongtao aut Wang, Yifan aut Liu, Shange aut Xu, Peng aut Luo, Zhen aut Guo, Lamei aut Zhu, Tao aut Rong, Hongpan aut Wang, Dingsheng aut Zhang, Jiatao aut Yi, Yu aut Wang, Hao aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 16(2023), 7 vom: 13. März, Seite 9752-9759 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759 https://dx.doi.org/10.1007/s12274-023-5588-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 13 03 9752-9759
allfields_unstemmed	10.1007/s12274-023-5588-z doi (DE-627)SPR052628302 (SPR)s12274-023-5588-z-e DE-627 ger DE-627 rakwb eng Jiang, Yuxing verfasserin aut Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213 Rong, Hongtao aut Wang, Yifan aut Liu, Shange aut Xu, Peng aut Luo, Zhen aut Guo, Lamei aut Zhu, Tao aut Rong, Hongpan aut Wang, Dingsheng aut Zhang, Jiatao aut Yi, Yu aut Wang, Hao aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 16(2023), 7 vom: 13. März, Seite 9752-9759 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759 https://dx.doi.org/10.1007/s12274-023-5588-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 13 03 9752-9759
allfieldsGer	10.1007/s12274-023-5588-z doi (DE-627)SPR052628302 (SPR)s12274-023-5588-z-e DE-627 ger DE-627 rakwb eng Jiang, Yuxing verfasserin aut Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213 Rong, Hongtao aut Wang, Yifan aut Liu, Shange aut Xu, Peng aut Luo, Zhen aut Guo, Lamei aut Zhu, Tao aut Rong, Hongpan aut Wang, Dingsheng aut Zhang, Jiatao aut Yi, Yu aut Wang, Hao aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 16(2023), 7 vom: 13. März, Seite 9752-9759 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759 https://dx.doi.org/10.1007/s12274-023-5588-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 13 03 9752-9759
allfieldsSound	10.1007/s12274-023-5588-z doi (DE-627)SPR052628302 (SPR)s12274-023-5588-z-e DE-627 ger DE-627 rakwb eng Jiang, Yuxing verfasserin aut Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213 Rong, Hongtao aut Wang, Yifan aut Liu, Shange aut Xu, Peng aut Luo, Zhen aut Guo, Lamei aut Zhu, Tao aut Rong, Hongpan aut Wang, Dingsheng aut Zhang, Jiatao aut Yi, Yu aut Wang, Hao aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 16(2023), 7 vom: 13. März, Seite 9752-9759 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759 https://dx.doi.org/10.1007/s12274-023-5588-z lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 16 2023 7 13 03 9752-9759
language	English
source	Enthalten in Nano research 16(2023), 7 vom: 13. März, Seite 9752-9759 volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759
sourceStr	Enthalten in Nano research 16(2023), 7 vom: 13. März, Seite 9752-9759 volume:16 year:2023 number:7 day:13 month:03 pages:9752-9759
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	single-atom catalysis spinal cord injury reactive oxygen and nitrogen species anti-inflammation neuroprotection
isfreeaccess_bool	false
container_title	Nano research
authorswithroles_txt_mv	Jiang, Yuxing @@aut@@ Rong, Hongtao @@aut@@ Wang, Yifan @@aut@@ Liu, Shange @@aut@@ Xu, Peng @@aut@@ Luo, Zhen @@aut@@ Guo, Lamei @@aut@@ Zhu, Tao @@aut@@ Rong, Hongpan @@aut@@ Wang, Dingsheng @@aut@@ Zhang, Jiatao @@aut@@ Yi, Yu @@aut@@ Wang, Hao @@aut@@
publishDateDaySort_date	2023-03-13T00:00:00Z
hierarchy_top_id	57375361X
id	SPR052628302
language_de	englisch
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Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. 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author	Jiang, Yuxing
spellingShingle	Jiang, Yuxing misc single-atom catalysis misc spinal cord injury misc reactive oxygen and nitrogen species misc anti-inflammation misc neuroprotection Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
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topic_title	Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection single-atom catalysis (dpeaa)DE-He213 spinal cord injury (dpeaa)DE-He213 reactive oxygen and nitrogen species (dpeaa)DE-He213 anti-inflammation (dpeaa)DE-He213 neuroprotection (dpeaa)DE-He213
topic	misc single-atom catalysis misc spinal cord injury misc reactive oxygen and nitrogen species misc anti-inflammation misc neuroprotection
topic_unstemmed	misc single-atom catalysis misc spinal cord injury misc reactive oxygen and nitrogen species misc anti-inflammation misc neuroprotection
topic_browse	misc single-atom catalysis misc spinal cord injury misc reactive oxygen and nitrogen species misc anti-inflammation misc neuroprotection
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title	Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
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title_full	Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
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author_browse	Jiang, Yuxing Rong, Hongtao Wang, Yifan Liu, Shange Xu, Peng Luo, Zhen Guo, Lamei Zhu, Tao Rong, Hongpan Wang, Dingsheng Zhang, Jiatao Yi, Yu Wang, Hao
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title_sort	single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
title_auth	Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
abstract	Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. © Tsinghua University Press 2023
abstractGer	Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. © Tsinghua University Press 2023
abstract_unstemmed	Abstract Oxidative stress and inflammation are central pathophysiological processes in a traumatic spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. In vitro results showed that the Co-SAzyme reduced the apoptosis and pro-inflammatory cytokine levels of microglial cells under oxidative stress. In addition, the Co-SAzyme combined with minocycline achieved remarkable improved functional recovery and neural repairs in the SCI-rat model. © Tsinghua University Press 2023
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title_short	Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection
url	https://dx.doi.org/10.1007/s12274-023-5588-z
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author2	Rong, Hongtao Wang, Yifan Liu, Shange Xu, Peng Luo, Zhen Guo, Lamei Zhu, Tao Rong, Hongpan Wang, Dingsheng Zhang, Jiatao Yi, Yu Wang, Hao
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doi_str	10.1007/s12274-023-5588-z
up_date	2024-07-03T13:38:05.407Z
_version_	1803565279909773312
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Antioxidant therapies that reduce the reactive oxygen and nitrogen species (RONS) overgeneration and inflammation are proved promising for improving the outcomes. However, efficient and long-lasting antioxidant therapy to eliminate multiple RONS with effective neuroprotection remains challenging. Here, a single-atom cobalt nanozyme (Co-SAzyme) with a hollow structure was reported to reduce the RONS and inflammation in the secondary injury of SCI. Among SAzymes featuring different single metal-N sites (e.g., Mn, Fe, Co, Ni, and Cu), this Co-SAzyme showed a versatile property to eliminate hydrogen peroxide ($ H_{2} %$ O_{2} $), superoxide anion (O2·−), hydroxyl radical (·OH), nitric oxide (·NO), and peroxynitrite ($ ONOO^{−} $) that overexpressed in the early stage of SCI. The porous hollow structure also allowed the encapsulation and sustained release of minocycline for neuroprotection in synergy. 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Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection

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