Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times

Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jannusch, Kai [verfasserIn] Lindemann, Maike E. Bruckmann, Nils Martin Morawitz, Janna Dietzel, Frederic Pomykala, Kelsey L. Herrmann, Ken Bittner, Ann-Kathrin Hoffmann, Oliver Mohrmann, Svjetlana Umutlu, Lale Antoch, Gerald Quick, Harald H. Kirchner, Julian

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Female Breast cancer Positron emission tomography/magnetic resonance imaging

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: European radiology - Berlin : Springer, 1991, 33(2023), 9 vom: 12. Apr., Seite 6179-6188
Übergeordnetes Werk:	volume:33 ; year:2023 ; number:9 ; day:12 ; month:04 ; pages:6179-6188

Links:	Volltext

DOI / URN:	10.1007/s00330-023-09580-6

Katalog-ID:	SPR052692167

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100	1		\|a Jannusch, Kai \|e verfasserin \|0 (orcid)0000-0001-7285-3430 \|4 aut
245	1	0	\|a Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
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520			\|a Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI.
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700	1		\|a Lindemann, Maike E. \|4 aut
700	1		\|a Bruckmann, Nils Martin \|4 aut
700	1		\|a Morawitz, Janna \|4 aut
700	1		\|a Dietzel, Frederic \|4 aut
700	1		\|a Pomykala, Kelsey L. \|4 aut
700	1		\|a Herrmann, Ken \|4 aut
700	1		\|a Bittner, Ann-Kathrin \|4 aut
700	1		\|a Hoffmann, Oliver \|4 aut
700	1		\|a Mohrmann, Svjetlana \|4 aut
700	1		\|a Umutlu, Lale \|4 aut
700	1		\|a Antoch, Gerald \|4 aut
700	1		\|a Quick, Harald H. \|4 aut
700	1		\|a Kirchner, Julian \|4 aut
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publishDate	2023
allfields	10.1007/s00330-023-09580-6 doi (DE-627)SPR052692167 (SPR)s00330-023-09580-6-e DE-627 ger DE-627 rakwb eng Jannusch, Kai verfasserin (orcid)0000-0001-7285-3430 aut Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213 Lindemann, Maike E. aut Bruckmann, Nils Martin aut Morawitz, Janna aut Dietzel, Frederic aut Pomykala, Kelsey L. aut Herrmann, Ken aut Bittner, Ann-Kathrin aut Hoffmann, Oliver aut Mohrmann, Svjetlana aut Umutlu, Lale aut Antoch, Gerald aut Quick, Harald H. aut Kirchner, Julian aut Enthalten in European radiology Berlin : Springer, 1991 33(2023), 9 vom: 12. Apr., Seite 6179-6188 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188 https://dx.doi.org/10.1007/s00330-023-09580-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 9 12 04 6179-6188
spelling	10.1007/s00330-023-09580-6 doi (DE-627)SPR052692167 (SPR)s00330-023-09580-6-e DE-627 ger DE-627 rakwb eng Jannusch, Kai verfasserin (orcid)0000-0001-7285-3430 aut Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213 Lindemann, Maike E. aut Bruckmann, Nils Martin aut Morawitz, Janna aut Dietzel, Frederic aut Pomykala, Kelsey L. aut Herrmann, Ken aut Bittner, Ann-Kathrin aut Hoffmann, Oliver aut Mohrmann, Svjetlana aut Umutlu, Lale aut Antoch, Gerald aut Quick, Harald H. aut Kirchner, Julian aut Enthalten in European radiology Berlin : Springer, 1991 33(2023), 9 vom: 12. Apr., Seite 6179-6188 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188 https://dx.doi.org/10.1007/s00330-023-09580-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 9 12 04 6179-6188
allfields_unstemmed	10.1007/s00330-023-09580-6 doi (DE-627)SPR052692167 (SPR)s00330-023-09580-6-e DE-627 ger DE-627 rakwb eng Jannusch, Kai verfasserin (orcid)0000-0001-7285-3430 aut Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213 Lindemann, Maike E. aut Bruckmann, Nils Martin aut Morawitz, Janna aut Dietzel, Frederic aut Pomykala, Kelsey L. aut Herrmann, Ken aut Bittner, Ann-Kathrin aut Hoffmann, Oliver aut Mohrmann, Svjetlana aut Umutlu, Lale aut Antoch, Gerald aut Quick, Harald H. aut Kirchner, Julian aut Enthalten in European radiology Berlin : Springer, 1991 33(2023), 9 vom: 12. Apr., Seite 6179-6188 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188 https://dx.doi.org/10.1007/s00330-023-09580-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 9 12 04 6179-6188
allfieldsGer	10.1007/s00330-023-09580-6 doi (DE-627)SPR052692167 (SPR)s00330-023-09580-6-e DE-627 ger DE-627 rakwb eng Jannusch, Kai verfasserin (orcid)0000-0001-7285-3430 aut Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213 Lindemann, Maike E. aut Bruckmann, Nils Martin aut Morawitz, Janna aut Dietzel, Frederic aut Pomykala, Kelsey L. aut Herrmann, Ken aut Bittner, Ann-Kathrin aut Hoffmann, Oliver aut Mohrmann, Svjetlana aut Umutlu, Lale aut Antoch, Gerald aut Quick, Harald H. aut Kirchner, Julian aut Enthalten in European radiology Berlin : Springer, 1991 33(2023), 9 vom: 12. Apr., Seite 6179-6188 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188 https://dx.doi.org/10.1007/s00330-023-09580-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 9 12 04 6179-6188
allfieldsSound	10.1007/s00330-023-09580-6 doi (DE-627)SPR052692167 (SPR)s00330-023-09580-6-e DE-627 ger DE-627 rakwb eng Jannusch, Kai verfasserin (orcid)0000-0001-7285-3430 aut Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213 Lindemann, Maike E. aut Bruckmann, Nils Martin aut Morawitz, Janna aut Dietzel, Frederic aut Pomykala, Kelsey L. aut Herrmann, Ken aut Bittner, Ann-Kathrin aut Hoffmann, Oliver aut Mohrmann, Svjetlana aut Umutlu, Lale aut Antoch, Gerald aut Quick, Harald H. aut Kirchner, Julian aut Enthalten in European radiology Berlin : Springer, 1991 33(2023), 9 vom: 12. Apr., Seite 6179-6188 (DE-627)268757526 (DE-600)1472718-3 1432-1084 nnns volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188 https://dx.doi.org/10.1007/s00330-023-09580-6 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 33 2023 9 12 04 6179-6188
language	English
source	Enthalten in European radiology 33(2023), 9 vom: 12. Apr., Seite 6179-6188 volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188
sourceStr	Enthalten in European radiology 33(2023), 9 vom: 12. Apr., Seite 6179-6188 volume:33 year:2023 number:9 day:12 month:04 pages:6179-6188
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Female Breast cancer Positron emission tomography/magnetic resonance imaging
isfreeaccess_bool	true
container_title	European radiology
authorswithroles_txt_mv	Jannusch, Kai @@aut@@ Lindemann, Maike E. @@aut@@ Bruckmann, Nils Martin @@aut@@ Morawitz, Janna @@aut@@ Dietzel, Frederic @@aut@@ Pomykala, Kelsey L. @@aut@@ Herrmann, Ken @@aut@@ Bittner, Ann-Kathrin @@aut@@ Hoffmann, Oliver @@aut@@ Mohrmann, Svjetlana @@aut@@ Umutlu, Lale @@aut@@ Antoch, Gerald @@aut@@ Quick, Harald H. @@aut@@ Kirchner, Julian @@aut@@
publishDateDaySort_date	2023-04-12T00:00:00Z
hierarchy_top_id	268757526
id	SPR052692167
language_de	englisch
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Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Female</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Breast cancer</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Positron emission tomography/magnetic resonance imaging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lindemann, Maike E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bruckmann, Nils Martin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Morawitz, Janna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dietzel, Frederic</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pomykala, Kelsey L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Herrmann, Ken</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bittner, Ann-Kathrin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hoffmann, Oliver</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mohrmann, Svjetlana</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Umutlu, Lale</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Antoch, Gerald</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Quick, Harald H.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kirchner, Julian</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">European radiology</subfield><subfield code="d">Berlin : Springer, 1991</subfield><subfield code="g">33(2023), 9 vom: 12. 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author	Jannusch, Kai
spellingShingle	Jannusch, Kai misc Female misc Breast cancer misc Positron emission tomography/magnetic resonance imaging Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
authorStr	Jannusch, Kai
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topic_title	Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times Female (dpeaa)DE-He213 Breast cancer (dpeaa)DE-He213 Positron emission tomography/magnetic resonance imaging (dpeaa)DE-He213
topic	misc Female misc Breast cancer misc Positron emission tomography/magnetic resonance imaging
topic_unstemmed	misc Female misc Breast cancer misc Positron emission tomography/magnetic resonance imaging
topic_browse	misc Female misc Breast cancer misc Positron emission tomography/magnetic resonance imaging
format_facet	Elektronische Aufsätze Aufsätze Elektronische Ressource
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title	Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
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title_full	Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
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author_browse	Jannusch, Kai Lindemann, Maike E. Bruckmann, Nils Martin Morawitz, Janna Dietzel, Frederic Pomykala, Kelsey L. Herrmann, Ken Bittner, Ann-Kathrin Hoffmann, Oliver Mohrmann, Svjetlana Umutlu, Lale Antoch, Gerald Quick, Harald H. Kirchner, Julian
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author-letter	Jannusch, Kai
doi_str_mv	10.1007/s00330-023-09580-6
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title_sort	towards a fast pet/mri protocol for breast cancer imaging: maintaining diagnostic confidence while reducing pet and mri acquisition times
title_auth	Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
abstract	Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. © The Author(s) 2023
abstractGer	Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. © The Author(s) 2023
abstract_unstemmed	Objectives To investigate the diagnostic feasibility of a shortened breast PET/MRI protocol in breast cancer patients. Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. Results In all PET reconstructions, 127 congruent breast lesions could be detected. Group comparison and $ T1_{ts} $ vs. $ T2_{ts} $ subgroup comparison revealed no significant difference of subjective image quality between 20, 15, 10, and 5 min acquisition times. SNR of qualitative image evaluation revealed no significant difference between different PET acquisition times. A slight but significant increase of IN with decreasing PET acquisition times could be detected. Lesion $ SUV_{max} $ group comparison between all PET acquisition times revealed no significant differences. Lesion-based evaluation revealed no significant difference in breast lesion detectability between original and fast breast MRI protocols. Conclusions Breast [18F]FDG-PET/MRI protocols can be shortened from 20 to below 10 min without losing essential diagnostic information. Key Points • A highly accurate breast cancer evaluation is possible by the shortened breast [18F]FDG-PET/MRI examination protocol. • Significant time saving at breast [18F]FDG-PET/MRI protocol could increase patient satisfaction and patient throughput for breast cancer patients at PET/MRI. © The Author(s) 2023
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container_issue	9
title_short	Towards a fast PET/MRI protocol for breast cancer imaging: maintaining diagnostic confidence while reducing PET and MRI acquisition times
url	https://dx.doi.org/10.1007/s00330-023-09580-6
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author2	Lindemann, Maike E. Bruckmann, Nils Martin Morawitz, Janna Dietzel, Frederic Pomykala, Kelsey L. Herrmann, Ken Bittner, Ann-Kathrin Hoffmann, Oliver Mohrmann, Svjetlana Umutlu, Lale Antoch, Gerald Quick, Harald H. Kirchner, Julian
author2Str	Lindemann, Maike E. Bruckmann, Nils Martin Morawitz, Janna Dietzel, Frederic Pomykala, Kelsey L. Herrmann, Ken Bittner, Ann-Kathrin Hoffmann, Oliver Mohrmann, Svjetlana Umutlu, Lale Antoch, Gerald Quick, Harald H. Kirchner, Julian
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doi_str	10.1007/s00330-023-09580-6
up_date	2024-07-03T14:06:20.107Z
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Methods Altogether 90 women with newly diagnosed $ T1_{tumor-staged} $ ($ T1_{ts} $) and $ T2_{tumor-staged} $ ($ T2_{ts} $) breast cancer were included in this retrospective study. All underwent a dedicated comprehensive breast [18F]FDG-PET/MRI. List-mode PET data were retrospectively reconstructed with 20, 15, 10, and 5 min for each patient to simulate the effect of reduced PET acquisition times. The $ SUV_{max/mean} $ of all malign breast lesions was measured. Furthermore, breast PET data reconstructions were analyzed regarding image quality, lesion detectability, signal-to-noise ratio (SNR), and image noise (IN). The simultaneously acquired comprehensive MRI protocol was then shortened by retrospectively removing sequences from the protocol. Differences in malignant breast lesion detectability between the original and the fast breast MRI protocol were evaluated lesion-based. The 20-min PET reconstructions and the original MRI protocol served as reference. 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