Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice
Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Musa, Aminu [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2022 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 |
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| Übergeordnetes Werk: |
Enthalten in: Oriental pharmacy and experimental medicine - Dordrecht : Springer, 2011, 23(2022), 3 vom: 27. Apr., Seite 803-818 |
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| Übergeordnetes Werk: |
volume:23 ; year:2022 ; number:3 ; day:27 ; month:04 ; pages:803-818 |
| Links: |
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| DOI / URN: |
10.1007/s13596-022-00644-4 |
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SPR052917436 |
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| 245 | 1 | 0 | |a Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice |
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| 520 | |a Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. | ||
| 650 | 4 | |a Analgesic activity |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Opioidergic pathway |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Ahmad, Mubarak Hussaini |0 (orcid)0000-0003-1721-5481 |4 aut | |
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10.1007/s13596-022-00644-4 doi (DE-627)SPR052917436 (SPR)s13596-022-00644-4-e DE-627 ger DE-627 rakwb eng Musa, Aminu verfasserin aut Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 Maje, Idris aut Chindo, Ben aut Ahmad, Mubarak Hussaini (orcid)0000-0003-1721-5481 aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 23(2022), 3 vom: 27. Apr., Seite 803-818 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:23 year:2022 number:3 day:27 month:04 pages:803-818 https://dx.doi.org/10.1007/s13596-022-00644-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 23 2022 3 27 04 803-818 |
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10.1007/s13596-022-00644-4 doi (DE-627)SPR052917436 (SPR)s13596-022-00644-4-e DE-627 ger DE-627 rakwb eng Musa, Aminu verfasserin aut Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 Maje, Idris aut Chindo, Ben aut Ahmad, Mubarak Hussaini (orcid)0000-0003-1721-5481 aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 23(2022), 3 vom: 27. Apr., Seite 803-818 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:23 year:2022 number:3 day:27 month:04 pages:803-818 https://dx.doi.org/10.1007/s13596-022-00644-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 23 2022 3 27 04 803-818 |
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10.1007/s13596-022-00644-4 doi (DE-627)SPR052917436 (SPR)s13596-022-00644-4-e DE-627 ger DE-627 rakwb eng Musa, Aminu verfasserin aut Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 Maje, Idris aut Chindo, Ben aut Ahmad, Mubarak Hussaini (orcid)0000-0003-1721-5481 aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 23(2022), 3 vom: 27. Apr., Seite 803-818 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:23 year:2022 number:3 day:27 month:04 pages:803-818 https://dx.doi.org/10.1007/s13596-022-00644-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 23 2022 3 27 04 803-818 |
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10.1007/s13596-022-00644-4 doi (DE-627)SPR052917436 (SPR)s13596-022-00644-4-e DE-627 ger DE-627 rakwb eng Musa, Aminu verfasserin aut Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 Maje, Idris aut Chindo, Ben aut Ahmad, Mubarak Hussaini (orcid)0000-0003-1721-5481 aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 23(2022), 3 vom: 27. Apr., Seite 803-818 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:23 year:2022 number:3 day:27 month:04 pages:803-818 https://dx.doi.org/10.1007/s13596-022-00644-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 23 2022 3 27 04 803-818 |
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10.1007/s13596-022-00644-4 doi (DE-627)SPR052917436 (SPR)s13596-022-00644-4-e DE-627 ger DE-627 rakwb eng Musa, Aminu verfasserin aut Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 Maje, Idris aut Chindo, Ben aut Ahmad, Mubarak Hussaini (orcid)0000-0003-1721-5481 aut Enthalten in Oriental pharmacy and experimental medicine Dordrecht : Springer, 2011 23(2022), 3 vom: 27. Apr., Seite 803-818 (DE-627)689127340 (DE-600)2655275-9 2211-1069 nnns volume:23 year:2022 number:3 day:27 month:04 pages:803-818 https://dx.doi.org/10.1007/s13596-022-00644-4 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 23 2022 3 27 04 803-818 |
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The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. 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Musa, Aminu misc Analgesic activity misc Opioidergic pathway misc Serotonergic pathway misc Adrenergic pathway misc Anti-nociceptive mechanisms Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice |
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Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice Analgesic activity (dpeaa)DE-He213 Opioidergic pathway (dpeaa)DE-He213 Serotonergic pathway (dpeaa)DE-He213 Adrenergic pathway (dpeaa)DE-He213 Anti-nociceptive mechanisms (dpeaa)DE-He213 |
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potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of tapinanthus globiferus a. rich (loranthaceae) in mice |
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Potential involvement of opioidergic, α1-adrenergic and serotonergic pathways in the anti-nociceptive actions of Tapinanthus globiferus A. Rich (Loranthaceae) in mice |
| abstract |
Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 |
| abstractGer |
Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 |
| abstract_unstemmed |
Abstract The plant Tapinanthus globiferus has gained ethnomedicinal values to manage pain, rheumatism and cancer. The current experiment investigated the anti-nociceptive action of the ethanol extract of the plant T. globiferus (EETG) and its possible mechanisms of action. Phytochemical studies and oral median lethal dose ($ LD_{50} $) determination were conducted as per standard experimental protocols. The anti-nociceptive properties of the EETG (250, 500 and 1,000 mg/kg) were checked against acetic acid-elicited writhing, hot plate and formalin-produced pain models in mice. To establish the potential pathways of analgesic effects of the EETG, the animals were pre-administered with naloxone (2 mg/kg, i.p), prazosin (1 mg/kg, i.p), yohimbine (1 mg/kg, i.p), propranolol (20 mg/kg, i.p), metergoline (2 mg/kg, i.p), and glibenclamide (5 mg/kg, i.p) 30 min before the EETG (500 mg/kg) administration. The phytochemical results revealed flavonoids, cardiac glycosides, phenols, steroids, saponins, tannins and triterpenes. The oral $ LD_{50} $ was above 5,000 mg/kg in mice. The EETG effectively (P < 0.001) reduced the acetic acid-produced writhes independent of dose. Besides, it significantly (P < 0.05, P < 0.01 and P < 0.001) increased the pain latency in the thermally induced pain at 30, 60, and 120 min. The EETG at 500 mg/kg efficiently (P < 0.05) declined the second stage of formalin-caused pain response in comparison to the control animals. The pre-administration of the naloxone, prazosin and metergoline to the mice reversed the anti-nociceptive effect elicited by the EETG in the formalin-produced pain in the second stage. The experimental outcomes have revealed that the plant Tapinanthus globiferus possesses analgesic activity which could be related to the opioidergic, α1-adrenergic and serotonergic pathways. © The Author(s), under exclusive licence to Institute of Korean Medicine, Kyung Hee University 2022 |
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