The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation
Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee...
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| Autor*in: |
Yong, Poi Yi Aw [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: BMC complementary and alternative medicine - London : BioMed Central, 2001, 23(2023), 1 vom: 04. Sept. |
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| Übergeordnetes Werk: |
volume:23 ; year:2023 ; number:1 ; day:04 ; month:09 |
| Links: |
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| DOI / URN: |
10.1186/s12906-023-04129-y |
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SPR052981371 |
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| 245 | 1 | 4 | |a The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation |
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| 520 | |a Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. | ||
| 650 | 4 | |a Stingless bee honey |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Kelulut honey |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Botanical sources |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-allergic |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Anti-inflammation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Human mast cells |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a PMACI |7 (dpeaa)DE-He213 | |
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| 700 | 1 | |a Yip, Ashley Jia Wen |4 aut | |
| 700 | 1 | |a Islam, Fahmida |4 aut | |
| 700 | 1 | |a Hong, Hui Jing |4 aut | |
| 700 | 1 | |a Teh, Yi En |4 aut | |
| 700 | 1 | |a Tham, Chau Ling |4 aut | |
| 700 | 1 | |a Tan, Ji Wei |4 aut | |
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10.1186/s12906-023-04129-y doi (DE-627)SPR052981371 (SPR)s12906-023-04129-y-e DE-627 ger DE-627 rakwb eng Yong, Poi Yi Aw verfasserin aut The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 Yip, Ashley Jia Wen aut Islam, Fahmida aut Hong, Hui Jing aut Teh, Yi En aut Tham, Chau Ling aut Tan, Ji Wei aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 23(2023), 1 vom: 04. Sept. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:23 year:2023 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12906-023-04129-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2023 1 04 09 |
| spelling |
10.1186/s12906-023-04129-y doi (DE-627)SPR052981371 (SPR)s12906-023-04129-y-e DE-627 ger DE-627 rakwb eng Yong, Poi Yi Aw verfasserin aut The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 Yip, Ashley Jia Wen aut Islam, Fahmida aut Hong, Hui Jing aut Teh, Yi En aut Tham, Chau Ling aut Tan, Ji Wei aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 23(2023), 1 vom: 04. Sept. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:23 year:2023 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12906-023-04129-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2023 1 04 09 |
| allfields_unstemmed |
10.1186/s12906-023-04129-y doi (DE-627)SPR052981371 (SPR)s12906-023-04129-y-e DE-627 ger DE-627 rakwb eng Yong, Poi Yi Aw verfasserin aut The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 Yip, Ashley Jia Wen aut Islam, Fahmida aut Hong, Hui Jing aut Teh, Yi En aut Tham, Chau Ling aut Tan, Ji Wei aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 23(2023), 1 vom: 04. Sept. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:23 year:2023 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12906-023-04129-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2023 1 04 09 |
| allfieldsGer |
10.1186/s12906-023-04129-y doi (DE-627)SPR052981371 (SPR)s12906-023-04129-y-e DE-627 ger DE-627 rakwb eng Yong, Poi Yi Aw verfasserin aut The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 Yip, Ashley Jia Wen aut Islam, Fahmida aut Hong, Hui Jing aut Teh, Yi En aut Tham, Chau Ling aut Tan, Ji Wei aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 23(2023), 1 vom: 04. Sept. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:23 year:2023 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12906-023-04129-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2023 1 04 09 |
| allfieldsSound |
10.1186/s12906-023-04129-y doi (DE-627)SPR052981371 (SPR)s12906-023-04129-y-e DE-627 ger DE-627 rakwb eng Yong, Poi Yi Aw verfasserin aut The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 Yip, Ashley Jia Wen aut Islam, Fahmida aut Hong, Hui Jing aut Teh, Yi En aut Tham, Chau Ling aut Tan, Ji Wei aut Enthalten in BMC complementary and alternative medicine London : BioMed Central, 2001 23(2023), 1 vom: 04. Sept. (DE-627)331018713 (DE-600)2050429-9 1472-6882 nnns volume:23 year:2023 number:1 day:04 month:09 https://dx.doi.org/10.1186/s12906-023-04129-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 23 2023 1 04 09 |
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The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. 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Yong, Poi Yi Aw misc Stingless bee honey misc Kelulut honey misc Botanical sources misc Anti-allergic misc Anti-inflammation misc Human mast cells misc PMACI misc Polyphenols misc In silico The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation |
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The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation Stingless bee honey (dpeaa)DE-He213 Kelulut honey (dpeaa)DE-He213 Botanical sources (dpeaa)DE-He213 Anti-allergic (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 Human mast cells (dpeaa)DE-He213 PMACI (dpeaa)DE-He213 Polyphenols (dpeaa)DE-He213 In silico (dpeaa)DE-He213 |
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anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation |
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The anti-allergic potential of stingless bee honey from different botanical sources via modulation of mast cell degranulation |
| abstract |
Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. © The Author(s) 2023 |
| abstractGer |
Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. © The Author(s) 2023 |
| abstract_unstemmed |
Background Allergy is an inflammatory disorder affecting around 20% of the global population. The adverse effects of current conventional treatments give rise to the increased popularity of using natural food products as complementary and alternative medicine against allergic diseases. Stingless bee honey, commonly known as Kelulut honey (KH) in Malaysia, has been used locally as a traditional remedy to relieve cough and asthma. This study evaluated the anti-allergic potential of KH collected from four different botanical sources on phorbol ester 12-myristate-3-acetate and calcium ionophore-activated human mast cells. Methods The present study examined the inhibitory effects of all collected honey on the release of selected inflammatory mediators, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-4, IL-6, IL-8, histamine, and β-hexosaminidase in an activated HMC. Besides that, all honey's total phenolic content (TPC) was also examined, followed by using liquid chromatography with tandem mass spectrometry (LC–MS/MS) to identify the phytochemicals in the honey. Further examination of the identified phytochemicals on their potential interaction with selected signaling molecules in an activated mast cell was conducted using computational methods. Results The results indicated that there were significant inhibitory effects on all selected inflammatory mediators’ release by KH sourced from bamboo (BH) and rubber tree (RH) at 0.5% and 1%, but not KH sourced from mango (AH) and noni (EH). BH and RH were found to have higher TPC values and were rich in their phytochemical profiles based on the LC–MS/MS results. Computational studies were employed to determine the possible molecular target of KH through molecular docking using HADDOCK and PRODIGY web servers. Conclusions In short, the results indicated that KH possesses anti-allergic effects towards an activated HMC, possibly by targeting downstream MAPKs. However, their anti-allergic effects may vary according to their botanical sources. Nevertheless, the present study has provided insight into the potential application of stingless bee honey as a complementary and alternative medicine to treat various allergic diseases. © The Author(s) 2023 |
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