The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort
Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study inclu...
Ausführliche Beschreibung
Autor*in: |
Plusquin, Michelle [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2023 |
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Übergeordnetes Werk: |
Enthalten in: Environmental health - London : BioMed Central, 2002, 22(2023), 1 vom: 07. Sept. |
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Übergeordnetes Werk: |
volume:22 ; year:2023 ; number:1 ; day:07 ; month:09 |
Links: |
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DOI / URN: |
10.1186/s12940-023-01010-w |
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Katalog-ID: |
SPR053002210 |
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245 | 1 | 4 | |a The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort |
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520 | |a Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. | ||
520 | |a Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. | ||
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700 | 1 | |a Fiers, Tom |4 aut | |
700 | 1 | |a T’Sjoen, Guy |4 aut | |
700 | 1 | |a Nawrot, Tim S. |4 aut | |
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10.1186/s12940-023-01010-w doi (DE-627)SPR053002210 (SPR)s12940-023-01010-w-e DE-627 ger DE-627 rakwb eng Plusquin, Michelle verfasserin aut The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 Wang, Congrong aut Cosemans, Charlotte aut Roels, Harry A. aut Vangeneugden, Maartje aut Lapauw, Bruno aut Fiers, Tom aut T’Sjoen, Guy aut Nawrot, Tim S. aut Enthalten in Environmental health London : BioMed Central, 2002 22(2023), 1 vom: 07. Sept. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:22 year:2023 number:1 day:07 month:09 https://dx.doi.org/10.1186/s12940-023-01010-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 07 09 |
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10.1186/s12940-023-01010-w doi (DE-627)SPR053002210 (SPR)s12940-023-01010-w-e DE-627 ger DE-627 rakwb eng Plusquin, Michelle verfasserin aut The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 Wang, Congrong aut Cosemans, Charlotte aut Roels, Harry A. aut Vangeneugden, Maartje aut Lapauw, Bruno aut Fiers, Tom aut T’Sjoen, Guy aut Nawrot, Tim S. aut Enthalten in Environmental health London : BioMed Central, 2002 22(2023), 1 vom: 07. Sept. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:22 year:2023 number:1 day:07 month:09 https://dx.doi.org/10.1186/s12940-023-01010-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 07 09 |
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10.1186/s12940-023-01010-w doi (DE-627)SPR053002210 (SPR)s12940-023-01010-w-e DE-627 ger DE-627 rakwb eng Plusquin, Michelle verfasserin aut The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 Wang, Congrong aut Cosemans, Charlotte aut Roels, Harry A. aut Vangeneugden, Maartje aut Lapauw, Bruno aut Fiers, Tom aut T’Sjoen, Guy aut Nawrot, Tim S. aut Enthalten in Environmental health London : BioMed Central, 2002 22(2023), 1 vom: 07. Sept. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:22 year:2023 number:1 day:07 month:09 https://dx.doi.org/10.1186/s12940-023-01010-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 07 09 |
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10.1186/s12940-023-01010-w doi (DE-627)SPR053002210 (SPR)s12940-023-01010-w-e DE-627 ger DE-627 rakwb eng Plusquin, Michelle verfasserin aut The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 Wang, Congrong aut Cosemans, Charlotte aut Roels, Harry A. aut Vangeneugden, Maartje aut Lapauw, Bruno aut Fiers, Tom aut T’Sjoen, Guy aut Nawrot, Tim S. aut Enthalten in Environmental health London : BioMed Central, 2002 22(2023), 1 vom: 07. Sept. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:22 year:2023 number:1 day:07 month:09 https://dx.doi.org/10.1186/s12940-023-01010-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 07 09 |
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10.1186/s12940-023-01010-w doi (DE-627)SPR053002210 (SPR)s12940-023-01010-w-e DE-627 ger DE-627 rakwb eng Plusquin, Michelle verfasserin aut The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 Wang, Congrong aut Cosemans, Charlotte aut Roels, Harry A. aut Vangeneugden, Maartje aut Lapauw, Bruno aut Fiers, Tom aut T’Sjoen, Guy aut Nawrot, Tim S. aut Enthalten in Environmental health London : BioMed Central, 2002 22(2023), 1 vom: 07. Sept. (DE-627)355849550 (DE-600)2092232-2 1476-069X nnns volume:22 year:2023 number:1 day:07 month:09 https://dx.doi.org/10.1186/s12940-023-01010-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 22 2023 1 07 09 |
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Enthalten in Environmental health 22(2023), 1 vom: 07. Sept. volume:22 year:2023 number:1 day:07 month:09 |
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Steroid Cord blood Air pollution Particulate matter Black carbon ENVIR AGE BKMR-DLM |
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Plusquin, Michelle @@aut@@ Wang, Congrong @@aut@@ Cosemans, Charlotte @@aut@@ Roels, Harry A. @@aut@@ Vangeneugden, Maartje @@aut@@ Lapauw, Bruno @@aut@@ Fiers, Tom @@aut@@ T’Sjoen, Guy @@aut@@ Nawrot, Tim S. @@aut@@ |
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Plusquin, Michelle misc Steroid misc Cord blood misc Air pollution misc Particulate matter misc Black carbon misc ENVIR misc AGE misc BKMR-DLM The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort |
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The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort Steroid (dpeaa)DE-He213 Cord blood (dpeaa)DE-He213 Air pollution (dpeaa)DE-He213 Particulate matter (dpeaa)DE-He213 Black carbon (dpeaa)DE-He213 ENVIR (dpeaa)DE-He213 AGE (dpeaa)DE-He213 BKMR-DLM (dpeaa)DE-He213 |
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The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort |
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Plusquin, Michelle Wang, Congrong Cosemans, Charlotte Roels, Harry A. Vangeneugden, Maartje Lapauw, Bruno Fiers, Tom T’Sjoen, Guy Nawrot, Tim S. |
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association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the environage birth cohort |
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The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort |
abstract |
Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. © The Author(s) 2023 |
abstractGer |
Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. © The Author(s) 2023 |
abstract_unstemmed |
Abstract Knowledge of whether prenatal exposure to ambient air pollution disrupts steroidogenesis is currently lacking. We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure. Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood. © The Author(s) 2023 |
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The association between newborn cord blood steroids and ambient prenatal exposure to air pollution: findings from the ENVIRONAGE birth cohort |
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We investigated the association between prenatal ambient air pollution and highly accurate measurements of cord blood steroid hormones from the androgenic pathway. This study included 397 newborns born between the years 2010 and 2015 from the ENVIRONAGE cohort in Belgium of whom six cord blood steroid levels were measured: 17α-hydroxypregnenolone, 17α-hydroxyprogesterone, dehydroepiandrosterone, pregnenolone, androstenedione, and testosterone. Maternal ambient exposure to $ PM_{2.5} $ (particles with aerodynamic diameter ≤ 2.5 μm), $ NO_{2,} $ and black carbon (BC) were estimated daily during the entire pregnancy using a high-resolution spatiotemporal model. The associations between the cord blood steroids and the air pollutants were tested and estimated by first fitting linear regression models and followed by fitting weekly prenatal exposures to distributed lag models (DLM). These analyses accounted for possible confounders, coexposures, and an interaction effect between sex and the exposure. We examined mixture effects and critical exposure windows of $ PM_{2.5} $, $ NO_{2} $ and BC on cord blood steroids via the Bayesian kernel machine regression distributed lag model (BKMR-DLM). An interquartile range (IQR) increment of 7.96 µg/$ m^{3} $ in $ PM_{2.5} $ exposure during pregnancy trimester 3 was associated with an increase of 23.01% (99% confidence interval: 3.26–46.54%) in cord blood levels of 17α-hydroxypregnenolone, and an IQR increment of 0.58 µg/m³ in BC exposure during trimester 1 was associated with a decrease of 11.00% (99% CI: -19.86 to -0.012%) in cord blood levels of androstenedione. For these two models, the DLM statistics identified sensitive gestational time windows for cord blood steroids and ambient air pollution exposures, in particular for 17α-hydroxypregnenolone and $ PM_{2.5} $ exposure during trimester 3 (weeks 28–36) and for androsterone and BC exposure during early pregnancy (weeks 2–13) as well as during mid-pregnancy (weeks 18–26). We identified interaction effects between pollutants, which has been suggested especially for $ NO_{2} $. Our results suggest that prenatal exposure to ambient air pollutants during pregnancy interferes with steroid levels in cord blood. Further studies should investigate potential early-life action mechanisms and possible later-in-life adverse effects of hormonal disturbances due to air pollution exposure.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Highlights $ PM_{2.5} $ exposure during trimester 3 is positively associated with cord blood 17α-hydroxypregnenolone. Black carbon exposure during pregnancy is negatively associated with cord blood androstenedione. Air pollutants during pregnancy interfere with in utero steroid levels in cord blood.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Steroid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cord blood</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Air pollution</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Particulate matter</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Black carbon</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">ENVIR</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">AGE</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">BKMR-DLM</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wang, Congrong</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cosemans, Charlotte</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Roels, Harry A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vangeneugden, Maartje</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lapauw, Bruno</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fiers, Tom</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">T’Sjoen, Guy</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nawrot, Tim S.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Environmental health</subfield><subfield code="d">London : BioMed Central, 2002</subfield><subfield code="g">22(2023), 1 vom: 07. 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