Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms
Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tri...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Yue [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© Science China Press 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Science in China - Asheville, NC : Science in China Press, 1995, 66(2023), 9 vom: 31. Juli, Seite 2645-2653 |
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| Übergeordnetes Werk: |
volume:66 ; year:2023 ; number:9 ; day:31 ; month:07 ; pages:2645-2653 |
| Links: |
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| DOI / URN: |
10.1007/s11426-023-1696-5 |
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SPR053037731 |
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| 520 | |a Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. | ||
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| 700 | 1 | |a Zhang, Pingyu |4 aut | |
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10.1007/s11426-023-1696-5 doi (DE-627)SPR053037731 (SPR)s11426-023-1696-5-e DE-627 ger DE-627 rakwb eng Li, Yue verfasserin aut Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Science China Press 2023 Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. sonodynamic therapy (dpeaa)DE-He213 gas therapy (dpeaa)DE-He213 antimycobacteria (dpeaa)DE-He213 metals in drug (dpeaa)DE-He213 bioinorganic chemistry (dpeaa)DE-He213 Wang, Haobing aut Lin, Qitian aut Yu, Xinyu aut Huang, Huaiyi aut Zhang, Pingyu aut Enthalten in Science in China Asheville, NC : Science in China Press, 1995 66(2023), 9 vom: 31. Juli, Seite 2645-2653 (DE-627)327310405 (DE-600)2043454-6 1862-2771 nnns volume:66 year:2023 number:9 day:31 month:07 pages:2645-2653 https://dx.doi.org/10.1007/s11426-023-1696-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 66 2023 9 31 07 2645-2653 |
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10.1007/s11426-023-1696-5 doi (DE-627)SPR053037731 (SPR)s11426-023-1696-5-e DE-627 ger DE-627 rakwb eng Li, Yue verfasserin aut Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Science China Press 2023 Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. sonodynamic therapy (dpeaa)DE-He213 gas therapy (dpeaa)DE-He213 antimycobacteria (dpeaa)DE-He213 metals in drug (dpeaa)DE-He213 bioinorganic chemistry (dpeaa)DE-He213 Wang, Haobing aut Lin, Qitian aut Yu, Xinyu aut Huang, Huaiyi aut Zhang, Pingyu aut Enthalten in Science in China Asheville, NC : Science in China Press, 1995 66(2023), 9 vom: 31. Juli, Seite 2645-2653 (DE-627)327310405 (DE-600)2043454-6 1862-2771 nnns volume:66 year:2023 number:9 day:31 month:07 pages:2645-2653 https://dx.doi.org/10.1007/s11426-023-1696-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 66 2023 9 31 07 2645-2653 |
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10.1007/s11426-023-1696-5 doi (DE-627)SPR053037731 (SPR)s11426-023-1696-5-e DE-627 ger DE-627 rakwb eng Li, Yue verfasserin aut Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Science China Press 2023 Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. sonodynamic therapy (dpeaa)DE-He213 gas therapy (dpeaa)DE-He213 antimycobacteria (dpeaa)DE-He213 metals in drug (dpeaa)DE-He213 bioinorganic chemistry (dpeaa)DE-He213 Wang, Haobing aut Lin, Qitian aut Yu, Xinyu aut Huang, Huaiyi aut Zhang, Pingyu aut Enthalten in Science in China Asheville, NC : Science in China Press, 1995 66(2023), 9 vom: 31. Juli, Seite 2645-2653 (DE-627)327310405 (DE-600)2043454-6 1862-2771 nnns volume:66 year:2023 number:9 day:31 month:07 pages:2645-2653 https://dx.doi.org/10.1007/s11426-023-1696-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 66 2023 9 31 07 2645-2653 |
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10.1007/s11426-023-1696-5 doi (DE-627)SPR053037731 (SPR)s11426-023-1696-5-e DE-627 ger DE-627 rakwb eng Li, Yue verfasserin aut Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Science China Press 2023 Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. sonodynamic therapy (dpeaa)DE-He213 gas therapy (dpeaa)DE-He213 antimycobacteria (dpeaa)DE-He213 metals in drug (dpeaa)DE-He213 bioinorganic chemistry (dpeaa)DE-He213 Wang, Haobing aut Lin, Qitian aut Yu, Xinyu aut Huang, Huaiyi aut Zhang, Pingyu aut Enthalten in Science in China Asheville, NC : Science in China Press, 1995 66(2023), 9 vom: 31. Juli, Seite 2645-2653 (DE-627)327310405 (DE-600)2043454-6 1862-2771 nnns volume:66 year:2023 number:9 day:31 month:07 pages:2645-2653 https://dx.doi.org/10.1007/s11426-023-1696-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 66 2023 9 31 07 2645-2653 |
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10.1007/s11426-023-1696-5 doi (DE-627)SPR053037731 (SPR)s11426-023-1696-5-e DE-627 ger DE-627 rakwb eng Li, Yue verfasserin aut Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Science China Press 2023 Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. sonodynamic therapy (dpeaa)DE-He213 gas therapy (dpeaa)DE-He213 antimycobacteria (dpeaa)DE-He213 metals in drug (dpeaa)DE-He213 bioinorganic chemistry (dpeaa)DE-He213 Wang, Haobing aut Lin, Qitian aut Yu, Xinyu aut Huang, Huaiyi aut Zhang, Pingyu aut Enthalten in Science in China Asheville, NC : Science in China Press, 1995 66(2023), 9 vom: 31. Juli, Seite 2645-2653 (DE-627)327310405 (DE-600)2043454-6 1862-2771 nnns volume:66 year:2023 number:9 day:31 month:07 pages:2645-2653 https://dx.doi.org/10.1007/s11426-023-1696-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 66 2023 9 31 07 2645-2653 |
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The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. 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ultrasound-active recorm-aiegen for gas and sonodynamic therapy of mycobacterium biofilms |
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Ultrasound-active ReCORM-AIEgen for gas and sonodynamic therapy of mycobacterium biofilms |
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Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. © Science China Press 2023 |
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Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. © Science China Press 2023 |
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Abstract Bacterial infection is the leading cause of many severe inflammation diseases. The development of novel and effective therapeutic approaches to counter bacterial infections, especially for drug-resistant bacteria, is essential. Herein, we have successfully developed an ultrasound-active tricarbonyl rhenium(I) complex with tetraphenylethylene (TPE) modification (RePy-TPE) for CO gas therapy and sonodynamic therapy of bacterial infections. RePy-TPE produced reactive oxygen species and released CO under ultrasound irradiation. In addition, RePy-TPE showed aggregation-induced emission in water due to the introduction of TPE, which enhanced the yield of 1$ O_{2} $ generation in a biological aqueous solution. The produced 1$ O_{2} $ and released CO killed mycobacterium smegmatis (M. smegmatis) and Escherichia coli (E. coli), as shown by bacterial membrane damage and biofilm elimination. Furthermore, ultrasound-active RePy-TPE perturbed the purine metabolism of the bacteria, which disturbed the biosynthesis of DNA and energy metabolism, eventually reducing the vitality of bacteria. This article provides a novel strategy for the development of ultrasound-active metal-based antibiotics. © Science China Press 2023 |
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