Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children
Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strain...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Puzia, Weronika [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
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2023 |
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| Schlagwörter: |
Antibiotic-resistant pneumococci Invasive pneumococcal infections |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Infectious diseases and therapy - Heidelberg : Springer, 2012, 12(2023), 8 vom: 13. Juli, Seite 2017-2037 |
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| Übergeordnetes Werk: |
volume:12 ; year:2023 ; number:8 ; day:13 ; month:07 ; pages:2017-2037 |
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| DOI / URN: |
10.1007/s40121-023-00842-w |
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SPR05309946X |
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| 245 | 1 | 0 | |a Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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| 520 | |a Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. | ||
| 650 | 4 | |a Antibiotic-resistant pneumococci |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Invasive pneumococcal infections |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pneumococcal conjugate vaccines |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Pneumococcal serotype 19A |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Gawor, Jan |0 (orcid)0000-0003-3800-2557 |4 aut | |
| 700 | 1 | |a Gromadka, Robert |0 (orcid)0000-0002-9941-6692 |4 aut | |
| 700 | 1 | |a Żuchniewicz, Karolina |0 (orcid)0000-0002-7097-4025 |4 aut | |
| 700 | 1 | |a Wróbel-Pawelczyk, Izabela |0 (orcid)0000-0002-4726-5984 |4 aut | |
| 700 | 1 | |a Ronkiewicz, Patrycja |0 (orcid)0000-0003-4427-5076 |4 aut | |
| 700 | 1 | |a Gołębiewska, Agnieszka |0 (orcid)0000-0002-9662-8243 |4 aut | |
| 700 | 1 | |a Hryniewicz, Waleria |0 (orcid)0000-0002-3651-9790 |4 aut | |
| 700 | 1 | |a Sadowy, Ewa |0 (orcid)0000-0003-0284-6440 |4 aut | |
| 700 | 1 | |a Skoczyńska, Anna |0 (orcid)0000-0002-2247-830X |4 aut | |
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10.1007/s40121-023-00842-w doi (DE-627)SPR05309946X (SPR)s40121-023-00842-w-e DE-627 ger DE-627 rakwb eng Puzia, Weronika verfasserin (orcid)0000-0002-3312-1875 aut Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 Gawor, Jan (orcid)0000-0003-3800-2557 aut Gromadka, Robert (orcid)0000-0002-9941-6692 aut Żuchniewicz, Karolina (orcid)0000-0002-7097-4025 aut Wróbel-Pawelczyk, Izabela (orcid)0000-0002-4726-5984 aut Ronkiewicz, Patrycja (orcid)0000-0003-4427-5076 aut Gołębiewska, Agnieszka (orcid)0000-0002-9662-8243 aut Hryniewicz, Waleria (orcid)0000-0002-3651-9790 aut Sadowy, Ewa (orcid)0000-0003-0284-6440 aut Skoczyńska, Anna (orcid)0000-0002-2247-830X aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 12(2023), 8 vom: 13. Juli, Seite 2017-2037 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:12 year:2023 number:8 day:13 month:07 pages:2017-2037 https://dx.doi.org/10.1007/s40121-023-00842-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8 13 07 2017-2037 |
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10.1007/s40121-023-00842-w doi (DE-627)SPR05309946X (SPR)s40121-023-00842-w-e DE-627 ger DE-627 rakwb eng Puzia, Weronika verfasserin (orcid)0000-0002-3312-1875 aut Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 Gawor, Jan (orcid)0000-0003-3800-2557 aut Gromadka, Robert (orcid)0000-0002-9941-6692 aut Żuchniewicz, Karolina (orcid)0000-0002-7097-4025 aut Wróbel-Pawelczyk, Izabela (orcid)0000-0002-4726-5984 aut Ronkiewicz, Patrycja (orcid)0000-0003-4427-5076 aut Gołębiewska, Agnieszka (orcid)0000-0002-9662-8243 aut Hryniewicz, Waleria (orcid)0000-0002-3651-9790 aut Sadowy, Ewa (orcid)0000-0003-0284-6440 aut Skoczyńska, Anna (orcid)0000-0002-2247-830X aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 12(2023), 8 vom: 13. Juli, Seite 2017-2037 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:12 year:2023 number:8 day:13 month:07 pages:2017-2037 https://dx.doi.org/10.1007/s40121-023-00842-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8 13 07 2017-2037 |
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10.1007/s40121-023-00842-w doi (DE-627)SPR05309946X (SPR)s40121-023-00842-w-e DE-627 ger DE-627 rakwb eng Puzia, Weronika verfasserin (orcid)0000-0002-3312-1875 aut Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 Gawor, Jan (orcid)0000-0003-3800-2557 aut Gromadka, Robert (orcid)0000-0002-9941-6692 aut Żuchniewicz, Karolina (orcid)0000-0002-7097-4025 aut Wróbel-Pawelczyk, Izabela (orcid)0000-0002-4726-5984 aut Ronkiewicz, Patrycja (orcid)0000-0003-4427-5076 aut Gołębiewska, Agnieszka (orcid)0000-0002-9662-8243 aut Hryniewicz, Waleria (orcid)0000-0002-3651-9790 aut Sadowy, Ewa (orcid)0000-0003-0284-6440 aut Skoczyńska, Anna (orcid)0000-0002-2247-830X aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 12(2023), 8 vom: 13. Juli, Seite 2017-2037 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:12 year:2023 number:8 day:13 month:07 pages:2017-2037 https://dx.doi.org/10.1007/s40121-023-00842-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8 13 07 2017-2037 |
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10.1007/s40121-023-00842-w doi (DE-627)SPR05309946X (SPR)s40121-023-00842-w-e DE-627 ger DE-627 rakwb eng Puzia, Weronika verfasserin (orcid)0000-0002-3312-1875 aut Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 Gawor, Jan (orcid)0000-0003-3800-2557 aut Gromadka, Robert (orcid)0000-0002-9941-6692 aut Żuchniewicz, Karolina (orcid)0000-0002-7097-4025 aut Wróbel-Pawelczyk, Izabela (orcid)0000-0002-4726-5984 aut Ronkiewicz, Patrycja (orcid)0000-0003-4427-5076 aut Gołębiewska, Agnieszka (orcid)0000-0002-9662-8243 aut Hryniewicz, Waleria (orcid)0000-0002-3651-9790 aut Sadowy, Ewa (orcid)0000-0003-0284-6440 aut Skoczyńska, Anna (orcid)0000-0002-2247-830X aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 12(2023), 8 vom: 13. Juli, Seite 2017-2037 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:12 year:2023 number:8 day:13 month:07 pages:2017-2037 https://dx.doi.org/10.1007/s40121-023-00842-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8 13 07 2017-2037 |
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10.1007/s40121-023-00842-w doi (DE-627)SPR05309946X (SPR)s40121-023-00842-w-e DE-627 ger DE-627 rakwb eng Puzia, Weronika verfasserin (orcid)0000-0002-3312-1875 aut Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 Gawor, Jan (orcid)0000-0003-3800-2557 aut Gromadka, Robert (orcid)0000-0002-9941-6692 aut Żuchniewicz, Karolina (orcid)0000-0002-7097-4025 aut Wróbel-Pawelczyk, Izabela (orcid)0000-0002-4726-5984 aut Ronkiewicz, Patrycja (orcid)0000-0003-4427-5076 aut Gołębiewska, Agnieszka (orcid)0000-0002-9662-8243 aut Hryniewicz, Waleria (orcid)0000-0002-3651-9790 aut Sadowy, Ewa (orcid)0000-0003-0284-6440 aut Skoczyńska, Anna (orcid)0000-0002-2247-830X aut Enthalten in Infectious diseases and therapy Heidelberg : Springer, 2012 12(2023), 8 vom: 13. Juli, Seite 2017-2037 (DE-627)735690766 (DE-600)2701611-0 2193-6382 nnns volume:12 year:2023 number:8 day:13 month:07 pages:2017-2037 https://dx.doi.org/10.1007/s40121-023-00842-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 12 2023 8 13 07 2017-2037 |
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Puzia, Weronika @@aut@@ Gawor, Jan @@aut@@ Gromadka, Robert @@aut@@ Żuchniewicz, Karolina @@aut@@ Wróbel-Pawelczyk, Izabela @@aut@@ Ronkiewicz, Patrycja @@aut@@ Gołębiewska, Agnieszka @@aut@@ Hryniewicz, Waleria @@aut@@ Sadowy, Ewa @@aut@@ Skoczyńska, Anna @@aut@@ |
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However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. 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Puzia, Weronika misc Antibiotic-resistant pneumococci misc Invasive pneumococcal infections misc Pneumococcal conjugate vaccines misc Pneumococcal serotype 19A Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children Antibiotic-resistant pneumococci (dpeaa)DE-He213 Invasive pneumococcal infections (dpeaa)DE-He213 Pneumococcal conjugate vaccines (dpeaa)DE-He213 Pneumococcal serotype 19A (dpeaa)DE-He213 |
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Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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Puzia, Weronika Gawor, Jan Gromadka, Robert Żuchniewicz, Karolina Wróbel-Pawelczyk, Izabela Ronkiewicz, Patrycja Gołębiewska, Agnieszka Hryniewicz, Waleria Sadowy, Ewa Skoczyńska, Anna |
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highly resistant serotype 19a streptococcus pneumoniae of the gpsc1/cc320 clone from invasive infections in poland prior to antipneumococcal vaccination of children |
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Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. © The Author(s) 2023 |
| abstractGer |
Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. © The Author(s) 2023 |
| abstract_unstemmed |
Introduction The introduction of pneumococcal conjugate vaccines (PCV) into the national immunization programs (NIPs) has significantly reduced the number of pneumococcal infections. However, infections caused by isolates of non-vaccine serotypes (NVT) started spreading shortly thereafter and strains of NVT 19A have become the main cause of invasive pneumococcal disease burden worldwide. The aim of the study was to characterize serotype 19A invasive pneumococci of GPSC1/CC320 circulating in Poland before the introduction of PCV into the Polish NIP in 2017 and to compare them to isolates from other countries where PCVs were implemented much earlier than in Poland. Methods All the GPSC1/CC320 isolates were analyzed by serotyping, susceptibility testing, and whole genome sequencing followed by analyses of resistome, virulome, and core genome multilocus sequence typing (cgMLST), including comparative analysis with isolates with publicly accessible genomic sequences (PubMLST). Results During continuous surveillance the NRCBM collected 4237 invasive Streptococcus pneumoniae isolates between 1997 and 2016, including 200 isolates (4.7%) of serotype 19A. The most prevalent among 19A pneumococci were highly resistant representatives of Global Pneumococcal Sequence Cluster 1/Clonal Complex 320, GPSC1/CC320 (n = 97, 48.5%). Isolates of GPSC1/CC320 belonged to three sequence types (STs): ST320 (75.2%) ST4768 (23.7%), and ST15047 (1.0%), which all represented the 19A-III cps subtype and had complete loci for both PI-1 and PI-2 pili types. On the basis of the cgMLST analysis the majority of Polish GPSC1/CC320 isolates formed a group clearly distinct from pneumococci of this clone observed in other countries. Conclusion Before introduction of PCV in the Polish NIP we noticed an unexpected increase of serotype 19A in invasive pneumococcal infections, with the most common being representatives of highly drug-resistant GPSC1/CC320 clone, rarely identified in Europe both before and even after PCV introduction. © The Author(s) 2023 |
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Highly Resistant Serotype 19A Streptococcus pneumoniae of the GPSC1/CC320 Clone from Invasive Infections in Poland Prior to Antipneumococcal Vaccination of Children |
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Gawor, Jan Gromadka, Robert Żuchniewicz, Karolina Wróbel-Pawelczyk, Izabela Ronkiewicz, Patrycja Gołębiewska, Agnieszka Hryniewicz, Waleria Sadowy, Ewa Skoczyńska, Anna |
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