$ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway
Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Li, Miao [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2023 |
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| Übergeordnetes Werk: |
Enthalten in: Hormones and cancer - New York, NY [u.a.] : Springer, 2010, 14(2023), 1 vom: 21. Sept. |
|---|---|
| Übergeordnetes Werk: |
volume:14 ; year:2023 ; number:1 ; day:21 ; month:09 |
| Links: |
|---|
| DOI / URN: |
10.1007/s12672-023-00786-0 |
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SPR053151704 |
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| 245 | 1 | 0 | |a $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway |
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| 520 | |a Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. | ||
| 520 | |a Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. | ||
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| 700 | 1 | |a Chen, Fangjie |4 aut | |
| 700 | 1 | |a Qi, Xun |4 aut | |
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10.1007/s12672-023-00786-0 doi (DE-627)SPR053151704 (SPR)s12672-023-00786-0-e DE-627 ger DE-627 rakwb eng Li, Miao verfasserin aut $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. HOXC10 HCC proliferation M6A PTEN (dpeaa)DE-He213 AKT (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 Guo, Qianwen aut Shi, Qian aut Rao, Yanzhi aut Dong, Yixin aut Chen, Fangjie aut Qi, Xun aut Enthalten in Hormones and cancer New York, NY [u.a.] : Springer, 2010 14(2023), 1 vom: 21. Sept. (DE-627)621547379 (DE-600)2543318-0 1868-8500 nnns volume:14 year:2023 number:1 day:21 month:09 https://dx.doi.org/10.1007/s12672-023-00786-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 14 2023 1 21 09 |
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10.1007/s12672-023-00786-0 doi (DE-627)SPR053151704 (SPR)s12672-023-00786-0-e DE-627 ger DE-627 rakwb eng Li, Miao verfasserin aut $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. HOXC10 HCC proliferation M6A PTEN (dpeaa)DE-He213 AKT (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 Guo, Qianwen aut Shi, Qian aut Rao, Yanzhi aut Dong, Yixin aut Chen, Fangjie aut Qi, Xun aut Enthalten in Hormones and cancer New York, NY [u.a.] : Springer, 2010 14(2023), 1 vom: 21. Sept. (DE-627)621547379 (DE-600)2543318-0 1868-8500 nnns volume:14 year:2023 number:1 day:21 month:09 https://dx.doi.org/10.1007/s12672-023-00786-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 14 2023 1 21 09 |
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10.1007/s12672-023-00786-0 doi (DE-627)SPR053151704 (SPR)s12672-023-00786-0-e DE-627 ger DE-627 rakwb eng Li, Miao verfasserin aut $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. HOXC10 HCC proliferation M6A PTEN (dpeaa)DE-He213 AKT (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 Guo, Qianwen aut Shi, Qian aut Rao, Yanzhi aut Dong, Yixin aut Chen, Fangjie aut Qi, Xun aut Enthalten in Hormones and cancer New York, NY [u.a.] : Springer, 2010 14(2023), 1 vom: 21. Sept. (DE-627)621547379 (DE-600)2543318-0 1868-8500 nnns volume:14 year:2023 number:1 day:21 month:09 https://dx.doi.org/10.1007/s12672-023-00786-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 14 2023 1 21 09 |
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10.1007/s12672-023-00786-0 doi (DE-627)SPR053151704 (SPR)s12672-023-00786-0-e DE-627 ger DE-627 rakwb eng Li, Miao verfasserin aut $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. HOXC10 HCC proliferation M6A PTEN (dpeaa)DE-He213 AKT (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 Guo, Qianwen aut Shi, Qian aut Rao, Yanzhi aut Dong, Yixin aut Chen, Fangjie aut Qi, Xun aut Enthalten in Hormones and cancer New York, NY [u.a.] : Springer, 2010 14(2023), 1 vom: 21. Sept. (DE-627)621547379 (DE-600)2543318-0 1868-8500 nnns volume:14 year:2023 number:1 day:21 month:09 https://dx.doi.org/10.1007/s12672-023-00786-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 14 2023 1 21 09 |
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10.1007/s12672-023-00786-0 doi (DE-627)SPR053151704 (SPR)s12672-023-00786-0-e DE-627 ger DE-627 rakwb eng Li, Miao verfasserin aut $ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. HOXC10 HCC proliferation M6A PTEN (dpeaa)DE-He213 AKT (dpeaa)DE-He213 mTOR pathway (dpeaa)DE-He213 Guo, Qianwen aut Shi, Qian aut Rao, Yanzhi aut Dong, Yixin aut Chen, Fangjie aut Qi, Xun aut Enthalten in Hormones and cancer New York, NY [u.a.] : Springer, 2010 14(2023), 1 vom: 21. Sept. (DE-627)621547379 (DE-600)2543318-0 1868-8500 nnns volume:14 year:2023 number:1 day:21 month:09 https://dx.doi.org/10.1007/s12672-023-00786-0 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_120 AR 14 2023 1 21 09 |
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$ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway |
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$ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway |
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Li, Miao |
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Li, Miao Guo, Qianwen Shi, Qian Rao, Yanzhi Dong, Yixin Chen, Fangjie Qi, Xun |
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10.1007/s12672-023-00786-0 |
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$ m^{6} $a-mediated upregulation of hoxc10 promotes human hepatocellular carcinoma development through pten/akt/mtor signaling pathway |
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$ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway |
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Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. © The Author(s) 2023 |
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Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. © The Author(s) 2023 |
| abstract_unstemmed |
Abstract Human Hox genes (Homeobox) play a crucial role in embryonic development and cancer. The HOXC10 gene, a member of the HOX family, has been reported abnormally expressed in several cancers. However, the association between HOXC10 and hepatocellular carcinoma (HCC) remains to be elucidated. In the present study, tissue microarray cohort data showed that high levels of HOXC10 expression predicted a poor survival in HCC patients. Meanwhile, HOXC10 was significantly upregulated in the Huh7 cell line compared with the well differentiated cell line HepG2 and human normal liver cells. Functionally, silencing HOXC10 in Huh7 cells inhibited cell proliferation, increased apoptosis, and inhibited invasion and migration of HCC cells. HOXC10 overexpression in HepG2 cells increased cell proliferation, decreased apoptosis, and increased invasion and migration of HCC cells. In the HepG2 xenograft models, HOXC10 increased the tumor volume and weight compared with control. Mechanistically, the m6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. Both the in vitro and in vivo results showed that overexpressed HOXC10 activated the PTEN/AKT/mTOR pathway. In summary, the findings highlight the importance of HOXC10 in the regulation of HCC progression. HOXC10 is potentially a future therapeutic target for HCC treatment. Highlights HOXC10 is a potential prognostic biomarker for HCC patients.HOXC10 upregulation in HCC could promote cell proliferation, migration and invasion.HOXC10 function in HCC cells might be associated with the modulation of PTEN/AKT/mTOR signaling pathway.M6A modification of HOXC10 by METTL3 enhanced its expression by enhancing its mRNA stability. © The Author(s) 2023 |
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$ M^{6} $A-mediated upregulation of HOXC10 promotes human hepatocellular carcinoma development through PTEN/AKT/mTOR signaling pathway |
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