Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties
Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and...
Ausführliche Beschreibung
Autor*in: |
da Silva Nascimento, Marcel [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2023 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2023 |
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Übergeordnetes Werk: |
Enthalten in: Inflammopharmacology - Cham : Springer International Publishing AG, 1991, 31(2023), 5 vom: 28. Aug., Seite 2505-2519 |
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Übergeordnetes Werk: |
volume:31 ; year:2023 ; number:5 ; day:28 ; month:08 ; pages:2505-2519 |
Links: |
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DOI / URN: |
10.1007/s10787-023-01316-8 |
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Katalog-ID: |
SPR053179110 |
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245 | 1 | 0 | |a Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
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520 | |a Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. | ||
650 | 4 | |a Oxidative stress |7 (dpeaa)DE-He213 | |
650 | 4 | |a Phenolic compounds |7 (dpeaa)DE-He213 | |
650 | 4 | |a Inflammation |7 (dpeaa)DE-He213 | |
650 | 4 | |a Cytokines |7 (dpeaa)DE-He213 | |
650 | 4 | |a Medicinal plant |7 (dpeaa)DE-He213 | |
700 | 1 | |a dos Santos, Péligris H. |4 aut | |
700 | 1 | |a de Abreu, Fabiula F. |4 aut | |
700 | 1 | |a Shan, Andrea Y. K. V. |4 aut | |
700 | 1 | |a Amaral, Ricardo G. |4 aut | |
700 | 1 | |a Andrade, Luciana N. |4 aut | |
700 | 1 | |a Souto, Eliana B. |0 (orcid)0000-0002-9737-6017 |4 aut | |
700 | 1 | |a Santos, Matheus I. S. |4 aut | |
700 | 1 | |a de Souza Graça, Ariel |4 aut | |
700 | 1 | |a Souza, Jesica B. |4 aut | |
700 | 1 | |a Raimundo e Silva, Joanda P. |4 aut | |
700 | 1 | |a Tavares, Josean F. |4 aut | |
700 | 1 | |a de Oliveira e Silva, Ana M. |4 aut | |
700 | 1 | |a Correa, Cristiane B. |4 aut | |
700 | 1 | |a Montalvão, Monalisa M. |4 aut | |
700 | 1 | |a Piacente, Sonia |4 aut | |
700 | 1 | |a Pizza, Cosimo |4 aut | |
700 | 1 | |a Camargo, Enilton A. |4 aut | |
700 | 1 | |a dos Santos Estevam, Charles |4 aut | |
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10.1007/s10787-023-01316-8 doi (DE-627)SPR053179110 (SPR)s10787-023-01316-8-e DE-627 ger DE-627 rakwb eng da Silva Nascimento, Marcel verfasserin aut Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 dos Santos, Péligris H. aut de Abreu, Fabiula F. aut Shan, Andrea Y. K. V. aut Amaral, Ricardo G. aut Andrade, Luciana N. aut Souto, Eliana B. (orcid)0000-0002-9737-6017 aut Santos, Matheus I. S. aut de Souza Graça, Ariel aut Souza, Jesica B. aut Raimundo e Silva, Joanda P. aut Tavares, Josean F. aut de Oliveira e Silva, Ana M. aut Correa, Cristiane B. aut Montalvão, Monalisa M. aut Piacente, Sonia aut Pizza, Cosimo aut Camargo, Enilton A. aut dos Santos Estevam, Charles aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 31(2023), 5 vom: 28. Aug., Seite 2505-2519 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 https://dx.doi.org/10.1007/s10787-023-01316-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 31 2023 5 28 08 2505-2519 |
spelling |
10.1007/s10787-023-01316-8 doi (DE-627)SPR053179110 (SPR)s10787-023-01316-8-e DE-627 ger DE-627 rakwb eng da Silva Nascimento, Marcel verfasserin aut Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 dos Santos, Péligris H. aut de Abreu, Fabiula F. aut Shan, Andrea Y. K. V. aut Amaral, Ricardo G. aut Andrade, Luciana N. aut Souto, Eliana B. (orcid)0000-0002-9737-6017 aut Santos, Matheus I. S. aut de Souza Graça, Ariel aut Souza, Jesica B. aut Raimundo e Silva, Joanda P. aut Tavares, Josean F. aut de Oliveira e Silva, Ana M. aut Correa, Cristiane B. aut Montalvão, Monalisa M. aut Piacente, Sonia aut Pizza, Cosimo aut Camargo, Enilton A. aut dos Santos Estevam, Charles aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 31(2023), 5 vom: 28. Aug., Seite 2505-2519 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 https://dx.doi.org/10.1007/s10787-023-01316-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 31 2023 5 28 08 2505-2519 |
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10.1007/s10787-023-01316-8 doi (DE-627)SPR053179110 (SPR)s10787-023-01316-8-e DE-627 ger DE-627 rakwb eng da Silva Nascimento, Marcel verfasserin aut Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 dos Santos, Péligris H. aut de Abreu, Fabiula F. aut Shan, Andrea Y. K. V. aut Amaral, Ricardo G. aut Andrade, Luciana N. aut Souto, Eliana B. (orcid)0000-0002-9737-6017 aut Santos, Matheus I. S. aut de Souza Graça, Ariel aut Souza, Jesica B. aut Raimundo e Silva, Joanda P. aut Tavares, Josean F. aut de Oliveira e Silva, Ana M. aut Correa, Cristiane B. aut Montalvão, Monalisa M. aut Piacente, Sonia aut Pizza, Cosimo aut Camargo, Enilton A. aut dos Santos Estevam, Charles aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 31(2023), 5 vom: 28. Aug., Seite 2505-2519 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 https://dx.doi.org/10.1007/s10787-023-01316-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 31 2023 5 28 08 2505-2519 |
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10.1007/s10787-023-01316-8 doi (DE-627)SPR053179110 (SPR)s10787-023-01316-8-e DE-627 ger DE-627 rakwb eng da Silva Nascimento, Marcel verfasserin aut Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 dos Santos, Péligris H. aut de Abreu, Fabiula F. aut Shan, Andrea Y. K. V. aut Amaral, Ricardo G. aut Andrade, Luciana N. aut Souto, Eliana B. (orcid)0000-0002-9737-6017 aut Santos, Matheus I. S. aut de Souza Graça, Ariel aut Souza, Jesica B. aut Raimundo e Silva, Joanda P. aut Tavares, Josean F. aut de Oliveira e Silva, Ana M. aut Correa, Cristiane B. aut Montalvão, Monalisa M. aut Piacente, Sonia aut Pizza, Cosimo aut Camargo, Enilton A. aut dos Santos Estevam, Charles aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 31(2023), 5 vom: 28. Aug., Seite 2505-2519 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 https://dx.doi.org/10.1007/s10787-023-01316-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 31 2023 5 28 08 2505-2519 |
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10.1007/s10787-023-01316-8 doi (DE-627)SPR053179110 (SPR)s10787-023-01316-8-e DE-627 ger DE-627 rakwb eng da Silva Nascimento, Marcel verfasserin aut Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 dos Santos, Péligris H. aut de Abreu, Fabiula F. aut Shan, Andrea Y. K. V. aut Amaral, Ricardo G. aut Andrade, Luciana N. aut Souto, Eliana B. (orcid)0000-0002-9737-6017 aut Santos, Matheus I. S. aut de Souza Graça, Ariel aut Souza, Jesica B. aut Raimundo e Silva, Joanda P. aut Tavares, Josean F. aut de Oliveira e Silva, Ana M. aut Correa, Cristiane B. aut Montalvão, Monalisa M. aut Piacente, Sonia aut Pizza, Cosimo aut Camargo, Enilton A. aut dos Santos Estevam, Charles aut Enthalten in Inflammopharmacology Cham : Springer International Publishing AG, 1991 31(2023), 5 vom: 28. Aug., Seite 2505-2519 (DE-627)329558315 (DE-600)2047989-X 1568-5608 nnns volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 https://dx.doi.org/10.1007/s10787-023-01316-8 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 31 2023 5 28 08 2505-2519 |
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Enthalten in Inflammopharmacology 31(2023), 5 vom: 28. Aug., Seite 2505-2519 volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 |
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Enthalten in Inflammopharmacology 31(2023), 5 vom: 28. Aug., Seite 2505-2519 volume:31 year:2023 number:5 day:28 month:08 pages:2505-2519 |
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da Silva Nascimento, Marcel @@aut@@ dos Santos, Péligris H. @@aut@@ de Abreu, Fabiula F. @@aut@@ Shan, Andrea Y. K. V. @@aut@@ Amaral, Ricardo G. @@aut@@ Andrade, Luciana N. @@aut@@ Souto, Eliana B. @@aut@@ Santos, Matheus I. S. @@aut@@ de Souza Graça, Ariel @@aut@@ Souza, Jesica B. @@aut@@ Raimundo e Silva, Joanda P. @@aut@@ Tavares, Josean F. @@aut@@ de Oliveira e Silva, Ana M. @@aut@@ Correa, Cristiane B. @@aut@@ Montalvão, Monalisa M. @@aut@@ Piacente, Sonia @@aut@@ Pizza, Cosimo @@aut@@ Camargo, Enilton A. @@aut@@ dos Santos Estevam, Charles @@aut@@ |
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Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. 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author |
da Silva Nascimento, Marcel |
spellingShingle |
da Silva Nascimento, Marcel misc Oxidative stress misc Phenolic compounds misc Inflammation misc Cytokines misc Medicinal plant Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
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Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties Oxidative stress (dpeaa)DE-He213 Phenolic compounds (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Medicinal plant (dpeaa)DE-He213 |
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misc Oxidative stress misc Phenolic compounds misc Inflammation misc Cytokines misc Medicinal plant |
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misc Oxidative stress misc Phenolic compounds misc Inflammation misc Cytokines misc Medicinal plant |
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Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
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Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
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da Silva Nascimento, Marcel |
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Inflammopharmacology |
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da Silva Nascimento, Marcel dos Santos, Péligris H. de Abreu, Fabiula F. Shan, Andrea Y. K. V. Amaral, Ricardo G. Andrade, Luciana N. Souto, Eliana B. Santos, Matheus I. S. de Souza Graça, Ariel Souza, Jesica B. Raimundo e Silva, Joanda P. Tavares, Josean F. de Oliveira e Silva, Ana M. Correa, Cristiane B. Montalvão, Monalisa M. Piacente, Sonia Pizza, Cosimo Camargo, Enilton A. dos Santos Estevam, Charles |
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Elektronische Aufsätze |
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da Silva Nascimento, Marcel |
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10.1007/s10787-023-01316-8 |
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title_sort |
schinus terebinthifolius raddi (brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
title_auth |
Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
abstract |
Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. © The Author(s) 2023 |
abstractGer |
Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. © The Author(s) 2023 |
abstract_unstemmed |
Abstract The aim of this work was to evaluate the anti-inflammatory and antioxidant effects of ethyl acetate extract obtained from the leaves of Brazilian peppertree Schinus terebinthifolius Raddi (EAELSt). Total phenols and flavonoids, chemical constituents, in vitro antioxidant activity (DPPH and lipoperoxidation assays), and cytotoxicity in L929 fibroblasts were determined. In vivo anti-inflammatory and antioxidant properties were evaluated using TPA-induced ear inflammation model in mice. Phenol and flavonoid contents were 19.2 ± 0.4 and 93.8 ± 5.2 of gallic acid or quercetin equivalents/g, respectively. LC–MS analysis identified 43 compounds, of which myricetin-O-pentoside and quercetin-O-rhamnoside were major peaks of chromatogram. Incubation with EAELSt decreased the amount of DPPH radical ($ EC_{50} $ of 54.5 ± 2.4 µg/mL) and lipoperoxidation at 200–500 µg/mL. The incubation with EAELSt did not change fibroblast viability up to 100 µg/mL. Topical treatment with EAELSt significantly reduced edema and myeloperoxidase activity at 0.3, 1, and 3 mg/ear when compared to the vehicle-treated group. In addition, EAELSt decreased IL-6 and TNF-α levels and increased IL-10 levels. Besides, it modulated markers of oxidative stress (reduced total hydroperoxides and increased sulfhydryl contents and ferrium reduction potential) and increased the activity of catalase and superoxide dismutase, without altering GPx activity. © The Author(s) 2023 |
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title_short |
Schinus terebinthifolius Raddi (Brazilian pepper) leaves extract: in vitro and in vivo evidence of anti-inflammatory and antioxidant properties |
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https://dx.doi.org/10.1007/s10787-023-01316-8 |
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dos Santos, Péligris H. de Abreu, Fabiula F. Shan, Andrea Y. K. V. Amaral, Ricardo G. Andrade, Luciana N. Souto, Eliana B. Santos, Matheus I. S. de Souza Graça, Ariel Souza, Jesica B. Raimundo e Silva, Joanda P. Tavares, Josean F. de Oliveira e Silva, Ana M. Correa, Cristiane B. Montalvão, Monalisa M. Piacente, Sonia Pizza, Cosimo Camargo, Enilton A. dos Santos Estevam, Charles |
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|
score |
7.40007 |