Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration

Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid st...
Ausführliche Beschreibung

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Autor*in:	Fortes, Blake H. [verfasserIn] Fairbanks, Aaron M. Nirmalan, Aravindh A. Hodge, David O. Ferenchak, Kevin Barkmeier, Andrew J.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Neovascular age-related macular degeneration Exudative age-related macular degeneration Wet age-related macular degeneration Optical coherence tomography Diurnal variation Intraretinal fluid Subretinal fluid Exudation Reproducibility

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: International Journal of Retina and Vitreous - London : BioMed Central, 2015, 9(2023), 1 vom: 25. Sept.
Übergeordnetes Werk:	volume:9 ; year:2023 ; number:1 ; day:25 ; month:09

Links:	Volltext

DOI / URN:	10.1186/s40942-023-00495-4

Katalog-ID:	SPR053197410

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520			\|a Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively.
650		4	\|a Neovascular age-related macular degeneration \|7 (dpeaa)DE-He213
650		4	\|a Exudative age-related macular degeneration \|7 (dpeaa)DE-He213
650		4	\|a Wet age-related macular degeneration \|7 (dpeaa)DE-He213
650		4	\|a Optical coherence tomography \|7 (dpeaa)DE-He213
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650		4	\|a Intraretinal fluid \|7 (dpeaa)DE-He213
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allfields	10.1186/s40942-023-00495-4 doi (DE-627)SPR053197410 (SPR)s40942-023-00495-4-e DE-627 ger DE-627 rakwb eng Fortes, Blake H. verfasserin aut Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Fairbanks, Aaron M. aut Nirmalan, Aravindh A. aut Hodge, David O. aut Ferenchak, Kevin aut Barkmeier, Andrew J. (orcid)0000-0002-2666-3828 aut Enthalten in International Journal of Retina and Vitreous London : BioMed Central, 2015 9(2023), 1 vom: 25. Sept. (DE-627)837397049 (DE-600)2836254-8 2056-9920 nnns volume:9 year:2023 number:1 day:25 month:09 https://dx.doi.org/10.1186/s40942-023-00495-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 1 25 09
spelling	10.1186/s40942-023-00495-4 doi (DE-627)SPR053197410 (SPR)s40942-023-00495-4-e DE-627 ger DE-627 rakwb eng Fortes, Blake H. verfasserin aut Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Fairbanks, Aaron M. aut Nirmalan, Aravindh A. aut Hodge, David O. aut Ferenchak, Kevin aut Barkmeier, Andrew J. (orcid)0000-0002-2666-3828 aut Enthalten in International Journal of Retina and Vitreous London : BioMed Central, 2015 9(2023), 1 vom: 25. Sept. (DE-627)837397049 (DE-600)2836254-8 2056-9920 nnns volume:9 year:2023 number:1 day:25 month:09 https://dx.doi.org/10.1186/s40942-023-00495-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 1 25 09
allfields_unstemmed	10.1186/s40942-023-00495-4 doi (DE-627)SPR053197410 (SPR)s40942-023-00495-4-e DE-627 ger DE-627 rakwb eng Fortes, Blake H. verfasserin aut Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Fairbanks, Aaron M. aut Nirmalan, Aravindh A. aut Hodge, David O. aut Ferenchak, Kevin aut Barkmeier, Andrew J. (orcid)0000-0002-2666-3828 aut Enthalten in International Journal of Retina and Vitreous London : BioMed Central, 2015 9(2023), 1 vom: 25. Sept. (DE-627)837397049 (DE-600)2836254-8 2056-9920 nnns volume:9 year:2023 number:1 day:25 month:09 https://dx.doi.org/10.1186/s40942-023-00495-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 1 25 09
allfieldsGer	10.1186/s40942-023-00495-4 doi (DE-627)SPR053197410 (SPR)s40942-023-00495-4-e DE-627 ger DE-627 rakwb eng Fortes, Blake H. verfasserin aut Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Fairbanks, Aaron M. aut Nirmalan, Aravindh A. aut Hodge, David O. aut Ferenchak, Kevin aut Barkmeier, Andrew J. (orcid)0000-0002-2666-3828 aut Enthalten in International Journal of Retina and Vitreous London : BioMed Central, 2015 9(2023), 1 vom: 25. Sept. (DE-627)837397049 (DE-600)2836254-8 2056-9920 nnns volume:9 year:2023 number:1 day:25 month:09 https://dx.doi.org/10.1186/s40942-023-00495-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 1 25 09
allfieldsSound	10.1186/s40942-023-00495-4 doi (DE-627)SPR053197410 (SPR)s40942-023-00495-4-e DE-627 ger DE-627 rakwb eng Fortes, Blake H. verfasserin aut Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213 Fairbanks, Aaron M. aut Nirmalan, Aravindh A. aut Hodge, David O. aut Ferenchak, Kevin aut Barkmeier, Andrew J. (orcid)0000-0002-2666-3828 aut Enthalten in International Journal of Retina and Vitreous London : BioMed Central, 2015 9(2023), 1 vom: 25. Sept. (DE-627)837397049 (DE-600)2836254-8 2056-9920 nnns volume:9 year:2023 number:1 day:25 month:09 https://dx.doi.org/10.1186/s40942-023-00495-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 9 2023 1 25 09
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source	Enthalten in International Journal of Retina and Vitreous 9(2023), 1 vom: 25. Sept. volume:9 year:2023 number:1 day:25 month:09
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topic_facet	Neovascular age-related macular degeneration Exudative age-related macular degeneration Wet age-related macular degeneration Optical coherence tomography Diurnal variation Intraretinal fluid Subretinal fluid Exudation Reproducibility
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OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. 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author	Fortes, Blake H.
spellingShingle	Fortes, Blake H. misc Neovascular age-related macular degeneration misc Exudative age-related macular degeneration misc Wet age-related macular degeneration misc Optical coherence tomography misc Diurnal variation misc Intraretinal fluid misc Subretinal fluid misc Exudation misc Reproducibility Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
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topic_title	Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration Neovascular age-related macular degeneration (dpeaa)DE-He213 Exudative age-related macular degeneration (dpeaa)DE-He213 Wet age-related macular degeneration (dpeaa)DE-He213 Optical coherence tomography (dpeaa)DE-He213 Diurnal variation (dpeaa)DE-He213 Intraretinal fluid (dpeaa)DE-He213 Subretinal fluid (dpeaa)DE-He213 Exudation (dpeaa)DE-He213 Reproducibility (dpeaa)DE-He213
topic	misc Neovascular age-related macular degeneration misc Exudative age-related macular degeneration misc Wet age-related macular degeneration misc Optical coherence tomography misc Diurnal variation misc Intraretinal fluid misc Subretinal fluid misc Exudation misc Reproducibility
topic_unstemmed	misc Neovascular age-related macular degeneration misc Exudative age-related macular degeneration misc Wet age-related macular degeneration misc Optical coherence tomography misc Diurnal variation misc Intraretinal fluid misc Subretinal fluid misc Exudation misc Reproducibility
topic_browse	misc Neovascular age-related macular degeneration misc Exudative age-related macular degeneration misc Wet age-related macular degeneration misc Optical coherence tomography misc Diurnal variation misc Intraretinal fluid misc Subretinal fluid misc Exudation misc Reproducibility
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title	Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
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title_full	Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
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title_sort	diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
title_auth	Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
abstract	Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. © The Author(s) 2023
abstractGer	Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. © The Author(s) 2023
abstract_unstemmed	Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively. © The Author(s) 2023
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title_short	Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration
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fullrecord_marcxml	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR053197410</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231121064917.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231002s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s40942-023-00495-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR053197410</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40942-023-00495-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Fortes, Blake H.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Significant diurnal fluctuation of optical coherence tomography (OCT)-based macular fluid occurs in patients with several macular conditions including diabetic macular edema (DME) and cystoid macular edema due to retinal venous occlusion (RVO). OCT imaging and analysis of macular fluid status plays a central role in clinical management of exudative age-related macular degeneration (eAMD), however diurnal variation of eAMD OCT findings has not yet been formally studied. Herein, we investigate whether clinically meaningful fluctuation of OCT-based macular fluid occurs in patients with eAMD. Methods Prospective observational study. Patients with eAMD and intra- and/or sub-retinal fluid on early AM OCT were enrolled to receive two consecutive OCT scans at least four hours later. Retinal layers were manually segmented on all OCT rasters and AM-to-PM and PM-to-PM image pairs were analyzed for total retinal and neurosensory retinal volume changes within the central 1 and 3 mm ETDRS subfields. Finally, two masked retinal specialists analyzed all OCT image pairs for qualitative differences that may impact clinical management. Results 21 patients with eAMD and fluid on OCT were recruited between January 2020 and November 2021. There was no mean difference between AM and PM central 3 mm total retinal volume (p = 0.56), central 3 mm neurosensory retinal volume (p = 0.25), central 1 mm total retinal mean thickness (p = 0.96), or central 1 mm neurosensory retinal mean thickness (p = 0.63), nor were any differences identified in PM-to-PM control comparisons. Qualitative analysis by two masked experts identified no clinically significant differences between any AM-to-PM OCT image pairs. Conclusions No significant diurnal variation in OCT-based macular fluid or thickness was identified in patients with eAMD, either quantitatively or qualitatively.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Neovascular age-related macular degeneration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exudative age-related macular degeneration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Wet age-related macular degeneration</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Optical coherence tomography</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Diurnal variation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Intraretinal fluid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Subretinal fluid</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Exudation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Reproducibility</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fairbanks, Aaron M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Nirmalan, Aravindh A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hodge, David O.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ferenchak, Kevin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Barkmeier, Andrew J.</subfield><subfield code="0">(orcid)0000-0002-2666-3828</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">International Journal of Retina and Vitreous</subfield><subfield code="d">London : BioMed Central, 2015</subfield><subfield code="g">9(2023), 1 vom: 25. 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Diurnal variation of optical coherence tomography–based macular fluid in exudative age-related macular degeneration

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