Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2

Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patient...
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Autor*in:	Mavromanoli, Anna C. [verfasserIn] Barco, Stefano Ageno, Walter Bouvaist, Hélène Brodmann, Marianne Cuccia, Claudio Couturaud, Francis Dellas, Claudia Dimopoulos, Konstantinos Duerschmied, Daniel Empen, Klaus Faggiano, Pompilio Ferrari, Emile Galiè, Nazzareno Galvani, Marcello Ghuysen, Alexandre Giannakoulas, George Huisman, Menno V. Jiménez, David Kozak, Matija Lang, Irene M. Meneveau, Nicolas Münzel, Thomas Palazzini, Massimiliano Petris, Antoniu Octavian Piovaccari, Giancarlo Salvi, Aldo Schellong, Sebastian Schmidt, Kai-Helge Verschuren, Franck Schmidtmann, Irene Toenges, Gerrit Klok, Frederikus A. Konstantinides, Stavros V.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2022

Schlagwörter:	Echocardiography Right ventricle Dysfunction Pulmonary embolism Intermediate-risk

Anmerkung:	© The Author(s) 2022

Übergeordnetes Werk:	Enthalten in: Zeitschrift für Kardiologie - Darmstadt : Steinkopff, 1997, 112(2022), 10 vom: 21. Dez., Seite 1372-1381
Übergeordnetes Werk:	volume:112 ; year:2022 ; number:10 ; day:21 ; month:12 ; pages:1372-1381

Links:	Volltext

DOI / URN:	10.1007/s00392-022-02138-4

Katalog-ID:	SPR053345649

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245	1	0	\|a Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
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520			\|a Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract
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allfields	10.1007/s00392-022-02138-4 doi (DE-627)SPR053345649 (SPR)s00392-022-02138-4-e DE-627 ger DE-627 rakwb eng Mavromanoli, Anna C. verfasserin aut Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213 Barco, Stefano aut Ageno, Walter aut Bouvaist, Hélène aut Brodmann, Marianne aut Cuccia, Claudio aut Couturaud, Francis aut Dellas, Claudia aut Dimopoulos, Konstantinos aut Duerschmied, Daniel aut Empen, Klaus aut Faggiano, Pompilio aut Ferrari, Emile aut Galiè, Nazzareno aut Galvani, Marcello aut Ghuysen, Alexandre aut Giannakoulas, George aut Huisman, Menno V. aut Jiménez, David aut Kozak, Matija aut Lang, Irene M. aut Meneveau, Nicolas aut Münzel, Thomas aut Palazzini, Massimiliano aut Petris, Antoniu Octavian aut Piovaccari, Giancarlo aut Salvi, Aldo aut Schellong, Sebastian aut Schmidt, Kai-Helge aut Verschuren, Franck aut Schmidtmann, Irene aut Toenges, Gerrit aut Klok, Frederikus A. aut Konstantinides, Stavros V. (orcid)0000-0001-6359-7279 aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 112(2022), 10 vom: 21. Dez., Seite 1372-1381 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381 https://dx.doi.org/10.1007/s00392-022-02138-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 112 2022 10 21 12 1372-1381
spelling	10.1007/s00392-022-02138-4 doi (DE-627)SPR053345649 (SPR)s00392-022-02138-4-e DE-627 ger DE-627 rakwb eng Mavromanoli, Anna C. verfasserin aut Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213 Barco, Stefano aut Ageno, Walter aut Bouvaist, Hélène aut Brodmann, Marianne aut Cuccia, Claudio aut Couturaud, Francis aut Dellas, Claudia aut Dimopoulos, Konstantinos aut Duerschmied, Daniel aut Empen, Klaus aut Faggiano, Pompilio aut Ferrari, Emile aut Galiè, Nazzareno aut Galvani, Marcello aut Ghuysen, Alexandre aut Giannakoulas, George aut Huisman, Menno V. aut Jiménez, David aut Kozak, Matija aut Lang, Irene M. aut Meneveau, Nicolas aut Münzel, Thomas aut Palazzini, Massimiliano aut Petris, Antoniu Octavian aut Piovaccari, Giancarlo aut Salvi, Aldo aut Schellong, Sebastian aut Schmidt, Kai-Helge aut Verschuren, Franck aut Schmidtmann, Irene aut Toenges, Gerrit aut Klok, Frederikus A. aut Konstantinides, Stavros V. (orcid)0000-0001-6359-7279 aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 112(2022), 10 vom: 21. Dez., Seite 1372-1381 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381 https://dx.doi.org/10.1007/s00392-022-02138-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 112 2022 10 21 12 1372-1381
allfields_unstemmed	10.1007/s00392-022-02138-4 doi (DE-627)SPR053345649 (SPR)s00392-022-02138-4-e DE-627 ger DE-627 rakwb eng Mavromanoli, Anna C. verfasserin aut Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213 Barco, Stefano aut Ageno, Walter aut Bouvaist, Hélène aut Brodmann, Marianne aut Cuccia, Claudio aut Couturaud, Francis aut Dellas, Claudia aut Dimopoulos, Konstantinos aut Duerschmied, Daniel aut Empen, Klaus aut Faggiano, Pompilio aut Ferrari, Emile aut Galiè, Nazzareno aut Galvani, Marcello aut Ghuysen, Alexandre aut Giannakoulas, George aut Huisman, Menno V. aut Jiménez, David aut Kozak, Matija aut Lang, Irene M. aut Meneveau, Nicolas aut Münzel, Thomas aut Palazzini, Massimiliano aut Petris, Antoniu Octavian aut Piovaccari, Giancarlo aut Salvi, Aldo aut Schellong, Sebastian aut Schmidt, Kai-Helge aut Verschuren, Franck aut Schmidtmann, Irene aut Toenges, Gerrit aut Klok, Frederikus A. aut Konstantinides, Stavros V. (orcid)0000-0001-6359-7279 aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 112(2022), 10 vom: 21. Dez., Seite 1372-1381 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381 https://dx.doi.org/10.1007/s00392-022-02138-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 112 2022 10 21 12 1372-1381
allfieldsGer	10.1007/s00392-022-02138-4 doi (DE-627)SPR053345649 (SPR)s00392-022-02138-4-e DE-627 ger DE-627 rakwb eng Mavromanoli, Anna C. verfasserin aut Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213 Barco, Stefano aut Ageno, Walter aut Bouvaist, Hélène aut Brodmann, Marianne aut Cuccia, Claudio aut Couturaud, Francis aut Dellas, Claudia aut Dimopoulos, Konstantinos aut Duerschmied, Daniel aut Empen, Klaus aut Faggiano, Pompilio aut Ferrari, Emile aut Galiè, Nazzareno aut Galvani, Marcello aut Ghuysen, Alexandre aut Giannakoulas, George aut Huisman, Menno V. aut Jiménez, David aut Kozak, Matija aut Lang, Irene M. aut Meneveau, Nicolas aut Münzel, Thomas aut Palazzini, Massimiliano aut Petris, Antoniu Octavian aut Piovaccari, Giancarlo aut Salvi, Aldo aut Schellong, Sebastian aut Schmidt, Kai-Helge aut Verschuren, Franck aut Schmidtmann, Irene aut Toenges, Gerrit aut Klok, Frederikus A. aut Konstantinides, Stavros V. (orcid)0000-0001-6359-7279 aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 112(2022), 10 vom: 21. Dez., Seite 1372-1381 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381 https://dx.doi.org/10.1007/s00392-022-02138-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 112 2022 10 21 12 1372-1381
allfieldsSound	10.1007/s00392-022-02138-4 doi (DE-627)SPR053345649 (SPR)s00392-022-02138-4-e DE-627 ger DE-627 rakwb eng Mavromanoli, Anna C. verfasserin aut Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 2022 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2022 Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213 Barco, Stefano aut Ageno, Walter aut Bouvaist, Hélène aut Brodmann, Marianne aut Cuccia, Claudio aut Couturaud, Francis aut Dellas, Claudia aut Dimopoulos, Konstantinos aut Duerschmied, Daniel aut Empen, Klaus aut Faggiano, Pompilio aut Ferrari, Emile aut Galiè, Nazzareno aut Galvani, Marcello aut Ghuysen, Alexandre aut Giannakoulas, George aut Huisman, Menno V. aut Jiménez, David aut Kozak, Matija aut Lang, Irene M. aut Meneveau, Nicolas aut Münzel, Thomas aut Palazzini, Massimiliano aut Petris, Antoniu Octavian aut Piovaccari, Giancarlo aut Salvi, Aldo aut Schellong, Sebastian aut Schmidt, Kai-Helge aut Verschuren, Franck aut Schmidtmann, Irene aut Toenges, Gerrit aut Klok, Frederikus A. aut Konstantinides, Stavros V. (orcid)0000-0001-6359-7279 aut Enthalten in Zeitschrift für Kardiologie Darmstadt : Steinkopff, 1997 112(2022), 10 vom: 21. Dez., Seite 1372-1381 (DE-627)254911137 (DE-600)1463330-9 1435-1285 nnns volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381 https://dx.doi.org/10.1007/s00392-022-02138-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 AR 112 2022 10 21 12 1372-1381
language	English
source	Enthalten in Zeitschrift für Kardiologie 112(2022), 10 vom: 21. Dez., Seite 1372-1381 volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381
sourceStr	Enthalten in Zeitschrift für Kardiologie 112(2022), 10 vom: 21. Dez., Seite 1372-1381 volume:112 year:2022 number:10 day:21 month:12 pages:1372-1381
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Echocardiography Right ventricle Dysfunction Pulmonary embolism Intermediate-risk
isfreeaccess_bool	true
container_title	Zeitschrift für Kardiologie
authorswithroles_txt_mv	Mavromanoli, Anna C. @@aut@@ Barco, Stefano @@aut@@ Ageno, Walter @@aut@@ Bouvaist, Hélène @@aut@@ Brodmann, Marianne @@aut@@ Cuccia, Claudio @@aut@@ Couturaud, Francis @@aut@@ Dellas, Claudia @@aut@@ Dimopoulos, Konstantinos @@aut@@ Duerschmied, Daniel @@aut@@ Empen, Klaus @@aut@@ Faggiano, Pompilio @@aut@@ Ferrari, Emile @@aut@@ Galiè, Nazzareno @@aut@@ Galvani, Marcello @@aut@@ Ghuysen, Alexandre @@aut@@ Giannakoulas, George @@aut@@ Huisman, Menno V. @@aut@@ Jiménez, David @@aut@@ Kozak, Matija @@aut@@ Lang, Irene M. @@aut@@ Meneveau, Nicolas @@aut@@ Münzel, Thomas @@aut@@ Palazzini, Massimiliano @@aut@@ Petris, Antoniu Octavian @@aut@@ Piovaccari, Giancarlo @@aut@@ Salvi, Aldo @@aut@@ Schellong, Sebastian @@aut@@ Schmidt, Kai-Helge @@aut@@ Verschuren, Franck @@aut@@ Schmidtmann, Irene @@aut@@ Toenges, Gerrit @@aut@@ Klok, Frederikus A. @@aut@@ Konstantinides, Stavros V. @@aut@@
publishDateDaySort_date	2022-12-21T00:00:00Z
hierarchy_top_id	254911137
id	SPR053345649
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR053345649</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231010064655.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231010s2022 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00392-022-02138-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR053345649</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00392-022-02138-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mavromanoli, Anna C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2022</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2022</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. 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author	Mavromanoli, Anna C.
spellingShingle	Mavromanoli, Anna C. misc Echocardiography misc Right ventricle misc Dysfunction misc Pulmonary embolism misc Intermediate-risk Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
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topic_title	Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2 Echocardiography (dpeaa)DE-He213 Right ventricle (dpeaa)DE-He213 Dysfunction (dpeaa)DE-He213 Pulmonary embolism (dpeaa)DE-He213 Intermediate-risk (dpeaa)DE-He213
topic	misc Echocardiography misc Right ventricle misc Dysfunction misc Pulmonary embolism misc Intermediate-risk
topic_unstemmed	misc Echocardiography misc Right ventricle misc Dysfunction misc Pulmonary embolism misc Intermediate-risk
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title	Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
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title_full	Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
author_sort	Mavromanoli, Anna C.
journal	Zeitschrift für Kardiologie
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author_browse	Mavromanoli, Anna C. Barco, Stefano Ageno, Walter Bouvaist, Hélène Brodmann, Marianne Cuccia, Claudio Couturaud, Francis Dellas, Claudia Dimopoulos, Konstantinos Duerschmied, Daniel Empen, Klaus Faggiano, Pompilio Ferrari, Emile Galiè, Nazzareno Galvani, Marcello Ghuysen, Alexandre Giannakoulas, George Huisman, Menno V. Jiménez, David Kozak, Matija Lang, Irene M. Meneveau, Nicolas Münzel, Thomas Palazzini, Massimiliano Petris, Antoniu Octavian Piovaccari, Giancarlo Salvi, Aldo Schellong, Sebastian Schmidt, Kai-Helge Verschuren, Franck Schmidtmann, Irene Toenges, Gerrit Klok, Frederikus A. Konstantinides, Stavros V.
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title_sort	recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre pulmonary embolism international trial (peitho)-2
title_auth	Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
abstract	Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract © The Author(s) 2022
abstractGer	Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract © The Author(s) 2022
abstract_unstemmed	Background Right ventricular (RV) function plays a critical role in the pathophysiology and acute prognosis of pulmonary embolism (PE). We analyzed the temporal changes of RV function in the cohort of a prospective multicentre study investigating if an early switch to oral anticoagulation in patients with intermediate-risk PE is effective and safe. Methods Echocardiographic and laboratory examinations were performed at baseline (PE diagnosis), 6 days and 6 months. Echocardiographic parameters were classified into categories representing RV size, RV free wall/tricuspid annulus motion, RV pressure overload and right atrial (RA)/central venous pressure. Results RV dysfunction based on any abnormal echocardiographic parameter was present in 84% of patients at baseline. RV dilatation was the most frequently abnormal finding (40.6%), followed by increased RA/central venous pressure (34.6%), RV pressure overload (32.1%), and reduced RV free wall/tricuspid annulus motion (20.9%). As early as day 6, RV size remained normal or improved in 260 patients (64.7%), RV free wall/tricuspid annulus motion in 301 (74.9%), RV pressure overload in 297 (73.9%), and RA/central venous pressure in 254 (63.2%). At day 180, the frequencies slightly increased. The median NT-proBNP level decreased from 1448 pg/ml at baseline to 256.5 on day 6 and 127 on day 180. Conclusion In the majority of patients with acute intermediate-risk PE switched early to a direct oral anticoagulant, echocardiographic parameters of RV function normalised within 6 days and remained normal throughout the first 6 months. Almost one in four patients, however, continued to have evidence of RV dysfunction over the long term. Graphical Abstract © The Author(s) 2022
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title_short	Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2
url	https://dx.doi.org/10.1007/s00392-022-02138-4
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author2	Barco, Stefano Ageno, Walter Bouvaist, Hélène Brodmann, Marianne Cuccia, Claudio Couturaud, Francis Dellas, Claudia Dimopoulos, Konstantinos Duerschmied, Daniel Empen, Klaus Faggiano, Pompilio Ferrari, Emile Galiè, Nazzareno Galvani, Marcello Ghuysen, Alexandre Giannakoulas, George Huisman, Menno V. Jiménez, David Kozak, Matija Lang, Irene M. Meneveau, Nicolas Münzel, Thomas Palazzini, Massimiliano Petris, Antoniu Octavian Piovaccari, Giancarlo Salvi, Aldo Schellong, Sebastian Schmidt, Kai-Helge Verschuren, Franck Schmidtmann, Irene Toenges, Gerrit Klok, Frederikus A. Konstantinides, Stavros V.
author2Str	Barco, Stefano Ageno, Walter Bouvaist, Hélène Brodmann, Marianne Cuccia, Claudio Couturaud, Francis Dellas, Claudia Dimopoulos, Konstantinos Duerschmied, Daniel Empen, Klaus Faggiano, Pompilio Ferrari, Emile Galiè, Nazzareno Galvani, Marcello Ghuysen, Alexandre Giannakoulas, George Huisman, Menno V. Jiménez, David Kozak, Matija Lang, Irene M. Meneveau, Nicolas Münzel, Thomas Palazzini, Massimiliano Petris, Antoniu Octavian Piovaccari, Giancarlo Salvi, Aldo Schellong, Sebastian Schmidt, Kai-Helge Verschuren, Franck Schmidtmann, Irene Toenges, Gerrit Klok, Frederikus A. Konstantinides, Stavros V.
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up_date	2024-07-03T18:51:00.994Z
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Recovery of right ventricular function after intermediate-risk pulmonary embolism: results from the multicentre Pulmonary Embolism International Trial (PEITHO)-2

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