Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar
Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-cent...
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2023 |
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© The Author(s) 2023 |
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Enthalten in: Egyptian liver journal - [London] : SpringerOpen, 2011, 13(2023), 1 vom: 31. Okt. |
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| Übergeordnetes Werk: |
volume:13 ; year:2023 ; number:1 ; day:31 ; month:10 |
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10.1186/s43066-023-00295-3 |
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SPR053595734 |
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| 100 | 1 | |a Razafindrazoto, Chantelli Iamblaudiot |e verfasserin |0 (orcid)0000-0002-5751-0373 |4 aut | |
| 245 | 1 | 0 | |a Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar |
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| 520 | |a Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. | ||
| 650 | 4 | |a Endoscopic variceal ligation |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Variceal bleeding |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Efficacy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Safety |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Madagascar |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Randriamifidy, Nitah Harivony |4 aut | |
| 700 | 1 | |a Rakotomalala, Jolivet Auguste |4 aut | |
| 700 | 1 | |a Rakotondrasoa, Sedera Radoniaina |4 aut | |
| 700 | 1 | |a Ralaizanaka, Behoavy Mahafaly |4 aut | |
| 700 | 1 | |a Rakotoniaina, Henintsoa |4 aut | |
| 700 | 1 | |a Randrianiaina, Antsa Fihobiana |4 aut | |
| 700 | 1 | |a Rakotomaharo, Mialitiana |4 aut | |
| 700 | 1 | |a Laingonirina, Domoina Harivonjy Hasina |4 aut | |
| 700 | 1 | |a Maherison, Sonny |4 aut | |
| 700 | 1 | |a Rasolonjatovo, Anjaramalala Sitraka |4 aut | |
| 700 | 1 | |a Rakotozafindrabe, Andry Lalaina Rinà |4 aut | |
| 700 | 1 | |a Rabenjanahary, Tovo Harimanana |4 aut | |
| 700 | 1 | |a Razafimahefa, Soloniaina Hélio |4 aut | |
| 700 | 1 | |a Ramanampamonjy, Rado Manitrala |4 aut | |
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10.1186/s43066-023-00295-3 doi (DE-627)SPR053595734 (SPR)s43066-023-00295-3-e DE-627 ger DE-627 rakwb eng Razafindrazoto, Chantelli Iamblaudiot verfasserin (orcid)0000-0002-5751-0373 aut Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 Randriamifidy, Nitah Harivony aut Rakotomalala, Jolivet Auguste aut Rakotondrasoa, Sedera Radoniaina aut Ralaizanaka, Behoavy Mahafaly aut Rakotoniaina, Henintsoa aut Randrianiaina, Antsa Fihobiana aut Rakotomaharo, Mialitiana aut Laingonirina, Domoina Harivonjy Hasina aut Maherison, Sonny aut Rasolonjatovo, Anjaramalala Sitraka aut Rakotozafindrabe, Andry Lalaina Rinà aut Rabenjanahary, Tovo Harimanana aut Razafimahefa, Soloniaina Hélio aut Ramanampamonjy, Rado Manitrala aut Enthalten in Egyptian liver journal [London] : SpringerOpen, 2011 13(2023), 1 vom: 31. Okt. (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:13 year:2023 number:1 day:31 month:10 https://dx.doi.org/10.1186/s43066-023-00295-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 13 2023 1 31 10 |
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10.1186/s43066-023-00295-3 doi (DE-627)SPR053595734 (SPR)s43066-023-00295-3-e DE-627 ger DE-627 rakwb eng Razafindrazoto, Chantelli Iamblaudiot verfasserin (orcid)0000-0002-5751-0373 aut Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 Randriamifidy, Nitah Harivony aut Rakotomalala, Jolivet Auguste aut Rakotondrasoa, Sedera Radoniaina aut Ralaizanaka, Behoavy Mahafaly aut Rakotoniaina, Henintsoa aut Randrianiaina, Antsa Fihobiana aut Rakotomaharo, Mialitiana aut Laingonirina, Domoina Harivonjy Hasina aut Maherison, Sonny aut Rasolonjatovo, Anjaramalala Sitraka aut Rakotozafindrabe, Andry Lalaina Rinà aut Rabenjanahary, Tovo Harimanana aut Razafimahefa, Soloniaina Hélio aut Ramanampamonjy, Rado Manitrala aut Enthalten in Egyptian liver journal [London] : SpringerOpen, 2011 13(2023), 1 vom: 31. Okt. (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:13 year:2023 number:1 day:31 month:10 https://dx.doi.org/10.1186/s43066-023-00295-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 13 2023 1 31 10 |
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10.1186/s43066-023-00295-3 doi (DE-627)SPR053595734 (SPR)s43066-023-00295-3-e DE-627 ger DE-627 rakwb eng Razafindrazoto, Chantelli Iamblaudiot verfasserin (orcid)0000-0002-5751-0373 aut Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 Randriamifidy, Nitah Harivony aut Rakotomalala, Jolivet Auguste aut Rakotondrasoa, Sedera Radoniaina aut Ralaizanaka, Behoavy Mahafaly aut Rakotoniaina, Henintsoa aut Randrianiaina, Antsa Fihobiana aut Rakotomaharo, Mialitiana aut Laingonirina, Domoina Harivonjy Hasina aut Maherison, Sonny aut Rasolonjatovo, Anjaramalala Sitraka aut Rakotozafindrabe, Andry Lalaina Rinà aut Rabenjanahary, Tovo Harimanana aut Razafimahefa, Soloniaina Hélio aut Ramanampamonjy, Rado Manitrala aut Enthalten in Egyptian liver journal [London] : SpringerOpen, 2011 13(2023), 1 vom: 31. Okt. (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:13 year:2023 number:1 day:31 month:10 https://dx.doi.org/10.1186/s43066-023-00295-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 13 2023 1 31 10 |
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10.1186/s43066-023-00295-3 doi (DE-627)SPR053595734 (SPR)s43066-023-00295-3-e DE-627 ger DE-627 rakwb eng Razafindrazoto, Chantelli Iamblaudiot verfasserin (orcid)0000-0002-5751-0373 aut Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 Randriamifidy, Nitah Harivony aut Rakotomalala, Jolivet Auguste aut Rakotondrasoa, Sedera Radoniaina aut Ralaizanaka, Behoavy Mahafaly aut Rakotoniaina, Henintsoa aut Randrianiaina, Antsa Fihobiana aut Rakotomaharo, Mialitiana aut Laingonirina, Domoina Harivonjy Hasina aut Maherison, Sonny aut Rasolonjatovo, Anjaramalala Sitraka aut Rakotozafindrabe, Andry Lalaina Rinà aut Rabenjanahary, Tovo Harimanana aut Razafimahefa, Soloniaina Hélio aut Ramanampamonjy, Rado Manitrala aut Enthalten in Egyptian liver journal [London] : SpringerOpen, 2011 13(2023), 1 vom: 31. Okt. (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:13 year:2023 number:1 day:31 month:10 https://dx.doi.org/10.1186/s43066-023-00295-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 13 2023 1 31 10 |
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10.1186/s43066-023-00295-3 doi (DE-627)SPR053595734 (SPR)s43066-023-00295-3-e DE-627 ger DE-627 rakwb eng Razafindrazoto, Chantelli Iamblaudiot verfasserin (orcid)0000-0002-5751-0373 aut Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 Randriamifidy, Nitah Harivony aut Rakotomalala, Jolivet Auguste aut Rakotondrasoa, Sedera Radoniaina aut Ralaizanaka, Behoavy Mahafaly aut Rakotoniaina, Henintsoa aut Randrianiaina, Antsa Fihobiana aut Rakotomaharo, Mialitiana aut Laingonirina, Domoina Harivonjy Hasina aut Maherison, Sonny aut Rasolonjatovo, Anjaramalala Sitraka aut Rakotozafindrabe, Andry Lalaina Rinà aut Rabenjanahary, Tovo Harimanana aut Razafimahefa, Soloniaina Hélio aut Ramanampamonjy, Rado Manitrala aut Enthalten in Egyptian liver journal [London] : SpringerOpen, 2011 13(2023), 1 vom: 31. Okt. (DE-627)1733559663 (DE-600)3038187-3 2090-6226 nnns volume:13 year:2023 number:1 day:31 month:10 https://dx.doi.org/10.1186/s43066-023-00295-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER AR 13 2023 1 31 10 |
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Razafindrazoto, Chantelli Iamblaudiot @@aut@@ Randriamifidy, Nitah Harivony @@aut@@ Rakotomalala, Jolivet Auguste @@aut@@ Rakotondrasoa, Sedera Radoniaina @@aut@@ Ralaizanaka, Behoavy Mahafaly @@aut@@ Rakotoniaina, Henintsoa @@aut@@ Randrianiaina, Antsa Fihobiana @@aut@@ Rakotomaharo, Mialitiana @@aut@@ Laingonirina, Domoina Harivonjy Hasina @@aut@@ Maherison, Sonny @@aut@@ Rasolonjatovo, Anjaramalala Sitraka @@aut@@ Rakotozafindrabe, Andry Lalaina Rinà @@aut@@ Rabenjanahary, Tovo Harimanana @@aut@@ Razafimahefa, Soloniaina Hélio @@aut@@ Ramanampamonjy, Rado Manitrala @@aut@@ |
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The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. 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Razafindrazoto, Chantelli Iamblaudiot |
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Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar Endoscopic variceal ligation (dpeaa)DE-He213 Variceal bleeding (dpeaa)DE-He213 Efficacy (dpeaa)DE-He213 Safety (dpeaa)DE-He213 Madagascar (dpeaa)DE-He213 |
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Razafindrazoto, Chantelli Iamblaudiot Randriamifidy, Nitah Harivony Rakotomalala, Jolivet Auguste Rakotondrasoa, Sedera Radoniaina Ralaizanaka, Behoavy Mahafaly Rakotoniaina, Henintsoa Randrianiaina, Antsa Fihobiana Rakotomaharo, Mialitiana Laingonirina, Domoina Harivonjy Hasina Maherison, Sonny Rasolonjatovo, Anjaramalala Sitraka Rakotozafindrabe, Andry Lalaina Rinà Rabenjanahary, Tovo Harimanana Razafimahefa, Soloniaina Hélio Ramanampamonjy, Rado Manitrala |
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endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in digestive endoscopy unit, university hospital joseph raseta befelatanana, antananarivo, madagascar |
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Endoscopic variceal ligation in primary and secondary prevention of variceal bleeding: a retrospective study in Digestive Endoscopy Unit, University Hospital Joseph Raseta Befelatanana, Antananarivo, Madagascar |
| abstract |
Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. © The Author(s) 2023 |
| abstractGer |
Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. © The Author(s) 2023 |
| abstract_unstemmed |
Introduction Endoscopic variceal ligation (EVL) is a crucial procedure for the primary and secondary prevention of variceal bleeding. The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. Its tolerance is good with post-ligation signs that are rapidly regressive. © The Author(s) 2023 |
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Randriamifidy, Nitah Harivony Rakotomalala, Jolivet Auguste Rakotondrasoa, Sedera Radoniaina Ralaizanaka, Behoavy Mahafaly Rakotoniaina, Henintsoa Randrianiaina, Antsa Fihobiana Rakotomaharo, Mialitiana Laingonirina, Domoina Harivonjy Hasina Maherison, Sonny Rasolonjatovo, Anjaramalala Sitraka Rakotozafindrabe, Andry Lalaina Rinà Rabenjanahary, Tovo Harimanana Razafimahefa, Soloniaina Hélio Ramanampamonjy, Rado Manitrala |
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The objective of this study was to evaluate the efficacy and tolerability of EVL in the prevention of variceal bleeding. Methods This was a retrospective, single-center study over 8 years, from January 2013 to December 2020, including all patients who came for EVL in primary or secondary prevention. Results Fifty-seven patients (male/female: 39/18) were included. The mean age of the patients was 40.02 ± 12.32 years (range: 19–68). Portal hypertension was secondary to cirrhosis in 13 patients (22.8%) and to a non-cirrhotic cause in 44 patients (77.2%). EVL was indicated for primary and secondary prevention in 5.3% and 94.7%, respectively. All patients had received propranolol with a mean daily dose of 108.07 ± 38.52 mg (extremes: 80–160). Eradication of varices was achieved in 33 patients (57.9%) with an average of 3.06 ± 0.70 sessions (extremes: 1–5) and an average duration of 10.12 ± 6.21 months (extremes: 1–24). Ten patients (17.5%) had variceal bleeding, and one patient (1.8%) died. There was no significant difference between patients with cirrhotic and non-cirrhotic portal hypertension in terms of varices eradication, variceal bleeding, and mortality. Gender (HR: 37.18; CI: 0.14–18.4; p = 0.009) and the number of previous bleeds (HR: 1.34; CI: 1.01–1.80; p = 0.041) were independent predictors of variceal bleeding during EVL. Dysphagia (73.7%) and retrosternal pain (78.9%) were the main adverse events after ligation. Conclusion EVL is an efficient technique to eradicate varices. 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