Regional differences in clear cell metastatic renal cell carcinoma patients across the USA

Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of...
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Autor*in:	Scheipner, Lukas [verfasserIn] Tappero, Stefano Piccinelli, Mattia Luca Barletta, Francesco Garcia, Cristina Cano Incesu, Reha-Baris Morra, Simone Baudo, Andrea Tian, Zhe Saad, Fred Shariat, Shahrokh F. Terrone, Carlo De Cobelli, Ottavio Briganti, Alberto Chun, Felix K. H. Tilki, Derya Longo, Nicola Carmignani, Luca Pichler, Martin Hutterer, Georg Ahyai, Sascha Karakiewicz, Pierre I.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	SEER Metastatic RCC Regional Outcome Clear cell Population

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: World journal of urology - Berlin : Springer, 1983, 41(2023), 11 vom: 27. Sept., Seite 2991-3000
Übergeordnetes Werk:	volume:41 ; year:2023 ; number:11 ; day:27 ; month:09 ; pages:2991-3000

Links:	Volltext

DOI / URN:	10.1007/s00345-023-04589-4

Katalog-ID:	SPR053661680

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100	1		\|a Scheipner, Lukas \|e verfasserin \|0 (orcid)0000-0003-2036-8438 \|4 aut
245	1	0	\|a Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
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520			\|a Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences.
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650		4	\|a Metastatic RCC \|7 (dpeaa)DE-He213
650		4	\|a Regional \|7 (dpeaa)DE-He213
650		4	\|a Outcome \|7 (dpeaa)DE-He213
650		4	\|a Clear cell \|7 (dpeaa)DE-He213
650		4	\|a Population \|7 (dpeaa)DE-He213
700	1		\|a Tappero, Stefano \|4 aut
700	1		\|a Piccinelli, Mattia Luca \|4 aut
700	1		\|a Barletta, Francesco \|4 aut
700	1		\|a Garcia, Cristina Cano \|4 aut
700	1		\|a Incesu, Reha-Baris \|4 aut
700	1		\|a Morra, Simone \|4 aut
700	1		\|a Baudo, Andrea \|4 aut
700	1		\|a Tian, Zhe \|4 aut
700	1		\|a Saad, Fred \|4 aut
700	1		\|a Shariat, Shahrokh F. \|4 aut
700	1		\|a Terrone, Carlo \|4 aut
700	1		\|a De Cobelli, Ottavio \|4 aut
700	1		\|a Briganti, Alberto \|4 aut
700	1		\|a Chun, Felix K. H. \|4 aut
700	1		\|a Tilki, Derya \|4 aut
700	1		\|a Longo, Nicola \|4 aut
700	1		\|a Carmignani, Luca \|4 aut
700	1		\|a Pichler, Martin \|4 aut
700	1		\|a Hutterer, Georg \|4 aut
700	1		\|a Ahyai, Sascha \|4 aut
700	1		\|a Karakiewicz, Pierre I. \|4 aut
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allfields	10.1007/s00345-023-04589-4 doi (DE-627)SPR053661680 (SPR)s00345-023-04589-4-e DE-627 ger DE-627 rakwb eng Scheipner, Lukas verfasserin (orcid)0000-0003-2036-8438 aut Regional differences in clear cell metastatic renal cell carcinoma patients across the USA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213 Tappero, Stefano aut Piccinelli, Mattia Luca aut Barletta, Francesco aut Garcia, Cristina Cano aut Incesu, Reha-Baris aut Morra, Simone aut Baudo, Andrea aut Tian, Zhe aut Saad, Fred aut Shariat, Shahrokh F. aut Terrone, Carlo aut De Cobelli, Ottavio aut Briganti, Alberto aut Chun, Felix K. H. aut Tilki, Derya aut Longo, Nicola aut Carmignani, Luca aut Pichler, Martin aut Hutterer, Georg aut Ahyai, Sascha aut Karakiewicz, Pierre I. aut Enthalten in World journal of urology Berlin : Springer, 1983 41(2023), 11 vom: 27. Sept., Seite 2991-3000 (DE-627)254910874 (DE-600)1463303-6 1433-8726 nnns volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000 https://dx.doi.org/10.1007/s00345-023-04589-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2023 11 27 09 2991-3000
spelling	10.1007/s00345-023-04589-4 doi (DE-627)SPR053661680 (SPR)s00345-023-04589-4-e DE-627 ger DE-627 rakwb eng Scheipner, Lukas verfasserin (orcid)0000-0003-2036-8438 aut Regional differences in clear cell metastatic renal cell carcinoma patients across the USA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213 Tappero, Stefano aut Piccinelli, Mattia Luca aut Barletta, Francesco aut Garcia, Cristina Cano aut Incesu, Reha-Baris aut Morra, Simone aut Baudo, Andrea aut Tian, Zhe aut Saad, Fred aut Shariat, Shahrokh F. aut Terrone, Carlo aut De Cobelli, Ottavio aut Briganti, Alberto aut Chun, Felix K. H. aut Tilki, Derya aut Longo, Nicola aut Carmignani, Luca aut Pichler, Martin aut Hutterer, Georg aut Ahyai, Sascha aut Karakiewicz, Pierre I. aut Enthalten in World journal of urology Berlin : Springer, 1983 41(2023), 11 vom: 27. Sept., Seite 2991-3000 (DE-627)254910874 (DE-600)1463303-6 1433-8726 nnns volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000 https://dx.doi.org/10.1007/s00345-023-04589-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2023 11 27 09 2991-3000
allfields_unstemmed	10.1007/s00345-023-04589-4 doi (DE-627)SPR053661680 (SPR)s00345-023-04589-4-e DE-627 ger DE-627 rakwb eng Scheipner, Lukas verfasserin (orcid)0000-0003-2036-8438 aut Regional differences in clear cell metastatic renal cell carcinoma patients across the USA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213 Tappero, Stefano aut Piccinelli, Mattia Luca aut Barletta, Francesco aut Garcia, Cristina Cano aut Incesu, Reha-Baris aut Morra, Simone aut Baudo, Andrea aut Tian, Zhe aut Saad, Fred aut Shariat, Shahrokh F. aut Terrone, Carlo aut De Cobelli, Ottavio aut Briganti, Alberto aut Chun, Felix K. H. aut Tilki, Derya aut Longo, Nicola aut Carmignani, Luca aut Pichler, Martin aut Hutterer, Georg aut Ahyai, Sascha aut Karakiewicz, Pierre I. aut Enthalten in World journal of urology Berlin : Springer, 1983 41(2023), 11 vom: 27. Sept., Seite 2991-3000 (DE-627)254910874 (DE-600)1463303-6 1433-8726 nnns volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000 https://dx.doi.org/10.1007/s00345-023-04589-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2023 11 27 09 2991-3000
allfieldsGer	10.1007/s00345-023-04589-4 doi (DE-627)SPR053661680 (SPR)s00345-023-04589-4-e DE-627 ger DE-627 rakwb eng Scheipner, Lukas verfasserin (orcid)0000-0003-2036-8438 aut Regional differences in clear cell metastatic renal cell carcinoma patients across the USA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213 Tappero, Stefano aut Piccinelli, Mattia Luca aut Barletta, Francesco aut Garcia, Cristina Cano aut Incesu, Reha-Baris aut Morra, Simone aut Baudo, Andrea aut Tian, Zhe aut Saad, Fred aut Shariat, Shahrokh F. aut Terrone, Carlo aut De Cobelli, Ottavio aut Briganti, Alberto aut Chun, Felix K. H. aut Tilki, Derya aut Longo, Nicola aut Carmignani, Luca aut Pichler, Martin aut Hutterer, Georg aut Ahyai, Sascha aut Karakiewicz, Pierre I. aut Enthalten in World journal of urology Berlin : Springer, 1983 41(2023), 11 vom: 27. Sept., Seite 2991-3000 (DE-627)254910874 (DE-600)1463303-6 1433-8726 nnns volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000 https://dx.doi.org/10.1007/s00345-023-04589-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2023 11 27 09 2991-3000
allfieldsSound	10.1007/s00345-023-04589-4 doi (DE-627)SPR053661680 (SPR)s00345-023-04589-4-e DE-627 ger DE-627 rakwb eng Scheipner, Lukas verfasserin (orcid)0000-0003-2036-8438 aut Regional differences in clear cell metastatic renal cell carcinoma patients across the USA 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213 Tappero, Stefano aut Piccinelli, Mattia Luca aut Barletta, Francesco aut Garcia, Cristina Cano aut Incesu, Reha-Baris aut Morra, Simone aut Baudo, Andrea aut Tian, Zhe aut Saad, Fred aut Shariat, Shahrokh F. aut Terrone, Carlo aut De Cobelli, Ottavio aut Briganti, Alberto aut Chun, Felix K. H. aut Tilki, Derya aut Longo, Nicola aut Carmignani, Luca aut Pichler, Martin aut Hutterer, Georg aut Ahyai, Sascha aut Karakiewicz, Pierre I. aut Enthalten in World journal of urology Berlin : Springer, 1983 41(2023), 11 vom: 27. Sept., Seite 2991-3000 (DE-627)254910874 (DE-600)1463303-6 1433-8726 nnns volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000 https://dx.doi.org/10.1007/s00345-023-04589-4 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_267 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_711 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 41 2023 11 27 09 2991-3000
language	English
source	Enthalten in World journal of urology 41(2023), 11 vom: 27. Sept., Seite 2991-3000 volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000
sourceStr	Enthalten in World journal of urology 41(2023), 11 vom: 27. Sept., Seite 2991-3000 volume:41 year:2023 number:11 day:27 month:09 pages:2991-3000
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	SEER Metastatic RCC Regional Outcome Clear cell Population
isfreeaccess_bool	true
container_title	World journal of urology
authorswithroles_txt_mv	Scheipner, Lukas @@aut@@ Tappero, Stefano @@aut@@ Piccinelli, Mattia Luca @@aut@@ Barletta, Francesco @@aut@@ Garcia, Cristina Cano @@aut@@ Incesu, Reha-Baris @@aut@@ Morra, Simone @@aut@@ Baudo, Andrea @@aut@@ Tian, Zhe @@aut@@ Saad, Fred @@aut@@ Shariat, Shahrokh F. @@aut@@ Terrone, Carlo @@aut@@ De Cobelli, Ottavio @@aut@@ Briganti, Alberto @@aut@@ Chun, Felix K. H. @@aut@@ Tilki, Derya @@aut@@ Longo, Nicola @@aut@@ Carmignani, Luca @@aut@@ Pichler, Martin @@aut@@ Hutterer, Georg @@aut@@ Ahyai, Sascha @@aut@@ Karakiewicz, Pierre I. @@aut@@
publishDateDaySort_date	2023-09-27T00:00:00Z
hierarchy_top_id	254910874
id	SPR053661680
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR053661680</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20231109064645.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">231109s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s00345-023-04589-4</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR053661680</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s00345-023-04589-4-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Scheipner, Lukas</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0003-2036-8438</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Regional differences in clear cell metastatic renal cell carcinoma patients across the USA</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. 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author	Scheipner, Lukas
spellingShingle	Scheipner, Lukas misc SEER misc Metastatic RCC misc Regional misc Outcome misc Clear cell misc Population Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
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topic_title	Regional differences in clear cell metastatic renal cell carcinoma patients across the USA SEER (dpeaa)DE-He213 Metastatic RCC (dpeaa)DE-He213 Regional (dpeaa)DE-He213 Outcome (dpeaa)DE-He213 Clear cell (dpeaa)DE-He213 Population (dpeaa)DE-He213
topic	misc SEER misc Metastatic RCC misc Regional misc Outcome misc Clear cell misc Population
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title	Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
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title_full	Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
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author_browse	Scheipner, Lukas Tappero, Stefano Piccinelli, Mattia Luca Barletta, Francesco Garcia, Cristina Cano Incesu, Reha-Baris Morra, Simone Baudo, Andrea Tian, Zhe Saad, Fred Shariat, Shahrokh F. Terrone, Carlo De Cobelli, Ottavio Briganti, Alberto Chun, Felix K. H. Tilki, Derya Longo, Nicola Carmignani, Luca Pichler, Martin Hutterer, Georg Ahyai, Sascha Karakiewicz, Pierre I.
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author-letter	Scheipner, Lukas
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title_sort	regional differences in clear cell metastatic renal cell carcinoma patients across the usa
title_auth	Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
abstract	Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. © The Author(s) 2023
abstractGer	Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. © The Author(s) 2023
abstract_unstemmed	Purpose To test for regional differences in clear cell metastatic renal cell carcinoma (ccmRCC) patients across the USA. Methods The Surveillance, Epidemiology, and End Results (SEER) database (2000–2018) was used to tabulate patient (age at diagnosis, sex, race/ethnicity), tumor (N stage, sites of metastasis) and treatment characteristics (proportions of nephrectomy and systemic therapy), according to 12 SEER registries. Multinomial regression models, as well as multivariable Cox regression models, tested the overall mortality (OM) adjusting for those patient, tumor and treatment characteristics. Results In 9882 ccmRCC patients, registry-specific patient counts ranged from 4025 (41%) to 189 (2%). Differences across registries existed for sex (24–36% female), race/ethnicity (1–75% non-Caucasian), N stage (N1 25–35%, NX 3–13%), proportions of nephrectomy (44–63%) and systemic therapy (41–56%). Significant inter-registry differences remained after adjustment for proportions of nephrectomy (46–63%) and systemic therapy (35–56%). Unadjusted 5-year OM ranged from 73 to 85%. In multivariable analyses, three registries exhibited significantly higher OM (SEER registry 5: hazard ratio (HR) 1.20, p = 0.0001; SEER registry 7:HR 1.15, p = 0.008M SEER registry 10: HR 1.15, p = 0.04), relative to the largest reference registry (n = 4025). Conclusion Important regional differences including patient, tumor and treatment characteristics exist, when ccmRCC patients included in the SEER database are studied. Even after adjustment for these characteristics, important OM differences persisted, which may require more detailed analyses to further investigate these unexpected differences. © The Author(s) 2023
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container_issue	11
title_short	Regional differences in clear cell metastatic renal cell carcinoma patients across the USA
url	https://dx.doi.org/10.1007/s00345-023-04589-4
remote_bool	true
author2	Tappero, Stefano Piccinelli, Mattia Luca Barletta, Francesco Garcia, Cristina Cano Incesu, Reha-Baris Morra, Simone Baudo, Andrea Tian, Zhe Saad, Fred Shariat, Shahrokh F. Terrone, Carlo De Cobelli, Ottavio Briganti, Alberto Chun, Felix K. H. Tilki, Derya Longo, Nicola Carmignani, Luca Pichler, Martin Hutterer, Georg Ahyai, Sascha Karakiewicz, Pierre I.
author2Str	Tappero, Stefano Piccinelli, Mattia Luca Barletta, Francesco Garcia, Cristina Cano Incesu, Reha-Baris Morra, Simone Baudo, Andrea Tian, Zhe Saad, Fred Shariat, Shahrokh F. Terrone, Carlo De Cobelli, Ottavio Briganti, Alberto Chun, Felix K. H. Tilki, Derya Longo, Nicola Carmignani, Luca Pichler, Martin Hutterer, Georg Ahyai, Sascha Karakiewicz, Pierre I.
ppnlink	254910874
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doi_str	10.1007/s00345-023-04589-4
up_date	2024-07-03T21:07:58.607Z
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Regional differences in clear cell metastatic renal cell carcinoma patients across the USA

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