Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo

Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Here...
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Autor*in:	Stock, Amanda J. [verfasserIn] Ayyar, Saipriya Kashyap, Amogh Wang, Yunong Yanai, Hagai Starost, Matthew F. Tanaka-Yano, Mayuri Bodogai, Monica Sun, Chongkui Wang, Yajun Gong, Yi Puligilla, Chandrakala Fang, Evandro F. Bohr, Vilhelm A. Liu, Yie Beerman, Isabel

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Telomere attrition/dysfunction Telomere biology disorders NAD metabolism Hematopoiesis

Anmerkung:	© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Übergeordnetes Werk:	Enthalten in: Age - New York, NY : Springer Science+Business Media, 1978, 45(2023), 4 vom: 24. Feb., Seite 2213-2228
Übergeordnetes Werk:	volume:45 ; year:2023 ; number:4 ; day:24 ; month:02 ; pages:2213-2228

Links:	Volltext

DOI / URN:	10.1007/s11357-023-00752-2

Katalog-ID:	SPR053750020

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author_variant	a j s aj ajs s a sa a k ak y w yw h y hy m f s mf mfs m t y mty m b mb c s cs y w yw y g yg c p cp e f f ef eff v a b va vab y l yl i b ib
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allfields	10.1007/s11357-023-00752-2 doi (DE-627)SPR053750020 (SPR)s11357-023-00752-2-e DE-627 ger DE-627 rakwb eng Stock, Amanda J. verfasserin aut Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213 Ayyar, Saipriya aut Kashyap, Amogh aut Wang, Yunong aut Yanai, Hagai aut Starost, Matthew F. aut Tanaka-Yano, Mayuri aut Bodogai, Monica aut Sun, Chongkui aut Wang, Yajun aut Gong, Yi aut Puligilla, Chandrakala aut Fang, Evandro F. aut Bohr, Vilhelm A. aut Liu, Yie aut Beerman, Isabel (orcid)0000-0002-7758-8231 aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 45(2023), 4 vom: 24. Feb., Seite 2213-2228 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228 https://dx.doi.org/10.1007/s11357-023-00752-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 45 2023 4 24 02 2213-2228
spelling	10.1007/s11357-023-00752-2 doi (DE-627)SPR053750020 (SPR)s11357-023-00752-2-e DE-627 ger DE-627 rakwb eng Stock, Amanda J. verfasserin aut Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213 Ayyar, Saipriya aut Kashyap, Amogh aut Wang, Yunong aut Yanai, Hagai aut Starost, Matthew F. aut Tanaka-Yano, Mayuri aut Bodogai, Monica aut Sun, Chongkui aut Wang, Yajun aut Gong, Yi aut Puligilla, Chandrakala aut Fang, Evandro F. aut Bohr, Vilhelm A. aut Liu, Yie aut Beerman, Isabel (orcid)0000-0002-7758-8231 aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 45(2023), 4 vom: 24. Feb., Seite 2213-2228 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228 https://dx.doi.org/10.1007/s11357-023-00752-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 45 2023 4 24 02 2213-2228
allfields_unstemmed	10.1007/s11357-023-00752-2 doi (DE-627)SPR053750020 (SPR)s11357-023-00752-2-e DE-627 ger DE-627 rakwb eng Stock, Amanda J. verfasserin aut Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213 Ayyar, Saipriya aut Kashyap, Amogh aut Wang, Yunong aut Yanai, Hagai aut Starost, Matthew F. aut Tanaka-Yano, Mayuri aut Bodogai, Monica aut Sun, Chongkui aut Wang, Yajun aut Gong, Yi aut Puligilla, Chandrakala aut Fang, Evandro F. aut Bohr, Vilhelm A. aut Liu, Yie aut Beerman, Isabel (orcid)0000-0002-7758-8231 aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 45(2023), 4 vom: 24. Feb., Seite 2213-2228 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228 https://dx.doi.org/10.1007/s11357-023-00752-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 45 2023 4 24 02 2213-2228
allfieldsGer	10.1007/s11357-023-00752-2 doi (DE-627)SPR053750020 (SPR)s11357-023-00752-2-e DE-627 ger DE-627 rakwb eng Stock, Amanda J. verfasserin aut Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213 Ayyar, Saipriya aut Kashyap, Amogh aut Wang, Yunong aut Yanai, Hagai aut Starost, Matthew F. aut Tanaka-Yano, Mayuri aut Bodogai, Monica aut Sun, Chongkui aut Wang, Yajun aut Gong, Yi aut Puligilla, Chandrakala aut Fang, Evandro F. aut Bohr, Vilhelm A. aut Liu, Yie aut Beerman, Isabel (orcid)0000-0002-7758-8231 aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 45(2023), 4 vom: 24. Feb., Seite 2213-2228 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228 https://dx.doi.org/10.1007/s11357-023-00752-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 45 2023 4 24 02 2213-2228
allfieldsSound	10.1007/s11357-023-00752-2 doi (DE-627)SPR053750020 (SPR)s11357-023-00752-2-e DE-627 ger DE-627 rakwb eng Stock, Amanda J. verfasserin aut Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023 Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213 Ayyar, Saipriya aut Kashyap, Amogh aut Wang, Yunong aut Yanai, Hagai aut Starost, Matthew F. aut Tanaka-Yano, Mayuri aut Bodogai, Monica aut Sun, Chongkui aut Wang, Yajun aut Gong, Yi aut Puligilla, Chandrakala aut Fang, Evandro F. aut Bohr, Vilhelm A. aut Liu, Yie aut Beerman, Isabel (orcid)0000-0002-7758-8231 aut Enthalten in Age New York, NY : Springer Science+Business Media, 1978 45(2023), 4 vom: 24. Feb., Seite 2213-2228 (DE-627)499546180 (DE-600)2201958-3 1574-4647 nnns volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228 https://dx.doi.org/10.1007/s11357-023-00752-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_40 GBV_ILN_60 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_110 GBV_ILN_120 GBV_ILN_161 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 AR 45 2023 4 24 02 2213-2228
language	English
source	Enthalten in Age 45(2023), 4 vom: 24. Feb., Seite 2213-2228 volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228
sourceStr	Enthalten in Age 45(2023), 4 vom: 24. Feb., Seite 2213-2228 volume:45 year:2023 number:4 day:24 month:02 pages:2213-2228
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Telomere attrition/dysfunction Telomere biology disorders NAD metabolism Hematopoiesis
isfreeaccess_bool	true
container_title	Age
authorswithroles_txt_mv	Stock, Amanda J. @@aut@@ Ayyar, Saipriya @@aut@@ Kashyap, Amogh @@aut@@ Wang, Yunong @@aut@@ Yanai, Hagai @@aut@@ Starost, Matthew F. @@aut@@ Tanaka-Yano, Mayuri @@aut@@ Bodogai, Monica @@aut@@ Sun, Chongkui @@aut@@ Wang, Yajun @@aut@@ Gong, Yi @@aut@@ Puligilla, Chandrakala @@aut@@ Fang, Evandro F. @@aut@@ Bohr, Vilhelm A. @@aut@@ Liu, Yie @@aut@@ Beerman, Isabel @@aut@@
publishDateDaySort_date	2023-02-24T00:00:00Z
hierarchy_top_id	499546180
id	SPR053750020
language_de	englisch
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author	Stock, Amanda J.
spellingShingle	Stock, Amanda J. misc Telomere attrition/dysfunction misc Telomere biology disorders misc NAD metabolism misc Hematopoiesis Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
authorStr	Stock, Amanda J.
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topic_title	Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo Telomere attrition/dysfunction (dpeaa)DE-He213 Telomere biology disorders (dpeaa)DE-He213 NAD metabolism (dpeaa)DE-He213 Hematopoiesis (dpeaa)DE-He213
topic	misc Telomere attrition/dysfunction misc Telomere biology disorders misc NAD metabolism misc Hematopoiesis
topic_unstemmed	misc Telomere attrition/dysfunction misc Telomere biology disorders misc NAD metabolism misc Hematopoiesis
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title	Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
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title_full	Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
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author_browse	Stock, Amanda J. Ayyar, Saipriya Kashyap, Amogh Wang, Yunong Yanai, Hagai Starost, Matthew F. Tanaka-Yano, Mayuri Bodogai, Monica Sun, Chongkui Wang, Yajun Gong, Yi Puligilla, Chandrakala Fang, Evandro F. Bohr, Vilhelm A. Liu, Yie Beerman, Isabel
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title_sort	boosting nad ameliorates hematopoietic impairment linked to short telomeres in vivo
title_auth	Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
abstract	Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023
abstractGer	Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023
abstract_unstemmed	Abstract Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coenzyme, is decreased in models of DC. Herein, using telomerase reverse transcriptase null (Tert−/−) mice with critically short telomeres, we investigated the effect of NAD supplementation with the NAD precursor, nicotinamide riboside (NR), on features of health span disrupted by telomere impairment. Our results revealed that NR ameliorated body weight loss in Tert−/− mice and improved telomere integrity and telomere dysfunction-induced systemic inflammation. NR supplementation also mitigated myeloid skewing of Tert−/− hematopoietic stem cells. Furthermore, NR alleviated villous atrophy and inflammation in the small intestine of Tert−/− transplant recipient mice. Altogether, our findings support NAD intervention as a potential therapeutic strategy to enhance aspects of health span compromised by telomere attrition. © This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023
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title_short	Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
url	https://dx.doi.org/10.1007/s11357-023-00752-2
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author2	Ayyar, Saipriya Kashyap, Amogh Wang, Yunong Yanai, Hagai Starost, Matthew F. Tanaka-Yano, Mayuri Bodogai, Monica Sun, Chongkui Wang, Yajun Gong, Yi Puligilla, Chandrakala Fang, Evandro F. Bohr, Vilhelm A. Liu, Yie Beerman, Isabel
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Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo

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