New insights into the regulation of METTL3 and its role in tumors

Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamicall...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Jin, Qiu [verfasserIn] Qu, Huinan Quan, Chengshi

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	METTL3 m A Cancer Epigenetics

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Cell communication and signaling - London : Biomed Central, 2003, 21(2023), 1 vom: 23. Nov.
Übergeordnetes Werk:	volume:21 ; year:2023 ; number:1 ; day:23 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s12964-023-01360-5

Katalog-ID:	SPR053841468

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520			\|a Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs.
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allfields	10.1186/s12964-023-01360-5 doi (DE-627)SPR053841468 (SPR)s12964-023-01360-5-e DE-627 ger DE-627 rakwb eng Jin, Qiu verfasserin aut New insights into the regulation of METTL3 and its role in tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Qu, Huinan aut Quan, Chengshi aut Enthalten in Cell communication and signaling London : Biomed Central, 2003 21(2023), 1 vom: 23. Nov. (DE-627)37375275X (DE-600)2126315-2 1478-811X nnns volume:21 year:2023 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12964-023-01360-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 23 11
spelling	10.1186/s12964-023-01360-5 doi (DE-627)SPR053841468 (SPR)s12964-023-01360-5-e DE-627 ger DE-627 rakwb eng Jin, Qiu verfasserin aut New insights into the regulation of METTL3 and its role in tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Qu, Huinan aut Quan, Chengshi aut Enthalten in Cell communication and signaling London : Biomed Central, 2003 21(2023), 1 vom: 23. Nov. (DE-627)37375275X (DE-600)2126315-2 1478-811X nnns volume:21 year:2023 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12964-023-01360-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 23 11
allfields_unstemmed	10.1186/s12964-023-01360-5 doi (DE-627)SPR053841468 (SPR)s12964-023-01360-5-e DE-627 ger DE-627 rakwb eng Jin, Qiu verfasserin aut New insights into the regulation of METTL3 and its role in tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Qu, Huinan aut Quan, Chengshi aut Enthalten in Cell communication and signaling London : Biomed Central, 2003 21(2023), 1 vom: 23. Nov. (DE-627)37375275X (DE-600)2126315-2 1478-811X nnns volume:21 year:2023 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12964-023-01360-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 23 11
allfieldsGer	10.1186/s12964-023-01360-5 doi (DE-627)SPR053841468 (SPR)s12964-023-01360-5-e DE-627 ger DE-627 rakwb eng Jin, Qiu verfasserin aut New insights into the regulation of METTL3 and its role in tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Qu, Huinan aut Quan, Chengshi aut Enthalten in Cell communication and signaling London : Biomed Central, 2003 21(2023), 1 vom: 23. Nov. (DE-627)37375275X (DE-600)2126315-2 1478-811X nnns volume:21 year:2023 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12964-023-01360-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 23 11
allfieldsSound	10.1186/s12964-023-01360-5 doi (DE-627)SPR053841468 (SPR)s12964-023-01360-5-e DE-627 ger DE-627 rakwb eng Jin, Qiu verfasserin aut New insights into the regulation of METTL3 and its role in tumors 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213 Qu, Huinan aut Quan, Chengshi aut Enthalten in Cell communication and signaling London : Biomed Central, 2003 21(2023), 1 vom: 23. Nov. (DE-627)37375275X (DE-600)2126315-2 1478-811X nnns volume:21 year:2023 number:1 day:23 month:11 https://dx.doi.org/10.1186/s12964-023-01360-5 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2023 1 23 11
language	English
source	Enthalten in Cell communication and signaling 21(2023), 1 vom: 23. Nov. volume:21 year:2023 number:1 day:23 month:11
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authorswithroles_txt_mv	Jin, Qiu @@aut@@ Qu, Huinan @@aut@@ Quan, Chengshi @@aut@@
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author	Jin, Qiu
spellingShingle	Jin, Qiu misc METTL3 misc m misc A misc Cancer misc Epigenetics New insights into the regulation of METTL3 and its role in tumors
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topic_title	New insights into the regulation of METTL3 and its role in tumors METTL3 (dpeaa)DE-He213 m (dpeaa)DE-He213 A (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Epigenetics (dpeaa)DE-He213
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title	New insights into the regulation of METTL3 and its role in tumors
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title_full	New insights into the regulation of METTL3 and its role in tumors
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title_sort	new insights into the regulation of mettl3 and its role in tumors
title_auth	New insights into the regulation of METTL3 and its role in tumors
abstract	Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. © The Author(s) 2023
abstractGer	Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. © The Author(s) 2023
abstract_unstemmed	Abstract As one of the most abundant epigenetic modifications in RNA, $ N^{6} $-methyladenosine ($ m^{6} $A) affects RNA transcription, splicing, stability, and posttranscriptional translation. Methyltransferase-like 3 (METTL3), a key component of the $ m^{6} $A methyltransferase complex, dynamically regulates target genes expression through $ m^{6} $A modification. METTL3 has been found to play a critical role in tumorigenesis, tumor growth, metastasis, metabolic reprogramming, immune cell infiltration, and tumor drug resistance. As a result, the development of targeted drugs against METTL3 is becoming increasingly popular. This review systematically summarizes the factors that regulate METTL3 expression and explores the specific mechanisms by which METTL3 affects multiple tumor biological behaviors. We aim to provide fundamental support for tumor diagnosis and treatment, at the same time, to offer new ideas for the development of tumor-targeting drugs. © The Author(s) 2023
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title_short	New insights into the regulation of METTL3 and its role in tumors
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