Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China

Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensiti...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Xu, Shiqin [verfasserIn] Wu, Jinsong Jin, Ying Ji, Liyin Zou, Xuan Hu, Qinghua Feng, Tiejian Wu, Shuang Jiang, Yixiang Chen, Qiongcheng Lu, Huiqun Qiu, Shuxiang Chen, Huaisheng Jiang, Min Cai, Rui Qiu, Yaqun Shi, Xiaolu

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Food Poisoning Antibiotic susceptibility Virulence testing Genome sequencing

Anmerkung:	© The Author(s) 2023

Übergeordnetes Werk:	Enthalten in: Gut pathogens - London : BioMed Central, 2009, 15(2023), 1 vom: 25. Nov.
Übergeordnetes Werk:	volume:15 ; year:2023 ; number:1 ; day:25 ; month:11

Links:	Volltext

DOI / URN:	10.1186/s13099-023-00580-x

Katalog-ID:	SPR053859995

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allfields	10.1186/s13099-023-00580-x doi (DE-627)SPR053859995 (SPR)s13099-023-00580-x-e DE-627 ger DE-627 rakwb eng Xu, Shiqin verfasserin aut Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213 Wu, Jinsong aut Jin, Ying aut Ji, Liyin aut Zou, Xuan aut Hu, Qinghua aut Feng, Tiejian aut Wu, Shuang aut Jiang, Yixiang aut Chen, Qiongcheng aut Lu, Huiqun aut Qiu, Shuxiang aut Chen, Huaisheng aut Jiang, Min aut Cai, Rui aut Qiu, Yaqun aut Shi, Xiaolu aut Enthalten in Gut pathogens London : BioMed Central, 2009 15(2023), 1 vom: 25. Nov. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:15 year:2023 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13099-023-00580-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 1 25 11
spelling	10.1186/s13099-023-00580-x doi (DE-627)SPR053859995 (SPR)s13099-023-00580-x-e DE-627 ger DE-627 rakwb eng Xu, Shiqin verfasserin aut Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213 Wu, Jinsong aut Jin, Ying aut Ji, Liyin aut Zou, Xuan aut Hu, Qinghua aut Feng, Tiejian aut Wu, Shuang aut Jiang, Yixiang aut Chen, Qiongcheng aut Lu, Huiqun aut Qiu, Shuxiang aut Chen, Huaisheng aut Jiang, Min aut Cai, Rui aut Qiu, Yaqun aut Shi, Xiaolu aut Enthalten in Gut pathogens London : BioMed Central, 2009 15(2023), 1 vom: 25. Nov. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:15 year:2023 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13099-023-00580-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 1 25 11
allfields_unstemmed	10.1186/s13099-023-00580-x doi (DE-627)SPR053859995 (SPR)s13099-023-00580-x-e DE-627 ger DE-627 rakwb eng Xu, Shiqin verfasserin aut Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213 Wu, Jinsong aut Jin, Ying aut Ji, Liyin aut Zou, Xuan aut Hu, Qinghua aut Feng, Tiejian aut Wu, Shuang aut Jiang, Yixiang aut Chen, Qiongcheng aut Lu, Huiqun aut Qiu, Shuxiang aut Chen, Huaisheng aut Jiang, Min aut Cai, Rui aut Qiu, Yaqun aut Shi, Xiaolu aut Enthalten in Gut pathogens London : BioMed Central, 2009 15(2023), 1 vom: 25. Nov. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:15 year:2023 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13099-023-00580-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 1 25 11
allfieldsGer	10.1186/s13099-023-00580-x doi (DE-627)SPR053859995 (SPR)s13099-023-00580-x-e DE-627 ger DE-627 rakwb eng Xu, Shiqin verfasserin aut Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213 Wu, Jinsong aut Jin, Ying aut Ji, Liyin aut Zou, Xuan aut Hu, Qinghua aut Feng, Tiejian aut Wu, Shuang aut Jiang, Yixiang aut Chen, Qiongcheng aut Lu, Huiqun aut Qiu, Shuxiang aut Chen, Huaisheng aut Jiang, Min aut Cai, Rui aut Qiu, Yaqun aut Shi, Xiaolu aut Enthalten in Gut pathogens London : BioMed Central, 2009 15(2023), 1 vom: 25. Nov. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:15 year:2023 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13099-023-00580-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 1 25 11
allfieldsSound	10.1186/s13099-023-00580-x doi (DE-627)SPR053859995 (SPR)s13099-023-00580-x-e DE-627 ger DE-627 rakwb eng Xu, Shiqin verfasserin aut Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2023 Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213 Wu, Jinsong aut Jin, Ying aut Ji, Liyin aut Zou, Xuan aut Hu, Qinghua aut Feng, Tiejian aut Wu, Shuang aut Jiang, Yixiang aut Chen, Qiongcheng aut Lu, Huiqun aut Qiu, Shuxiang aut Chen, Huaisheng aut Jiang, Min aut Cai, Rui aut Qiu, Yaqun aut Shi, Xiaolu aut Enthalten in Gut pathogens London : BioMed Central, 2009 15(2023), 1 vom: 25. Nov. (DE-627)591514133 (DE-600)2478277-4 1757-4749 nnns volume:15 year:2023 number:1 day:25 month:11 https://dx.doi.org/10.1186/s13099-023-00580-x kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 15 2023 1 25 11
language	English
source	Enthalten in Gut pathogens 15(2023), 1 vom: 25. Nov. volume:15 year:2023 number:1 day:25 month:11
sourceStr	Enthalten in Gut pathogens 15(2023), 1 vom: 25. Nov. volume:15 year:2023 number:1 day:25 month:11
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Food Poisoning Antibiotic susceptibility Virulence testing Genome sequencing
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container_title	Gut pathogens
authorswithroles_txt_mv	Xu, Shiqin @@aut@@ Wu, Jinsong @@aut@@ Jin, Ying @@aut@@ Ji, Liyin @@aut@@ Zou, Xuan @@aut@@ Hu, Qinghua @@aut@@ Feng, Tiejian @@aut@@ Wu, Shuang @@aut@@ Jiang, Yixiang @@aut@@ Chen, Qiongcheng @@aut@@ Lu, Huiqun @@aut@@ Qiu, Shuxiang @@aut@@ Chen, Huaisheng @@aut@@ Jiang, Min @@aut@@ Cai, Rui @@aut@@ Qiu, Yaqun @@aut@@ Shi, Xiaolu @@aut@@
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author	Xu, Shiqin
spellingShingle	Xu, Shiqin misc Food Poisoning misc Antibiotic susceptibility misc Virulence testing misc Genome sequencing Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
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topic_title	Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China Food Poisoning (dpeaa)DE-He213 Antibiotic susceptibility (dpeaa)DE-He213 Virulence testing (dpeaa)DE-He213 Genome sequencing (dpeaa)DE-He213
topic	misc Food Poisoning misc Antibiotic susceptibility misc Virulence testing misc Genome sequencing
topic_unstemmed	misc Food Poisoning misc Antibiotic susceptibility misc Virulence testing misc Genome sequencing
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title	Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
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title_full	Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
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author_browse	Xu, Shiqin Wu, Jinsong Jin, Ying Ji, Liyin Zou, Xuan Hu, Qinghua Feng, Tiejian Wu, Shuang Jiang, Yixiang Chen, Qiongcheng Lu, Huiqun Qiu, Shuxiang Chen, Huaisheng Jiang, Min Cai, Rui Qiu, Yaqun Shi, Xiaolu
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title_sort	pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of vibrio vulnificus in shenzhen, china
title_auth	Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
abstract	Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. © The Author(s) 2023
abstractGer	Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. © The Author(s) 2023
abstract_unstemmed	Abstract We report a 36-year-old male patient died of V. vulnificus-induced septicaemia and multiple organ failure syndrome after oyster consumption at a restaurant. We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). The human and environment distribution of V. vulnificus in Shenzhen is sporadic and heterogeneous, and vv16015 is highly virulent compared to other strains. © The Author(s) 2023
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title_short	Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China
url	https://dx.doi.org/10.1186/s13099-023-00580-x
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author2	Wu, Jinsong Jin, Ying Ji, Liyin Zou, Xuan Hu, Qinghua Feng, Tiejian Wu, Shuang Jiang, Yixiang Chen, Qiongcheng Lu, Huiqun Qiu, Shuxiang Chen, Huaisheng Jiang, Min Cai, Rui Qiu, Yaqun Shi, Xiaolu
author2Str	Wu, Jinsong Jin, Ying Ji, Liyin Zou, Xuan Hu, Qinghua Feng, Tiejian Wu, Shuang Jiang, Yixiang Chen, Qiongcheng Lu, Huiqun Qiu, Shuxiang Chen, Huaisheng Jiang, Min Cai, Rui Qiu, Yaqun Shi, Xiaolu
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up_date	2024-07-03T22:31:40.938Z
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We isolated and identified V. vulnificus vv16015 from the patient’s blood sample and antibiotic susceptibility tests indicated sensitivity to all 21 antibiotics. Oyster samples were subsequently collected from the restaurant’s supplier and three strains of V. vulnificus were isolated. Whole genome sequencing and analysis revealed vv16015 to be distantly related to these strains and confirmed that V. vulnificus contamination was present in the seafood of the restaurant and supplier. Using a Galleria mellonella larvae infection model, the virulence of vv16015 was determined to be higher than that of comparison strains isolated from a surviving patient (vv15018) and an oyster (vv220015). 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Pathogenetic detection, retrospective and pathogenicity analysis of a fatal case of Vibrio vulnificus in Shenzhen, China

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