Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia
Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includ...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Beksaç, Meral [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
1998 |
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| Schlagwörter: |
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| Anmerkung: |
© Stockton Press 1998 |
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| Übergeordnetes Werk: |
Enthalten in: Medical oncology - New York, NY : Springer, 1984, 15(1998), 3 vom: 01. Sept., Seite 183-190 |
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| Übergeordnetes Werk: |
volume:15 ; year:1998 ; number:3 ; day:01 ; month:09 ; pages:183-190 |
| Links: |
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| DOI / URN: |
10.1007/BF02821937 |
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| Katalog-ID: |
SPR053958098 |
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| 100 | 1 | |a Beksaç, Meral |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
| 264 | 1 | |c 1998 | |
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| 500 | |a © Stockton Press 1998 | ||
| 520 | |a Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. | ||
| 650 | 4 | |a acute nonlymphoblastic leukemia |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a idarubicin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a daunorubicin |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a mitoxantron |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a randomised trial |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Arslan, Önder |4 aut | |
| 700 | 1 | |a Koç, Haluk |4 aut | |
| 700 | 1 | |a Akan, Hamdi |4 aut | |
| 700 | 1 | |a Ilhan, Osman |4 aut | |
| 700 | 1 | |a Arat, Mutlu |4 aut | |
| 700 | 1 | |a Özcan, Muhit |4 aut | |
| 700 | 1 | |a Gürman, Günhan |4 aut | |
| 700 | 1 | |a Konuk, Nahide |4 aut | |
| 700 | 1 | |a Uysal, Akin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medical oncology |d New York, NY : Springer, 1984 |g 15(1998), 3 vom: 01. Sept., Seite 183-190 |w (DE-627)320468240 |w (DE-600)2008172-8 |x 1559-131X |7 nnns |
| 773 | 1 | 8 | |g volume:15 |g year:1998 |g number:3 |g day:01 |g month:09 |g pages:183-190 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1007/BF02821937 |z lizenzpflichtig |3 Volltext |
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1998 |
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1998 |
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10.1007/BF02821937 doi (DE-627)SPR053958098 (SPR)BF02821937-e DE-627 ger DE-627 rakwb eng Beksaç, Meral verfasserin aut Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stockton Press 1998 Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 Arslan, Önder aut Koç, Haluk aut Akan, Hamdi aut Ilhan, Osman aut Arat, Mutlu aut Özcan, Muhit aut Gürman, Günhan aut Konuk, Nahide aut Uysal, Akin aut Enthalten in Medical oncology New York, NY : Springer, 1984 15(1998), 3 vom: 01. Sept., Seite 183-190 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:15 year:1998 number:3 day:01 month:09 pages:183-190 https://dx.doi.org/10.1007/BF02821937 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 1998 3 01 09 183-190 |
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10.1007/BF02821937 doi (DE-627)SPR053958098 (SPR)BF02821937-e DE-627 ger DE-627 rakwb eng Beksaç, Meral verfasserin aut Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stockton Press 1998 Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 Arslan, Önder aut Koç, Haluk aut Akan, Hamdi aut Ilhan, Osman aut Arat, Mutlu aut Özcan, Muhit aut Gürman, Günhan aut Konuk, Nahide aut Uysal, Akin aut Enthalten in Medical oncology New York, NY : Springer, 1984 15(1998), 3 vom: 01. Sept., Seite 183-190 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:15 year:1998 number:3 day:01 month:09 pages:183-190 https://dx.doi.org/10.1007/BF02821937 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 1998 3 01 09 183-190 |
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10.1007/BF02821937 doi (DE-627)SPR053958098 (SPR)BF02821937-e DE-627 ger DE-627 rakwb eng Beksaç, Meral verfasserin aut Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stockton Press 1998 Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 Arslan, Önder aut Koç, Haluk aut Akan, Hamdi aut Ilhan, Osman aut Arat, Mutlu aut Özcan, Muhit aut Gürman, Günhan aut Konuk, Nahide aut Uysal, Akin aut Enthalten in Medical oncology New York, NY : Springer, 1984 15(1998), 3 vom: 01. Sept., Seite 183-190 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:15 year:1998 number:3 day:01 month:09 pages:183-190 https://dx.doi.org/10.1007/BF02821937 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 1998 3 01 09 183-190 |
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10.1007/BF02821937 doi (DE-627)SPR053958098 (SPR)BF02821937-e DE-627 ger DE-627 rakwb eng Beksaç, Meral verfasserin aut Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stockton Press 1998 Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 Arslan, Önder aut Koç, Haluk aut Akan, Hamdi aut Ilhan, Osman aut Arat, Mutlu aut Özcan, Muhit aut Gürman, Günhan aut Konuk, Nahide aut Uysal, Akin aut Enthalten in Medical oncology New York, NY : Springer, 1984 15(1998), 3 vom: 01. Sept., Seite 183-190 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:15 year:1998 number:3 day:01 month:09 pages:183-190 https://dx.doi.org/10.1007/BF02821937 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 1998 3 01 09 183-190 |
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10.1007/BF02821937 doi (DE-627)SPR053958098 (SPR)BF02821937-e DE-627 ger DE-627 rakwb eng Beksaç, Meral verfasserin aut Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia 1998 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Stockton Press 1998 Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 Arslan, Önder aut Koç, Haluk aut Akan, Hamdi aut Ilhan, Osman aut Arat, Mutlu aut Özcan, Muhit aut Gürman, Günhan aut Konuk, Nahide aut Uysal, Akin aut Enthalten in Medical oncology New York, NY : Springer, 1984 15(1998), 3 vom: 01. Sept., Seite 183-190 (DE-627)320468240 (DE-600)2008172-8 1559-131X nnns volume:15 year:1998 number:3 day:01 month:09 pages:183-190 https://dx.doi.org/10.1007/BF02821937 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 15 1998 3 01 09 183-190 |
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English |
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Enthalten in Medical oncology 15(1998), 3 vom: 01. Sept., Seite 183-190 volume:15 year:1998 number:3 day:01 month:09 pages:183-190 |
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Enthalten in Medical oncology 15(1998), 3 vom: 01. Sept., Seite 183-190 volume:15 year:1998 number:3 day:01 month:09 pages:183-190 |
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acute nonlymphoblastic leukemia idarubicin daunorubicin mitoxantron randomised trial |
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Beksaç, Meral @@aut@@ Arslan, Önder @@aut@@ Koç, Haluk @@aut@@ Akan, Hamdi @@aut@@ Ilhan, Osman @@aut@@ Arat, Mutlu @@aut@@ Özcan, Muhit @@aut@@ Gürman, Günhan @@aut@@ Konuk, Nahide @@aut@@ Uysal, Akin @@aut@@ |
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1998-09-01T00:00:00Z |
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| author |
Beksaç, Meral |
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Beksaç, Meral misc acute nonlymphoblastic leukemia misc idarubicin misc daunorubicin misc mitoxantron misc randomised trial Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
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Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia acute nonlymphoblastic leukemia (dpeaa)DE-He213 idarubicin (dpeaa)DE-He213 daunorubicin (dpeaa)DE-He213 mitoxantron (dpeaa)DE-He213 randomised trial (dpeaa)DE-He213 |
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misc acute nonlymphoblastic leukemia misc idarubicin misc daunorubicin misc mitoxantron misc randomised trial |
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Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
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Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
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Beksaç, Meral Arslan, Önder Koç, Haluk Akan, Hamdi Ilhan, Osman Arat, Mutlu Özcan, Muhit Gürman, Günhan Konuk, Nahide Uysal, Akin |
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Beksaç, Meral |
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10.1007/BF02821937 |
| title_sort |
randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
| title_auth |
Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
| abstract |
Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. © Stockton Press 1998 |
| abstractGer |
Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. © Stockton Press 1998 |
| abstract_unstemmed |
Abstract Various regimens have been explored in the treatment of acute nonlymphoblastic leukaemia (AML), but so far none has been shown to be superior. Here we report on a comparison of three widely used protocols defined by Berman (Group 1), MRC AML 10 (Group 2), and Arlin (Group 3). Group 1 includes cytosine arabinoside (Ara-C) (100 mg/$ m^{2} $/d, days 1–7) and idarubicin (Ida) (12 mg/$ m^{2} $/d, days 1–3) for induction, and Ara-C (200 mg/$ m^{2} $/d, days 1–6) and Ida (15 mg/$ m^{2} $/d, day 1) twice for consolidation. Group 2 includes Ara-C (200 mg/$ m^{2} $/d, days 1–10), daunorubicin (Dnc) (50 mg/$ m^{2} $/d, days 1, 3, 5) and etoposide (VP16) (100 mg/$ m^{2} $/d, days 1–5) for induction. The first consolidation therapy consisted of the same schedule except for Ara-C given on days 1–8. The second consolidation regimen consisted of Ara-C (200 mg/$ m^{2} $/d, days 1–8), VP16 (100 mg/$ m^{2} $/d, days 1–5) and amsacrine (100 mg/$ m^{2} $/d, days 1–5). Mitoxantrone (Mitox) (10 mg/$ m^{2} $/d, days 1–5) and Ara-C (200 mg/$ m^{2} $/d, days 1–3) were given as the third consolidation therapy. Group 3 was identical to Group 1 except for Ida being replaced with Mitox. During the study period 99 patients were enrolled and 34 were allocated randomly to Group 1, 36 to Group 2, and 29 to Group 3. Except for age distribution all patients’ characteristics were similar between the groups. As there were more elderly patients in Group 1, time to complete remission (CR) was longer in this group as they needed more second induction. Induction deaths were 9.7%, 12.9% and 14.8% in Groups 1, 2 and 3, respectively. Patients in Group 2 received a higher amount of Ara-C compared with the other groups (P<0.001). After a median follow-up period of 45 months (1–67 for survivors) an advantage in Group 1 was observed. Relapse-free survival (RFS) was better in Group 1 (P=0.014) at 3 years. Fourteen of the patients were transplanted (11 allografts, 3 autografts). When patients with transplants were excluded, overall survival was longer in Group 1 both at 3 years and 5 years (P=0.05). In conclusion, despite patient advanced age and lower dose of Ara-C, the idarubicin-containing treatment was superior to the other regimens. © Stockton Press 1998 |
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Randomised unicenter trial for comparison of three regimens inde novo adult acute nonlymphoblastic leukaemia |
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Arslan, Önder Koç, Haluk Akan, Hamdi Ilhan, Osman Arat, Mutlu Özcan, Muhit Gürman, Günhan Konuk, Nahide Uysal, Akin |
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Arslan, Önder Koç, Haluk Akan, Hamdi Ilhan, Osman Arat, Mutlu Özcan, Muhit Gürman, Günhan Konuk, Nahide Uysal, Akin |
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| score |
7.3995886 |