Portal Vein Thrombosis in Adults without Cirrhosis

Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. R...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Wallace, Franklyn [verfasserIn] Simonetto, Douglas A

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Portal vein thrombosis Splanchnic vein thrombosis Portal hypertension Extrahepatic portal vein obstruction Portal cavernoma Portal cavernoma cholangiopathy

Anmerkung:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Current hepatitis reports - Philadelphia, Pa : Current Science Inc., 2002, 22(2023), 4 vom: 01. Aug., Seite 244-251
Übergeordnetes Werk:	volume:22 ; year:2023 ; number:4 ; day:01 ; month:08 ; pages:244-251

Links:	Volltext

DOI / URN:	10.1007/s11901-023-00616-5

Katalog-ID:	SPR054246253

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520			\|a Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT.
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allfields	10.1007/s11901-023-00616-5 doi (DE-627)SPR054246253 (SPR)s11901-023-00616-5-e DE-627 ger DE-627 rakwb eng Wallace, Franklyn verfasserin aut Portal Vein Thrombosis in Adults without Cirrhosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213 Simonetto, Douglas A aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 22(2023), 4 vom: 01. Aug., Seite 244-251 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:22 year:2023 number:4 day:01 month:08 pages:244-251 https://dx.doi.org/10.1007/s11901-023-00616-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 AR 22 2023 4 01 08 244-251
spelling	10.1007/s11901-023-00616-5 doi (DE-627)SPR054246253 (SPR)s11901-023-00616-5-e DE-627 ger DE-627 rakwb eng Wallace, Franklyn verfasserin aut Portal Vein Thrombosis in Adults without Cirrhosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213 Simonetto, Douglas A aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 22(2023), 4 vom: 01. Aug., Seite 244-251 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:22 year:2023 number:4 day:01 month:08 pages:244-251 https://dx.doi.org/10.1007/s11901-023-00616-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 AR 22 2023 4 01 08 244-251
allfields_unstemmed	10.1007/s11901-023-00616-5 doi (DE-627)SPR054246253 (SPR)s11901-023-00616-5-e DE-627 ger DE-627 rakwb eng Wallace, Franklyn verfasserin aut Portal Vein Thrombosis in Adults without Cirrhosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213 Simonetto, Douglas A aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 22(2023), 4 vom: 01. Aug., Seite 244-251 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:22 year:2023 number:4 day:01 month:08 pages:244-251 https://dx.doi.org/10.1007/s11901-023-00616-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 AR 22 2023 4 01 08 244-251
allfieldsGer	10.1007/s11901-023-00616-5 doi (DE-627)SPR054246253 (SPR)s11901-023-00616-5-e DE-627 ger DE-627 rakwb eng Wallace, Franklyn verfasserin aut Portal Vein Thrombosis in Adults without Cirrhosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213 Simonetto, Douglas A aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 22(2023), 4 vom: 01. Aug., Seite 244-251 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:22 year:2023 number:4 day:01 month:08 pages:244-251 https://dx.doi.org/10.1007/s11901-023-00616-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 AR 22 2023 4 01 08 244-251
allfieldsSound	10.1007/s11901-023-00616-5 doi (DE-627)SPR054246253 (SPR)s11901-023-00616-5-e DE-627 ger DE-627 rakwb eng Wallace, Franklyn verfasserin aut Portal Vein Thrombosis in Adults without Cirrhosis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213 Simonetto, Douglas A aut Enthalten in Current hepatitis reports Philadelphia, Pa : Current Science Inc., 2002 22(2023), 4 vom: 01. Aug., Seite 244-251 (DE-627)357168275 (DE-600)2094164-X 1541-0706 nnns volume:22 year:2023 number:4 day:01 month:08 pages:244-251 https://dx.doi.org/10.1007/s11901-023-00616-5 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_120 GBV_ILN_152 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_224 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2059 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 AR 22 2023 4 01 08 244-251
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author	Wallace, Franklyn
spellingShingle	Wallace, Franklyn misc Portal vein thrombosis misc Splanchnic vein thrombosis misc Portal hypertension misc Extrahepatic portal vein obstruction misc Portal cavernoma misc Portal cavernoma cholangiopathy Portal Vein Thrombosis in Adults without Cirrhosis
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topic_title	Portal Vein Thrombosis in Adults without Cirrhosis Portal vein thrombosis (dpeaa)DE-He213 Splanchnic vein thrombosis (dpeaa)DE-He213 Portal hypertension (dpeaa)DE-He213 Extrahepatic portal vein obstruction (dpeaa)DE-He213 Portal cavernoma (dpeaa)DE-He213 Portal cavernoma cholangiopathy (dpeaa)DE-He213
topic	misc Portal vein thrombosis misc Splanchnic vein thrombosis misc Portal hypertension misc Extrahepatic portal vein obstruction misc Portal cavernoma misc Portal cavernoma cholangiopathy
topic_unstemmed	misc Portal vein thrombosis misc Splanchnic vein thrombosis misc Portal hypertension misc Extrahepatic portal vein obstruction misc Portal cavernoma misc Portal cavernoma cholangiopathy
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title_sort	portal vein thrombosis in adults without cirrhosis
title_auth	Portal Vein Thrombosis in Adults without Cirrhosis
abstract	Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose of Review The management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of data. The purpose of this review is to summarize the recommendations from major society guidelines and to highlight emerging evidence from recent years. Recent Findings While direct oral anticoagulants are increasingly used for the treatment of non-cirrhotic PVT, prospective comparison with warfarin or low molecular weight heparin remains uninvestigated in this population. There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. Future studies should focus on refining the preferred approach to treatment based on etiology of PVT. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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title_short	Portal Vein Thrombosis in Adults without Cirrhosis
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There is growing evidence that optimal treatment requires a tailored approach based on the underlying etiology of PVT, with options ranging from a relatively short course of anticoagulation to an aggressive combined medical/procedural approach. Summary Anticoagulation remains the mainstay of treatment for non-cirrhotic PVT. Current therapies are effective at reducing the risk of both immediate complications and long-term sequelae. 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Portal Vein Thrombosis in Adults without Cirrhosis

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