Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis

Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity....
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Bahamon, Ivan [verfasserIn] Strassner, James P. Ko, Wei-Che C.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Contact dermatitis Patch testing Th1 Th2 Th17 inflammation Allergy

Anmerkung:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Current dermatology reports - New York, NY : Springer, 2012, 12(2023), 4 vom: 09. Nov., Seite 245-253
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:4 ; day:09 ; month:11 ; pages:245-253

Links:	Volltext

DOI / URN:	10.1007/s13671-023-00410-y

Katalog-ID:	SPR054283922

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allfields	10.1007/s13671-023-00410-y doi (DE-627)SPR054283922 (SPR)s13671-023-00410-y-e DE-627 ger DE-627 rakwb eng Bahamon, Ivan verfasserin aut Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213 Strassner, James P. aut Ko, Wei-Che C. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 09. Nov., Seite 245-253 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:09 month:11 pages:245-253 https://dx.doi.org/10.1007/s13671-023-00410-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 09 11 245-253
spelling	10.1007/s13671-023-00410-y doi (DE-627)SPR054283922 (SPR)s13671-023-00410-y-e DE-627 ger DE-627 rakwb eng Bahamon, Ivan verfasserin aut Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213 Strassner, James P. aut Ko, Wei-Che C. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 09. Nov., Seite 245-253 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:09 month:11 pages:245-253 https://dx.doi.org/10.1007/s13671-023-00410-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 09 11 245-253
allfields_unstemmed	10.1007/s13671-023-00410-y doi (DE-627)SPR054283922 (SPR)s13671-023-00410-y-e DE-627 ger DE-627 rakwb eng Bahamon, Ivan verfasserin aut Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213 Strassner, James P. aut Ko, Wei-Che C. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 09. Nov., Seite 245-253 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:09 month:11 pages:245-253 https://dx.doi.org/10.1007/s13671-023-00410-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 09 11 245-253
allfieldsGer	10.1007/s13671-023-00410-y doi (DE-627)SPR054283922 (SPR)s13671-023-00410-y-e DE-627 ger DE-627 rakwb eng Bahamon, Ivan verfasserin aut Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213 Strassner, James P. aut Ko, Wei-Che C. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 09. Nov., Seite 245-253 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:09 month:11 pages:245-253 https://dx.doi.org/10.1007/s13671-023-00410-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 09 11 245-253
allfieldsSound	10.1007/s13671-023-00410-y doi (DE-627)SPR054283922 (SPR)s13671-023-00410-y-e DE-627 ger DE-627 rakwb eng Bahamon, Ivan verfasserin aut Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213 Strassner, James P. aut Ko, Wei-Che C. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 09. Nov., Seite 245-253 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:09 month:11 pages:245-253 https://dx.doi.org/10.1007/s13671-023-00410-y lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 09 11 245-253
language	English
source	Enthalten in Current dermatology reports 12(2023), 4 vom: 09. Nov., Seite 245-253 volume:12 year:2023 number:4 day:09 month:11 pages:245-253
sourceStr	Enthalten in Current dermatology reports 12(2023), 4 vom: 09. Nov., Seite 245-253 volume:12 year:2023 number:4 day:09 month:11 pages:245-253
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Contact dermatitis Patch testing Th1 Th2 Th17 inflammation Allergy
isfreeaccess_bool	false
container_title	Current dermatology reports
authorswithroles_txt_mv	Bahamon, Ivan @@aut@@ Strassner, James P. @@aut@@ Ko, Wei-Che C. @@aut@@
publishDateDaySort_date	2023-11-09T00:00:00Z
hierarchy_top_id	718611063
id	SPR054283922
language_de	englisch
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Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. 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author	Bahamon, Ivan
spellingShingle	Bahamon, Ivan misc Contact dermatitis misc Patch testing misc Th1 Th2 Th17 inflammation misc Allergy Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis
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topic_title	Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis Contact dermatitis (dpeaa)DE-He213 Patch testing (dpeaa)DE-He213 Th1 Th2 Th17 inflammation (dpeaa)DE-He213 Allergy (dpeaa)DE-He213
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title	Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis
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title_full	Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis
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title_sort	toward a molecular diagnosis: looking under the skin at allergic contact dermatitis
title_auth	Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis
abstract	Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose of Review Allergic contact dermatitis (ACD) is diagnosed by patch testing, which is a visual examination. This review summarizes research studies that have identified inflammatory pathways involved in ACD. Recent Findings ACD was historically thought to be driven solely through Th1 immunity. More recent clinical insights in the era of targeted immunotherapy have revealed an important, but not a paramount, role for Th2 immunity in promoting ACD inflammation. Pioneering studies done first in animal models of ACD suggest there are unique T cell responses dependent upon contact allergen and recent human translational studies demonstrate the diversity of T cell responses to various allergens, which may in part explain the mixed success of immunotherapy in ACD. Summary Unbiased machine learning approaches in the era of single-cell transcriptome and proteome studies have the potential to revolutionize our understanding of the pathophysiology of ACD, identify common pathways in responses to allergens, and perhaps discover central targets for universal therapy. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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container_issue	4
title_short	Toward a Molecular Diagnosis: Looking Under the Skin at Allergic Contact Dermatitis
url	https://dx.doi.org/10.1007/s13671-023-00410-y
remote_bool	true
author2	Strassner, James P. Ko, Wei-Che C.
author2Str	Strassner, James P. Ko, Wei-Che C.
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doi_str	10.1007/s13671-023-00410-y
up_date	2024-07-04T00:52:14.008Z
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