Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist

Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse eff...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Taritsa, Iulianna [verfasserIn] Choi, Jennifer N.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	Immune checkpoint inhibitors Immune checkpoint blockade Oncodermatology Immune checkpoint inhibitors/adverse effects PD-L1 inhibitors CTLA-4 inhibitors

Anmerkung:	© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Übergeordnetes Werk:	Enthalten in: Current dermatology reports - New York, NY : Springer, 2012, 12(2023), 4 vom: 30. Nov., Seite 225-232
Übergeordnetes Werk:	volume:12 ; year:2023 ; number:4 ; day:30 ; month:11 ; pages:225-232

Links:	Volltext

DOI / URN:	10.1007/s13671-023-00415-7

Katalog-ID:	SPR054283973

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allfields	10.1007/s13671-023-00415-7 doi (DE-627)SPR054283973 (SPR)s13671-023-00415-7-e DE-627 ger DE-627 rakwb eng Taritsa, Iulianna verfasserin (orcid)0000-0002-6627-8967 aut Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213 Choi, Jennifer N. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 30. Nov., Seite 225-232 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:30 month:11 pages:225-232 https://dx.doi.org/10.1007/s13671-023-00415-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 30 11 225-232
spelling	10.1007/s13671-023-00415-7 doi (DE-627)SPR054283973 (SPR)s13671-023-00415-7-e DE-627 ger DE-627 rakwb eng Taritsa, Iulianna verfasserin (orcid)0000-0002-6627-8967 aut Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213 Choi, Jennifer N. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 30. Nov., Seite 225-232 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:30 month:11 pages:225-232 https://dx.doi.org/10.1007/s13671-023-00415-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 30 11 225-232
allfields_unstemmed	10.1007/s13671-023-00415-7 doi (DE-627)SPR054283973 (SPR)s13671-023-00415-7-e DE-627 ger DE-627 rakwb eng Taritsa, Iulianna verfasserin (orcid)0000-0002-6627-8967 aut Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213 Choi, Jennifer N. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 30. Nov., Seite 225-232 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:30 month:11 pages:225-232 https://dx.doi.org/10.1007/s13671-023-00415-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 30 11 225-232
allfieldsGer	10.1007/s13671-023-00415-7 doi (DE-627)SPR054283973 (SPR)s13671-023-00415-7-e DE-627 ger DE-627 rakwb eng Taritsa, Iulianna verfasserin (orcid)0000-0002-6627-8967 aut Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213 Choi, Jennifer N. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 30. Nov., Seite 225-232 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:30 month:11 pages:225-232 https://dx.doi.org/10.1007/s13671-023-00415-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 30 11 225-232
allfieldsSound	10.1007/s13671-023-00415-7 doi (DE-627)SPR054283973 (SPR)s13671-023-00415-7-e DE-627 ger DE-627 rakwb eng Taritsa, Iulianna verfasserin (orcid)0000-0002-6627-8967 aut Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213 Choi, Jennifer N. aut Enthalten in Current dermatology reports New York, NY : Springer, 2012 12(2023), 4 vom: 30. Nov., Seite 225-232 (DE-627)718611063 (DE-600)2660493-0 2162-4933 nnns volume:12 year:2023 number:4 day:30 month:11 pages:225-232 https://dx.doi.org/10.1007/s13671-023-00415-7 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 12 2023 4 30 11 225-232
language	English
source	Enthalten in Current dermatology reports 12(2023), 4 vom: 30. Nov., Seite 225-232 volume:12 year:2023 number:4 day:30 month:11 pages:225-232
sourceStr	Enthalten in Current dermatology reports 12(2023), 4 vom: 30. Nov., Seite 225-232 volume:12 year:2023 number:4 day:30 month:11 pages:225-232
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Immune checkpoint inhibitors Immune checkpoint blockade Oncodermatology Immune checkpoint inhibitors/adverse effects PD-L1 inhibitors CTLA-4 inhibitors
isfreeaccess_bool	false
container_title	Current dermatology reports
authorswithroles_txt_mv	Taritsa, Iulianna @@aut@@ Choi, Jennifer N. @@aut@@
publishDateDaySort_date	2023-11-30T00:00:00Z
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author	Taritsa, Iulianna
spellingShingle	Taritsa, Iulianna misc Immune checkpoint inhibitors misc Immune checkpoint blockade misc Oncodermatology misc Immune checkpoint inhibitors/adverse effects misc PD-L1 inhibitors misc CTLA-4 inhibitors Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist
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topic_title	Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist Immune checkpoint inhibitors (dpeaa)DE-He213 Immune checkpoint blockade (dpeaa)DE-He213 Oncodermatology (dpeaa)DE-He213 Immune checkpoint inhibitors/adverse effects (dpeaa)DE-He213 PD-L1 inhibitors (dpeaa)DE-He213 CTLA-4 inhibitors (dpeaa)DE-He213
topic	misc Immune checkpoint inhibitors misc Immune checkpoint blockade misc Oncodermatology misc Immune checkpoint inhibitors/adverse effects misc PD-L1 inhibitors misc CTLA-4 inhibitors
topic_unstemmed	misc Immune checkpoint inhibitors misc Immune checkpoint blockade misc Oncodermatology misc Immune checkpoint inhibitors/adverse effects misc PD-L1 inhibitors misc CTLA-4 inhibitors
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title	Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist
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title_full	Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist
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title_sort	immune checkpoint inhibitors and systemic side effects: overview for the inpatient dermatologist
title_auth	Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist
abstract	Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstractGer	Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
abstract_unstemmed	Purpose of Review Immune checkpoint inhibitor (ICI) therapy has changed the landscape of cancer treatment and now represents part of the treatment regimen for approximately half of all cancer patients in high-income countries. The nonspecific immune activation of ICIs creates a myriad of adverse effects, most commonly of the skin but also affecting other organ systems with potentially devastating consequences. We aim to highlight the most common or life-threatening systemic toxicities associated with ICIs such that oncodermatologists may be more able to recognize their early clinical signs and symptoms. This knowledge will be helpful in effectively managing follow-up testing and coordinating with other specialty services to improve patient outcomes on ICIs. Recent Findings In the past 5 years, immune checkpoint inhibitor safety profiles have been updated in several studies and case reports. Multiple guideline statements published by the American Society of Clinical Oncology, the Society for Immunotherapy of Cancer, and the Multinational Association of Supportive Care in Cancer have been recently released on the toxicity management for patients on immune checkpoint inhibitors. These organizations have updated what is known about adverse events for ICIs ranging from gastrointestinal, pulmonary, and hepatic to endocrine complications, as well as immune-mediated cardiovascular, rheumatic, and renal toxicities. Summary Cutaneous immune-related adverse events to immune checkpoint inhibitor therapies are the most common and earliest complications of these treatment modalities. For the oncodermatologist, recognizing symptoms and signs of rare but dangerous systemic toxicities across various organ systems is important to improve patient outcomes on these therapies. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
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title_short	Immune Checkpoint Inhibitors and Systemic Side Effects: Overview for the Inpatient Dermatologist
url	https://dx.doi.org/10.1007/s13671-023-00415-7
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author2	Choi, Jennifer N.
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doi_str	10.1007/s13671-023-00415-7
up_date	2024-07-04T00:52:14.752Z
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