The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women

Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of e...
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Autor*in:	Monshizadeh, Kimia [verfasserIn] Tajamolian, Masoud Anbari, Fatemeh Mehrjardi, Mohammad Yahya Vahidi Kalantar, Seyed Mehdi Dehghani, Mohammadreza

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Cumulus cells Oocyte maturation Polycystic ovarian syndrome

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC medical genomics - London : BioMed Central, 2008, 17(2024), 1 vom: 18. Jan.
Übergeordnetes Werk:	volume:17 ; year:2024 ; number:1 ; day:18 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12920-024-01800-2

Katalog-ID:	SPR054438888

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520			\|a Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women.
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allfields	10.1186/s12920-024-01800-2 doi (DE-627)SPR054438888 (SPR)s12920-024-01800-2-e DE-627 ger DE-627 rakwb eng Monshizadeh, Kimia verfasserin aut The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213 Tajamolian, Masoud aut Anbari, Fatemeh aut Mehrjardi, Mohammad Yahya Vahidi aut Kalantar, Seyed Mehdi aut Dehghani, Mohammadreza aut Enthalten in BMC medical genomics London : BioMed Central, 2008 17(2024), 1 vom: 18. Jan. (DE-627)559080824 (DE-600)2411865-5 1755-8794 nnns volume:17 year:2024 number:1 day:18 month:01 https://dx.doi.org/10.1186/s12920-024-01800-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 18 01
spelling	10.1186/s12920-024-01800-2 doi (DE-627)SPR054438888 (SPR)s12920-024-01800-2-e DE-627 ger DE-627 rakwb eng Monshizadeh, Kimia verfasserin aut The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213 Tajamolian, Masoud aut Anbari, Fatemeh aut Mehrjardi, Mohammad Yahya Vahidi aut Kalantar, Seyed Mehdi aut Dehghani, Mohammadreza aut Enthalten in BMC medical genomics London : BioMed Central, 2008 17(2024), 1 vom: 18. Jan. (DE-627)559080824 (DE-600)2411865-5 1755-8794 nnns volume:17 year:2024 number:1 day:18 month:01 https://dx.doi.org/10.1186/s12920-024-01800-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 18 01
allfields_unstemmed	10.1186/s12920-024-01800-2 doi (DE-627)SPR054438888 (SPR)s12920-024-01800-2-e DE-627 ger DE-627 rakwb eng Monshizadeh, Kimia verfasserin aut The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213 Tajamolian, Masoud aut Anbari, Fatemeh aut Mehrjardi, Mohammad Yahya Vahidi aut Kalantar, Seyed Mehdi aut Dehghani, Mohammadreza aut Enthalten in BMC medical genomics London : BioMed Central, 2008 17(2024), 1 vom: 18. Jan. (DE-627)559080824 (DE-600)2411865-5 1755-8794 nnns volume:17 year:2024 number:1 day:18 month:01 https://dx.doi.org/10.1186/s12920-024-01800-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 18 01
allfieldsGer	10.1186/s12920-024-01800-2 doi (DE-627)SPR054438888 (SPR)s12920-024-01800-2-e DE-627 ger DE-627 rakwb eng Monshizadeh, Kimia verfasserin aut The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213 Tajamolian, Masoud aut Anbari, Fatemeh aut Mehrjardi, Mohammad Yahya Vahidi aut Kalantar, Seyed Mehdi aut Dehghani, Mohammadreza aut Enthalten in BMC medical genomics London : BioMed Central, 2008 17(2024), 1 vom: 18. Jan. (DE-627)559080824 (DE-600)2411865-5 1755-8794 nnns volume:17 year:2024 number:1 day:18 month:01 https://dx.doi.org/10.1186/s12920-024-01800-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 18 01
allfieldsSound	10.1186/s12920-024-01800-2 doi (DE-627)SPR054438888 (SPR)s12920-024-01800-2-e DE-627 ger DE-627 rakwb eng Monshizadeh, Kimia verfasserin aut The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213 Tajamolian, Masoud aut Anbari, Fatemeh aut Mehrjardi, Mohammad Yahya Vahidi aut Kalantar, Seyed Mehdi aut Dehghani, Mohammadreza aut Enthalten in BMC medical genomics London : BioMed Central, 2008 17(2024), 1 vom: 18. Jan. (DE-627)559080824 (DE-600)2411865-5 1755-8794 nnns volume:17 year:2024 number:1 day:18 month:01 https://dx.doi.org/10.1186/s12920-024-01800-2 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 17 2024 1 18 01
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author	Monshizadeh, Kimia
spellingShingle	Monshizadeh, Kimia misc Cumulus cells misc Oocyte maturation misc Polycystic ovarian syndrome The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women
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topic_title	The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women Cumulus cells (dpeaa)DE-He213 Oocyte maturation (dpeaa)DE-He213 Polycystic ovarian syndrome (dpeaa)DE-He213
topic	misc Cumulus cells misc Oocyte maturation misc Polycystic ovarian syndrome
topic_unstemmed	misc Cumulus cells misc Oocyte maturation misc Polycystic ovarian syndrome
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title	The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women
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title_full	The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women
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author_browse	Monshizadeh, Kimia Tajamolian, Masoud Anbari, Fatemeh Mehrjardi, Mohammad Yahya Vahidi Kalantar, Seyed Mehdi Dehghani, Mohammadreza
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title_sort	association of rbx1 and bambi gene expression with oocyte maturation in pcos women
title_auth	The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women
abstract	Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. © The Author(s) 2024
abstractGer	Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. © The Author(s) 2024
abstract_unstemmed	Background Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects 6–20% of women of reproductive age. One of the symptoms of PCOS is hyperandrogenism, which can impair follicular development. This disruption can cause issues with the development of oocytes and the growth of embryos. Although the exact cause of PCOS is not yet fully understood, studying the gene expression pattern of cumulus cells, which play a crucial role in the maturation and quality of oocytes, could help identify the genes associated with oocyte maturation in PCOS women. Through indirect activation of APC/Cdc20, RBX1 enables oocytes to bypass the GV (germinal vesicles) stage and advance to the MII (metaphase II) stage. our other gene is the BAMBI gene which stimulates WNT signaling, that is a crucial pathway for healthy ovarian function. This study aims to explore the expression level of the RBX1 and BAMBI genes between GV and MII oocytes of PCOS and non-PCOS groups. Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. Conclusion This research raises the possibility of RBX1 and BAMBI involvement in oocyte quality in PCOS women. © The Author(s) 2024
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title_short	The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women
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author2	Tajamolian, Masoud Anbari, Fatemeh Mehrjardi, Mohammad Yahya Vahidi Kalantar, Seyed Mehdi Dehghani, Mohammadreza
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up_date	2024-07-04T01:37:46.397Z
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Methods In this experiment, we gathered the cumulus cells of MII (38 cases and 33 control) and GV (38 cases and 33 control) oocytes from women with/without PCOS. Besides, quantitative RT-PCR was used to assess the semi-quantitative expression of BAMBI and RBX1. Results According to our research, the expression level of RBX1 and BAMBI in MII and GV cumulus cells of PCOS patients was significantly lower than that in non-PCOS ones. 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The association of RBX1 and BAMBI gene expression with oocyte maturation in PCOS women

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