PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy

Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photother...
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Autor*in:	Ye, Zichen [verfasserIn] Li, Yun Li, Jingchao Hu, Xinyan Zheng, Jinyang Zhang, Gongxin Xiang, Sijin Zhu, Tianbao Guo, Zhide Chen, Xiaolan

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2023

Schlagwörter:	lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment

Anmerkung:	© Tsinghua University Press 2023

Übergeordnetes Werk:	Enthalten in: Nano research - [S.l.] : Tsinghua Press, 2008, 17(2023), 1 vom: 23. Juni, Seite 270-281
Übergeordnetes Werk:	volume:17 ; year:2023 ; number:1 ; day:23 ; month:06 ; pages:270-281

Links:	Volltext

DOI / URN:	10.1007/s12274-023-5764-1

Katalog-ID:	SPR054476941

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245	1	2	\|a PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
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520			\|a Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward.
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650		4	\|a chemodynamic therapy \|7 (dpeaa)DE-He213
650		4	\|a photothermal therapy \|7 (dpeaa)DE-He213
650		4	\|a cascade reaction \|7 (dpeaa)DE-He213
650		4	\|a tumor microenvironment \|7 (dpeaa)DE-He213
700	1		\|a Li, Yun \|4 aut
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700	1		\|a Hu, Xinyan \|4 aut
700	1		\|a Zheng, Jinyang \|4 aut
700	1		\|a Zhang, Gongxin \|4 aut
700	1		\|a Xiang, Sijin \|4 aut
700	1		\|a Zhu, Tianbao \|4 aut
700	1		\|a Guo, Zhide \|4 aut
700	1		\|a Chen, Xiaolan \|4 aut
773	0	8	\|i Enthalten in \|t Nano research \|d [S.l.] : Tsinghua Press, 2008 \|g 17(2023), 1 vom: 23. Juni, Seite 270-281 \|w (DE-627)57375361X \|w (DE-600)2442216-2 \|x 1998-0000 \|7 nnns
773	1	8	\|g volume:17 \|g year:2023 \|g number:1 \|g day:23 \|g month:06 \|g pages:270-281
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912			\|a GBV_ILN_120
912			\|a GBV_ILN_138
912			\|a GBV_ILN_150
912			\|a GBV_ILN_151
912			\|a GBV_ILN_152
912			\|a GBV_ILN_161
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912			\|a GBV_ILN_171
912			\|a GBV_ILN_187
912			\|a GBV_ILN_213
912			\|a GBV_ILN_224
912			\|a GBV_ILN_230
912			\|a GBV_ILN_250
912			\|a GBV_ILN_281
912			\|a GBV_ILN_285
912			\|a GBV_ILN_293
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912			\|a GBV_ILN_602
912			\|a GBV_ILN_636
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912			\|a GBV_ILN_2007
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912			\|a GBV_ILN_2010
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
912			\|a GBV_ILN_2025
912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
912			\|a GBV_ILN_2031
912			\|a GBV_ILN_2034
912			\|a GBV_ILN_2037
912			\|a GBV_ILN_2038
912			\|a GBV_ILN_2039
912			\|a GBV_ILN_2044
912			\|a GBV_ILN_2048
912			\|a GBV_ILN_2049
912			\|a GBV_ILN_2050
912			\|a GBV_ILN_2055
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912			\|a GBV_ILN_2057
912			\|a GBV_ILN_2059
912			\|a GBV_ILN_2061
912			\|a GBV_ILN_2064
912			\|a GBV_ILN_2065
912			\|a GBV_ILN_2068
912			\|a GBV_ILN_2088
912			\|a GBV_ILN_2093
912			\|a GBV_ILN_2106
912			\|a GBV_ILN_2107
912			\|a GBV_ILN_2108
912			\|a GBV_ILN_2110
912			\|a GBV_ILN_2111
912			\|a GBV_ILN_2112
912			\|a GBV_ILN_2113
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allfields	10.1007/s12274-023-5764-1 doi (DE-627)SPR054476941 (SPR)s12274-023-5764-1-e DE-627 ger DE-627 rakwb eng Ye, Zichen verfasserin aut PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213 Li, Yun aut Li, Jingchao aut Hu, Xinyan aut Zheng, Jinyang aut Zhang, Gongxin aut Xiang, Sijin aut Zhu, Tianbao aut Guo, Zhide aut Chen, Xiaolan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 17(2023), 1 vom: 23. Juni, Seite 270-281 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:17 year:2023 number:1 day:23 month:06 pages:270-281 https://dx.doi.org/10.1007/s12274-023-5764-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 1 23 06 270-281
spelling	10.1007/s12274-023-5764-1 doi (DE-627)SPR054476941 (SPR)s12274-023-5764-1-e DE-627 ger DE-627 rakwb eng Ye, Zichen verfasserin aut PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213 Li, Yun aut Li, Jingchao aut Hu, Xinyan aut Zheng, Jinyang aut Zhang, Gongxin aut Xiang, Sijin aut Zhu, Tianbao aut Guo, Zhide aut Chen, Xiaolan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 17(2023), 1 vom: 23. Juni, Seite 270-281 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:17 year:2023 number:1 day:23 month:06 pages:270-281 https://dx.doi.org/10.1007/s12274-023-5764-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 1 23 06 270-281
allfields_unstemmed	10.1007/s12274-023-5764-1 doi (DE-627)SPR054476941 (SPR)s12274-023-5764-1-e DE-627 ger DE-627 rakwb eng Ye, Zichen verfasserin aut PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213 Li, Yun aut Li, Jingchao aut Hu, Xinyan aut Zheng, Jinyang aut Zhang, Gongxin aut Xiang, Sijin aut Zhu, Tianbao aut Guo, Zhide aut Chen, Xiaolan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 17(2023), 1 vom: 23. Juni, Seite 270-281 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:17 year:2023 number:1 day:23 month:06 pages:270-281 https://dx.doi.org/10.1007/s12274-023-5764-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 1 23 06 270-281
allfieldsGer	10.1007/s12274-023-5764-1 doi (DE-627)SPR054476941 (SPR)s12274-023-5764-1-e DE-627 ger DE-627 rakwb eng Ye, Zichen verfasserin aut PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213 Li, Yun aut Li, Jingchao aut Hu, Xinyan aut Zheng, Jinyang aut Zhang, Gongxin aut Xiang, Sijin aut Zhu, Tianbao aut Guo, Zhide aut Chen, Xiaolan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 17(2023), 1 vom: 23. Juni, Seite 270-281 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:17 year:2023 number:1 day:23 month:06 pages:270-281 https://dx.doi.org/10.1007/s12274-023-5764-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 1 23 06 270-281
allfieldsSound	10.1007/s12274-023-5764-1 doi (DE-627)SPR054476941 (SPR)s12274-023-5764-1-e DE-627 ger DE-627 rakwb eng Ye, Zichen verfasserin aut PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Tsinghua University Press 2023 Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213 Li, Yun aut Li, Jingchao aut Hu, Xinyan aut Zheng, Jinyang aut Zhang, Gongxin aut Xiang, Sijin aut Zhu, Tianbao aut Guo, Zhide aut Chen, Xiaolan aut Enthalten in Nano research [S.l.] : Tsinghua Press, 2008 17(2023), 1 vom: 23. Juni, Seite 270-281 (DE-627)57375361X (DE-600)2442216-2 1998-0000 nnns volume:17 year:2023 number:1 day:23 month:06 pages:270-281 https://dx.doi.org/10.1007/s12274-023-5764-1 lizenzpflichtig Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 17 2023 1 23 06 270-281
language	English
source	Enthalten in Nano research 17(2023), 1 vom: 23. Juni, Seite 270-281 volume:17 year:2023 number:1 day:23 month:06 pages:270-281
sourceStr	Enthalten in Nano research 17(2023), 1 vom: 23. Juni, Seite 270-281 volume:17 year:2023 number:1 day:23 month:06 pages:270-281
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	lactate oxidase chemodynamic therapy photothermal therapy cascade reaction tumor microenvironment
isfreeaccess_bool	false
container_title	Nano research
authorswithroles_txt_mv	Ye, Zichen @@aut@@ Li, Yun @@aut@@ Li, Jingchao @@aut@@ Hu, Xinyan @@aut@@ Zheng, Jinyang @@aut@@ Zhang, Gongxin @@aut@@ Xiang, Sijin @@aut@@ Zhu, Tianbao @@aut@@ Guo, Zhide @@aut@@ Chen, Xiaolan @@aut@@
publishDateDaySort_date	2023-06-23T00:00:00Z
hierarchy_top_id	57375361X
id	SPR054476941
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR054476941</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240123064823.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240123s2023 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s12274-023-5764-1</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR054476941</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12274-023-5764-1-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ye, Zichen</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2023</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Tsinghua University Press 2023</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. 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author	Ye, Zichen
spellingShingle	Ye, Zichen misc lactate oxidase misc chemodynamic therapy misc photothermal therapy misc cascade reaction misc tumor microenvironment PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
authorStr	Ye, Zichen
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topic_title	PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy lactate oxidase (dpeaa)DE-He213 chemodynamic therapy (dpeaa)DE-He213 photothermal therapy (dpeaa)DE-He213 cascade reaction (dpeaa)DE-He213 tumor microenvironment (dpeaa)DE-He213
topic	misc lactate oxidase misc chemodynamic therapy misc photothermal therapy misc cascade reaction misc tumor microenvironment
topic_unstemmed	misc lactate oxidase misc chemodynamic therapy misc photothermal therapy misc cascade reaction misc tumor microenvironment
topic_browse	misc lactate oxidase misc chemodynamic therapy misc photothermal therapy misc cascade reaction misc tumor microenvironment
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title	PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
ctrlnum	(DE-627)SPR054476941 (SPR)s12274-023-5764-1-e
title_full	PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
author_sort	Ye, Zichen
journal	Nano research
journalStr	Nano research
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container_start_page	270
author_browse	Ye, Zichen Li, Yun Li, Jingchao Hu, Xinyan Zheng, Jinyang Zhang, Gongxin Xiang, Sijin Zhu, Tianbao Guo, Zhide Chen, Xiaolan
container_volume	17
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author-letter	Ye, Zichen
doi_str_mv	10.1007/s12274-023-5764-1
title_sort	ir-lod multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
title_auth	PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
abstract	Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. © Tsinghua University Press 2023
abstractGer	Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. © Tsinghua University Press 2023
abstract_unstemmed	Abstract Lactic acid (LA) plays a major role in the occurrence, development, and spread of cancer. Enlightened by its high accumulation in tumor site, a novel lactate oxidase (LOD) conjugated two-dimensional PdIr nanoplatform (Pd@Ir-LOD, PIL) was fabricated to combine cascade reaction with photothermal for tumor therapy. In detail, the overexpressed LA in tumor microenvironment (TME) was a key factor to activate the PIL-based cascade reaction: (1) Plenty of $ H_{2} %$ O_{2} $ could be generated from LA by the catalysis of LOD with $ O_{2} $; (2) potent OH was produced from $ H_{2} %$ O_{2} $ due to the peroxidase (POD)-like activity of PIL; (3) meantime, PIL’s catalase (CAT)-like activity could decompose part $ H_{2} %$ O_{2} $ into $ O_{2} $ to achieve the purpose of LA cyclic oxidization. Moreover, the reduced glutathione (GSH) scavenging capability of PIL might protect the produced reactive oxygen species (ROS) from being cleared to further improve the cascade therapeutic effect. More importantly, PIL had excellent photothermal conversion efficiency (37.35%) and manifested a surprising temperature rising effect in tumor. Taken together, the decreasing LA concentration, accumulation of high-toxic ROS, the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy. Therefore, a promising therapeutic tactic based on PIL integrating endogenous LA consumption, chemodynamic therapy (CDT), and photothermal therapy (PTT) has been put forward. © Tsinghua University Press 2023
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title_short	PdIr-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy
url	https://dx.doi.org/10.1007/s12274-023-5764-1
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author2	Li, Yun Li, Jingchao Hu, Xinyan Zheng, Jinyang Zhang, Gongxin Xiang, Sijin Zhu, Tianbao Guo, Zhide Chen, Xiaolan
author2Str	Li, Yun Li, Jingchao Hu, Xinyan Zheng, Jinyang Zhang, Gongxin Xiang, Sijin Zhu, Tianbao Guo, Zhide Chen, Xiaolan
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doi_str	10.1007/s12274-023-5764-1
up_date	2024-07-04T01:48:13.938Z
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