Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems,...
Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Rodrigues, Daniel B. [verfasserIn] Reis, Rui L. Pirraco, Rogério P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Spheroids 3D tumor models Cancer Tumor microenvironment

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Journal of biomedical science - London : BioMed Central, 1994, 31(2024), 1 vom: 23. Jan.
Übergeordnetes Werk:	volume:31 ; year:2024 ; number:1 ; day:23 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12929-024-00997-9

Katalog-ID:	SPR054478693

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allfields	10.1186/s12929-024-00997-9 doi (DE-627)SPR054478693 (SPR)s12929-024-00997-9-e DE-627 ger DE-627 rakwb eng Rodrigues, Daniel B. verfasserin (orcid)0000-0002-0560-2962 aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Reis, Rui L. (orcid)0000-0002-4295-6129 aut Pirraco, Rogério P. (orcid)0000-0001-5521-950X aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 31(2024), 1 vom: 23. Jan. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:31 year:2024 number:1 day:23 month:01 https://dx.doi.org/10.1186/s12929-024-00997-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 23 01
spelling	10.1186/s12929-024-00997-9 doi (DE-627)SPR054478693 (SPR)s12929-024-00997-9-e DE-627 ger DE-627 rakwb eng Rodrigues, Daniel B. verfasserin (orcid)0000-0002-0560-2962 aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Reis, Rui L. (orcid)0000-0002-4295-6129 aut Pirraco, Rogério P. (orcid)0000-0001-5521-950X aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 31(2024), 1 vom: 23. Jan. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:31 year:2024 number:1 day:23 month:01 https://dx.doi.org/10.1186/s12929-024-00997-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 23 01
allfields_unstemmed	10.1186/s12929-024-00997-9 doi (DE-627)SPR054478693 (SPR)s12929-024-00997-9-e DE-627 ger DE-627 rakwb eng Rodrigues, Daniel B. verfasserin (orcid)0000-0002-0560-2962 aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Reis, Rui L. (orcid)0000-0002-4295-6129 aut Pirraco, Rogério P. (orcid)0000-0001-5521-950X aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 31(2024), 1 vom: 23. Jan. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:31 year:2024 number:1 day:23 month:01 https://dx.doi.org/10.1186/s12929-024-00997-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 23 01
allfieldsGer	10.1186/s12929-024-00997-9 doi (DE-627)SPR054478693 (SPR)s12929-024-00997-9-e DE-627 ger DE-627 rakwb eng Rodrigues, Daniel B. verfasserin (orcid)0000-0002-0560-2962 aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Reis, Rui L. (orcid)0000-0002-4295-6129 aut Pirraco, Rogério P. (orcid)0000-0001-5521-950X aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 31(2024), 1 vom: 23. Jan. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:31 year:2024 number:1 day:23 month:01 https://dx.doi.org/10.1186/s12929-024-00997-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 23 01
allfieldsSound	10.1186/s12929-024-00997-9 doi (DE-627)SPR054478693 (SPR)s12929-024-00997-9-e DE-627 ger DE-627 rakwb eng Rodrigues, Daniel B. verfasserin (orcid)0000-0002-0560-2962 aut Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213 Reis, Rui L. (orcid)0000-0002-4295-6129 aut Pirraco, Rogério P. (orcid)0000-0001-5521-950X aut Enthalten in Journal of biomedical science London : BioMed Central, 1994 31(2024), 1 vom: 23. Jan. (DE-627)300593724 (DE-600)1482918-6 1423-0127 nnns volume:31 year:2024 number:1 day:23 month:01 https://dx.doi.org/10.1186/s12929-024-00997-9 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4328 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 31 2024 1 23 01
language	English
source	Enthalten in Journal of biomedical science 31(2024), 1 vom: 23. Jan. volume:31 year:2024 number:1 day:23 month:01
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author	Rodrigues, Daniel B.
spellingShingle	Rodrigues, Daniel B. misc Spheroids misc 3D tumor models misc Cancer misc Tumor microenvironment Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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topic_title	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool Spheroids (dpeaa)DE-He213 3D tumor models (dpeaa)DE-He213 Cancer (dpeaa)DE-He213 Tumor microenvironment (dpeaa)DE-He213
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title	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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title_full	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
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author_browse	Rodrigues, Daniel B. Reis, Rui L. Pirraco, Rogério P.
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title_sort	modelling the complex nature of the tumor microenvironment: 3d tumor spheroids as an evolving tool
title_auth	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
abstract	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. © The Author(s) 2024
abstractGer	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. © The Author(s) 2024
abstract_unstemmed	Abstract Cancer remains a serious burden in society and while the pace in the development of novel and more effective therapeutics is increasing, testing platforms that faithfully mimic the tumor microenvironment are lacking. With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. We finish by speculating on future advancements in the field and on how these can shape the relevance of spherical 3D models for tumor modelling. © The Author(s) 2024
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title_short	Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool
url	https://dx.doi.org/10.1186/s12929-024-00997-9
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up_date	2024-07-04T01:48:45.365Z
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With a clear shift from animal models to more complex in vitro 3D systems, spheroids emerge as strong options in this regard. Years of development have allowed spheroid-based models to better reproduce the biomechanical cues that are observed in the tumor-associated extracellular matrix (ECM) and cellular interactions that occur in both a cell–cell and cell-ECM manner. Here, we summarize some of the key cellular interactions that drive tumor development, progression and invasion, and how successfully are these interactions recapitulated in 3D spheroid models currently in use in the field. 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Modelling the complex nature of the tumor microenvironment: 3D tumor spheroids as an evolving tool

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