Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion

Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 i...
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Autor*in:	Yu, Wangyang [verfasserIn] Zhou, Minfeng Niu, Huifang Li, Jinxiao Li, Qiumeng Xu, Xiaoyun Liang, Fengxia Rui, Chen

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Glioblastoma multiforme (GBM) CXCL5 Immune invasion Brain cancer Immunoinfiltration

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC cancer - London : BioMed Central, 2001, 24(2024), 1 vom: 29. Jan.
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:29 ; month:01

Links:	Volltext

DOI / URN:	10.1186/s12885-023-11650-3

Katalog-ID:	SPR054566991

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allfields	10.1186/s12885-023-11650-3 doi (DE-627)SPR054566991 (SPR)s12885-023-11650-3-e DE-627 ger DE-627 rakwb eng Yu, Wangyang verfasserin aut Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213 Zhou, Minfeng aut Niu, Huifang aut Li, Jinxiao aut Li, Qiumeng aut Xu, Xiaoyun aut Liang, Fengxia aut Rui, Chen aut Enthalten in BMC cancer London : BioMed Central, 2001 24(2024), 1 vom: 29. Jan. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:29 month:01 https://dx.doi.org/10.1186/s12885-023-11650-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 29 01
spelling	10.1186/s12885-023-11650-3 doi (DE-627)SPR054566991 (SPR)s12885-023-11650-3-e DE-627 ger DE-627 rakwb eng Yu, Wangyang verfasserin aut Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213 Zhou, Minfeng aut Niu, Huifang aut Li, Jinxiao aut Li, Qiumeng aut Xu, Xiaoyun aut Liang, Fengxia aut Rui, Chen aut Enthalten in BMC cancer London : BioMed Central, 2001 24(2024), 1 vom: 29. Jan. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:29 month:01 https://dx.doi.org/10.1186/s12885-023-11650-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 29 01
allfields_unstemmed	10.1186/s12885-023-11650-3 doi (DE-627)SPR054566991 (SPR)s12885-023-11650-3-e DE-627 ger DE-627 rakwb eng Yu, Wangyang verfasserin aut Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213 Zhou, Minfeng aut Niu, Huifang aut Li, Jinxiao aut Li, Qiumeng aut Xu, Xiaoyun aut Liang, Fengxia aut Rui, Chen aut Enthalten in BMC cancer London : BioMed Central, 2001 24(2024), 1 vom: 29. Jan. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:29 month:01 https://dx.doi.org/10.1186/s12885-023-11650-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 29 01
allfieldsGer	10.1186/s12885-023-11650-3 doi (DE-627)SPR054566991 (SPR)s12885-023-11650-3-e DE-627 ger DE-627 rakwb eng Yu, Wangyang verfasserin aut Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213 Zhou, Minfeng aut Niu, Huifang aut Li, Jinxiao aut Li, Qiumeng aut Xu, Xiaoyun aut Liang, Fengxia aut Rui, Chen aut Enthalten in BMC cancer London : BioMed Central, 2001 24(2024), 1 vom: 29. Jan. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:29 month:01 https://dx.doi.org/10.1186/s12885-023-11650-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 29 01
allfieldsSound	10.1186/s12885-023-11650-3 doi (DE-627)SPR054566991 (SPR)s12885-023-11650-3-e DE-627 ger DE-627 rakwb eng Yu, Wangyang verfasserin aut Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213 Zhou, Minfeng aut Niu, Huifang aut Li, Jinxiao aut Li, Qiumeng aut Xu, Xiaoyun aut Liang, Fengxia aut Rui, Chen aut Enthalten in BMC cancer London : BioMed Central, 2001 24(2024), 1 vom: 29. Jan. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:29 month:01 https://dx.doi.org/10.1186/s12885-023-11650-3 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 24 2024 1 29 01
language	English
source	Enthalten in BMC cancer 24(2024), 1 vom: 29. Jan. volume:24 year:2024 number:1 day:29 month:01
sourceStr	Enthalten in BMC cancer 24(2024), 1 vom: 29. Jan. volume:24 year:2024 number:1 day:29 month:01
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Glioblastoma multiforme (GBM) CXCL5 Immune invasion Brain cancer Immunoinfiltration
isfreeaccess_bool	true
container_title	BMC cancer
authorswithroles_txt_mv	Yu, Wangyang @@aut@@ Zhou, Minfeng @@aut@@ Niu, Huifang @@aut@@ Li, Jinxiao @@aut@@ Li, Qiumeng @@aut@@ Xu, Xiaoyun @@aut@@ Liang, Fengxia @@aut@@ Rui, Chen @@aut@@
publishDateDaySort_date	2024-01-29T00:00:00Z
hierarchy_top_id	326643710
id	SPR054566991
language_de	englisch
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author	Yu, Wangyang
spellingShingle	Yu, Wangyang misc Glioblastoma multiforme (GBM) misc CXCL5 misc Immune invasion misc Brain cancer misc Immunoinfiltration Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion
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topic_title	Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion Glioblastoma multiforme (GBM) (dpeaa)DE-He213 CXCL5 (dpeaa)DE-He213 Immune invasion (dpeaa)DE-He213 Brain cancer (dpeaa)DE-He213 Immunoinfiltration (dpeaa)DE-He213
topic	misc Glioblastoma multiforme (GBM) misc CXCL5 misc Immune invasion misc Brain cancer misc Immunoinfiltration
topic_unstemmed	misc Glioblastoma multiforme (GBM) misc CXCL5 misc Immune invasion misc Brain cancer misc Immunoinfiltration
topic_browse	misc Glioblastoma multiforme (GBM) misc CXCL5 misc Immune invasion misc Brain cancer misc Immunoinfiltration
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title	Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion
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title_full	Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion
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author_browse	Yu, Wangyang Zhou, Minfeng Niu, Huifang Li, Jinxiao Li, Qiumeng Xu, Xiaoyun Liang, Fengxia Rui, Chen
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title_sort	prognostic marker cxcl5 in glioblastoma polyformis and its mechanism of immune invasion
title_auth	Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion
abstract	Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. © The Author(s) 2024
abstractGer	Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. © The Author(s) 2024
abstract_unstemmed	Abstract Glioblastoma multiforme (GBM) is the most aggressive brain cancer with a poor prognosis. Therefore, the correlative molecular markers and molecular mechanisms should be explored to assess the occurrence and treatment of glioma.WB and qPCR assays were used to detect the expression of CXCL5 in human GBM tissues. The relationship between CXCL5 expression and clinicopathological features was evaluated using logistic regression analysis, Wilcoxon symbolic rank test, and Kruskal–Wallis test. Univariate, multivariate Cox regression and Kaplan–Meier methods were used to assess CXCL5 and other prognostic factors of GBM. Gene set enrichment analysis (GSEA) was used to identify pathways associated with CXCL5. The correlation between CXCL5 and tumor immunoinfiltration was investigated using single sample gene set enrichment analysis (ssGSEA) of TCGA data. Cell experiments and mouse subcutaneous transplanted tumor models were used to evaluate the role of CXCL5 in GBM. WB, qPCR, immunofluorescence, and immunohistochemical assays showed that CXCL5 expression was increased in human GBM tissues. Furthermore, high CXCL5 expression was closely related to poor disease-specific survival and overall survival of GBM patients. The ssGSEA suggested that CXCL5 is closely related to the cell cycle and immune response through PPAR signaling pathway. GSEA also showed that CXCL5 expression was positively correlated with macrophage cell infiltration level and negatively correlated with cytotoxic cell infiltration level. CXCL5 may be associated with the prognosis and immunoinfiltration of GBM. © The Author(s) 2024
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title_short	Prognostic marker CXCL5 in glioblastoma polyformis and its mechanism of immune invasion
url	https://dx.doi.org/10.1186/s12885-023-11650-3
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author2	Zhou, Minfeng Niu, Huifang Li, Jinxiao Li, Qiumeng Xu, Xiaoyun Liang, Fengxia Rui, Chen
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up_date	2024-07-04T02:12:46.571Z
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