Correlation between fetuin-A and matrix Gla protein levels in human serum

Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to in...
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Autor*in:	Mori, Katsuhito [verfasserIn] Ikari, Yuji Jono, Shuichi Emoto, Masanori Shioi, Atsushi Koyama, Hidenori Shoji, Tetsuo Ishimura, Eiji lnaba, Masaaki Hara, Kazuhiro Nishizawa, Yoshiki

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Schlagwörter:	Fetuin-A Matrix Gla protein Osteoprotegerin Osteopontin Vascular calcification

Anmerkung:	© Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 4(2010), 3 vom: 24. Juli, Seite 91-93
Übergeordnetes Werk:	volume:4 ; year:2010 ; number:3 ; day:24 ; month:07 ; pages:91-93

Links:	Volltext

DOI / URN:	10.1016/j.artres.2010.06.002

Katalog-ID:	SPR054649692

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520			\|a Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification.
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650		4	\|a Vascular calcification \|7 (dpeaa)DE-He213
700	1		\|a Ikari, Yuji \|4 aut
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700	1		\|a lnaba, Masaaki \|4 aut
700	1		\|a Hara, Kazuhiro \|4 aut
700	1		\|a Nishizawa, Yoshiki \|4 aut
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allfields	10.1016/j.artres.2010.06.002 doi (DE-627)SPR054649692 (SPR)j.artres.2010.06.002-e DE-627 ger DE-627 rakwb eng Mori, Katsuhito verfasserin aut Correlation between fetuin-A and matrix Gla protein levels in human serum 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010 Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213 Ikari, Yuji aut Jono, Shuichi aut Emoto, Masanori aut Shioi, Atsushi aut Koyama, Hidenori aut Shoji, Tetsuo aut Ishimura, Eiji aut lnaba, Masaaki aut Hara, Kazuhiro aut Nishizawa, Yoshiki aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 3 vom: 24. Juli, Seite 91-93 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:3 day:24 month:07 pages:91-93 https://dx.doi.org/10.1016/j.artres.2010.06.002 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 3 24 07 91-93
spelling	10.1016/j.artres.2010.06.002 doi (DE-627)SPR054649692 (SPR)j.artres.2010.06.002-e DE-627 ger DE-627 rakwb eng Mori, Katsuhito verfasserin aut Correlation between fetuin-A and matrix Gla protein levels in human serum 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010 Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213 Ikari, Yuji aut Jono, Shuichi aut Emoto, Masanori aut Shioi, Atsushi aut Koyama, Hidenori aut Shoji, Tetsuo aut Ishimura, Eiji aut lnaba, Masaaki aut Hara, Kazuhiro aut Nishizawa, Yoshiki aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 3 vom: 24. Juli, Seite 91-93 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:3 day:24 month:07 pages:91-93 https://dx.doi.org/10.1016/j.artres.2010.06.002 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 3 24 07 91-93
allfields_unstemmed	10.1016/j.artres.2010.06.002 doi (DE-627)SPR054649692 (SPR)j.artres.2010.06.002-e DE-627 ger DE-627 rakwb eng Mori, Katsuhito verfasserin aut Correlation between fetuin-A and matrix Gla protein levels in human serum 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010 Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213 Ikari, Yuji aut Jono, Shuichi aut Emoto, Masanori aut Shioi, Atsushi aut Koyama, Hidenori aut Shoji, Tetsuo aut Ishimura, Eiji aut lnaba, Masaaki aut Hara, Kazuhiro aut Nishizawa, Yoshiki aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 3 vom: 24. Juli, Seite 91-93 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:3 day:24 month:07 pages:91-93 https://dx.doi.org/10.1016/j.artres.2010.06.002 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 3 24 07 91-93
allfieldsGer	10.1016/j.artres.2010.06.002 doi (DE-627)SPR054649692 (SPR)j.artres.2010.06.002-e DE-627 ger DE-627 rakwb eng Mori, Katsuhito verfasserin aut Correlation between fetuin-A and matrix Gla protein levels in human serum 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010 Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213 Ikari, Yuji aut Jono, Shuichi aut Emoto, Masanori aut Shioi, Atsushi aut Koyama, Hidenori aut Shoji, Tetsuo aut Ishimura, Eiji aut lnaba, Masaaki aut Hara, Kazuhiro aut Nishizawa, Yoshiki aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 3 vom: 24. Juli, Seite 91-93 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:3 day:24 month:07 pages:91-93 https://dx.doi.org/10.1016/j.artres.2010.06.002 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 3 24 07 91-93
allfieldsSound	10.1016/j.artres.2010.06.002 doi (DE-627)SPR054649692 (SPR)j.artres.2010.06.002-e DE-627 ger DE-627 rakwb eng Mori, Katsuhito verfasserin aut Correlation between fetuin-A and matrix Gla protein levels in human serum 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010 Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213 Ikari, Yuji aut Jono, Shuichi aut Emoto, Masanori aut Shioi, Atsushi aut Koyama, Hidenori aut Shoji, Tetsuo aut Ishimura, Eiji aut lnaba, Masaaki aut Hara, Kazuhiro aut Nishizawa, Yoshiki aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 3 vom: 24. Juli, Seite 91-93 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:3 day:24 month:07 pages:91-93 https://dx.doi.org/10.1016/j.artres.2010.06.002 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 3 24 07 91-93
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Published by Elsevier B.V. All rights reserved 2010</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. 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author	Mori, Katsuhito
spellingShingle	Mori, Katsuhito misc Fetuin-A misc Matrix Gla protein misc Osteoprotegerin misc Osteopontin misc Vascular calcification Correlation between fetuin-A and matrix Gla protein levels in human serum
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topic_title	Correlation between fetuin-A and matrix Gla protein levels in human serum Fetuin-A (dpeaa)DE-He213 Matrix Gla protein (dpeaa)DE-He213 Osteoprotegerin (dpeaa)DE-He213 Osteopontin (dpeaa)DE-He213 Vascular calcification (dpeaa)DE-He213
topic	misc Fetuin-A misc Matrix Gla protein misc Osteoprotegerin misc Osteopontin misc Vascular calcification
topic_unstemmed	misc Fetuin-A misc Matrix Gla protein misc Osteoprotegerin misc Osteopontin misc Vascular calcification
topic_browse	misc Fetuin-A misc Matrix Gla protein misc Osteoprotegerin misc Osteopontin misc Vascular calcification
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title	Correlation between fetuin-A and matrix Gla protein levels in human serum
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title_full	Correlation between fetuin-A and matrix Gla protein levels in human serum
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author_browse	Mori, Katsuhito Ikari, Yuji Jono, Shuichi Emoto, Masanori Shioi, Atsushi Koyama, Hidenori Shoji, Tetsuo Ishimura, Eiji lnaba, Masaaki Hara, Kazuhiro Nishizawa, Yoshiki
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title_sort	correlation between fetuin-a and matrix gla protein levels in human serum
title_auth	Correlation between fetuin-A and matrix Gla protein levels in human serum
abstract	Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010
abstractGer	Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010
abstract_unstemmed	Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. Fetuin-A may collaborate with MGP to inhibit vascular calcification. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2010
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title_short	Correlation between fetuin-A and matrix Gla protein levels in human serum
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author2	Ikari, Yuji Jono, Shuichi Emoto, Masanori Shioi, Atsushi Koyama, Hidenori Shoji, Tetsuo Ishimura, Eiji lnaba, Masaaki Hara, Kazuhiro Nishizawa, Yoshiki
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Published by Elsevier B.V. All rights reserved 2010</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Vascular calcification is frequently found in hemodialysis patients. Fetuin-A is a well-characterized circulating inhibitor of calcification. Several other bone-associated proteins, such as the matrix Gla protein (MGP), osteoprotegerin (OPG), and osteopontin (OPN), are also presumed to inhibit vascular calcification. However, little is known about the relationship between fetuin-A and other calcification inhibitors. In this study, we examined the association of fetuin-A with MGP, OPG, and OPN. Methods We consecutively enrolled 92 subjects who were suspected to have coronary artery diseases. Serum levels of fetuin-A, MGP, OPG, and OPN were measured using ELISA. Results: Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Results Fetuin-A level was significantly correlated with MGP level (p = 0.242, p = 0.021). On the other hand, the fetuin-A level was not correlated with OPG (p = 0.048, p = 0.649) and OPN (p = 0.007, p = 0.948) levels. Conclusions We found the positive correlation between fetuin-A and MGP levels in human serum. 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Correlation between fetuin-A and matrix Gla protein levels in human serum

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