P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease

Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate th...
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Autor*in:	Badhwar, Smriti [verfasserIn] Chandran, Dinu Jaryal, Ashok Narang, Rajiv Patel, Chetan Deepak, Kishore Kumar

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2020

Schlagwörter:	Low-flow-mediated constriction flow profile

Anmerkung:	© Association for Research into Arterial Structure and Physiology 2020

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 26(2020), Suppl 1 vom: Dez., Seite S22-S22
Übergeordnetes Werk:	volume:26 ; year:2020 ; number:Suppl 1 ; month:12 ; pages:S22-S22

Links:	Volltext

DOI / URN:	10.2991/artres.k.201209.016

Katalog-ID:	SPR054760313

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520			\|a Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased.
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allfields	10.2991/artres.k.201209.016 doi (DE-627)SPR054760313 (SPR)artres.k.201209.016-e DE-627 ger DE-627 rakwb eng Badhwar, Smriti verfasserin aut P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2020 Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213 Chandran, Dinu aut Jaryal, Ashok aut Narang, Rajiv aut Patel, Chetan aut Deepak, Kishore Kumar aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 26(2020), Suppl 1 vom: Dez., Seite S22-S22 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:26 year:2020 number:Suppl 1 month:12 pages:S22-S22 https://dx.doi.org/10.2991/artres.k.201209.016 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2020 Suppl 1 12 S22-S22
spelling	10.2991/artres.k.201209.016 doi (DE-627)SPR054760313 (SPR)artres.k.201209.016-e DE-627 ger DE-627 rakwb eng Badhwar, Smriti verfasserin aut P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2020 Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213 Chandran, Dinu aut Jaryal, Ashok aut Narang, Rajiv aut Patel, Chetan aut Deepak, Kishore Kumar aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 26(2020), Suppl 1 vom: Dez., Seite S22-S22 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:26 year:2020 number:Suppl 1 month:12 pages:S22-S22 https://dx.doi.org/10.2991/artres.k.201209.016 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2020 Suppl 1 12 S22-S22
allfields_unstemmed	10.2991/artres.k.201209.016 doi (DE-627)SPR054760313 (SPR)artres.k.201209.016-e DE-627 ger DE-627 rakwb eng Badhwar, Smriti verfasserin aut P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2020 Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213 Chandran, Dinu aut Jaryal, Ashok aut Narang, Rajiv aut Patel, Chetan aut Deepak, Kishore Kumar aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 26(2020), Suppl 1 vom: Dez., Seite S22-S22 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:26 year:2020 number:Suppl 1 month:12 pages:S22-S22 https://dx.doi.org/10.2991/artres.k.201209.016 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2020 Suppl 1 12 S22-S22
allfieldsGer	10.2991/artres.k.201209.016 doi (DE-627)SPR054760313 (SPR)artres.k.201209.016-e DE-627 ger DE-627 rakwb eng Badhwar, Smriti verfasserin aut P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2020 Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213 Chandran, Dinu aut Jaryal, Ashok aut Narang, Rajiv aut Patel, Chetan aut Deepak, Kishore Kumar aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 26(2020), Suppl 1 vom: Dez., Seite S22-S22 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:26 year:2020 number:Suppl 1 month:12 pages:S22-S22 https://dx.doi.org/10.2991/artres.k.201209.016 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2020 Suppl 1 12 S22-S22
allfieldsSound	10.2991/artres.k.201209.016 doi (DE-627)SPR054760313 (SPR)artres.k.201209.016-e DE-627 ger DE-627 rakwb eng Badhwar, Smriti verfasserin aut P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease 2020 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology 2020 Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213 Chandran, Dinu aut Jaryal, Ashok aut Narang, Rajiv aut Patel, Chetan aut Deepak, Kishore Kumar aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 26(2020), Suppl 1 vom: Dez., Seite S22-S22 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:26 year:2020 number:Suppl 1 month:12 pages:S22-S22 https://dx.doi.org/10.2991/artres.k.201209.016 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 26 2020 Suppl 1 12 S22-S22
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There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Low-flow-mediated</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">constriction</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">flow profile</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chandran, Dinu</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jaryal, Ashok</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" 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author	Badhwar, Smriti
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topic_title	P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease Low-flow-mediated (dpeaa)DE-He213 constriction (dpeaa)DE-He213 flow profile (dpeaa)DE-He213
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topic_unstemmed	misc Low-flow-mediated misc constriction misc flow profile
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title	P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease
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author_browse	Badhwar, Smriti Chandran, Dinu Jaryal, Ashok Narang, Rajiv Patel, Chetan Deepak, Kishore Kumar
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title_sort	p.02 differential ‘mediators’ of low-flow ‘mediated’ constriction in healthy vs patients of ischemic heart disease
title_auth	P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease
abstract	Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. © Association for Research into Arterial Structure and Physiology 2020
abstractGer	Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. © Association for Research into Arterial Structure and Physiology 2020
abstract_unstemmed	Background Low-flow mediated constriction (LFMC) has emerged as a non-invasive tool for assessment of endothelial dysfunction [1]. There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. Conclusion Brachial-artery constriction during occlusion is ‘mediated’ by decrease in ASR in patients of IHD and decrease in NSR and increase in RSR in healthy, highlighting the possibility of differential ‘mediators’ of constriction in healthy vs diseased. © Association for Research into Arterial Structure and Physiology 2020
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title_short	P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease
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author2	Chandran, Dinu Jaryal, Ashok Narang, Rajiv Patel, Chetan Deepak, Kishore Kumar
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up_date	2024-07-04T02:55:15.327Z
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There is insufficient data on association between change in artery diameter during occlusion with its possible stimulus; ‘low flow’ state. This study aims to evaluate the association between change in brachial-artery diameter during constriction with alterations in retrograde, anterograde and oscillatory flow profile in healthy subjects and patients with ischemic heart disease (IHD). Methods Brachial-artery responses to occlusion were assessed from artery diameter and blood flow using B-mode and pulsed-wave doppler ultrasound respectively in 89 patients with IHD and 29 healthy subjects. Change in anterograde, retrograde and net flow velocity, shear rate (AFV, RFV, NFV, ASR, RSR and NSR respectively) and oscillatory shear index (OSI) during forearm occlusion at 50 mmHg above systolic pressure, from baseline was calculated. Result Diameter deceased significantly in healthy subjects and patients during occlusion compared to baseline. Interestingly, in stepwise forward-selection analysis, change in maximum AFV, ASR, RSV and RSR emerged in best fit model, explaining 76.2% of total variability in delta LFMC in IHD patients, with maximum contribution by ASR (70.4%). On the other hand, in healthy, change in maximum RFV, RSR, NFV and NSR emerged in best-fit model explaining 89.9% of total variability, of which 47% was by NSR and 33% by RSR. 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P.02 Differential ‘Mediators’ of Low-Flow ‘Mediated’ Constriction in Healthy vs Patients of Ischemic Heart Disease

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