Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages

Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that...
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Autor*in:	Kim, Minji [verfasserIn] An, Jangeun Shin, Seong-Ah Moon, Sun Young Kim, Moonsu Choi, Seyeon Kim, Huiji Phi, Kim-Hoa Lee, Jun Hyuck Youn, Ui Joung Park, Hyun Ho Lee, Chang Sup

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	TP1 Anti-inflammation NF-κB MAPK

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Journal of the Korean Society for Applied Biological Chemistry - [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009, 67(2024), 1 vom: 15. Feb.
Übergeordnetes Werk:	volume:67 ; year:2024 ; number:1 ; day:15 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s13765-024-00873-y

Katalog-ID:	SPR054775027

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allfields	10.1186/s13765-024-00873-y doi (DE-627)SPR054775027 (SPR)s13765-024-00873-y-e DE-627 ger DE-627 rakwb eng Kim, Minji verfasserin aut Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213 An, Jangeun aut Shin, Seong-Ah aut Moon, Sun Young aut Kim, Moonsu aut Choi, Seyeon aut Kim, Huiji aut Phi, Kim-Hoa aut Lee, Jun Hyuck aut Youn, Ui Joung aut Park, Hyun Ho aut Lee, Chang Sup (orcid)0000-0002-2384-7576 aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 67(2024), 1 vom: 15. Feb. (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:67 year:2024 number:1 day:15 month:02 https://dx.doi.org/10.1186/s13765-024-00873-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 67 2024 1 15 02
spelling	10.1186/s13765-024-00873-y doi (DE-627)SPR054775027 (SPR)s13765-024-00873-y-e DE-627 ger DE-627 rakwb eng Kim, Minji verfasserin aut Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213 An, Jangeun aut Shin, Seong-Ah aut Moon, Sun Young aut Kim, Moonsu aut Choi, Seyeon aut Kim, Huiji aut Phi, Kim-Hoa aut Lee, Jun Hyuck aut Youn, Ui Joung aut Park, Hyun Ho aut Lee, Chang Sup (orcid)0000-0002-2384-7576 aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 67(2024), 1 vom: 15. Feb. (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:67 year:2024 number:1 day:15 month:02 https://dx.doi.org/10.1186/s13765-024-00873-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 67 2024 1 15 02
allfields_unstemmed	10.1186/s13765-024-00873-y doi (DE-627)SPR054775027 (SPR)s13765-024-00873-y-e DE-627 ger DE-627 rakwb eng Kim, Minji verfasserin aut Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213 An, Jangeun aut Shin, Seong-Ah aut Moon, Sun Young aut Kim, Moonsu aut Choi, Seyeon aut Kim, Huiji aut Phi, Kim-Hoa aut Lee, Jun Hyuck aut Youn, Ui Joung aut Park, Hyun Ho aut Lee, Chang Sup (orcid)0000-0002-2384-7576 aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 67(2024), 1 vom: 15. Feb. (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:67 year:2024 number:1 day:15 month:02 https://dx.doi.org/10.1186/s13765-024-00873-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 67 2024 1 15 02
allfieldsGer	10.1186/s13765-024-00873-y doi (DE-627)SPR054775027 (SPR)s13765-024-00873-y-e DE-627 ger DE-627 rakwb eng Kim, Minji verfasserin aut Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213 An, Jangeun aut Shin, Seong-Ah aut Moon, Sun Young aut Kim, Moonsu aut Choi, Seyeon aut Kim, Huiji aut Phi, Kim-Hoa aut Lee, Jun Hyuck aut Youn, Ui Joung aut Park, Hyun Ho aut Lee, Chang Sup (orcid)0000-0002-2384-7576 aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 67(2024), 1 vom: 15. Feb. (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:67 year:2024 number:1 day:15 month:02 https://dx.doi.org/10.1186/s13765-024-00873-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 67 2024 1 15 02
allfieldsSound	10.1186/s13765-024-00873-y doi (DE-627)SPR054775027 (SPR)s13765-024-00873-y-e DE-627 ger DE-627 rakwb eng Kim, Minji verfasserin aut Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213 An, Jangeun aut Shin, Seong-Ah aut Moon, Sun Young aut Kim, Moonsu aut Choi, Seyeon aut Kim, Huiji aut Phi, Kim-Hoa aut Lee, Jun Hyuck aut Youn, Ui Joung aut Park, Hyun Ho aut Lee, Chang Sup (orcid)0000-0002-2384-7576 aut Enthalten in Journal of the Korean Society for Applied Biological Chemistry [Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009 67(2024), 1 vom: 15. Feb. (DE-627)684967510 (DE-600)2649483-8 2234-344X nnns volume:67 year:2024 number:1 day:15 month:02 https://dx.doi.org/10.1186/s13765-024-00873-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_110 GBV_ILN_161 GBV_ILN_293 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 AR 67 2024 1 15 02
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source	Enthalten in Journal of the Korean Society for Applied Biological Chemistry 67(2024), 1 vom: 15. Feb. volume:67 year:2024 number:1 day:15 month:02
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authorswithroles_txt_mv	Kim, Minji @@aut@@ An, Jangeun @@aut@@ Shin, Seong-Ah @@aut@@ Moon, Sun Young @@aut@@ Kim, Moonsu @@aut@@ Choi, Seyeon @@aut@@ Kim, Huiji @@aut@@ Phi, Kim-Hoa @@aut@@ Lee, Jun Hyuck @@aut@@ Youn, Ui Joung @@aut@@ Park, Hyun Ho @@aut@@ Lee, Chang Sup @@aut@@
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author	Kim, Minji
spellingShingle	Kim, Minji misc TP1 misc Anti-inflammation misc NF-κB misc MAPK Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
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topic_title	Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages TP1 (dpeaa)DE-He213 Anti-inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 MAPK (dpeaa)DE-He213
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title	Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
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title_full	Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
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author_browse	Kim, Minji An, Jangeun Shin, Seong-Ah Moon, Sun Young Kim, Moonsu Choi, Seyeon Kim, Huiji Phi, Kim-Hoa Lee, Jun Hyuck Youn, Ui Joung Park, Hyun Ho Lee, Chang Sup
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title_sort	anti-inflammatory effects of tp1 in lps-induced raw264.7 macrophages
title_auth	Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
abstract	Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. © The Author(s) 2024
abstractGer	Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. © The Author(s) 2024
abstract_unstemmed	Abstract Inflammation is an essential defense mechanism in health; however, excessive inflammation contributes to the pathophysiology of several chronic diseases. Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases. © The Author(s) 2024
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title_short	Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages
url	https://dx.doi.org/10.1186/s13765-024-00873-y
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author2	An, Jangeun Shin, Seong-Ah Moon, Sun Young Kim, Moonsu Choi, Seyeon Kim, Huiji Phi, Kim-Hoa Lee, Jun Hyuck Youn, Ui Joung Park, Hyun Ho Lee, Chang Sup
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up_date	2024-07-04T02:58:29.447Z
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Although anti-inflammatory drugs are essential for controlling inflammation, they have several side effects. Recent findings suggest that naturally derived compounds possess physiological activities, including anti-inflammatory, antifungal, antiviral, anticancer, and immunomodulatory activities. Therefore, this study aimed to investigate the anti-inflammatory effects and molecular mechanisms of 2,5,6-trimethoxy-p-terphenyl (TP1), extracted from the Antarctic lichen Stereocaulon alpinum, using in vitro models. TP1 treatment decreased the production of nitric oxide (NO) and reactive oxygen species (ROS) in LPS-stimulated Raw264.7 macrophages. Additionally, TP1 treatment significantly decreased the mRNA levels of pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and the mRNA and protein levels of the pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2). Moreover, TP1 suppressed lipopolysaccharide-induced phosphorylation of the NF-κB and MAPK signaling pathways in Raw264.7 macrophages. Conclusively, these results suggest that TP1 ameliorates inflammation by suppressing the expression of pro-inflammatory cytokines, making it a potential anti-inflammatory drug for the treatment of severe inflammatory diseases.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TP1</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Anti-inflammation</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">NF-κB</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">MAPK</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">An, Jangeun</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shin, Seong-Ah</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Moon, Sun Young</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Moonsu</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Choi, Seyeon</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kim, Huiji</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Phi, Kim-Hoa</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Jun Hyuck</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Youn, Ui Joung</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Park, Hyun Ho</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lee, Chang Sup</subfield><subfield code="0">(orcid)0000-0002-2384-7576</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Journal of the Korean Society for Applied Biological Chemistry</subfield><subfield code="d">[Seoul] : The Korean Society for Applied Biological Chemistry, co-published with Springer, 2009</subfield><subfield code="g">67(2024), 1 vom: 15. 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Anti-inflammatory effects of TP1 in LPS-induced Raw264.7 macrophages

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