Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application

Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, hav...
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Autor*in:	Huang, Zongyao [verfasserIn] Fu, Yao Yang, Hong Zhou, Yehan Shi, Min Li, Qingyun Liu, Weiping Liang, Junheng Zhu, Liuqing Qin, Sheng Hong, Huangming Liu, Yang

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	T-cell lymphoma Liquid biopsy cfDNA/ctDNA CTCs EBV DNA Antibody Cytokines

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Molecular cancer - London : Biomed Central, 2002, 23(2024), 1 vom: 17. Feb.
Übergeordnetes Werk:	volume:23 ; year:2024 ; number:1 ; day:17 ; month:02

Links:	Volltext

DOI / URN:	10.1186/s12943-024-01947-7

Katalog-ID:	SPR054802636

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allfields	10.1186/s12943-024-01947-7 doi (DE-627)SPR054802636 (SPR)s12943-024-01947-7-e DE-627 ger DE-627 rakwb eng Huang, Zongyao verfasserin aut Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Fu, Yao aut Yang, Hong aut Zhou, Yehan aut Shi, Min aut Li, Qingyun aut Liu, Weiping aut Liang, Junheng aut Zhu, Liuqing aut Qin, Sheng aut Hong, Huangming aut Liu, Yang aut Enthalten in Molecular cancer London : Biomed Central, 2002 23(2024), 1 vom: 17. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:23 year:2024 number:1 day:17 month:02 https://dx.doi.org/10.1186/s12943-024-01947-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2024 1 17 02
spelling	10.1186/s12943-024-01947-7 doi (DE-627)SPR054802636 (SPR)s12943-024-01947-7-e DE-627 ger DE-627 rakwb eng Huang, Zongyao verfasserin aut Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Fu, Yao aut Yang, Hong aut Zhou, Yehan aut Shi, Min aut Li, Qingyun aut Liu, Weiping aut Liang, Junheng aut Zhu, Liuqing aut Qin, Sheng aut Hong, Huangming aut Liu, Yang aut Enthalten in Molecular cancer London : Biomed Central, 2002 23(2024), 1 vom: 17. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:23 year:2024 number:1 day:17 month:02 https://dx.doi.org/10.1186/s12943-024-01947-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2024 1 17 02
allfields_unstemmed	10.1186/s12943-024-01947-7 doi (DE-627)SPR054802636 (SPR)s12943-024-01947-7-e DE-627 ger DE-627 rakwb eng Huang, Zongyao verfasserin aut Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Fu, Yao aut Yang, Hong aut Zhou, Yehan aut Shi, Min aut Li, Qingyun aut Liu, Weiping aut Liang, Junheng aut Zhu, Liuqing aut Qin, Sheng aut Hong, Huangming aut Liu, Yang aut Enthalten in Molecular cancer London : Biomed Central, 2002 23(2024), 1 vom: 17. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:23 year:2024 number:1 day:17 month:02 https://dx.doi.org/10.1186/s12943-024-01947-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2024 1 17 02
allfieldsGer	10.1186/s12943-024-01947-7 doi (DE-627)SPR054802636 (SPR)s12943-024-01947-7-e DE-627 ger DE-627 rakwb eng Huang, Zongyao verfasserin aut Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Fu, Yao aut Yang, Hong aut Zhou, Yehan aut Shi, Min aut Li, Qingyun aut Liu, Weiping aut Liang, Junheng aut Zhu, Liuqing aut Qin, Sheng aut Hong, Huangming aut Liu, Yang aut Enthalten in Molecular cancer London : Biomed Central, 2002 23(2024), 1 vom: 17. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:23 year:2024 number:1 day:17 month:02 https://dx.doi.org/10.1186/s12943-024-01947-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2024 1 17 02
allfieldsSound	10.1186/s12943-024-01947-7 doi (DE-627)SPR054802636 (SPR)s12943-024-01947-7-e DE-627 ger DE-627 rakwb eng Huang, Zongyao verfasserin aut Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213 Fu, Yao aut Yang, Hong aut Zhou, Yehan aut Shi, Min aut Li, Qingyun aut Liu, Weiping aut Liang, Junheng aut Zhu, Liuqing aut Qin, Sheng aut Hong, Huangming aut Liu, Yang aut Enthalten in Molecular cancer London : Biomed Central, 2002 23(2024), 1 vom: 17. Feb. (DE-627)355987619 (DE-600)2091373-4 1476-4598 nnns volume:23 year:2024 number:1 day:17 month:02 https://dx.doi.org/10.1186/s12943-024-01947-7 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 23 2024 1 17 02
language	English
source	Enthalten in Molecular cancer 23(2024), 1 vom: 17. Feb. volume:23 year:2024 number:1 day:17 month:02
sourceStr	Enthalten in Molecular cancer 23(2024), 1 vom: 17. Feb. volume:23 year:2024 number:1 day:17 month:02
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	T-cell lymphoma Liquid biopsy cfDNA/ctDNA CTCs EBV DNA Antibody Cytokines
isfreeaccess_bool	true
container_title	Molecular cancer
authorswithroles_txt_mv	Huang, Zongyao @@aut@@ Fu, Yao @@aut@@ Yang, Hong @@aut@@ Zhou, Yehan @@aut@@ Shi, Min @@aut@@ Li, Qingyun @@aut@@ Liu, Weiping @@aut@@ Liang, Junheng @@aut@@ Zhu, Liuqing @@aut@@ Qin, Sheng @@aut@@ Hong, Huangming @@aut@@ Liu, Yang @@aut@@
publishDateDaySort_date	2024-02-17T00:00:00Z
hierarchy_top_id	355987619
id	SPR054802636
language_de	englisch
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author	Huang, Zongyao
spellingShingle	Huang, Zongyao misc T-cell lymphoma misc Liquid biopsy misc cfDNA/ctDNA misc CTCs misc EBV DNA misc Antibody misc Cytokines Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
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topic_title	Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application T-cell lymphoma (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 cfDNA/ctDNA (dpeaa)DE-He213 CTCs (dpeaa)DE-He213 EBV DNA (dpeaa)DE-He213 Antibody (dpeaa)DE-He213 Cytokines (dpeaa)DE-He213
topic	misc T-cell lymphoma misc Liquid biopsy misc cfDNA/ctDNA misc CTCs misc EBV DNA misc Antibody misc Cytokines
topic_unstemmed	misc T-cell lymphoma misc Liquid biopsy misc cfDNA/ctDNA misc CTCs misc EBV DNA misc Antibody misc Cytokines
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title	Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
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title_full	Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
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author_browse	Huang, Zongyao Fu, Yao Yang, Hong Zhou, Yehan Shi, Min Li, Qingyun Liu, Weiping Liang, Junheng Zhu, Liuqing Qin, Sheng Hong, Huangming Liu, Yang
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title_sort	liquid biopsy in t-cell lymphoma: biomarker detection techniques and clinical application
title_auth	Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
abstract	Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. © The Author(s) 2024
abstractGer	Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. © The Author(s) 2024
abstract_unstemmed	Abstract T-cell lymphoma is a highly invasive tumor with significant heterogeneity. Invasive tissue biopsy is the gold standard for acquiring molecular data and categorizing lymphoma patients into genetic subtypes. However, surgical intervention is unfeasible for patients who are critically ill, have unresectable tumors, or demonstrate low compliance, making tissue biopsies inaccessible to these patients. A critical need for a minimally invasive approach in T-cell lymphoma is evident, particularly in the areas of early diagnosis, prognostic monitoring, treatment response, and drug resistance. Therefore, the clinical application of liquid biopsy techniques has gained significant attention in T-cell lymphoma. Moreover, liquid biopsy requires fewer samples, exhibits good reproducibility, and enables real-time monitoring at molecular levels, thereby facilitating personalized health care. In this review, we provide a comprehensive overview of the current liquid biopsy biomarkers used for T-cell lymphoma, focusing on circulating cell-free DNA (cfDNA), circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), Epstein-Barr virus (EBV) DNA, antibodies, and cytokines. Additionally, we discuss their clinical application, detection methodologies, ongoing clinical trials, and the challenges faced in the field of liquid biopsy. © The Author(s) 2024
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title_short	Liquid biopsy in T-cell lymphoma: biomarker detection techniques and clinical application
url	https://dx.doi.org/10.1186/s12943-024-01947-7
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author2	Fu, Yao Yang, Hong Zhou, Yehan Shi, Min Li, Qingyun Liu, Weiping Liang, Junheng Zhu, Liuqing Qin, Sheng Hong, Huangming Liu, Yang
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