P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension

Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery...
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Autor*in:	Saladini, F. [verfasserIn] Benetti, E. Santonastaso, M. Mos, L. Cozzio, S. Garavelli, G. Bortolazzi, A. Palatini, P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2011

Anmerkung:	© Atlantis Press 2011

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 5(2011), 4 vom: 29. Nov., Seite 152-152
Übergeordnetes Werk:	volume:5 ; year:2011 ; number:4 ; day:29 ; month:11 ; pages:152-152

Links:	Volltext

DOI / URN:	10.1016/j.artres.2011.10.019

Katalog-ID:	SPR054844290

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520			\|a Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP.
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700	1		\|a Santonastaso, M. \|4 aut
700	1		\|a Mos, L. \|4 aut
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700	1		\|a Garavelli, G. \|4 aut
700	1		\|a Bortolazzi, A. \|4 aut
700	1		\|a Palatini, P. \|4 aut
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allfields	10.1016/j.artres.2011.10.019 doi (DE-627)SPR054844290 (SPR)j.artres.2011.10.019-e DE-627 ger DE-627 rakwb eng Saladini, F. verfasserin aut P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2011 Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. Benetti, E. aut Santonastaso, M. aut Mos, L. aut Cozzio, S. aut Garavelli, G. aut Bortolazzi, A. aut Palatini, P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 5(2011), 4 vom: 29. Nov., Seite 152-152 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:5 year:2011 number:4 day:29 month:11 pages:152-152 https://dx.doi.org/10.1016/j.artres.2011.10.019 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2011 4 29 11 152-152
spelling	10.1016/j.artres.2011.10.019 doi (DE-627)SPR054844290 (SPR)j.artres.2011.10.019-e DE-627 ger DE-627 rakwb eng Saladini, F. verfasserin aut P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2011 Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. Benetti, E. aut Santonastaso, M. aut Mos, L. aut Cozzio, S. aut Garavelli, G. aut Bortolazzi, A. aut Palatini, P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 5(2011), 4 vom: 29. Nov., Seite 152-152 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:5 year:2011 number:4 day:29 month:11 pages:152-152 https://dx.doi.org/10.1016/j.artres.2011.10.019 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2011 4 29 11 152-152
allfields_unstemmed	10.1016/j.artres.2011.10.019 doi (DE-627)SPR054844290 (SPR)j.artres.2011.10.019-e DE-627 ger DE-627 rakwb eng Saladini, F. verfasserin aut P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2011 Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. Benetti, E. aut Santonastaso, M. aut Mos, L. aut Cozzio, S. aut Garavelli, G. aut Bortolazzi, A. aut Palatini, P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 5(2011), 4 vom: 29. Nov., Seite 152-152 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:5 year:2011 number:4 day:29 month:11 pages:152-152 https://dx.doi.org/10.1016/j.artres.2011.10.019 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2011 4 29 11 152-152
allfieldsGer	10.1016/j.artres.2011.10.019 doi (DE-627)SPR054844290 (SPR)j.artres.2011.10.019-e DE-627 ger DE-627 rakwb eng Saladini, F. verfasserin aut P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2011 Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. Benetti, E. aut Santonastaso, M. aut Mos, L. aut Cozzio, S. aut Garavelli, G. aut Bortolazzi, A. aut Palatini, P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 5(2011), 4 vom: 29. Nov., Seite 152-152 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:5 year:2011 number:4 day:29 month:11 pages:152-152 https://dx.doi.org/10.1016/j.artres.2011.10.019 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2011 4 29 11 152-152
allfieldsSound	10.1016/j.artres.2011.10.019 doi (DE-627)SPR054844290 (SPR)j.artres.2011.10.019-e DE-627 ger DE-627 rakwb eng Saladini, F. verfasserin aut P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension 2011 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2011 Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. Benetti, E. aut Santonastaso, M. aut Mos, L. aut Cozzio, S. aut Garavelli, G. aut Bortolazzi, A. aut Palatini, P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 5(2011), 4 vom: 29. Nov., Seite 152-152 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:5 year:2011 number:4 day:29 month:11 pages:152-152 https://dx.doi.org/10.1016/j.artres.2011.10.019 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 5 2011 4 29 11 152-152
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Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benetti, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santonastaso, M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mos, L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cozzio, S.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garavelli, G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bortolazzi, A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Palatini, P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Artery research</subfield><subfield code="d">Amsterdam : Atlantis Press, 2006</subfield><subfield code="g">5(2011), 4 vom: 29. 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author	Saladini, F.
spellingShingle	Saladini, F. P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
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topic_title	P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
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title	P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
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title_full	P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
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title_sort	p1.13: central blood pressure (bp) is an independent predictor of worse outcome in young to middle age subjects screened for stage i hypertension
title_auth	P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
abstract	Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. © Atlantis Press 2011
abstractGer	Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. © Atlantis Press 2011
abstract_unstemmed	Objective The aim was to evaluate the association of central BP with target organ damage (TOD) and the risk of future hypertension in a cohort of subjects from the HARVEST study. Methods. We studied 305 stage I hypertensive subjects (mean age, 38±10 years). Central BP was obtained from radial artery tonometry. TOD included left ventricular hypertrophy and/or microalbuminuria. Results At baseline peripheral BP was 138±12/86±7 mmHg, average 24-hour BP was 130±11/80±8 mmHg, central BP was 125±13/86±8 mmHg. In a multiple logistic regression including ambulatory BP, central mean BP was associated with TOD (p = 0.01). In the subjects divided according to whether their central mean BP was above or below the median (98.7 mmHg), during 9-year follow-up, sustained hypertension was developed by 38.8% of subjects with low central mean BP and by 64.5% of subjects with high central mean BP (p<0.001). Central mean BP was used because it was a better predictor of future hypertension (OR 2.5) compared to central SBP or DBP. In a multiple logistic regression central mean BP and not central pulse pressure, was an independent predictor of future hypertension (p = 0.004). Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP. © Atlantis Press 2011
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title_short	P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension
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Also ambulatory systolic (p = 0.002) and diastolic (p = 0.02) BPs were independent predictors. When all pressures were included in the same model, central mean BP remained a predictor of future hypertension (p = 0.004) on top of ambulatory BP. Conclusion In young-to-middle-age stage I hypertensive subjects central mean BP, but not pulse pressure, was associated with TOD and central BP was a significant predictor of adverse outcome on top of 24-hour BP.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benetti, E.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Santonastaso, M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mos, L.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cozzio, S.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Garavelli, G.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bortolazzi, A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Palatini, P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Artery research</subfield><subfield code="d">Amsterdam : Atlantis Press, 2006</subfield><subfield code="g">5(2011), 4 vom: 29. 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P1.13: Central Blood Pressure (BP) is An Independent Predictor of Worse Outcome in Young to Middle Age Subjects Screened for Stage I Hypertension

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