Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice
Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneup...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Salame, Anastasia A. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|---|
| Sprache: |
Englisch |
| Erschienen: |
2024 |
|---|
| Schlagwörter: |
|---|
| Anmerkung: |
© The Author(s) 2024 |
|---|
| Übergeordnetes Werk: |
Enthalten in: Middle East Fertility Society journal - [S.l.] : Elsevier, 2004, 29(2024), 1 vom: 23. Feb. |
|---|---|
| Übergeordnetes Werk: |
volume:29 ; year:2024 ; number:1 ; day:23 ; month:02 |
| Links: |
|---|
| DOI / URN: |
10.1186/s43043-024-00172-y |
|---|
| Katalog-ID: |
SPR054874130 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | SPR054874130 | ||
| 003 | DE-627 | ||
| 005 | 20240224064723.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240224s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s43043-024-00172-y |2 doi | |
| 035 | |a (DE-627)SPR054874130 | ||
| 035 | |a (SPR)s43043-024-00172-y-e | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Salame, Anastasia A. |e verfasserin |0 (orcid)0000-0003-0510-1081 |4 aut | |
| 245 | 1 | 0 | |a Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a © The Author(s) 2024 | ||
| 520 | |a Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. | ||
| 650 | 4 | |a Preimplantation genetic testing for aneuploidy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Aneuploidy |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Blastocyst |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a In vitro fertilization |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Maternal age |7 (dpeaa)DE-He213 | |
| 650 | 4 | |a Consanguineous marriage |7 (dpeaa)DE-He213 | |
| 700 | 1 | |a Dahdouh, Elias M. |4 aut | |
| 700 | 1 | |a Aljafari, Rania |4 aut | |
| 700 | 1 | |a Samuel, David A. |4 aut | |
| 700 | 1 | |a Koodathingal, Bhavya P. |4 aut | |
| 700 | 1 | |a Bajpai, Aparna |4 aut | |
| 700 | 1 | |a Kainoth, Shabin |4 aut | |
| 700 | 1 | |a Fakih, Michael |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Middle East Fertility Society journal |d [S.l.] : Elsevier, 2004 |g 29(2024), 1 vom: 23. Feb. |w (DE-627)494831642 |w (DE-600)2196955-3 |x 2090-3251 |7 nnns |
| 773 | 1 | 8 | |g volume:29 |g year:2024 |g number:1 |g day:23 |g month:02 |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1186/s43043-024-00172-y |z kostenfrei |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a SYSFLAG_A | ||
| 912 | |a GBV_SPRINGER | ||
| 912 | |a GBV_ILN_206 | ||
| 912 | |a GBV_ILN_2004 | ||
| 912 | |a GBV_ILN_2005 | ||
| 912 | |a GBV_ILN_2009 | ||
| 912 | |a GBV_ILN_2011 | ||
| 912 | |a GBV_ILN_2055 | ||
| 912 | |a GBV_ILN_2111 | ||
| 912 | |a GBV_ILN_4305 | ||
| 951 | |a AR | ||
| 952 | |d 29 |j 2024 |e 1 |b 23 |c 02 | ||
| author_variant |
a a s aa aas e m d em emd r a ra d a s da das b p k bp bpk a b ab s k sk m f mf |
|---|---|
| matchkey_str |
article:20903251:2024----::rdcieatroaepodiifrieainsnegigvaersetvaa |
| hierarchy_sort_str |
2024 |
| publishDate |
2024 |
| allfields |
10.1186/s43043-024-00172-y doi (DE-627)SPR054874130 (SPR)s43043-024-00172-y-e DE-627 ger DE-627 rakwb eng Salame, Anastasia A. verfasserin (orcid)0000-0003-0510-1081 aut Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 Dahdouh, Elias M. aut Aljafari, Rania aut Samuel, David A. aut Koodathingal, Bhavya P. aut Bajpai, Aparna aut Kainoth, Shabin aut Fakih, Michael aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 29(2024), 1 vom: 23. Feb. (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:29 year:2024 number:1 day:23 month:02 https://dx.doi.org/10.1186/s43043-024-00172-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 29 2024 1 23 02 |
| spelling |
10.1186/s43043-024-00172-y doi (DE-627)SPR054874130 (SPR)s43043-024-00172-y-e DE-627 ger DE-627 rakwb eng Salame, Anastasia A. verfasserin (orcid)0000-0003-0510-1081 aut Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 Dahdouh, Elias M. aut Aljafari, Rania aut Samuel, David A. aut Koodathingal, Bhavya P. aut Bajpai, Aparna aut Kainoth, Shabin aut Fakih, Michael aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 29(2024), 1 vom: 23. Feb. (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:29 year:2024 number:1 day:23 month:02 https://dx.doi.org/10.1186/s43043-024-00172-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 29 2024 1 23 02 |
| allfields_unstemmed |
10.1186/s43043-024-00172-y doi (DE-627)SPR054874130 (SPR)s43043-024-00172-y-e DE-627 ger DE-627 rakwb eng Salame, Anastasia A. verfasserin (orcid)0000-0003-0510-1081 aut Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 Dahdouh, Elias M. aut Aljafari, Rania aut Samuel, David A. aut Koodathingal, Bhavya P. aut Bajpai, Aparna aut Kainoth, Shabin aut Fakih, Michael aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 29(2024), 1 vom: 23. Feb. (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:29 year:2024 number:1 day:23 month:02 https://dx.doi.org/10.1186/s43043-024-00172-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 29 2024 1 23 02 |
| allfieldsGer |
10.1186/s43043-024-00172-y doi (DE-627)SPR054874130 (SPR)s43043-024-00172-y-e DE-627 ger DE-627 rakwb eng Salame, Anastasia A. verfasserin (orcid)0000-0003-0510-1081 aut Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 Dahdouh, Elias M. aut Aljafari, Rania aut Samuel, David A. aut Koodathingal, Bhavya P. aut Bajpai, Aparna aut Kainoth, Shabin aut Fakih, Michael aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 29(2024), 1 vom: 23. Feb. (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:29 year:2024 number:1 day:23 month:02 https://dx.doi.org/10.1186/s43043-024-00172-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 29 2024 1 23 02 |
| allfieldsSound |
10.1186/s43043-024-00172-y doi (DE-627)SPR054874130 (SPR)s43043-024-00172-y-e DE-627 ger DE-627 rakwb eng Salame, Anastasia A. verfasserin (orcid)0000-0003-0510-1081 aut Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 Dahdouh, Elias M. aut Aljafari, Rania aut Samuel, David A. aut Koodathingal, Bhavya P. aut Bajpai, Aparna aut Kainoth, Shabin aut Fakih, Michael aut Enthalten in Middle East Fertility Society journal [S.l.] : Elsevier, 2004 29(2024), 1 vom: 23. Feb. (DE-627)494831642 (DE-600)2196955-3 2090-3251 nnns volume:29 year:2024 number:1 day:23 month:02 https://dx.doi.org/10.1186/s43043-024-00172-y kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 AR 29 2024 1 23 02 |
| language |
English |
| source |
Enthalten in Middle East Fertility Society journal 29(2024), 1 vom: 23. Feb. volume:29 year:2024 number:1 day:23 month:02 |
| sourceStr |
Enthalten in Middle East Fertility Society journal 29(2024), 1 vom: 23. Feb. volume:29 year:2024 number:1 day:23 month:02 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Preimplantation genetic testing for aneuploidy Aneuploidy Blastocyst In vitro fertilization Maternal age Consanguineous marriage |
| isfreeaccess_bool |
true |
| container_title |
Middle East Fertility Society journal |
| authorswithroles_txt_mv |
Salame, Anastasia A. @@aut@@ Dahdouh, Elias M. @@aut@@ Aljafari, Rania @@aut@@ Samuel, David A. @@aut@@ Koodathingal, Bhavya P. @@aut@@ Bajpai, Aparna @@aut@@ Kainoth, Shabin @@aut@@ Fakih, Michael @@aut@@ |
| publishDateDaySort_date |
2024-02-23T00:00:00Z |
| hierarchy_top_id |
494831642 |
| id |
SPR054874130 |
| language_de |
englisch |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR054874130</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240224064723.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240224s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s43043-024-00172-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR054874130</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s43043-024-00172-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Salame, Anastasia A.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0003-0510-1081</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Preimplantation genetic testing for aneuploidy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aneuploidy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Blastocyst</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">In vitro fertilization</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Maternal age</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Consanguineous marriage</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dahdouh, Elias M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Aljafari, Rania</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Samuel, David A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koodathingal, Bhavya P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bajpai, Aparna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kainoth, Shabin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fakih, Michael</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Middle East Fertility Society journal</subfield><subfield code="d">[S.l.] : Elsevier, 2004</subfield><subfield code="g">29(2024), 1 vom: 23. Feb.</subfield><subfield code="w">(DE-627)494831642</subfield><subfield code="w">(DE-600)2196955-3</subfield><subfield code="x">2090-3251</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:2024</subfield><subfield code="g">number:1</subfield><subfield code="g">day:23</subfield><subfield code="g">month:02</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s43043-024-00172-y</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">2024</subfield><subfield code="e">1</subfield><subfield code="b">23</subfield><subfield code="c">02</subfield></datafield></record></collection>
|
| author |
Salame, Anastasia A. |
| spellingShingle |
Salame, Anastasia A. misc Preimplantation genetic testing for aneuploidy misc Aneuploidy misc Blastocyst misc In vitro fertilization misc Maternal age misc Consanguineous marriage Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| authorStr |
Salame, Anastasia A. |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)494831642 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut aut aut aut aut aut |
| collection |
springer |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
2090-3251 |
| topic_title |
Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice Preimplantation genetic testing for aneuploidy (dpeaa)DE-He213 Aneuploidy (dpeaa)DE-He213 Blastocyst (dpeaa)DE-He213 In vitro fertilization (dpeaa)DE-He213 Maternal age (dpeaa)DE-He213 Consanguineous marriage (dpeaa)DE-He213 |
| topic |
misc Preimplantation genetic testing for aneuploidy misc Aneuploidy misc Blastocyst misc In vitro fertilization misc Maternal age misc Consanguineous marriage |
| topic_unstemmed |
misc Preimplantation genetic testing for aneuploidy misc Aneuploidy misc Blastocyst misc In vitro fertilization misc Maternal age misc Consanguineous marriage |
| topic_browse |
misc Preimplantation genetic testing for aneuploidy misc Aneuploidy misc Blastocyst misc In vitro fertilization misc Maternal age misc Consanguineous marriage |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
cr |
| hierarchy_parent_title |
Middle East Fertility Society journal |
| hierarchy_parent_id |
494831642 |
| hierarchy_top_title |
Middle East Fertility Society journal |
| isfreeaccess_txt |
true |
| familylinks_str_mv |
(DE-627)494831642 (DE-600)2196955-3 |
| title |
Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| ctrlnum |
(DE-627)SPR054874130 (SPR)s43043-024-00172-y-e |
| title_full |
Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| author_sort |
Salame, Anastasia A. |
| journal |
Middle East Fertility Society journal |
| journalStr |
Middle East Fertility Society journal |
| lang_code |
eng |
| isOA_bool |
true |
| recordtype |
marc |
| publishDateSort |
2024 |
| contenttype_str_mv |
txt |
| author_browse |
Salame, Anastasia A. Dahdouh, Elias M. Aljafari, Rania Samuel, David A. Koodathingal, Bhavya P. Bajpai, Aparna Kainoth, Shabin Fakih, Michael |
| container_volume |
29 |
| format_se |
Elektronische Aufsätze |
| author-letter |
Salame, Anastasia A. |
| doi_str_mv |
10.1186/s43043-024-00172-y |
| normlink |
(ORCID)0000-0003-0510-1081 |
| normlink_prefix_str_mv |
(orcid)0000-0003-0510-1081 |
| title_sort |
predictive factors of aneuploidy in infertile patients undergoing ivf: a retrospective analysis in a private ivf practice |
| title_auth |
Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| abstract |
Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. © The Author(s) 2024 |
| abstractGer |
Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. © The Author(s) 2024 |
| abstract_unstemmed |
Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy. © The Author(s) 2024 |
| collection_details |
GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_206 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4305 |
| container_issue |
1 |
| title_short |
Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice |
| url |
https://dx.doi.org/10.1186/s43043-024-00172-y |
| remote_bool |
true |
| author2 |
Dahdouh, Elias M. Aljafari, Rania Samuel, David A. Koodathingal, Bhavya P. Bajpai, Aparna Kainoth, Shabin Fakih, Michael |
| author2Str |
Dahdouh, Elias M. Aljafari, Rania Samuel, David A. Koodathingal, Bhavya P. Bajpai, Aparna Kainoth, Shabin Fakih, Michael |
| ppnlink |
494831642 |
| mediatype_str_mv |
c |
| isOA_txt |
true |
| hochschulschrift_bool |
false |
| doi_str |
10.1186/s43043-024-00172-y |
| up_date |
2024-07-04T03:20:45.172Z |
| _version_ |
1803617037365280768 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR054874130</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240224064723.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240224s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s43043-024-00172-y</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR054874130</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s43043-024-00172-y-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Salame, Anastasia A.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0003-0510-1081</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Predictive factors of aneuploidy in infertile patients undergoing IVF: a retrospective analysis in a private IVF practice</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background PGT-A has become an important part of IVF treatments. Despite its increased use, there are contradicting results on its role in improving reproductive outcomes of ART cycles. Given that aneuploidy is a main limiting factor for IVF success, we aimed to study the predictive factors of aneuploidy in infertile patients undergoing IVF and hence highlight the patients who would benefit the most from genetic testing. Results A retrospective analysis of 1242 blastocysts biopsied in the setting of PGT-A cycles was performed. The euploid group included 703 embryos, while the aneuploid group had 539 embryos. The factors included in the analyses were the couple’s history as well as the embryo characteristics. The primary outcome was the rate of aneuploid embryos per patient’s history as well as per embryo characteristics. The aneuploidy rate (AR) in our cohort was 43.4%. The woman’s age was found to be a significant predictor (OR 1.045, 95% CI 1.008–1.084, p = 0.016). Biopsy on day 5 as well as degree of expansion 3 was also found to affect significantly (OR 0.724, 95% CI .541–.970, p = 0.03 and OR 2.645, 95% CI 1.252–5.585, p = 0.011). Lack of consanguinity decreased the AR by an OR 0.274 with 95% CI .137–.547, p < 0.001. The number of blastocysts available, trophectoderm quality, embryo grade, gonadotropins as well as trigger used were not found to be significant predictors (p = 0.495, 0.649, 0.264, 0.717 and 0.659 respectively). Conclusion Advanced female age, consanguinity, the day of embryo biopsy, and the degree of blastocyst expansion were all found to affect the incidence of AR. The age of the male partner, cause of infertility, and grade of embryo at biopsy were not found to correlate with aneuploidy.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Preimplantation genetic testing for aneuploidy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Aneuploidy</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Blastocyst</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">In vitro fertilization</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Maternal age</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Consanguineous marriage</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Dahdouh, Elias M.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Aljafari, Rania</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Samuel, David A.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koodathingal, Bhavya P.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Bajpai, Aparna</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kainoth, Shabin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Fakih, Michael</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Middle East Fertility Society journal</subfield><subfield code="d">[S.l.] : Elsevier, 2004</subfield><subfield code="g">29(2024), 1 vom: 23. Feb.</subfield><subfield code="w">(DE-627)494831642</subfield><subfield code="w">(DE-600)2196955-3</subfield><subfield code="x">2090-3251</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:29</subfield><subfield code="g">year:2024</subfield><subfield code="g">number:1</subfield><subfield code="g">day:23</subfield><subfield code="g">month:02</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s43043-024-00172-y</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_A</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2004</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">29</subfield><subfield code="j">2024</subfield><subfield code="e">1</subfield><subfield code="b">23</subfield><subfield code="c">02</subfield></datafield></record></collection>
|
| score |
7.3995123 |