10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)

Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudin...
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Autor*in:	Ferreira, I. [verfasserIn] Twisk, J. W. Stehouwer, C. D.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2007

Anmerkung:	© Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 1(2007), 2 vom: 30. Aug., Seite 52-52
Übergeordnetes Werk:	volume:1 ; year:2007 ; number:2 ; day:30 ; month:08 ; pages:52-52

Links:	Volltext

DOI / URN:	10.1016/j.artres.2007.07.055

Katalog-ID:	SPR054874521

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245	1	0	\|a 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
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520			\|a Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control.
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allfields	10.1016/j.artres.2007.07.055 doi (DE-627)SPR054874521 (SPR)j.artres.2007.07.055-e DE-627 ger DE-627 rakwb eng Ferreira, I. verfasserin aut 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS) 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007 Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. Twisk, J. W. aut Stehouwer, C. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 1(2007), 2 vom: 30. Aug., Seite 52-52 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:1 year:2007 number:2 day:30 month:08 pages:52-52 https://dx.doi.org/10.1016/j.artres.2007.07.055 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2007 2 30 08 52-52
spelling	10.1016/j.artres.2007.07.055 doi (DE-627)SPR054874521 (SPR)j.artres.2007.07.055-e DE-627 ger DE-627 rakwb eng Ferreira, I. verfasserin aut 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS) 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007 Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. Twisk, J. W. aut Stehouwer, C. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 1(2007), 2 vom: 30. Aug., Seite 52-52 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:1 year:2007 number:2 day:30 month:08 pages:52-52 https://dx.doi.org/10.1016/j.artres.2007.07.055 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2007 2 30 08 52-52
allfields_unstemmed	10.1016/j.artres.2007.07.055 doi (DE-627)SPR054874521 (SPR)j.artres.2007.07.055-e DE-627 ger DE-627 rakwb eng Ferreira, I. verfasserin aut 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS) 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007 Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. Twisk, J. W. aut Stehouwer, C. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 1(2007), 2 vom: 30. Aug., Seite 52-52 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:1 year:2007 number:2 day:30 month:08 pages:52-52 https://dx.doi.org/10.1016/j.artres.2007.07.055 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2007 2 30 08 52-52
allfieldsGer	10.1016/j.artres.2007.07.055 doi (DE-627)SPR054874521 (SPR)j.artres.2007.07.055-e DE-627 ger DE-627 rakwb eng Ferreira, I. verfasserin aut 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS) 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007 Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. Twisk, J. W. aut Stehouwer, C. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 1(2007), 2 vom: 30. Aug., Seite 52-52 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:1 year:2007 number:2 day:30 month:08 pages:52-52 https://dx.doi.org/10.1016/j.artres.2007.07.055 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2007 2 30 08 52-52
allfieldsSound	10.1016/j.artres.2007.07.055 doi (DE-627)SPR054874521 (SPR)j.artres.2007.07.055-e DE-627 ger DE-627 rakwb eng Ferreira, I. verfasserin aut 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS) 2007 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007 Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. Twisk, J. W. aut Stehouwer, C. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 1(2007), 2 vom: 30. Aug., Seite 52-52 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:1 year:2007 number:2 day:30 month:08 pages:52-52 https://dx.doi.org/10.1016/j.artres.2007.07.055 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 1 2007 2 30 08 52-52
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The Amsterdam Growth and Health Longitudinal Study (AGAHLS)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2007</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Twisk, J. 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author	Ferreira, I.
spellingShingle	Ferreira, I. 10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
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topic_title	10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
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title	10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
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title_full	10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
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title_sort	10.02 longitudinal development of fitness and fatness from adolescence to adulthood: impact on arterial stiffness at the age of 36 years. the amsterdam growth and health longitudinal study (agahls)
title_auth	10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
abstract	Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007
abstractGer	Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007
abstract_unstemmed	Introduction Body fatness (BF) and low levels of cardiopulmonary fitness (CF) during adolescence have been associated with arterial stiffness (AS) later in life. How the development over time (i.e. from adolescence to adulthood) of BF and CF impact on AS in adulthood is not known. Methods Longitudinal data on BF (sum of 4 skinfolds – SSKF) and CF (VO2max) were derived from the AGAHLS (n = 372, 197 women; 8 follow-up measures at the ages of 13, 14, 15, 16, 21, 27, 32 and 36 yrs). Arterial stiffness (i.e. carotid, brachial and femoral distensibility and compliance coefficients) was assessed by non-invasive ultrasonography when subjects were 36-yrs-old; a stiffness score (average of the z-scores of these 6 estimates) was calculated. We used generalized estimating equations to compare the patterns of development of SSKF and VO2max levels (adjusted for each other and for potential confounders) over the 24-yr follow-up period between those subjects with ‘higher’ (i.e. lowest sex-specific quartile) vs. ‘normal’ (higher 3 quartiles) levels of stiffness score at the age of 36 yrs. Results In all subjects, SSKF increased and VO2max decreased between the ages of 13 and 36 (p<0.001); higher increases in SSKF during adolescence and decreased levels of VO2max in recent but not early years characterized individuals with higher arterial stiffness at the of age 36 as compared to their ‘normal’ counterparts (Figure). Conclusion Increases in body fatness rather than decreases in cardiopul-monary fitness during adolescence impact on arterial stiffness later in life; lifestyle interventions in the young should therefore target weight control. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2007
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title_short	10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)
url	https://dx.doi.org/10.1016/j.artres.2007.07.055
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10.02 Longitudinal Development of Fitness and Fatness from Adolescence to Adulthood: Impact on Arterial Stiffness at the Age of 36 Years. The Amsterdam Growth and Health Longitudinal Study (AGAHLS)

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