P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction

Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in...
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Autor*in:	Collin, C. [verfasserIn] Ait-Oufella, H. Ong, K. T. Beaussier, H. Bozec, E. Dufouil, C. Boutouyrie, P. Laurent, S.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2009

Anmerkung:	© Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 3(2009), 4 vom: Dez., Seite 171-171
Übergeordnetes Werk:	volume:3 ; year:2009 ; number:4 ; month:12 ; pages:171-171

Links:	Volltext

DOI / URN:	10.1016/j.artres.2009.10.045

Katalog-ID:	SPR05487629X

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520			\|a Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP.
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allfields	10.1016/j.artres.2009.10.045 doi (DE-627)SPR05487629X (SPR)j.artres.2009.10.045-e DE-627 ger DE-627 rakwb eng Collin, C. verfasserin aut P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009 Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. Ait-Oufella, H. aut Ong, K. T. aut Beaussier, H. aut Bozec, E. aut Dufouil, C. aut Boutouyrie, P. aut Laurent, S. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 3(2009), 4 vom: Dez., Seite 171-171 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:3 year:2009 number:4 month:12 pages:171-171 https://dx.doi.org/10.1016/j.artres.2009.10.045 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2009 4 12 171-171
spelling	10.1016/j.artres.2009.10.045 doi (DE-627)SPR05487629X (SPR)j.artres.2009.10.045-e DE-627 ger DE-627 rakwb eng Collin, C. verfasserin aut P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009 Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. Ait-Oufella, H. aut Ong, K. T. aut Beaussier, H. aut Bozec, E. aut Dufouil, C. aut Boutouyrie, P. aut Laurent, S. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 3(2009), 4 vom: Dez., Seite 171-171 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:3 year:2009 number:4 month:12 pages:171-171 https://dx.doi.org/10.1016/j.artres.2009.10.045 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2009 4 12 171-171
allfields_unstemmed	10.1016/j.artres.2009.10.045 doi (DE-627)SPR05487629X (SPR)j.artres.2009.10.045-e DE-627 ger DE-627 rakwb eng Collin, C. verfasserin aut P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009 Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. Ait-Oufella, H. aut Ong, K. T. aut Beaussier, H. aut Bozec, E. aut Dufouil, C. aut Boutouyrie, P. aut Laurent, S. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 3(2009), 4 vom: Dez., Seite 171-171 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:3 year:2009 number:4 month:12 pages:171-171 https://dx.doi.org/10.1016/j.artres.2009.10.045 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2009 4 12 171-171
allfieldsGer	10.1016/j.artres.2009.10.045 doi (DE-627)SPR05487629X (SPR)j.artres.2009.10.045-e DE-627 ger DE-627 rakwb eng Collin, C. verfasserin aut P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009 Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. Ait-Oufella, H. aut Ong, K. T. aut Beaussier, H. aut Bozec, E. aut Dufouil, C. aut Boutouyrie, P. aut Laurent, S. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 3(2009), 4 vom: Dez., Seite 171-171 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:3 year:2009 number:4 month:12 pages:171-171 https://dx.doi.org/10.1016/j.artres.2009.10.045 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2009 4 12 171-171
allfieldsSound	10.1016/j.artres.2009.10.045 doi (DE-627)SPR05487629X (SPR)j.artres.2009.10.045-e DE-627 ger DE-627 rakwb eng Collin, C. verfasserin aut P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction 2009 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009 Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. Ait-Oufella, H. aut Ong, K. T. aut Beaussier, H. aut Bozec, E. aut Dufouil, C. aut Boutouyrie, P. aut Laurent, S. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 3(2009), 4 vom: Dez., Seite 171-171 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:3 year:2009 number:4 month:12 pages:171-171 https://dx.doi.org/10.1016/j.artres.2009.10.045 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 3 2009 4 12 171-171
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spellingShingle	Collin, C. P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
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topic_title	P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
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title	P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
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title_full	P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
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title_sort	p4.04 long-term reduction in aortic stiffness in hypertensive patients is partly independent of mbp reduction
title_auth	P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
abstract	Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009
abstractGer	Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009
abstract_unstemmed	Purpose A decrease in aortic stiffness could theoretically occur after several years of treatment but reduction has never been unequivocally demonstrated in clinical practice. Association with changes in blood pressure remained unclear. Methods: This longitudinal observational study was conducted in 97 patients (63 ± 1 yrs, 47 women) with treated essential hypertension attending the outpatient hypertension clinic at Pompidou Hospital. Aortic stiffness and carotid pulse pressure (CPP) were determined through carotid-femoral PWV and applanation tonometry. The first measurement of PWV was performed when brachial SBP was lowered below 140 mmHg under treatment. 66 patients had 3 PWV measurements, and 31 patients had 2 measurements during an extended follow-up (5.3 ± 1.2 yrs). Results: The reduction in PWV (from 14.2 ± 4.2 to 11.1 ± 2.4 m/s, linear mixed model, P < 0.0001) was associated with a reduction in central SBP (from 132 ± 2 to 122 ± 2 mmHg, P < 0.0001) and central PP (from 59 ± 2 to 54 ± 2, P < 0.001), whereas brachial SBP and PP did not significantly change. In multivariate analysis, the decrease in PWV was significantly associated with age (P < 0.005), duration of follow-up (P < 0.0001), presence of diabetes (P < 0.005) and reduction in brachial MBP (P < 0.005), independently of gender, changes in brachial PP, glomerular filtration rate and hypercholesterolemia. Conclusion: These results indicate that a large decrease in aortic stiffness (−22%) can be observed in the long term when hypertensive patients were treated under conditions of routine clinical practice. This reduction of aortic stiffness was associated with a reduction in central SBP and PP contrasting with no change in brachial SBP and PP. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved 2009
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title_short	P4.04 Long-Term Reduction in Aortic Stiffness in Hypertensive Patients is Partly Independent of Mbp Reduction
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author2	Ait-Oufella, H. Ong, K. T. Beaussier, H. Bozec, E. Dufouil, C. Boutouyrie, P. Laurent, S.
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