P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats

Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries...
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Autor*in:	Kristek, F. [verfasserIn] Cacanyiova, S. Gerova, M.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2010

Anmerkung:	© Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 4(2010), 4 vom: Dez., Seite 168-168
Übergeordnetes Werk:	volume:4 ; year:2010 ; number:4 ; month:12 ; pages:168-168

Links:	Volltext

DOI / URN:	10.1016/j.artres.2010.10.080

Katalog-ID:	SPR054918685

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520			\|a Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition.
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allfields	10.1016/j.artres.2010.10.080 doi (DE-627)SPR054918685 (SPR)j.artres.2010.10.080-e DE-627 ger DE-627 rakwb eng Kristek, F. verfasserin aut P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010 Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. Cacanyiova, S. aut Gerova, M. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 4 vom: Dez., Seite 168-168 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:4 month:12 pages:168-168 https://dx.doi.org/10.1016/j.artres.2010.10.080 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 4 12 168-168
spelling	10.1016/j.artres.2010.10.080 doi (DE-627)SPR054918685 (SPR)j.artres.2010.10.080-e DE-627 ger DE-627 rakwb eng Kristek, F. verfasserin aut P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010 Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. Cacanyiova, S. aut Gerova, M. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 4 vom: Dez., Seite 168-168 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:4 month:12 pages:168-168 https://dx.doi.org/10.1016/j.artres.2010.10.080 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 4 12 168-168
allfields_unstemmed	10.1016/j.artres.2010.10.080 doi (DE-627)SPR054918685 (SPR)j.artres.2010.10.080-e DE-627 ger DE-627 rakwb eng Kristek, F. verfasserin aut P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010 Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. Cacanyiova, S. aut Gerova, M. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 4 vom: Dez., Seite 168-168 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:4 month:12 pages:168-168 https://dx.doi.org/10.1016/j.artres.2010.10.080 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 4 12 168-168
allfieldsGer	10.1016/j.artres.2010.10.080 doi (DE-627)SPR054918685 (SPR)j.artres.2010.10.080-e DE-627 ger DE-627 rakwb eng Kristek, F. verfasserin aut P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010 Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. Cacanyiova, S. aut Gerova, M. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 4 vom: Dez., Seite 168-168 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:4 month:12 pages:168-168 https://dx.doi.org/10.1016/j.artres.2010.10.080 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 4 12 168-168
allfieldsSound	10.1016/j.artres.2010.10.080 doi (DE-627)SPR054918685 (SPR)j.artres.2010.10.080-e DE-627 ger DE-627 rakwb eng Kristek, F. verfasserin aut P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats 2010 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010 Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. Cacanyiova, S. aut Gerova, M. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 4(2010), 4 vom: Dez., Seite 168-168 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:4 year:2010 number:4 month:12 pages:168-168 https://dx.doi.org/10.1016/j.artres.2010.10.080 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2010 4 12 168-168
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author	Kristek, F.
spellingShingle	Kristek, F. P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats
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title	P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats
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title_sort	p7.03 different effect of neuronal and endothelial nos inhibition on heart, coronary and carotid artery of wistar rats
title_auth	P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats
abstract	Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010
abstractGer	Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010
abstract_unstemmed	Abstract Long-term decrease of nitric oxide (NO) production evokes alterations in function and structure of cardiovascular system. We demonstrate the long-term effect of NO synthases inhibition with two different inhibitors on blood pressure (BP), heart and structure of coronary and carotid arteries. Four groups of ten weeks old Wistar rats were used: 1) control rats and rats receiving 2) $ N^{G} $-nitro-L-arginine methylester (L-NAME) (50 mg/kg/day in tap water), 3) 7-nitroindazole (7NI) (10 mg/kg/day in tap water), 4) the same doses of L-NAME (in tap water) and 7NI (in pellet diet). The experiment lasted 6 weeks. BP was measured by the plethysmographic method weekly. At the end of the experiment the animals were perfusion with a glutaraldehyde fixative (120 mmHg) and heart, coronary and carotid artery were excised and processed for electron microscopy. Blood pressure (BP), heart/body weight (H/B), cross sectional area – intima +media (CSA). *p<0.01 vs. Wistar, +p<0.01 vs. L-NAME, #p<0.01 vs. 7NI The study revealed, for the first time, that long-term inhibition of nNOS with 7NI, contrary to eNOS inhibition with nonspecific inhibitor L-NAME, evoked pressure independent cardiac hypotrophy and hypotrophy of the vessel wall. The data suggested that long-term nNOS inhibition likely iniciates a different chain of events leading to alterations in cardiovacular system then those after eNOS inhibition. © Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights 2010
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title_short	P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats
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P7.03 Different Effect of Neuronal and Endothelial Nos Inhibition on Heart, Coronary and Carotid Artery of Wistar Rats

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