P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand

Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial...
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Autor*in:	Park, C. M. [verfasserIn] March, K. Tillin, T. Chaturvedi, N. Hughes, A. D.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2012

Anmerkung:	© Atlantis Press 2012

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 6(2012), 4 vom: 17. Nov., Seite 154-154
Übergeordnetes Werk:	volume:6 ; year:2012 ; number:4 ; day:17 ; month:11 ; pages:154-154

Links:	Volltext

DOI / URN:	10.1016/j.artres.2012.09.049

Katalog-ID:	SPR054919800

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520			\|a Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD.
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allfields	10.1016/j.artres.2012.09.049 doi (DE-627)SPR054919800 (SPR)j.artres.2012.09.049-e DE-627 ger DE-627 rakwb eng Park, C. M. verfasserin aut P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2012 Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. March, K. aut Tillin, T. aut Chaturvedi, N. aut Hughes, A. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 6(2012), 4 vom: 17. Nov., Seite 154-154 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:6 year:2012 number:4 day:17 month:11 pages:154-154 https://dx.doi.org/10.1016/j.artres.2012.09.049 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012 4 17 11 154-154
spelling	10.1016/j.artres.2012.09.049 doi (DE-627)SPR054919800 (SPR)j.artres.2012.09.049-e DE-627 ger DE-627 rakwb eng Park, C. M. verfasserin aut P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2012 Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. March, K. aut Tillin, T. aut Chaturvedi, N. aut Hughes, A. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 6(2012), 4 vom: 17. Nov., Seite 154-154 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:6 year:2012 number:4 day:17 month:11 pages:154-154 https://dx.doi.org/10.1016/j.artres.2012.09.049 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012 4 17 11 154-154
allfields_unstemmed	10.1016/j.artres.2012.09.049 doi (DE-627)SPR054919800 (SPR)j.artres.2012.09.049-e DE-627 ger DE-627 rakwb eng Park, C. M. verfasserin aut P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2012 Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. March, K. aut Tillin, T. aut Chaturvedi, N. aut Hughes, A. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 6(2012), 4 vom: 17. Nov., Seite 154-154 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:6 year:2012 number:4 day:17 month:11 pages:154-154 https://dx.doi.org/10.1016/j.artres.2012.09.049 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012 4 17 11 154-154
allfieldsGer	10.1016/j.artres.2012.09.049 doi (DE-627)SPR054919800 (SPR)j.artres.2012.09.049-e DE-627 ger DE-627 rakwb eng Park, C. M. verfasserin aut P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2012 Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. March, K. aut Tillin, T. aut Chaturvedi, N. aut Hughes, A. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 6(2012), 4 vom: 17. Nov., Seite 154-154 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:6 year:2012 number:4 day:17 month:11 pages:154-154 https://dx.doi.org/10.1016/j.artres.2012.09.049 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012 4 17 11 154-154
allfieldsSound	10.1016/j.artres.2012.09.049 doi (DE-627)SPR054919800 (SPR)j.artres.2012.09.049-e DE-627 ger DE-627 rakwb eng Park, C. M. verfasserin aut P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand 2012 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2012 Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. March, K. aut Tillin, T. aut Chaturvedi, N. aut Hughes, A. D. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 6(2012), 4 vom: 17. Nov., Seite 154-154 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:6 year:2012 number:4 day:17 month:11 pages:154-154 https://dx.doi.org/10.1016/j.artres.2012.09.049 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 6 2012 4 17 11 154-154
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M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Atlantis Press 2012</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">March, K.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tillin, T.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Chaturvedi, N.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hughes, A. D.</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Artery research</subfield><subfield code="d">Amsterdam : Atlantis Press, 2006</subfield><subfield code="g">6(2012), 4 vom: 17. 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spellingShingle	Park, C. M. P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand
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title_sort	p1.12 ethnic differences in left ventricle myocardial oxygen demand
title_auth	P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand
abstract	Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. © Atlantis Press 2012
abstractGer	Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. © Atlantis Press 2012
abstract_unstemmed	Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. This implies that IA have increased myocardial oxygen demand which may increase susceptibility to myocardial ischemia, and which could contribute to their excess risk of CHD. © Atlantis Press 2012
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title_short	P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand
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M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">P1.12 Ethnic Differences in Left Ventricle Myocardial Oxygen Demand</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2012</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Atlantis Press 2012</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background There are marked inter-ethnic differences in coronary heart disease (CHD). Indian Asians (IA) have 50% greater and African Caribbeans (AC) 50% less CHD than white Europeans (E) in the UK. Reasons for this are unclear. We compared ventricular structure and function, specifically myocardial oxygen demand, by ethnicity. Methods and Results 3D echocardiography (Philips iE33) and radial applanation tonometry (SphygmoCor) were performed on 800 men and women (age 55–85) from the Southall And Brent REvisited (SABRE) tri-ethnic population-based cohort. Left ventricular mass index (LVMI) was measured, and 3D LV remodelling index (LVRI) was calculated as LV mass/LV end diastolic volume. 3D cardiac output (CO) and total peripheral resistance (TPR) were calculated and 3D LV end systolic active fibre stress (AFS) and wasted effort ($ E_{w} $) were derived as markers of myocardial oxygen demand. LVMI did not differ between E and AC but was significantly lower in IA. LVRI was greatest in AC and smallest in IA. IA and AC had lower CO and higher TPR compared to E. AFS and $ E_{w} $ were significantly higher in IA. These ethnic differences persisted after multivariate adjustment for age, sex, heart rate, systolic blood pressure, fasting blood glucose and insulin concentrations and medication. Conclusions AC have comparable LVMI and myocardial oxygen demand to E. In contrast IA generate significantly more AFS and $ E_{w} $ despite having less myocardial muscle. 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