P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors

New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Paini, Anna [verfasserIn] Salvetti, Massimo Buglione, Michela Bertacchini, Fabio Maruelli, Giulia Trevisan, Francesca Baushi, Liliana Magrini, Stefano Maria Muiesan, Maria Lorenza

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Anmerkung:	© Atlantis Press 2017

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 20(2017), 1 vom: Dez., Seite 108-108
Übergeordnetes Werk:	volume:20 ; year:2017 ; number:1 ; month:12 ; pages:108-108

Links:	Volltext

DOI / URN:	10.1016/j.artres.2017.10.189

Katalog-ID:	SPR054923077

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520			\|a New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage.
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700	1		\|a Buglione, Michela \|4 aut
700	1		\|a Bertacchini, Fabio \|4 aut
700	1		\|a Maruelli, Giulia \|4 aut
700	1		\|a Trevisan, Francesca \|4 aut
700	1		\|a Baushi, Liliana \|4 aut
700	1		\|a Magrini, Stefano Maria \|4 aut
700	1		\|a Muiesan, Maria Lorenza \|4 aut
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allfields	10.1016/j.artres.2017.10.189 doi (DE-627)SPR054923077 (SPR)j.artres.2017.10.189-e DE-627 ger DE-627 rakwb eng Paini, Anna verfasserin aut P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Salvetti, Massimo aut Buglione, Michela aut Bertacchini, Fabio aut Maruelli, Giulia aut Trevisan, Francesca aut Baushi, Liliana aut Magrini, Stefano Maria aut Muiesan, Maria Lorenza aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 108-108 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:108-108 https://dx.doi.org/10.1016/j.artres.2017.10.189 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 108-108
spelling	10.1016/j.artres.2017.10.189 doi (DE-627)SPR054923077 (SPR)j.artres.2017.10.189-e DE-627 ger DE-627 rakwb eng Paini, Anna verfasserin aut P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Salvetti, Massimo aut Buglione, Michela aut Bertacchini, Fabio aut Maruelli, Giulia aut Trevisan, Francesca aut Baushi, Liliana aut Magrini, Stefano Maria aut Muiesan, Maria Lorenza aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 108-108 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:108-108 https://dx.doi.org/10.1016/j.artres.2017.10.189 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 108-108
allfields_unstemmed	10.1016/j.artres.2017.10.189 doi (DE-627)SPR054923077 (SPR)j.artres.2017.10.189-e DE-627 ger DE-627 rakwb eng Paini, Anna verfasserin aut P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Salvetti, Massimo aut Buglione, Michela aut Bertacchini, Fabio aut Maruelli, Giulia aut Trevisan, Francesca aut Baushi, Liliana aut Magrini, Stefano Maria aut Muiesan, Maria Lorenza aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 108-108 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:108-108 https://dx.doi.org/10.1016/j.artres.2017.10.189 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 108-108
allfieldsGer	10.1016/j.artres.2017.10.189 doi (DE-627)SPR054923077 (SPR)j.artres.2017.10.189-e DE-627 ger DE-627 rakwb eng Paini, Anna verfasserin aut P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Salvetti, Massimo aut Buglione, Michela aut Bertacchini, Fabio aut Maruelli, Giulia aut Trevisan, Francesca aut Baushi, Liliana aut Magrini, Stefano Maria aut Muiesan, Maria Lorenza aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 108-108 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:108-108 https://dx.doi.org/10.1016/j.artres.2017.10.189 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 108-108
allfieldsSound	10.1016/j.artres.2017.10.189 doi (DE-627)SPR054923077 (SPR)j.artres.2017.10.189-e DE-627 ger DE-627 rakwb eng Paini, Anna verfasserin aut P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. Salvetti, Massimo aut Buglione, Michela aut Bertacchini, Fabio aut Maruelli, Giulia aut Trevisan, Francesca aut Baushi, Liliana aut Magrini, Stefano Maria aut Muiesan, Maria Lorenza aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 108-108 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:108-108 https://dx.doi.org/10.1016/j.artres.2017.10.189 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 108-108
language	English
source	Enthalten in Artery research 20(2017), 1 vom: Dez., Seite 108-108 volume:20 year:2017 number:1 month:12 pages:108-108
sourceStr	Enthalten in Artery research 20(2017), 1 vom: Dez., Seite 108-108 volume:20 year:2017 number:1 month:12 pages:108-108
format_phy_str_mv	Article
institution	findex.gbv.de
isfreeaccess_bool	true
container_title	Artery research
authorswithroles_txt_mv	Paini, Anna @@aut@@ Salvetti, Massimo @@aut@@ Buglione, Michela @@aut@@ Bertacchini, Fabio @@aut@@ Maruelli, Giulia @@aut@@ Trevisan, Francesca @@aut@@ Baushi, Liliana @@aut@@ Magrini, Stefano Maria @@aut@@ Muiesan, Maria Lorenza @@aut@@
publishDateDaySort_date	2017-12-01T00:00:00Z
hierarchy_top_id	534057489
id	SPR054923077
language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR054923077</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240227064753.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240227s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1016/j.artres.2017.10.189</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR054923077</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)j.artres.2017.10.189-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Paini, Anna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2017</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Atlantis Press 2017</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. 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author	Paini, Anna
spellingShingle	Paini, Anna P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
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topic_title	P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
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title	P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
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title_full	P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
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author_browse	Paini, Anna Salvetti, Massimo Buglione, Michela Bertacchini, Fabio Maruelli, Giulia Trevisan, Francesca Baushi, Liliana Magrini, Stefano Maria Muiesan, Maria Lorenza
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title_sort	p188: effects of radiotherapy on large vessels in hodgkin lymphoma survivors
title_auth	P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
abstract	New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. © Atlantis Press 2017
abstractGer	New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. © Atlantis Press 2017
abstract_unstemmed	New chemotherapeutic drugs and radiation therapy have significantly improved cancer patient’s survival, although the cardiovascular (CV) side effects of cancer treatment are increasingly important. In previous studies, an increased risk of cerebrovascular complications such as stroke and transient ischemic attack was described in patients undergoing neck radiotherapy. Aim To evaluate vascular carotid structural (IMT, plaque) and functional (carotid stiffness) damage, and changes in arterial stiffness (Carotido-femoral pulse wave velocity; cf- PWV) in Hodgkin Lymphoma survivors previously treated with radiotherapy. Patients and methods We enrolled206 Hodgkin lymphoma survivors (mean age 54 ± 14years, 51%males, mean follow-up of9 ± 6years).CV risk factors were investigated and atherosclerotic carotid damage was assessed by standard carotid ultrasound evaluation for intima-media thickness (IMT) measurement (MeanMax- IMT, CBMax, Tmax; n = 167); in 141 patients radiofrequency-based carotid stiffness analysis (distensibility; distensibility coefficient, DC; compliance coefficient; CC) was also performed.Cf-PWV measurement were obtained in 154 patients. Results A significant correlation between radiotherapy dose and: MeanMax-IMT (r = 0.20; p < 0.05), Tmax (r = 0.20; p < 0.05), distensibility (r = 0.24; p < 0.05), DC(r = 0.24; p < 0.05), CC(r = 0.24; p < 0.05) was observed. Patients were divided into 4 groups according to radiotherapy dose (Dose: 20e30; 31e36; 37–42;>42Gy). An increase in Tmax (1.27 ± 0.61, 1.35 ± 0.59, 1.46 ± 0.69, 1.76 ± 1.12 mm, p for trend <0.05) and in the prevalence of carotid plaque (29%, 31%, 47% and 55%, p for trend <0.05) was observed as related to dose-category. One-hundred-seventeen patients received neck irradiation (67 bilateral; 50 unilateral).In unilaterally irradiated patients, MeanMaxIMT was greater in the irradiated side as compared to unirradiated carotid artery and the difference reached statistical significance in the group of patients who received a high radiotherapy dose (0.97 ± 0.35 vs 0.92 ± 0.34 p < 0.05).Cf-PWV was significantly greater only in patients that received high dose (>42Gy), as compared to all the other dose groups (9.7 ± 2.3 vs 8.3±2.2,8.0 ± 1.5 and 8.3±1.4, p<0.05). Conclusions In this large number of HL survivors, carotid IMT, plaque prevalence and aortic and carotid stiffness were significantly related with radiotherapy doses. Carotid IMT, carotid and aortic stiffness were significantly higher in the irradiated carotid arteries, but only at doses >42Gy, suggesting that there may be a dose threshold for radiotherapy-induced carotid wall damage. © Atlantis Press 2017
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title_short	P188: Effects of Radiotherapy on Large Vessels in Hodgkin Lymphoma Survivors
url	https://dx.doi.org/10.1016/j.artres.2017.10.189
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author2	Salvetti, Massimo Buglione, Michela Bertacchini, Fabio Maruelli, Giulia Trevisan, Francesca Baushi, Liliana Magrini, Stefano Maria Muiesan, Maria Lorenza
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