P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy

Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-medi...
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Autor*in:	Ioakeimidis, Nikolaos [verfasserIn] Vlachopoulos, Charalambos Angelis, Athanasios Printzios, Dimitrios Terentes- Georgakopoulos, Christos Aznaouridis, Konstantinos Koutagiar, Iosif Skoumas, John Tousoulis, Dimitrios

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2017

Anmerkung:	© Atlantis Press 2017

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 20(2017), 1 vom: Dez., Seite 109-109
Übergeordnetes Werk:	volume:20 ; year:2017 ; number:1 ; month:12 ; pages:109-109

Links:	Volltext

DOI / URN:	10.1016/j.artres.2017.10.194

Katalog-ID:	SPR054923123

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520			\|a Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired.
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700	1		\|a Tousoulis, Dimitrios \|4 aut
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hierarchy_sort_str	2017
publishDate	2017
allfields	10.1016/j.artres.2017.10.194 doi (DE-627)SPR054923123 (SPR)j.artres.2017.10.194-e DE-627 ger DE-627 rakwb eng Ioakeimidis, Nikolaos verfasserin aut P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. Vlachopoulos, Charalambos aut Angelis, Athanasios aut Printzios, Dimitrios Terentes- aut Georgakopoulos, Christos aut Aznaouridis, Konstantinos aut Koutagiar, Iosif aut Skoumas, John aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 109-109 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:109-109 https://dx.doi.org/10.1016/j.artres.2017.10.194 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 109-109
spelling	10.1016/j.artres.2017.10.194 doi (DE-627)SPR054923123 (SPR)j.artres.2017.10.194-e DE-627 ger DE-627 rakwb eng Ioakeimidis, Nikolaos verfasserin aut P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. Vlachopoulos, Charalambos aut Angelis, Athanasios aut Printzios, Dimitrios Terentes- aut Georgakopoulos, Christos aut Aznaouridis, Konstantinos aut Koutagiar, Iosif aut Skoumas, John aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 109-109 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:109-109 https://dx.doi.org/10.1016/j.artres.2017.10.194 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 109-109
allfields_unstemmed	10.1016/j.artres.2017.10.194 doi (DE-627)SPR054923123 (SPR)j.artres.2017.10.194-e DE-627 ger DE-627 rakwb eng Ioakeimidis, Nikolaos verfasserin aut P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. Vlachopoulos, Charalambos aut Angelis, Athanasios aut Printzios, Dimitrios Terentes- aut Georgakopoulos, Christos aut Aznaouridis, Konstantinos aut Koutagiar, Iosif aut Skoumas, John aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 109-109 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:109-109 https://dx.doi.org/10.1016/j.artres.2017.10.194 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 109-109
allfieldsGer	10.1016/j.artres.2017.10.194 doi (DE-627)SPR054923123 (SPR)j.artres.2017.10.194-e DE-627 ger DE-627 rakwb eng Ioakeimidis, Nikolaos verfasserin aut P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. Vlachopoulos, Charalambos aut Angelis, Athanasios aut Printzios, Dimitrios Terentes- aut Georgakopoulos, Christos aut Aznaouridis, Konstantinos aut Koutagiar, Iosif aut Skoumas, John aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 109-109 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:109-109 https://dx.doi.org/10.1016/j.artres.2017.10.194 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 109-109
allfieldsSound	10.1016/j.artres.2017.10.194 doi (DE-627)SPR054923123 (SPR)j.artres.2017.10.194-e DE-627 ger DE-627 rakwb eng Ioakeimidis, Nikolaos verfasserin aut P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy 2017 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2017 Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. Vlachopoulos, Charalambos aut Angelis, Athanasios aut Printzios, Dimitrios Terentes- aut Georgakopoulos, Christos aut Aznaouridis, Konstantinos aut Koutagiar, Iosif aut Skoumas, John aut Tousoulis, Dimitrios aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 20(2017), 1 vom: Dez., Seite 109-109 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:20 year:2017 number:1 month:12 pages:109-109 https://dx.doi.org/10.1016/j.artres.2017.10.194 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 20 2017 1 12 109-109
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Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Vlachopoulos, Charalambos</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Angelis, Athanasios</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Printzios, Dimitrios Terentes-</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Georgakopoulos, Christos</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Aznaouridis, Konstantinos</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koutagiar, 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author	Ioakeimidis, Nikolaos
spellingShingle	Ioakeimidis, Nikolaos P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy
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title	P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy
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title_full	P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy
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author_browse	Ioakeimidis, Nikolaos Vlachopoulos, Charalambos Angelis, Athanasios Printzios, Dimitrios Terentes- Georgakopoulos, Christos Aznaouridis, Konstantinos Koutagiar, Iosif Skoumas, John Tousoulis, Dimitrios
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doi_str_mv	10.1016/j.artres.2017.10.194
title_sort	p193: carotid atherosclerosis, aortic stiffness and penile vascular damage in patients with erectile dysfunction: relation to low density lipoprotein levels and statin therapy
title_auth	P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy
abstract	Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. © Atlantis Press 2017
abstractGer	Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. © Atlantis Press 2017
abstract_unstemmed	Purpose/Background/Objectives Aim of the study is to examine the possible differentiation of aortic stiffness, carotid atherosclerosis and penile vascular function among patients with erectile dysfunction (ED) according to cholesterol level and statin therapy. Methods We measured carotid intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV) and penile peak systolic velocity (PSV) 20 min after intracavernous injection of prostaglandin E1 in 356 consecutive ED patients (mean age 57 ± 9 years). Lipid parameters and total testosterone were measured in all patients. Results 95 (26.7%) ED patients are treated with statins. The patients not receiving statin therapy (n = 261) were subsequently divided into three groups according to LDL level (group 1: LDL <100 mg/dl, group 2: LDL: 100–155 mg/dl, group 3: LDL > 155 mg/dl). Patients with statin therapy and subjects in group 2 have similar mean LDL level. Carotid IMT was higher in patients with LDL >155 mg/dl (group 3) compared to patients treated with statins (P = 0.01) and subjects with LDL: 100–155 mg/dl (P = 0.005) and LDL < 100 mg/dl (left plot, P < 0.001). Post hoc analysis showed that patients treated with a statin and subjects in group 3 had comparable penile PSV and lower mean value compared to that of patients in group 1 and group 2 (right plot). Carotid-femoral PWV was similar between the studied groups. Testosterone levels were similar between patients treated with a statin and males not receiving hypolipidemic therapy (groups 2 and 3). Conclusions Although treated hypercholesterolemic patients exhibited lower atherosclerotic burden compared to untreated individuals with high LDL levels, penile blood inflow remains significantly impaired. © Atlantis Press 2017
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title_short	P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy
url	https://dx.doi.org/10.1016/j.artres.2017.10.194
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author2	Vlachopoulos, Charalambos Angelis, Athanasios Printzios, Dimitrios Terentes- Georgakopoulos, Christos Aznaouridis, Konstantinos Koutagiar, Iosif Skoumas, John Tousoulis, Dimitrios
author2Str	Vlachopoulos, Charalambos Angelis, Athanasios Printzios, Dimitrios Terentes- Georgakopoulos, Christos Aznaouridis, Konstantinos Koutagiar, Iosif Skoumas, John Tousoulis, Dimitrios
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up_date	2024-07-04T03:31:18.990Z
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P193: Carotid Atherosclerosis, Aortic Stiffness and Penile Vascular Damage in Patients with Erectile Dysfunction: Relation to Low Density Lipoprotein Levels and Statin therapy

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