P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives

Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patient...
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Autor*in:	Rosenbaum, D. [verfasserIn] Redheuil, A. Kachenoura, N. Cluzel, P. Decesare, A. Koch, E. Paques, M. Girerd, X.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Anmerkung:	© Atlantis Press 2013

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 7(2013), 3-4 vom: Sept., Seite 118-118
Übergeordnetes Werk:	volume:7 ; year:2013 ; number:3-4 ; month:09 ; pages:118-118

Links:	Volltext

DOI / URN:	10.1016/j.artres.2013.10.059

Katalog-ID:	SPR055020135

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520			\|a Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR.
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allfields	10.1016/j.artres.2013.10.059 doi (DE-627)SPR055020135 (SPR)j.artres.2013.10.059-e DE-627 ger DE-627 rakwb eng Rosenbaum, D. verfasserin aut P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. Redheuil, A. aut Kachenoura, N. aut Cluzel, P. aut Decesare, A. aut Koch, E. aut Paques, M. aut Girerd, X. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 118-118 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:118-118 https://dx.doi.org/10.1016/j.artres.2013.10.059 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 118-118
spelling	10.1016/j.artres.2013.10.059 doi (DE-627)SPR055020135 (SPR)j.artres.2013.10.059-e DE-627 ger DE-627 rakwb eng Rosenbaum, D. verfasserin aut P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. Redheuil, A. aut Kachenoura, N. aut Cluzel, P. aut Decesare, A. aut Koch, E. aut Paques, M. aut Girerd, X. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 118-118 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:118-118 https://dx.doi.org/10.1016/j.artres.2013.10.059 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 118-118
allfields_unstemmed	10.1016/j.artres.2013.10.059 doi (DE-627)SPR055020135 (SPR)j.artres.2013.10.059-e DE-627 ger DE-627 rakwb eng Rosenbaum, D. verfasserin aut P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. Redheuil, A. aut Kachenoura, N. aut Cluzel, P. aut Decesare, A. aut Koch, E. aut Paques, M. aut Girerd, X. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 118-118 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:118-118 https://dx.doi.org/10.1016/j.artres.2013.10.059 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 118-118
allfieldsGer	10.1016/j.artres.2013.10.059 doi (DE-627)SPR055020135 (SPR)j.artres.2013.10.059-e DE-627 ger DE-627 rakwb eng Rosenbaum, D. verfasserin aut P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. Redheuil, A. aut Kachenoura, N. aut Cluzel, P. aut Decesare, A. aut Koch, E. aut Paques, M. aut Girerd, X. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 118-118 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:118-118 https://dx.doi.org/10.1016/j.artres.2013.10.059 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 118-118
allfieldsSound	10.1016/j.artres.2013.10.059 doi (DE-627)SPR055020135 (SPR)j.artres.2013.10.059-e DE-627 ger DE-627 rakwb eng Rosenbaum, D. verfasserin aut P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. Redheuil, A. aut Kachenoura, N. aut Cluzel, P. aut Decesare, A. aut Koch, E. aut Paques, M. aut Girerd, X. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 118-118 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:118-118 https://dx.doi.org/10.1016/j.artres.2013.10.059 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 118-118
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Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. 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author	Rosenbaum, D.
spellingShingle	Rosenbaum, D. P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives
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title	P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives
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title_sort	p1.30: differential meaning of retinal arterial remodeling and aortic distensibility in young hypertensives
title_auth	P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives
abstract	Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. © Atlantis Press 2013
abstractGer	Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. © Atlantis Press 2013
abstract_unstemmed	Objectives Microvascular arterial remodelling has been linked with target organ damage and cardiovascular events. Our objective was to link retinal arterial remodelling assessed using a new interferometry technique (adaptative optics, AO) and ascending aortic function and geometry. Methods 9 patients (median age 43, range 30 to 58, 60% male) with primary hypertension underwent AO to measure retinal arteries wall to lumen ratio (WLR) index and a cardiovascular magnetic resonance exam (1.5T Siemens) of the proximal aorta. Ascending aortic diameters and strain were calculated using the ARTFUN software and an automated segmentation of SSFP cine acquisitions acquired in the axial view, during breath-holding, at the level of pulmonary bifurcation perpendicular to the aorta. Aortic strain was used to calculate aortic distensibility in each subject: distensibility (AD)=strain/cPP where cPP is the central pulse pressure obtained by tonometry (sphygmocor®). Home Blood pressure (hBP) records were used to define BP levels Results Characteristics of the population are shown in table 1. In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. Conclusion In young hypertensives, AD and WLR are representative of 2 different arterial aging factors: age for AD and hypertension for WLR. © Atlantis Press 2013
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title_short	P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives
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up_date	2024-07-04T03:52:44.105Z
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In univariate analysis, retinal WLR was linked to systolic hBP (r = 0.53, p = 0,006) and weight (r = 0.38, p = 0,03) but not with any other risk factors. AD was linked to age (r = 0.53, p = 0,006), systolic hBP (r = 0.53, p = 0,006) and tobacco status. In multivariate analysis, the only significant determinants remaining were age for AD and systolic hBP for WLR. 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P1.30: Differential Meaning of Retinal Arterial Remodeling and Aortic Distensibility in Young Hypertensives

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