P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure

Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow ve...
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Autor*in:	Kim, M. O. [verfasserIn] Butlin, M. Li, Y. Wei, F. Wang, J. O’Rourke, M. Avolio, A. P.

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2013

Anmerkung:	© Atlantis Press 2013

Übergeordnetes Werk:	Enthalten in: Artery research - Amsterdam : Atlantis Press, 2006, 7(2013), 3-4 vom: Sept., Seite 119-119
Übergeordnetes Werk:	volume:7 ; year:2013 ; number:3-4 ; month:09 ; pages:119-119

Links:	Volltext

DOI / URN:	10.1016/j.artres.2013.10.065

Katalog-ID:	SPR055020194

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520			\|a Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used.
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allfields	10.1016/j.artres.2013.10.065 doi (DE-627)SPR055020194 (SPR)j.artres.2013.10.065-e DE-627 ger DE-627 rakwb eng Kim, M. O. verfasserin aut P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. Butlin, M. aut Li, Y. aut Wei, F. aut Wang, J. aut O’Rourke, M. aut Avolio, A. P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 119-119 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:119-119 https://dx.doi.org/10.1016/j.artres.2013.10.065 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 119-119
spelling	10.1016/j.artres.2013.10.065 doi (DE-627)SPR055020194 (SPR)j.artres.2013.10.065-e DE-627 ger DE-627 rakwb eng Kim, M. O. verfasserin aut P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. Butlin, M. aut Li, Y. aut Wei, F. aut Wang, J. aut O’Rourke, M. aut Avolio, A. P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 119-119 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:119-119 https://dx.doi.org/10.1016/j.artres.2013.10.065 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 119-119
allfields_unstemmed	10.1016/j.artres.2013.10.065 doi (DE-627)SPR055020194 (SPR)j.artres.2013.10.065-e DE-627 ger DE-627 rakwb eng Kim, M. O. verfasserin aut P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. Butlin, M. aut Li, Y. aut Wei, F. aut Wang, J. aut O’Rourke, M. aut Avolio, A. P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 119-119 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:119-119 https://dx.doi.org/10.1016/j.artres.2013.10.065 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 119-119
allfieldsGer	10.1016/j.artres.2013.10.065 doi (DE-627)SPR055020194 (SPR)j.artres.2013.10.065-e DE-627 ger DE-627 rakwb eng Kim, M. O. verfasserin aut P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. Butlin, M. aut Li, Y. aut Wei, F. aut Wang, J. aut O’Rourke, M. aut Avolio, A. P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 119-119 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:119-119 https://dx.doi.org/10.1016/j.artres.2013.10.065 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 119-119
allfieldsSound	10.1016/j.artres.2013.10.065 doi (DE-627)SPR055020194 (SPR)j.artres.2013.10.065-e DE-627 ger DE-627 rakwb eng Kim, M. O. verfasserin aut P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure 2013 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © Atlantis Press 2013 Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. Butlin, M. aut Li, Y. aut Wei, F. aut Wang, J. aut O’Rourke, M. aut Avolio, A. P. aut Enthalten in Artery research Amsterdam : Atlantis Press, 2006 7(2013), 3-4 vom: Sept., Seite 119-119 (DE-627)534057489 (DE-600)2364789-9 1876-4401 nnns volume:7 year:2013 number:3-4 month:09 pages:119-119 https://dx.doi.org/10.1016/j.artres.2013.10.065 kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2004 GBV_ILN_2014 GBV_ILN_2068 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 7 2013 3-4 09 119-119
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O.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2013</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© Atlantis Press 2013</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. 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author	Kim, M. O.
spellingShingle	Kim, M. O. P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure
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title	P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure
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title_sort	p2.03: aortic, but not radial pressure gives a model independent estimate of cerebral artery critical closing pressure
title_auth	P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure
abstract	Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. © Atlantis Press 2013
abstractGer	Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. © Atlantis Press 2013
abstract_unstemmed	Objectives Cerebral artery critical closing pressure (CCP) is an estimated parameter with no single accepted method of calculation. Variation between methods could be significant. This study investigates two models to estimate CCP using arterial blood pressure (BP) and middle cerebral artery flow velocity (FV) waveforms, quantifying the difference between radial and aortic BP as the BP input signal. Methods Suspected and untreated hypertensive subjects (n=445, 203 female, 50±10 years, range 21 to 73 years old), referred to Ruijin Hospital in Shanghai, China, for 24-hours BP monitoring, were recruited. Radial BP and FV waveforms were acquired by applanation tonometry and transcranial Doppler respectively. Aortic BP waveforms were synthesised from the radial waveform using a validated transfer function (SphygmoCor®). CCP was estimated using the relationship between BP and FV waveforms by both linear regression (LR), and the first harmonic (H1) in Fourier decomposition. The difference between the two models was quantified if the BP waveform input signal was radial or aortic and compared by Student’s paired t-test. Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. However, estimated CCP within a model was significantly different depending on whether radial or aortic pressure was used. © Atlantis Press 2013
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title_short	P2.03: Aortic, But Not Radial Pressure Gives a Model Independent Estimate of Cerebral Artery Critical Closing Pressure
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Results Use of aortic instead of radial BP resulted in a 29% increase in estimated CCP using the LR model, and 25% increase using the H1 model (Figure, p<0.001). Radial BP resulted in variation between the models (4%, p<0.001). Aortic BP did not cause this variation (0.6%, p=0.49). Conclusions Aortic, but not radial pressure gave a model independent estimate of CCP. 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