A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus
Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Conseq...
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Gespeichert in:
| Autor*in: |
Lefta, Ridha M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s) 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Umweltwissenschaften und Schadstoff-Forschung - Heidelberg : Springer, 1989, 36(2024), 1 vom: 05. März |
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| Übergeordnetes Werk: |
volume:36 ; year:2024 ; number:1 ; day:05 ; month:03 |
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| DOI / URN: |
10.1186/s12302-024-00878-w |
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| 245 | 1 | 2 | |a A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus |
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| 520 | |a Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. | ||
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10.1186/s12302-024-00878-w doi (DE-627)SPR055032419 (SPR)s12302-024-00878-w-e DE-627 ger DE-627 rakwb eng Lefta, Ridha M. verfasserin aut A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Hjazi, Ahmed aut Skakodub, Alla A. aut Dham, Ammar aut Sapaev, I. B. aut Khlewee, Ibrahim Hammoud aut Alawadi, Ahmed Hussien aut Alsaalamy, Ali aut Habash, Ruqayah Taher aut Lari Najafi, Moslem aut Enthalten in Umweltwissenschaften und Schadstoff-Forschung Heidelberg : Springer, 1989 36(2024), 1 vom: 05. März (DE-627)319337200 (DE-600)2014183-X 1865-5084 nnns volume:36 year:2024 number:1 day:05 month:03 https://dx.doi.org/10.1186/s12302-024-00878-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_60 GBV_ILN_95 GBV_ILN_370 GBV_ILN_2360 AR 36 2024 1 05 03 |
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10.1186/s12302-024-00878-w doi (DE-627)SPR055032419 (SPR)s12302-024-00878-w-e DE-627 ger DE-627 rakwb eng Lefta, Ridha M. verfasserin aut A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Hjazi, Ahmed aut Skakodub, Alla A. aut Dham, Ammar aut Sapaev, I. B. aut Khlewee, Ibrahim Hammoud aut Alawadi, Ahmed Hussien aut Alsaalamy, Ali aut Habash, Ruqayah Taher aut Lari Najafi, Moslem aut Enthalten in Umweltwissenschaften und Schadstoff-Forschung Heidelberg : Springer, 1989 36(2024), 1 vom: 05. März (DE-627)319337200 (DE-600)2014183-X 1865-5084 nnns volume:36 year:2024 number:1 day:05 month:03 https://dx.doi.org/10.1186/s12302-024-00878-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_60 GBV_ILN_95 GBV_ILN_370 GBV_ILN_2360 AR 36 2024 1 05 03 |
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10.1186/s12302-024-00878-w doi (DE-627)SPR055032419 (SPR)s12302-024-00878-w-e DE-627 ger DE-627 rakwb eng Lefta, Ridha M. verfasserin aut A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Hjazi, Ahmed aut Skakodub, Alla A. aut Dham, Ammar aut Sapaev, I. B. aut Khlewee, Ibrahim Hammoud aut Alawadi, Ahmed Hussien aut Alsaalamy, Ali aut Habash, Ruqayah Taher aut Lari Najafi, Moslem aut Enthalten in Umweltwissenschaften und Schadstoff-Forschung Heidelberg : Springer, 1989 36(2024), 1 vom: 05. März (DE-627)319337200 (DE-600)2014183-X 1865-5084 nnns volume:36 year:2024 number:1 day:05 month:03 https://dx.doi.org/10.1186/s12302-024-00878-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_60 GBV_ILN_95 GBV_ILN_370 GBV_ILN_2360 AR 36 2024 1 05 03 |
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10.1186/s12302-024-00878-w doi (DE-627)SPR055032419 (SPR)s12302-024-00878-w-e DE-627 ger DE-627 rakwb eng Lefta, Ridha M. verfasserin aut A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Hjazi, Ahmed aut Skakodub, Alla A. aut Dham, Ammar aut Sapaev, I. B. aut Khlewee, Ibrahim Hammoud aut Alawadi, Ahmed Hussien aut Alsaalamy, Ali aut Habash, Ruqayah Taher aut Lari Najafi, Moslem aut Enthalten in Umweltwissenschaften und Schadstoff-Forschung Heidelberg : Springer, 1989 36(2024), 1 vom: 05. März (DE-627)319337200 (DE-600)2014183-X 1865-5084 nnns volume:36 year:2024 number:1 day:05 month:03 https://dx.doi.org/10.1186/s12302-024-00878-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_60 GBV_ILN_95 GBV_ILN_370 GBV_ILN_2360 AR 36 2024 1 05 03 |
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10.1186/s12302-024-00878-w doi (DE-627)SPR055032419 (SPR)s12302-024-00878-w-e DE-627 ger DE-627 rakwb eng Lefta, Ridha M. verfasserin aut A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 Hjazi, Ahmed aut Skakodub, Alla A. aut Dham, Ammar aut Sapaev, I. B. aut Khlewee, Ibrahim Hammoud aut Alawadi, Ahmed Hussien aut Alsaalamy, Ali aut Habash, Ruqayah Taher aut Lari Najafi, Moslem aut Enthalten in Umweltwissenschaften und Schadstoff-Forschung Heidelberg : Springer, 1989 36(2024), 1 vom: 05. März (DE-627)319337200 (DE-600)2014183-X 1865-5084 nnns volume:36 year:2024 number:1 day:05 month:03 https://dx.doi.org/10.1186/s12302-024-00878-w kostenfrei Volltext GBV_USEFLAG_A SYSFLAG_A GBV_SPRINGER GBV_ILN_60 GBV_ILN_95 GBV_ILN_370 GBV_ILN_2360 AR 36 2024 1 05 03 |
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A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus Heavy metals (dpeaa)DE-He213 Pregnancy complications (dpeaa)DE-He213 Pregnancy outcomes (dpeaa)DE-He213 Diabetes (dpeaa)DE-He213 |
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Lefta, Ridha M. Hjazi, Ahmed Skakodub, Alla A. Dham, Ammar Sapaev, I. B. Khlewee, Ibrahim Hammoud Alawadi, Ahmed Hussien Alsaalamy, Ali Habash, Ruqayah Taher Lari Najafi, Moslem |
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systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus |
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A systematic review and meta-analysis of the association between exposure to potentially toxic elements and gestational diabetes mellitus |
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Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. © The Author(s) 2024 |
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Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. © The Author(s) 2024 |
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Abstract Potentially toxic elements (PTEs), including heavy metal exposures, have been associated with numerous negative pregnancy and birth outcomes. However, the association between PTE exposure and gestational diabetes mellitus (GDM) has not yet undergone a comprehensive systematic review. Consequently, this study undertook the first-ever systematic review and meta-analysis of observational studies concerning this association. All relevant articles published in English were searched in Scopus, PubMed, and Web of Science until November 6, 2023, adhering to the MOOSE guidelines. The quality of retrieved studies was evaluated based on the Gascon et al. method. The meta-analysis of association estimates was performed using random effects meta-analysis. Egger’s regression was employed to evaluate publication bias. In total, 16 articles (n = 116,728 participants) were included in our review, with 11 eligible for meta-analysis. Quality assessment categorized five studies (31%) as excellent, nine studies (56%) as good, and two studies (13%) as fair. Maternal high levels of Hg during pregnancy were associated with an increased risk of GDM (for each one-quartile increase in Hg: 1.20, 95% CI 1.08, 1.31), while serum Cd levels during the second trimester were associated with a lower risk of GDM (for each one-quartile increase in Cd: 0.76, 95% CI 0.65, 0.87). Furthermore, exposure to Pb was not associated with higher risk of GDM. In summary, our comprehensive review and meta-analysis underscore the possible negative influence of Hg exposure on GDM. © The Author(s) 2024 |
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