Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity

Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and sho...
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Autor*in:	Thulasi Devendrakumar, Karen [verfasserIn] Peng, Tony ShengZhe Pierdzig, Leon Jackson, Edan Lipka, Volker Li, Xin

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Signal peptide peptidase Plant immunity ER stress EMS mutagenesis

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Stress biology - Springer Nature Singapore, 2021, 4(2024), 1 vom: 20. März
Übergeordnetes Werk:	volume:4 ; year:2024 ; number:1 ; day:20 ; month:03

Links:	Volltext

DOI / URN:	10.1007/s44154-024-00155-z

Katalog-ID:	SPR055233007

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520			\|a Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity.
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allfields	10.1007/s44154-024-00155-z doi (DE-627)SPR055233007 (SPR)s44154-024-00155-z-e DE-627 ger DE-627 rakwb eng Thulasi Devendrakumar, Karen verfasserin (orcid)0000-0002-6652-5032 aut Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213 Peng, Tony ShengZhe (orcid)0009-0000-2482-9786 aut Pierdzig, Leon aut Jackson, Edan aut Lipka, Volker (orcid)0000-0002-9759-5906 aut Li, Xin (orcid)0000-0002-6354-2021 aut Enthalten in Stress biology Springer Nature Singapore, 2021 4(2024), 1 vom: 20. März (DE-627)1770765034 (DE-600)3093255-5 2731-0450 nnns volume:4 year:2024 number:1 day:20 month:03 https://dx.doi.org/10.1007/s44154-024-00155-z kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2024 1 20 03
spelling	10.1007/s44154-024-00155-z doi (DE-627)SPR055233007 (SPR)s44154-024-00155-z-e DE-627 ger DE-627 rakwb eng Thulasi Devendrakumar, Karen verfasserin (orcid)0000-0002-6652-5032 aut Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213 Peng, Tony ShengZhe (orcid)0009-0000-2482-9786 aut Pierdzig, Leon aut Jackson, Edan aut Lipka, Volker (orcid)0000-0002-9759-5906 aut Li, Xin (orcid)0000-0002-6354-2021 aut Enthalten in Stress biology Springer Nature Singapore, 2021 4(2024), 1 vom: 20. März (DE-627)1770765034 (DE-600)3093255-5 2731-0450 nnns volume:4 year:2024 number:1 day:20 month:03 https://dx.doi.org/10.1007/s44154-024-00155-z kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2024 1 20 03
allfields_unstemmed	10.1007/s44154-024-00155-z doi (DE-627)SPR055233007 (SPR)s44154-024-00155-z-e DE-627 ger DE-627 rakwb eng Thulasi Devendrakumar, Karen verfasserin (orcid)0000-0002-6652-5032 aut Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213 Peng, Tony ShengZhe (orcid)0009-0000-2482-9786 aut Pierdzig, Leon aut Jackson, Edan aut Lipka, Volker (orcid)0000-0002-9759-5906 aut Li, Xin (orcid)0000-0002-6354-2021 aut Enthalten in Stress biology Springer Nature Singapore, 2021 4(2024), 1 vom: 20. März (DE-627)1770765034 (DE-600)3093255-5 2731-0450 nnns volume:4 year:2024 number:1 day:20 month:03 https://dx.doi.org/10.1007/s44154-024-00155-z kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2024 1 20 03
allfieldsGer	10.1007/s44154-024-00155-z doi (DE-627)SPR055233007 (SPR)s44154-024-00155-z-e DE-627 ger DE-627 rakwb eng Thulasi Devendrakumar, Karen verfasserin (orcid)0000-0002-6652-5032 aut Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213 Peng, Tony ShengZhe (orcid)0009-0000-2482-9786 aut Pierdzig, Leon aut Jackson, Edan aut Lipka, Volker (orcid)0000-0002-9759-5906 aut Li, Xin (orcid)0000-0002-6354-2021 aut Enthalten in Stress biology Springer Nature Singapore, 2021 4(2024), 1 vom: 20. März (DE-627)1770765034 (DE-600)3093255-5 2731-0450 nnns volume:4 year:2024 number:1 day:20 month:03 https://dx.doi.org/10.1007/s44154-024-00155-z kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2024 1 20 03
allfieldsSound	10.1007/s44154-024-00155-z doi (DE-627)SPR055233007 (SPR)s44154-024-00155-z-e DE-627 ger DE-627 rakwb eng Thulasi Devendrakumar, Karen verfasserin (orcid)0000-0002-6652-5032 aut Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213 Peng, Tony ShengZhe (orcid)0009-0000-2482-9786 aut Pierdzig, Leon aut Jackson, Edan aut Lipka, Volker (orcid)0000-0002-9759-5906 aut Li, Xin (orcid)0000-0002-6354-2021 aut Enthalten in Stress biology Springer Nature Singapore, 2021 4(2024), 1 vom: 20. März (DE-627)1770765034 (DE-600)3093255-5 2731-0450 nnns volume:4 year:2024 number:1 day:20 month:03 https://dx.doi.org/10.1007/s44154-024-00155-z kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_20 GBV_ILN_22 GBV_ILN_24 GBV_ILN_31 GBV_ILN_40 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 4 2024 1 20 03
language	English
source	Enthalten in Stress biology 4(2024), 1 vom: 20. März volume:4 year:2024 number:1 day:20 month:03
sourceStr	Enthalten in Stress biology 4(2024), 1 vom: 20. März volume:4 year:2024 number:1 day:20 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Signal peptide peptidase Plant immunity ER stress EMS mutagenesis
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container_title	Stress biology
authorswithroles_txt_mv	Thulasi Devendrakumar, Karen @@aut@@ Peng, Tony ShengZhe @@aut@@ Pierdzig, Leon @@aut@@ Jackson, Edan @@aut@@ Lipka, Volker @@aut@@ Li, Xin @@aut@@
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author	Thulasi Devendrakumar, Karen
spellingShingle	Thulasi Devendrakumar, Karen misc Signal peptide peptidase misc Plant immunity misc ER stress misc EMS mutagenesis Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity
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topic_title	Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity Signal peptide peptidase (dpeaa)DE-He213 Plant immunity (dpeaa)DE-He213 ER stress (dpeaa)DE-He213 EMS mutagenesis (dpeaa)DE-He213
topic	misc Signal peptide peptidase misc Plant immunity misc ER stress misc EMS mutagenesis
topic_unstemmed	misc Signal peptide peptidase misc Plant immunity misc ER stress misc EMS mutagenesis
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title	Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity
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title_full	Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity
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author_browse	Thulasi Devendrakumar, Karen Peng, Tony ShengZhe Pierdzig, Leon Jackson, Edan Lipka, Volker Li, Xin
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title_sort	signal peptide peptidase and pi4kβ1/2 play opposite roles in plant er stress response and immunity
title_auth	Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity
abstract	Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. © The Author(s) 2024
abstractGer	Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. © The Author(s) 2024
abstract_unstemmed	Abstract The Arabidopsis pi4kβ1,2 mutant is mutated in the phosphatidylinositol 4-kinase (PI4K) β1 and PI4Kβ2 enzymes which are involved in the biosynthesis of phosphatidylinositol 4-phosphate (PI4P), a minor membrane lipid with important signaling roles. pi4kβ1,2 plants display autoimmunity and shorter roots. Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. Overall, our study reveals a previously unknown function of PI4Kβ and SPP in ER stress and plant immunity. © The Author(s) 2024
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title_short	Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity
url	https://dx.doi.org/10.1007/s44154-024-00155-z
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author2	Peng, Tony ShengZhe Pierdzig, Leon Jackson, Edan Lipka, Volker Li, Xin
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up_date	2024-07-03T14:14:30.687Z
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Though the pi4kβ1,2 mutant has been extensively characterized, the source of its autoimmunity remains largely unknown. In this study, through a genetic suppressor screen, we identified multiple partial loss-of-function alleles of signal peptide peptidase (spp) that can suppress all the defects of pi4kβ1,2. SPP is an intramembrane cleaving aspartic protease. Interestingly, pi4kβ1,2 plants display enhanced ER stress response and mutations in SPP can suppress such phenotype. Furthermore, reduced ER stress responses were observed in the spp single mutants. 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Signal Peptide Peptidase and PI4Kβ1/2 play opposite roles in plant ER stress response and immunity

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