Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI

Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Howe, Emilie Isager [verfasserIn] Andelic, Nada Brunborg, Cathrine Zeldovich, Marina Helseth, Eirik Skandsen, Toril Olsen, Alexander Fure, Silje C. R. Theadom, Alice Rauen, Katrin Madsen, Benedikte Å. Jacobs, Bram van der Naalt, Joukje Tartaglia, Maria Carmela Einarsen, Cathrine Elisabeth Storvig, Gøril Tronvik, Erling Tverdal, Cathrine von Steinbüchel, Nicole Røe, Cecilie Hellstrøm, Torgeir

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Post-traumatic headache Brain trauma Observational study Secondary headache disorders

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: The journal of headache and pain - Springer Milan, 2000, 25(2024), 1 vom: 25. März
Übergeordnetes Werk:	volume:25 ; year:2024 ; number:1 ; day:25 ; month:03

Links:	Volltext

DOI / URN:	10.1186/s10194-024-01751-0

Katalog-ID:	SPR055283020

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520			\|a Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221.
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spelling	10.1186/s10194-024-01751-0 doi (DE-627)SPR055283020 (SPR)s10194-024-01751-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Howe, Emilie Isager verfasserin aut Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. Post-traumatic headache (dpeaa)DE-He213 Brain trauma (dpeaa)DE-He213 Observational study (dpeaa)DE-He213 Secondary headache disorders (dpeaa)DE-He213 Andelic, Nada aut Brunborg, Cathrine aut Zeldovich, Marina aut Helseth, Eirik aut Skandsen, Toril aut Olsen, Alexander aut Fure, Silje C. R. aut Theadom, Alice aut Rauen, Katrin aut Madsen, Benedikte Å. aut Jacobs, Bram aut van der Naalt, Joukje aut Tartaglia, Maria Carmela aut Einarsen, Cathrine Elisabeth aut Storvig, Gøril aut Tronvik, Erling aut Tverdal, Cathrine aut von Steinbüchel, Nicole aut Røe, Cecilie aut Hellstrøm, Torgeir aut Enthalten in The journal of headache and pain Springer Milan, 2000 25(2024), 1 vom: 25. März (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:25 year:2024 number:1 day:25 month:03 https://dx.doi.org/10.1186/s10194-024-01751-0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 VZ AR 25 2024 1 25 03
allfields_unstemmed	10.1186/s10194-024-01751-0 doi (DE-627)SPR055283020 (SPR)s10194-024-01751-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Howe, Emilie Isager verfasserin aut Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. Post-traumatic headache (dpeaa)DE-He213 Brain trauma (dpeaa)DE-He213 Observational study (dpeaa)DE-He213 Secondary headache disorders (dpeaa)DE-He213 Andelic, Nada aut Brunborg, Cathrine aut Zeldovich, Marina aut Helseth, Eirik aut Skandsen, Toril aut Olsen, Alexander aut Fure, Silje C. R. aut Theadom, Alice aut Rauen, Katrin aut Madsen, Benedikte Å. aut Jacobs, Bram aut van der Naalt, Joukje aut Tartaglia, Maria Carmela aut Einarsen, Cathrine Elisabeth aut Storvig, Gøril aut Tronvik, Erling aut Tverdal, Cathrine aut von Steinbüchel, Nicole aut Røe, Cecilie aut Hellstrøm, Torgeir aut Enthalten in The journal of headache and pain Springer Milan, 2000 25(2024), 1 vom: 25. März (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:25 year:2024 number:1 day:25 month:03 https://dx.doi.org/10.1186/s10194-024-01751-0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 VZ AR 25 2024 1 25 03
allfieldsGer	10.1186/s10194-024-01751-0 doi (DE-627)SPR055283020 (SPR)s10194-024-01751-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Howe, Emilie Isager verfasserin aut Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. Post-traumatic headache (dpeaa)DE-He213 Brain trauma (dpeaa)DE-He213 Observational study (dpeaa)DE-He213 Secondary headache disorders (dpeaa)DE-He213 Andelic, Nada aut Brunborg, Cathrine aut Zeldovich, Marina aut Helseth, Eirik aut Skandsen, Toril aut Olsen, Alexander aut Fure, Silje C. R. aut Theadom, Alice aut Rauen, Katrin aut Madsen, Benedikte Å. aut Jacobs, Bram aut van der Naalt, Joukje aut Tartaglia, Maria Carmela aut Einarsen, Cathrine Elisabeth aut Storvig, Gøril aut Tronvik, Erling aut Tverdal, Cathrine aut von Steinbüchel, Nicole aut Røe, Cecilie aut Hellstrøm, Torgeir aut Enthalten in The journal of headache and pain Springer Milan, 2000 25(2024), 1 vom: 25. März (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:25 year:2024 number:1 day:25 month:03 https://dx.doi.org/10.1186/s10194-024-01751-0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 VZ AR 25 2024 1 25 03
allfieldsSound	10.1186/s10194-024-01751-0 doi (DE-627)SPR055283020 (SPR)s10194-024-01751-0-e DE-627 ger DE-627 rakwb eng 610 VZ 610 VZ 44.90 bkl Howe, Emilie Isager verfasserin aut Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. Post-traumatic headache (dpeaa)DE-He213 Brain trauma (dpeaa)DE-He213 Observational study (dpeaa)DE-He213 Secondary headache disorders (dpeaa)DE-He213 Andelic, Nada aut Brunborg, Cathrine aut Zeldovich, Marina aut Helseth, Eirik aut Skandsen, Toril aut Olsen, Alexander aut Fure, Silje C. R. aut Theadom, Alice aut Rauen, Katrin aut Madsen, Benedikte Å. aut Jacobs, Bram aut van der Naalt, Joukje aut Tartaglia, Maria Carmela aut Einarsen, Cathrine Elisabeth aut Storvig, Gøril aut Tronvik, Erling aut Tverdal, Cathrine aut von Steinbüchel, Nicole aut Røe, Cecilie aut Hellstrøm, Torgeir aut Enthalten in The journal of headache and pain Springer Milan, 2000 25(2024), 1 vom: 25. März (DE-627)320600963 (DE-600)2020168-0 1129-2377 nnns volume:25 year:2024 number:1 day:25 month:03 https://dx.doi.org/10.1186/s10194-024-01751-0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_267 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2014 GBV_ILN_2153 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.90 VZ AR 25 2024 1 25 03
language	English
source	Enthalten in The journal of headache and pain 25(2024), 1 vom: 25. März volume:25 year:2024 number:1 day:25 month:03
sourceStr	Enthalten in The journal of headache and pain 25(2024), 1 vom: 25. März volume:25 year:2024 number:1 day:25 month:03
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Post-traumatic headache Brain trauma Observational study Secondary headache disorders
dewey-raw	610
isfreeaccess_bool	true
container_title	The journal of headache and pain
authorswithroles_txt_mv	Howe, Emilie Isager @@aut@@ Andelic, Nada @@aut@@ Brunborg, Cathrine @@aut@@ Zeldovich, Marina @@aut@@ Helseth, Eirik @@aut@@ Skandsen, Toril @@aut@@ Olsen, Alexander @@aut@@ Fure, Silje C. R. @@aut@@ Theadom, Alice @@aut@@ Rauen, Katrin @@aut@@ Madsen, Benedikte Å. @@aut@@ Jacobs, Bram @@aut@@ van der Naalt, Joukje @@aut@@ Tartaglia, Maria Carmela @@aut@@ Einarsen, Cathrine Elisabeth @@aut@@ Storvig, Gøril @@aut@@ Tronvik, Erling @@aut@@ Tverdal, Cathrine @@aut@@ von Steinbüchel, Nicole @@aut@@ Røe, Cecilie @@aut@@ Hellstrøm, Torgeir @@aut@@
publishDateDaySort_date	2024-03-25T00:00:00Z
hierarchy_top_id	320600963
dewey-sort	3610
id	SPR055283020
language_de	englisch
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Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. 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author	Howe, Emilie Isager
spellingShingle	Howe, Emilie Isager ddc 610 bkl 44.90 misc Post-traumatic headache misc Brain trauma misc Observational study misc Secondary headache disorders Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI
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topic_title	610 VZ 44.90 bkl Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI Post-traumatic headache (dpeaa)DE-He213 Brain trauma (dpeaa)DE-He213 Observational study (dpeaa)DE-He213 Secondary headache disorders (dpeaa)DE-He213
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title	Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI
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title_full	Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI
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author_browse	Howe, Emilie Isager Andelic, Nada Brunborg, Cathrine Zeldovich, Marina Helseth, Eirik Skandsen, Toril Olsen, Alexander Fure, Silje C. R. Theadom, Alice Rauen, Katrin Madsen, Benedikte Å. Jacobs, Bram van der Naalt, Joukje Tartaglia, Maria Carmela Einarsen, Cathrine Elisabeth Storvig, Gøril Tronvik, Erling Tverdal, Cathrine von Steinbüchel, Nicole Røe, Cecilie Hellstrøm, Torgeir
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title_sort	frequency and predictors of headache in the first 12 months after traumatic brain injury: results from center-tbi
title_auth	Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI
abstract	Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. © The Author(s) 2024
abstractGer	Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. © The Author(s) 2024
abstract_unstemmed	Background Headache is a prevalent and debilitating symptom following traumatic brain injury (TBI). Large-scale, prospective cohort studies are needed to establish long-term headache prevalence and associated factors after TBI. This study aimed to assess the frequency and severity of headache after TBI and determine whether sociodemographic factors, injury severity characteristics, and pre- and post-injury comorbidities predicted changes in headache frequency and severity during the first 12 months after injury. Methods A large patient sample from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) prospective observational cohort study was used. Patients were stratified based on their clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU) in the acute phase. Headache was assessed using a single item from the Rivermead Post-Concussion Symptoms Questionnaire measured at baseline, 3, 6 and 12 months after injury. Mixed-effect logistic regression analyses were applied to investigate changes in headache frequency and associated predictors. Results A total of 2,291 patients responded to the headache item at baseline. At study enrolment, 59.3% of patients reported acute headache, with similar frequencies across all strata. Female patients and those aged up to 40 years reported a higher frequency of headache at baseline compared to males and older adults. The frequency of severe headache was highest in patients admitted to the ICU. The frequency of headache in the ER stratum decreased substantially from baseline to 3 months and remained from 3 to 6 months. Similar trajectory trends were observed in the ICU and ADM strata across 12 months. Younger age, more severe TBI, fatigue, neck pain and vision problems were among the predictors of more severe headache over time. More than 25% of patients experienced headache at 12 months after injury. Conclusions Headache is a common symptom after TBI, especially in female and younger patients. It typically decreases in the first 3 months before stabilising. However, more than a quarter of patients still experienced headache at 12 months after injury. Translational research is needed to advance the clinical decision-making process and improve targeted medical treatment for headache. Trial registration ClinicalTrials.gov NCT02210221. © The Author(s) 2024
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title_short	Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI
url	https://dx.doi.org/10.1186/s10194-024-01751-0
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author2	Andelic, Nada Brunborg, Cathrine Zeldovich, Marina Helseth, Eirik Skandsen, Toril Olsen, Alexander Fure, Silje C. R. Theadom, Alice Rauen, Katrin Madsen, Benedikte Å. Jacobs, Bram van der Naalt, Joukje Tartaglia, Maria Carmela Einarsen, Cathrine Elisabeth Storvig, Gøril Tronvik, Erling Tverdal, Cathrine von Steinbüchel, Nicole Røe, Cecilie Hellstrøm, Torgeir
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Frequency and predictors of headache in the first 12 months after traumatic brain injury: results from CENTER-TBI

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