Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride
Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Garg, Yogesh [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2023 |
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| Schlagwörter: |
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| Anmerkung: |
© The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Journal of cluster science - Springer US, 1990, 35(2023), 4 vom: 21. Dez., Seite 1007-1019 |
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| Übergeordnetes Werk: |
volume:35 ; year:2023 ; number:4 ; day:21 ; month:12 ; pages:1007-1019 |
| Links: |
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| DOI / URN: |
10.1007/s10876-023-02528-2 |
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SPR055319491 |
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| 520 | |a Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. | ||
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10.1007/s10876-023-02528-2 doi (DE-627)SPR055319491 (SPR)s10876-023-02528-2-e DE-627 ger DE-627 rakwb eng 500 VZ 31.00 bkl Garg, Yogesh verfasserin aut Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 Kumar, Mohit aut Sharma, Gajanand aut Katare, Om Prakash aut Chopra, Shruti aut Bhatia, Amit aut Enthalten in Journal of cluster science Springer US, 1990 35(2023), 4 vom: 21. Dez., Seite 1007-1019 (DE-627)320573427 (DE-600)2016762-3 1572-8862 nnns volume:35 year:2023 number:4 day:21 month:12 pages:1007-1019 https://dx.doi.org/10.1007/s10876-023-02528-2 lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 VZ AR 35 2023 4 21 12 1007-1019 |
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10.1007/s10876-023-02528-2 doi (DE-627)SPR055319491 (SPR)s10876-023-02528-2-e DE-627 ger DE-627 rakwb eng 500 VZ 31.00 bkl Garg, Yogesh verfasserin aut Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 Kumar, Mohit aut Sharma, Gajanand aut Katare, Om Prakash aut Chopra, Shruti aut Bhatia, Amit aut Enthalten in Journal of cluster science Springer US, 1990 35(2023), 4 vom: 21. Dez., Seite 1007-1019 (DE-627)320573427 (DE-600)2016762-3 1572-8862 nnns volume:35 year:2023 number:4 day:21 month:12 pages:1007-1019 https://dx.doi.org/10.1007/s10876-023-02528-2 lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 VZ AR 35 2023 4 21 12 1007-1019 |
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10.1007/s10876-023-02528-2 doi (DE-627)SPR055319491 (SPR)s10876-023-02528-2-e DE-627 ger DE-627 rakwb eng 500 VZ 31.00 bkl Garg, Yogesh verfasserin aut Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 Kumar, Mohit aut Sharma, Gajanand aut Katare, Om Prakash aut Chopra, Shruti aut Bhatia, Amit aut Enthalten in Journal of cluster science Springer US, 1990 35(2023), 4 vom: 21. Dez., Seite 1007-1019 (DE-627)320573427 (DE-600)2016762-3 1572-8862 nnns volume:35 year:2023 number:4 day:21 month:12 pages:1007-1019 https://dx.doi.org/10.1007/s10876-023-02528-2 lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 VZ AR 35 2023 4 21 12 1007-1019 |
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10.1007/s10876-023-02528-2 doi (DE-627)SPR055319491 (SPR)s10876-023-02528-2-e DE-627 ger DE-627 rakwb eng 500 VZ 31.00 bkl Garg, Yogesh verfasserin aut Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 Kumar, Mohit aut Sharma, Gajanand aut Katare, Om Prakash aut Chopra, Shruti aut Bhatia, Amit aut Enthalten in Journal of cluster science Springer US, 1990 35(2023), 4 vom: 21. Dez., Seite 1007-1019 (DE-627)320573427 (DE-600)2016762-3 1572-8862 nnns volume:35 year:2023 number:4 day:21 month:12 pages:1007-1019 https://dx.doi.org/10.1007/s10876-023-02528-2 lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 VZ AR 35 2023 4 21 12 1007-1019 |
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10.1007/s10876-023-02528-2 doi (DE-627)SPR055319491 (SPR)s10876-023-02528-2-e DE-627 ger DE-627 rakwb eng 500 VZ 31.00 bkl Garg, Yogesh verfasserin aut Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride 2023 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 Kumar, Mohit aut Sharma, Gajanand aut Katare, Om Prakash aut Chopra, Shruti aut Bhatia, Amit aut Enthalten in Journal of cluster science Springer US, 1990 35(2023), 4 vom: 21. Dez., Seite 1007-1019 (DE-627)320573427 (DE-600)2016762-3 1572-8862 nnns volume:35 year:2023 number:4 day:21 month:12 pages:1007-1019 https://dx.doi.org/10.1007/s10876-023-02528-2 lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER SSG-OPC-MAT GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 31.00 VZ AR 35 2023 4 21 12 1007-1019 |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. 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Garg, Yogesh |
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Garg, Yogesh ddc 500 bkl 31.00 misc Alzheimer’s disease misc Chitosan nanoparticles misc Nose-to-brain delivery misc Donepezil hydrochloride Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride |
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500 VZ 31.00 bkl Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride Alzheimer’s disease (dpeaa)DE-He213 Chitosan nanoparticles (dpeaa)DE-He213 Nose-to-brain delivery (dpeaa)DE-He213 Donepezil hydrochloride (dpeaa)DE-He213 |
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systematic designing and optimization of polymeric nanoparticles using central composite design: a novel approach for nose-to-brain delivery of donepezil hydrochloride |
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Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride |
| abstract |
Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Abstract The oral administration of donepezil hydrochloride has low brain targeting efficiency especially due to the presence of the blood–brain barrier leading to poor quality of treatment. Hence, this study aimed to systematically design chitosan nanoparticles for direct nose-to-brain delivery of donepezil hydrochloride using the Quality by Design approach for better transport to the brain avoiding the blood–brain barrier. The optimized formulation showed 180.2 nm average particle size and 0.282 polydispersity index, + 16.6 mV zeta potential, more than 90% drug release, and more than 70% drug permeation in 24 h. The studies on in-vitro drug release and ex-vivo permeation showed a sustained release pattern fulfilling Korsemeyer Peppa’s model. The confocal laser scanning micrographs showed the spherical nature of nanoparticles. The intranasal administration of donepezil hydrochloride nanoparticles in Wistar rats showed approximately 2.6 times more drug than donepezil hydrochloride solution given intranasally and approximately 10 times more drug than donepezil hydrochloride solution given orally in the brain respectively after 6 h. Further, confocal micrographs using Rhodamine B (fluorescent dye) loaded nanoparticles confirmed the localization of nanoparticles in the brain post-intranasal administration. The obtained results suggested that the chitosan nanoparticles are promising drug carriers for the nose-to-brain delivery of donepezil hydrochloride for the treatment of Alzheimer’s disease. © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Systematic Designing and Optimization of Polymeric Nanoparticles Using Central Composite Design: A Novel Approach for Nose-to-Brain Delivery of Donepezil Hydrochloride |
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https://dx.doi.org/10.1007/s10876-023-02528-2 |
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Kumar, Mohit Sharma, Gajanand Katare, Om Prakash Chopra, Shruti Bhatia, Amit |
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| score |
7.3988304 |