Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database
Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent ad...
Ausführliche Beschreibung
Autor*in: |
Panzuto, Francesco [verfasserIn] |
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Format: |
E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Schlagwörter: |
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Anmerkung: |
© The Author(s) 2024 |
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Übergeordnetes Werk: |
Enthalten in: Endocrine - Springer US, 1995, 84(2024), 1 vom: 04. Jan., Seite 42-47 |
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Übergeordnetes Werk: |
volume:84 ; year:2024 ; number:1 ; day:04 ; month:01 ; pages:42-47 |
Links: |
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DOI / URN: |
10.1007/s12020-023-03649-4 |
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Katalog-ID: |
SPR055386598 |
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520 | |a Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). | ||
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10.1007/s12020-023-03649-4 doi (DE-627)SPR055386598 (SPR)s12020-023-03649-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.89 bkl Panzuto, Francesco verfasserin (orcid)0000-0003-2789-4289 aut Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 Partelli, Stefano aut Campana, Davide aut de Braud, Filippo aut Spada, Francesca aut Cives, Mauro aut Tafuto, Salvatore aut Bertuzzi, Alexia aut Gelsomino, Fabio aut Bergamo, Francesca aut Marcucci, Stefano aut Mastrangelo, Laura aut Massironi, Sara aut Appetecchia, Marialuisa aut Filice, Angelina aut Badalamenti, Giuseppe aut Bartolomei, Mirco aut Amoroso, Vito aut Landoni, Luca aut Rodriquenz, Maria Grazia aut Valente, Monica aut Colao, Annamaria aut Isidori, Andrea aut Fanciulli, Giuseppe aut Bollina, Roberto aut Ciola, Michele aut Butturini, Giovanni aut Marconcini, Riccardo aut Arvat, Emanuela aut Cinieri, Saverio aut Berardi, Rossana aut Baldari, Sergio aut Riccardi, Ferdinando aut Spoto, Chiara aut Giuffrida, Dario aut Gattuso, Domenico aut Ferone, Diego aut Rinzivillo, Maria aut Bertani, Emilio aut Versari, Annibale aut Zerbi, Alessandro aut Lamberti, Giuseppe aut Lauricella, Eleonora aut Pusceddu, Sara aut Fazio, Nicola aut Dell’Unto, Elisabetta aut Marini, Marco aut Falconi, Massimo aut Enthalten in Endocrine Springer US, 1995 84(2024), 1 vom: 04. 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10.1007/s12020-023-03649-4 doi (DE-627)SPR055386598 (SPR)s12020-023-03649-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.89 bkl Panzuto, Francesco verfasserin (orcid)0000-0003-2789-4289 aut Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 Partelli, Stefano aut Campana, Davide aut de Braud, Filippo aut Spada, Francesca aut Cives, Mauro aut Tafuto, Salvatore aut Bertuzzi, Alexia aut Gelsomino, Fabio aut Bergamo, Francesca aut Marcucci, Stefano aut Mastrangelo, Laura aut Massironi, Sara aut Appetecchia, Marialuisa aut Filice, Angelina aut Badalamenti, Giuseppe aut Bartolomei, Mirco aut Amoroso, Vito aut Landoni, Luca aut Rodriquenz, Maria Grazia aut Valente, Monica aut Colao, Annamaria aut Isidori, Andrea aut Fanciulli, Giuseppe aut Bollina, Roberto aut Ciola, Michele aut Butturini, Giovanni aut Marconcini, Riccardo aut Arvat, Emanuela aut Cinieri, Saverio aut Berardi, Rossana aut Baldari, Sergio aut Riccardi, Ferdinando aut Spoto, Chiara aut Giuffrida, Dario aut Gattuso, Domenico aut Ferone, Diego aut Rinzivillo, Maria aut Bertani, Emilio aut Versari, Annibale aut Zerbi, Alessandro aut Lamberti, Giuseppe aut Lauricella, Eleonora aut Pusceddu, Sara aut Fazio, Nicola aut Dell’Unto, Elisabetta aut Marini, Marco aut Falconi, Massimo aut Enthalten in Endocrine Springer US, 1995 84(2024), 1 vom: 04. Jan., Seite 42-47 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:84 year:2024 number:1 day:04 month:01 pages:42-47 https://dx.doi.org/10.1007/s12020-023-03649-4 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 VZ AR 84 2024 1 04 01 42-47 |
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10.1007/s12020-023-03649-4 doi (DE-627)SPR055386598 (SPR)s12020-023-03649-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.89 bkl Panzuto, Francesco verfasserin (orcid)0000-0003-2789-4289 aut Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 Partelli, Stefano aut Campana, Davide aut de Braud, Filippo aut Spada, Francesca aut Cives, Mauro aut Tafuto, Salvatore aut Bertuzzi, Alexia aut Gelsomino, Fabio aut Bergamo, Francesca aut Marcucci, Stefano aut Mastrangelo, Laura aut Massironi, Sara aut Appetecchia, Marialuisa aut Filice, Angelina aut Badalamenti, Giuseppe aut Bartolomei, Mirco aut Amoroso, Vito aut Landoni, Luca aut Rodriquenz, Maria Grazia aut Valente, Monica aut Colao, Annamaria aut Isidori, Andrea aut Fanciulli, Giuseppe aut Bollina, Roberto aut Ciola, Michele aut Butturini, Giovanni aut Marconcini, Riccardo aut Arvat, Emanuela aut Cinieri, Saverio aut Berardi, Rossana aut Baldari, Sergio aut Riccardi, Ferdinando aut Spoto, Chiara aut Giuffrida, Dario aut Gattuso, Domenico aut Ferone, Diego aut Rinzivillo, Maria aut Bertani, Emilio aut Versari, Annibale aut Zerbi, Alessandro aut Lamberti, Giuseppe aut Lauricella, Eleonora aut Pusceddu, Sara aut Fazio, Nicola aut Dell’Unto, Elisabetta aut Marini, Marco aut Falconi, Massimo aut Enthalten in Endocrine Springer US, 1995 84(2024), 1 vom: 04. Jan., Seite 42-47 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:84 year:2024 number:1 day:04 month:01 pages:42-47 https://dx.doi.org/10.1007/s12020-023-03649-4 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 VZ AR 84 2024 1 04 01 42-47 |
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10.1007/s12020-023-03649-4 doi (DE-627)SPR055386598 (SPR)s12020-023-03649-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.89 bkl Panzuto, Francesco verfasserin (orcid)0000-0003-2789-4289 aut Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 Partelli, Stefano aut Campana, Davide aut de Braud, Filippo aut Spada, Francesca aut Cives, Mauro aut Tafuto, Salvatore aut Bertuzzi, Alexia aut Gelsomino, Fabio aut Bergamo, Francesca aut Marcucci, Stefano aut Mastrangelo, Laura aut Massironi, Sara aut Appetecchia, Marialuisa aut Filice, Angelina aut Badalamenti, Giuseppe aut Bartolomei, Mirco aut Amoroso, Vito aut Landoni, Luca aut Rodriquenz, Maria Grazia aut Valente, Monica aut Colao, Annamaria aut Isidori, Andrea aut Fanciulli, Giuseppe aut Bollina, Roberto aut Ciola, Michele aut Butturini, Giovanni aut Marconcini, Riccardo aut Arvat, Emanuela aut Cinieri, Saverio aut Berardi, Rossana aut Baldari, Sergio aut Riccardi, Ferdinando aut Spoto, Chiara aut Giuffrida, Dario aut Gattuso, Domenico aut Ferone, Diego aut Rinzivillo, Maria aut Bertani, Emilio aut Versari, Annibale aut Zerbi, Alessandro aut Lamberti, Giuseppe aut Lauricella, Eleonora aut Pusceddu, Sara aut Fazio, Nicola aut Dell’Unto, Elisabetta aut Marini, Marco aut Falconi, Massimo aut Enthalten in Endocrine Springer US, 1995 84(2024), 1 vom: 04. Jan., Seite 42-47 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:84 year:2024 number:1 day:04 month:01 pages:42-47 https://dx.doi.org/10.1007/s12020-023-03649-4 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 VZ AR 84 2024 1 04 01 42-47 |
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10.1007/s12020-023-03649-4 doi (DE-627)SPR055386598 (SPR)s12020-023-03649-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.89 bkl Panzuto, Francesco verfasserin (orcid)0000-0003-2789-4289 aut Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 Partelli, Stefano aut Campana, Davide aut de Braud, Filippo aut Spada, Francesca aut Cives, Mauro aut Tafuto, Salvatore aut Bertuzzi, Alexia aut Gelsomino, Fabio aut Bergamo, Francesca aut Marcucci, Stefano aut Mastrangelo, Laura aut Massironi, Sara aut Appetecchia, Marialuisa aut Filice, Angelina aut Badalamenti, Giuseppe aut Bartolomei, Mirco aut Amoroso, Vito aut Landoni, Luca aut Rodriquenz, Maria Grazia aut Valente, Monica aut Colao, Annamaria aut Isidori, Andrea aut Fanciulli, Giuseppe aut Bollina, Roberto aut Ciola, Michele aut Butturini, Giovanni aut Marconcini, Riccardo aut Arvat, Emanuela aut Cinieri, Saverio aut Berardi, Rossana aut Baldari, Sergio aut Riccardi, Ferdinando aut Spoto, Chiara aut Giuffrida, Dario aut Gattuso, Domenico aut Ferone, Diego aut Rinzivillo, Maria aut Bertani, Emilio aut Versari, Annibale aut Zerbi, Alessandro aut Lamberti, Giuseppe aut Lauricella, Eleonora aut Pusceddu, Sara aut Fazio, Nicola aut Dell’Unto, Elisabetta aut Marini, Marco aut Falconi, Massimo aut Enthalten in Endocrine Springer US, 1995 84(2024), 1 vom: 04. Jan., Seite 42-47 (DE-627)343970171 (DE-600)2074043-8 1559-0100 nnns volume:84 year:2024 number:1 day:04 month:01 pages:42-47 https://dx.doi.org/10.1007/s12020-023-03649-4 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 44.89 VZ AR 84 2024 1 04 01 42-47 |
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Endocrine |
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Panzuto, Francesco @@aut@@ Partelli, Stefano @@aut@@ Campana, Davide @@aut@@ de Braud, Filippo @@aut@@ Spada, Francesca @@aut@@ Cives, Mauro @@aut@@ Tafuto, Salvatore @@aut@@ Bertuzzi, Alexia @@aut@@ Gelsomino, Fabio @@aut@@ Bergamo, Francesca @@aut@@ Marcucci, Stefano @@aut@@ Mastrangelo, Laura @@aut@@ Massironi, Sara @@aut@@ Appetecchia, Marialuisa @@aut@@ Filice, Angelina @@aut@@ Badalamenti, Giuseppe @@aut@@ Bartolomei, Mirco @@aut@@ Amoroso, Vito @@aut@@ Landoni, Luca @@aut@@ Rodriquenz, Maria Grazia @@aut@@ Valente, Monica @@aut@@ Colao, Annamaria @@aut@@ Isidori, Andrea @@aut@@ Fanciulli, Giuseppe @@aut@@ Bollina, Roberto @@aut@@ Ciola, Michele @@aut@@ Butturini, Giovanni @@aut@@ Marconcini, Riccardo @@aut@@ Arvat, Emanuela @@aut@@ Cinieri, Saverio @@aut@@ Berardi, Rossana @@aut@@ Baldari, Sergio @@aut@@ Riccardi, Ferdinando @@aut@@ Spoto, Chiara @@aut@@ Giuffrida, Dario @@aut@@ Gattuso, Domenico @@aut@@ Ferone, Diego @@aut@@ Rinzivillo, Maria @@aut@@ Bertani, Emilio @@aut@@ Versari, Annibale @@aut@@ Zerbi, Alessandro @@aut@@ Lamberti, Giuseppe @@aut@@ Lauricella, Eleonora @@aut@@ Pusceddu, Sara @@aut@@ Fazio, Nicola @@aut@@ Dell’Unto, Elisabetta @@aut@@ Marini, Marco @@aut@@ Falconi, Massimo @@aut@@ |
publishDateDaySort_date |
2024-01-04T00:00:00Z |
hierarchy_top_id |
343970171 |
dewey-sort |
3610 |
id |
SPR055386598 |
language_de |
englisch |
fullrecord |
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Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. 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610 VZ 44.89 bkl Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database Neuroendocrine tumors (dpeaa)DE-He213 epidemiology (dpeaa)DE-He213 registry (dpeaa)DE-He213 management (dpeaa)DE-He213 database. (dpeaa)DE-He213 |
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Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database |
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Panzuto, Francesco Partelli, Stefano Campana, Davide de Braud, Filippo Spada, Francesca Cives, Mauro Tafuto, Salvatore Bertuzzi, Alexia Gelsomino, Fabio Bergamo, Francesca Marcucci, Stefano Mastrangelo, Laura Massironi, Sara Appetecchia, Marialuisa Filice, Angelina Badalamenti, Giuseppe Bartolomei, Mirco Amoroso, Vito Landoni, Luca Rodriquenz, Maria Grazia Valente, Monica Colao, Annamaria Isidori, Andrea Fanciulli, Giuseppe Bollina, Roberto Ciola, Michele Butturini, Giovanni Marconcini, Riccardo Arvat, Emanuela Cinieri, Saverio Berardi, Rossana Baldari, Sergio Riccardi, Ferdinando Spoto, Chiara Giuffrida, Dario Gattuso, Domenico Ferone, Diego Rinzivillo, Maria Bertani, Emilio Versari, Annibale Zerbi, Alessandro Lamberti, Giuseppe Lauricella, Eleonora Pusceddu, Sara Fazio, Nicola Dell’Unto, Elisabetta Marini, Marco Falconi, Massimo |
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epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the italian association for neuroendocrine tumors (itanet) national database |
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Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database |
abstract |
Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). © The Author(s) 2024 |
abstractGer |
Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). © The Author(s) 2024 |
abstract_unstemmed |
Abstract Neuroendocrine neoplasms (NENs) are rare tumors with diverse clinical behaviors. Large databases like the Surveillance, Epidemiology, and End Results (SEER) program and national NEN registries have provided significant epidemiological knowledge, but they have limitations given the recent advancements in NEN diagnostics and treatments. For instance, newer imaging techniques and therapies have revolutionized NEN management, rendering older data less representative. Additionally, crucial parameters, like the Ki67 index, are missing from many databases. Acknowledging these gaps, the Italian Association for Neuroendocrine Tumors (Itanet) initiated a national multicenter prospective database in 2019, aiming to gather data on newly-diagnosed gastroenteropancreatic neuroendocrine (GEP) NENs. This observational study, coordinated by Itanet, includes patients from 37 Italian centers. The database, which is rigorously maintained and updated, focuses on diverse parameters including age, diagnostic techniques, tumor stage, treatments, and survival metrics. As of October 2023, data from 1,600 patients have been recorded, with an anticipation of reaching 3600 by the end of 2025. This study aims at understanding the epidemiology, clinical attributes, and treatment strategies for GEP-NENs in Italy, and to introduce the Itanet database project. Once comprehensive follow-up data will be acquired, the goal will be to discern predictors of treatment outcomes and disease prognosis. The Itanet database will offer an unparalleled, updated perspective on GEP-NENs, addressing the limitations of older databases and aiding in optimizing patient care. Study registration This protocol was registered in clinicaltriasl.gov (NCT04282083). © The Author(s) 2024 |
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Epidemiology of gastroenteropancreatic neuroendocrine neoplasms: a review and protocol presentation for bridging tumor registry data with the Italian association for neuroendocrine tumors (Itanet) national database |
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