Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model

Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, a...
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Autor*in:	Fei, Xiaowei [verfasserIn] Wang, Li [verfasserIn] Dou, Ya-nan [verfasserIn] Fei, Fei [verfasserIn] Zhang, Yanyu [verfasserIn] Lv, Weihao [verfasserIn] He, Xin [verfasserIn] Wu, Xiuquan [verfasserIn] Chao, Wangshu [verfasserIn] Chen, Hongqing [verfasserIn] Wei, Jialiang [verfasserIn] Gao, Dakuan [verfasserIn] Fei, Zhou [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Intracerebral hemorrhage Homer1a Extracellular vehicles A2 astrocyte Inflammation NF-κB

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: Journal of neuroinflammation - BioMed Central, 2004, 21(2024), 1 vom: 06. Apr.
Übergeordnetes Werk:	volume:21 ; year:2024 ; number:1 ; day:06 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s12974-024-03088-6

Katalog-ID:	SPR055445454

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520			\|a Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH.
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allfields	10.1186/s12974-024-03088-6 doi (DE-627)SPR055445454 (SPR)s12974-024-03088-6-e DE-627 ger DE-627 rakwb eng 610 VZ Fei, Xiaowei verfasserin aut Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 Wang, Li verfasserin aut Dou, Ya-nan verfasserin aut Fei, Fei verfasserin aut Zhang, Yanyu verfasserin aut Lv, Weihao verfasserin aut He, Xin verfasserin aut Wu, Xiuquan verfasserin aut Chao, Wangshu verfasserin aut Chen, Hongqing verfasserin aut Wei, Jialiang verfasserin aut Gao, Dakuan verfasserin aut Fei, Zhou verfasserin aut Enthalten in Journal of neuroinflammation BioMed Central, 2004 21(2024), 1 vom: 06. Apr. (DE-627)391784781 (DE-600)2156455-3 1742-2094 nnns volume:21 year:2024 number:1 day:06 month:04 https://dx.doi.org/10.1186/s12974-024-03088-6 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 06 04
spelling	10.1186/s12974-024-03088-6 doi (DE-627)SPR055445454 (SPR)s12974-024-03088-6-e DE-627 ger DE-627 rakwb eng 610 VZ Fei, Xiaowei verfasserin aut Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 Wang, Li verfasserin aut Dou, Ya-nan verfasserin aut Fei, Fei verfasserin aut Zhang, Yanyu verfasserin aut Lv, Weihao verfasserin aut He, Xin verfasserin aut Wu, Xiuquan verfasserin aut Chao, Wangshu verfasserin aut Chen, Hongqing verfasserin aut Wei, Jialiang verfasserin aut Gao, Dakuan verfasserin aut Fei, Zhou verfasserin aut Enthalten in Journal of neuroinflammation BioMed Central, 2004 21(2024), 1 vom: 06. Apr. (DE-627)391784781 (DE-600)2156455-3 1742-2094 nnns volume:21 year:2024 number:1 day:06 month:04 https://dx.doi.org/10.1186/s12974-024-03088-6 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 06 04
allfields_unstemmed	10.1186/s12974-024-03088-6 doi (DE-627)SPR055445454 (SPR)s12974-024-03088-6-e DE-627 ger DE-627 rakwb eng 610 VZ Fei, Xiaowei verfasserin aut Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 Wang, Li verfasserin aut Dou, Ya-nan verfasserin aut Fei, Fei verfasserin aut Zhang, Yanyu verfasserin aut Lv, Weihao verfasserin aut He, Xin verfasserin aut Wu, Xiuquan verfasserin aut Chao, Wangshu verfasserin aut Chen, Hongqing verfasserin aut Wei, Jialiang verfasserin aut Gao, Dakuan verfasserin aut Fei, Zhou verfasserin aut Enthalten in Journal of neuroinflammation BioMed Central, 2004 21(2024), 1 vom: 06. Apr. (DE-627)391784781 (DE-600)2156455-3 1742-2094 nnns volume:21 year:2024 number:1 day:06 month:04 https://dx.doi.org/10.1186/s12974-024-03088-6 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 06 04
allfieldsGer	10.1186/s12974-024-03088-6 doi (DE-627)SPR055445454 (SPR)s12974-024-03088-6-e DE-627 ger DE-627 rakwb eng 610 VZ Fei, Xiaowei verfasserin aut Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 Wang, Li verfasserin aut Dou, Ya-nan verfasserin aut Fei, Fei verfasserin aut Zhang, Yanyu verfasserin aut Lv, Weihao verfasserin aut He, Xin verfasserin aut Wu, Xiuquan verfasserin aut Chao, Wangshu verfasserin aut Chen, Hongqing verfasserin aut Wei, Jialiang verfasserin aut Gao, Dakuan verfasserin aut Fei, Zhou verfasserin aut Enthalten in Journal of neuroinflammation BioMed Central, 2004 21(2024), 1 vom: 06. Apr. (DE-627)391784781 (DE-600)2156455-3 1742-2094 nnns volume:21 year:2024 number:1 day:06 month:04 https://dx.doi.org/10.1186/s12974-024-03088-6 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 06 04
allfieldsSound	10.1186/s12974-024-03088-6 doi (DE-627)SPR055445454 (SPR)s12974-024-03088-6-e DE-627 ger DE-627 rakwb eng 610 VZ Fei, Xiaowei verfasserin aut Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213 Wang, Li verfasserin aut Dou, Ya-nan verfasserin aut Fei, Fei verfasserin aut Zhang, Yanyu verfasserin aut Lv, Weihao verfasserin aut He, Xin verfasserin aut Wu, Xiuquan verfasserin aut Chao, Wangshu verfasserin aut Chen, Hongqing verfasserin aut Wei, Jialiang verfasserin aut Gao, Dakuan verfasserin aut Fei, Zhou verfasserin aut Enthalten in Journal of neuroinflammation BioMed Central, 2004 21(2024), 1 vom: 06. Apr. (DE-627)391784781 (DE-600)2156455-3 1742-2094 nnns volume:21 year:2024 number:1 day:06 month:04 https://dx.doi.org/10.1186/s12974-024-03088-6 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 06 04
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author	Fei, Xiaowei
spellingShingle	Fei, Xiaowei ddc 610 misc Intracerebral hemorrhage misc Homer1a misc Extracellular vehicles misc A2 astrocyte misc Inflammation misc NF-κB Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
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topic_title	610 VZ Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model Intracerebral hemorrhage (dpeaa)DE-He213 Homer1a (dpeaa)DE-He213 Extracellular vehicles (dpeaa)DE-He213 A2 astrocyte (dpeaa)DE-He213 Inflammation (dpeaa)DE-He213 NF-κB (dpeaa)DE-He213
topic	ddc 610 misc Intracerebral hemorrhage misc Homer1a misc Extracellular vehicles misc A2 astrocyte misc Inflammation misc NF-κB
topic_unstemmed	ddc 610 misc Intracerebral hemorrhage misc Homer1a misc Extracellular vehicles misc A2 astrocyte misc Inflammation misc NF-κB
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title	Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
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title_full	Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
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author_browse	Fei, Xiaowei Wang, Li Dou, Ya-nan Fei, Fei Zhang, Yanyu Lv, Weihao He, Xin Wu, Xiuquan Chao, Wangshu Chen, Hongqing Wei, Jialiang Gao, Dakuan Fei, Zhou
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title_sort	extracellular vesicle encapsulated homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
title_auth	Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
abstract	Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. © The Author(s) 2024
abstractGer	Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. © The Author(s) 2024
abstract_unstemmed	Abstract Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. Our study provides a novel insight and potential for the clinical translation of $ Homer1a^{+} $ EVs in the treatment of ICH. © The Author(s) 2024
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title_short	Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model
url	https://dx.doi.org/10.1186/s12974-024-03088-6
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author2	Wang, Li Dou, Ya-nan Fei, Fei Zhang, Yanyu Lv, Weihao He, Xin Wu, Xiuquan Chao, Wangshu Chen, Hongqing Wei, Jialiang Gao, Dakuan Fei, Zhou
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up_date	2024-07-03T15:42:26.498Z
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However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare $ Homer1a^{+} $ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. $ Homer1a^{+} $ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. $ Homer1a^{+} $ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. $ Homer1a^{+} $ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and RAGE: DIAPH1. In addition, $ Homer1a^{+} $ EVs ameliorates the pathology, behavior, and survival rate in $ GFAP^{Cre} $$ Homer1^{fl/−} $$ Homer1a^{±} $ and $ Nestin^{Cre} $$ RAGE^{fl/fl} $ ICH mice. 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Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model

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