Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications
Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Wang, Jiachen [verfasserIn] Li, Shenglan [verfasserIn] Lan, Yanjie [verfasserIn] Liu, Xinrui [verfasserIn] Li, Wenbin [verfasserIn] |
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E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Schlagwörter: |
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© The Author(s) 2024 |
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| Übergeordnetes Werk: |
Enthalten in: Current medicine - Springer Nature Singapore, 2022, 3(2024), 1 vom: 07. Apr. |
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volume:3 ; year:2024 ; number:1 ; day:07 ; month:04 |
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10.1007/s44194-024-00031-y |
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10.1007/s44194-024-00031-y doi (DE-627)SPR055450202 (SPR)s44194-024-00031-y-e DE-627 ger DE-627 rakwb eng 610 VZ Wang, Jiachen verfasserin aut Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. Glioma (dpeaa)DE-He213 Glioma-Associated macrophages (dpeaa)DE-He213 Tumor-Associated macrophages (dpeaa)DE-He213 Tumor Microenvironment (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Li, Shenglan verfasserin aut Lan, Yanjie verfasserin aut Liu, Xinrui verfasserin aut Li, Wenbin verfasserin (orcid)0000-0002-8940-8402 aut Enthalten in Current medicine Springer Nature Singapore, 2022 3(2024), 1 vom: 07. Apr. (DE-627)1770076247 (DE-600)3092984-2 2731-0868 nnns volume:3 year:2024 number:1 day:07 month:04 https://dx.doi.org/10.1007/s44194-024-00031-y X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA AR 3 2024 1 07 04 |
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10.1007/s44194-024-00031-y doi (DE-627)SPR055450202 (SPR)s44194-024-00031-y-e DE-627 ger DE-627 rakwb eng 610 VZ Wang, Jiachen verfasserin aut Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. Glioma (dpeaa)DE-He213 Glioma-Associated macrophages (dpeaa)DE-He213 Tumor-Associated macrophages (dpeaa)DE-He213 Tumor Microenvironment (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Li, Shenglan verfasserin aut Lan, Yanjie verfasserin aut Liu, Xinrui verfasserin aut Li, Wenbin verfasserin (orcid)0000-0002-8940-8402 aut Enthalten in Current medicine Springer Nature Singapore, 2022 3(2024), 1 vom: 07. Apr. (DE-627)1770076247 (DE-600)3092984-2 2731-0868 nnns volume:3 year:2024 number:1 day:07 month:04 https://dx.doi.org/10.1007/s44194-024-00031-y X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA AR 3 2024 1 07 04 |
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10.1007/s44194-024-00031-y doi (DE-627)SPR055450202 (SPR)s44194-024-00031-y-e DE-627 ger DE-627 rakwb eng 610 VZ Wang, Jiachen verfasserin aut Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. Glioma (dpeaa)DE-He213 Glioma-Associated macrophages (dpeaa)DE-He213 Tumor-Associated macrophages (dpeaa)DE-He213 Tumor Microenvironment (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Li, Shenglan verfasserin aut Lan, Yanjie verfasserin aut Liu, Xinrui verfasserin aut Li, Wenbin verfasserin (orcid)0000-0002-8940-8402 aut Enthalten in Current medicine Springer Nature Singapore, 2022 3(2024), 1 vom: 07. Apr. (DE-627)1770076247 (DE-600)3092984-2 2731-0868 nnns volume:3 year:2024 number:1 day:07 month:04 https://dx.doi.org/10.1007/s44194-024-00031-y X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA AR 3 2024 1 07 04 |
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10.1007/s44194-024-00031-y doi (DE-627)SPR055450202 (SPR)s44194-024-00031-y-e DE-627 ger DE-627 rakwb eng 610 VZ Wang, Jiachen verfasserin aut Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. Glioma (dpeaa)DE-He213 Glioma-Associated macrophages (dpeaa)DE-He213 Tumor-Associated macrophages (dpeaa)DE-He213 Tumor Microenvironment (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Li, Shenglan verfasserin aut Lan, Yanjie verfasserin aut Liu, Xinrui verfasserin aut Li, Wenbin verfasserin (orcid)0000-0002-8940-8402 aut Enthalten in Current medicine Springer Nature Singapore, 2022 3(2024), 1 vom: 07. Apr. (DE-627)1770076247 (DE-600)3092984-2 2731-0868 nnns volume:3 year:2024 number:1 day:07 month:04 https://dx.doi.org/10.1007/s44194-024-00031-y X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA AR 3 2024 1 07 04 |
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10.1007/s44194-024-00031-y doi (DE-627)SPR055450202 (SPR)s44194-024-00031-y-e DE-627 ger DE-627 rakwb eng 610 VZ Wang, Jiachen verfasserin aut Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. Glioma (dpeaa)DE-He213 Glioma-Associated macrophages (dpeaa)DE-He213 Tumor-Associated macrophages (dpeaa)DE-He213 Tumor Microenvironment (dpeaa)DE-He213 Immunotherapy (dpeaa)DE-He213 Li, Shenglan verfasserin aut Lan, Yanjie verfasserin aut Liu, Xinrui verfasserin aut Li, Wenbin verfasserin (orcid)0000-0002-8940-8402 aut Enthalten in Current medicine Springer Nature Singapore, 2022 3(2024), 1 vom: 07. Apr. (DE-627)1770076247 (DE-600)3092984-2 2731-0868 nnns volume:3 year:2024 number:1 day:07 month:04 https://dx.doi.org/10.1007/s44194-024-00031-y X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA AR 3 2024 1 07 04 |
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Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. © The Author(s) 2024 |
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Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. © The Author(s) 2024 |
| abstract_unstemmed |
Abstract Glioblastoma (GBM) is a malignant brain glioma characterized by a high number of tumor-associated macrophages (TAMs) within its tissues. These TAMs have a close relationship with tumor grade and prognosis. Targeting TAMs has been identified as a promising therapeutic strategy. However, TAM cells play both tumor-killing and tumor-promoting roles, making them a double-edged sword in the immune environment. The different subtypes of macrophages and their effects on the tumor microenvironment remain poorly understood. This study comprehensively elucidates the immunobiology of glioma-associated macrophages (GAMs), including their origin, classification, molecular mechanisms underlying glioma promotion and inhibition, polarization strategies, targeted therapy for GAMs and the current challenges and perspectives in immune modulation. Further research on macrophage function and mechanism may provide a new immunological basis for treating GBM patients and enhancing the efficacy of glioma immunotherapy. © The Author(s) 2024 |
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Glioma-associated macrophages: unraveling their dual role in the microenvironment and therapeutic implications |
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Li, Shenglan Lan, Yanjie Liu, Xinrui Li, Wenbin |
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