Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07)
Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurologica...
Ausführliche Beschreibung
Autor*in: |
Deng, Maximilian Y. [verfasserIn] da Silva, Amanda Salviano [verfasserIn] Göller, Pauline Carlotta [verfasserIn] König, Laila [verfasserIn] Schäfer, Henning [verfasserIn] Maire, Cecile [verfasserIn] Lentz-Hommertgen, Adriane [verfasserIn] Held, Thomas [verfasserIn] Regnery, Sebastian [verfasserIn] Eichkorn, Tanja [verfasserIn] Stritzke, Florian [verfasserIn] Bauer, Lukas [verfasserIn] Schnell, Daniel [verfasserIn] Herfarth, Klaus [verfasserIn] von Deimling, Andreas [verfasserIn] Krieg, Sandro [verfasserIn] Wick, Antje [verfasserIn] Wick, Wolfgang [verfasserIn] Grosu, Anca [verfasserIn] Debus, Jürgen [verfasserIn] Sahm, Felix [verfasserIn] Ricklefs, Franz [verfasserIn] |
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E-Artikel |
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Sprache: |
Englisch |
Erschienen: |
2024 |
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Anmerkung: |
© The Author(s) 2024 |
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Übergeordnetes Werk: |
Enthalten in: BMC cancer - BioMed Central, 2001, 24(2024), 1 vom: 11. Apr. |
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Übergeordnetes Werk: |
volume:24 ; year:2024 ; number:1 ; day:11 ; month:04 |
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DOI / URN: |
10.1186/s12885-024-12170-4 |
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Katalog-ID: |
SPR055491243 |
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520 | |a Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. | ||
650 | 4 | |a Radiotherapy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Liquid biopsy |7 (dpeaa)DE-He213 | |
650 | 4 | |a Extracellular vesicles |7 (dpeaa)DE-He213 | |
650 | 4 | |a Meningioma. |7 (dpeaa)DE-He213 | |
700 | 1 | |a da Silva, Amanda Salviano |e verfasserin |4 aut | |
700 | 1 | |a Göller, Pauline Carlotta |e verfasserin |4 aut | |
700 | 1 | |a König, Laila |e verfasserin |4 aut | |
700 | 1 | |a Schäfer, Henning |e verfasserin |4 aut | |
700 | 1 | |a Maire, Cecile |e verfasserin |4 aut | |
700 | 1 | |a Lentz-Hommertgen, Adriane |e verfasserin |4 aut | |
700 | 1 | |a Held, Thomas |e verfasserin |4 aut | |
700 | 1 | |a Regnery, Sebastian |e verfasserin |4 aut | |
700 | 1 | |a Eichkorn, Tanja |e verfasserin |4 aut | |
700 | 1 | |a Stritzke, Florian |e verfasserin |4 aut | |
700 | 1 | |a Bauer, Lukas |e verfasserin |4 aut | |
700 | 1 | |a Schnell, Daniel |e verfasserin |4 aut | |
700 | 1 | |a Herfarth, Klaus |e verfasserin |4 aut | |
700 | 1 | |a von Deimling, Andreas |e verfasserin |4 aut | |
700 | 1 | |a Krieg, Sandro |e verfasserin |4 aut | |
700 | 1 | |a Wick, Antje |e verfasserin |4 aut | |
700 | 1 | |a Wick, Wolfgang |e verfasserin |4 aut | |
700 | 1 | |a Grosu, Anca |e verfasserin |4 aut | |
700 | 1 | |a Debus, Jürgen |e verfasserin |4 aut | |
700 | 1 | |a Sahm, Felix |e verfasserin |4 aut | |
700 | 1 | |a Ricklefs, Franz |e verfasserin |4 aut | |
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10.1186/s12885-024-12170-4 doi (DE-627)SPR055491243 (SPR)s12885-024-12170-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Deng, Maximilian Y. verfasserin aut Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 da Silva, Amanda Salviano verfasserin aut Göller, Pauline Carlotta verfasserin aut König, Laila verfasserin aut Schäfer, Henning verfasserin aut Maire, Cecile verfasserin aut Lentz-Hommertgen, Adriane verfasserin aut Held, Thomas verfasserin aut Regnery, Sebastian verfasserin aut Eichkorn, Tanja verfasserin aut Stritzke, Florian verfasserin aut Bauer, Lukas verfasserin aut Schnell, Daniel verfasserin aut Herfarth, Klaus verfasserin aut von Deimling, Andreas verfasserin aut Krieg, Sandro verfasserin aut Wick, Antje verfasserin aut Wick, Wolfgang verfasserin aut Grosu, Anca verfasserin aut Debus, Jürgen verfasserin aut Sahm, Felix verfasserin aut Ricklefs, Franz verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 11. Apr. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:11 month:04 https://dx.doi.org/10.1186/s12885-024-12170-4 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 11 04 |
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10.1186/s12885-024-12170-4 doi (DE-627)SPR055491243 (SPR)s12885-024-12170-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Deng, Maximilian Y. verfasserin aut Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 da Silva, Amanda Salviano verfasserin aut Göller, Pauline Carlotta verfasserin aut König, Laila verfasserin aut Schäfer, Henning verfasserin aut Maire, Cecile verfasserin aut Lentz-Hommertgen, Adriane verfasserin aut Held, Thomas verfasserin aut Regnery, Sebastian verfasserin aut Eichkorn, Tanja verfasserin aut Stritzke, Florian verfasserin aut Bauer, Lukas verfasserin aut Schnell, Daniel verfasserin aut Herfarth, Klaus verfasserin aut von Deimling, Andreas verfasserin aut Krieg, Sandro verfasserin aut Wick, Antje verfasserin aut Wick, Wolfgang verfasserin aut Grosu, Anca verfasserin aut Debus, Jürgen verfasserin aut Sahm, Felix verfasserin aut Ricklefs, Franz verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 11. Apr. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:11 month:04 https://dx.doi.org/10.1186/s12885-024-12170-4 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 11 04 |
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10.1186/s12885-024-12170-4 doi (DE-627)SPR055491243 (SPR)s12885-024-12170-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Deng, Maximilian Y. verfasserin aut Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 da Silva, Amanda Salviano verfasserin aut Göller, Pauline Carlotta verfasserin aut König, Laila verfasserin aut Schäfer, Henning verfasserin aut Maire, Cecile verfasserin aut Lentz-Hommertgen, Adriane verfasserin aut Held, Thomas verfasserin aut Regnery, Sebastian verfasserin aut Eichkorn, Tanja verfasserin aut Stritzke, Florian verfasserin aut Bauer, Lukas verfasserin aut Schnell, Daniel verfasserin aut Herfarth, Klaus verfasserin aut von Deimling, Andreas verfasserin aut Krieg, Sandro verfasserin aut Wick, Antje verfasserin aut Wick, Wolfgang verfasserin aut Grosu, Anca verfasserin aut Debus, Jürgen verfasserin aut Sahm, Felix verfasserin aut Ricklefs, Franz verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 11. Apr. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:11 month:04 https://dx.doi.org/10.1186/s12885-024-12170-4 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 11 04 |
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10.1186/s12885-024-12170-4 doi (DE-627)SPR055491243 (SPR)s12885-024-12170-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Deng, Maximilian Y. verfasserin aut Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 da Silva, Amanda Salviano verfasserin aut Göller, Pauline Carlotta verfasserin aut König, Laila verfasserin aut Schäfer, Henning verfasserin aut Maire, Cecile verfasserin aut Lentz-Hommertgen, Adriane verfasserin aut Held, Thomas verfasserin aut Regnery, Sebastian verfasserin aut Eichkorn, Tanja verfasserin aut Stritzke, Florian verfasserin aut Bauer, Lukas verfasserin aut Schnell, Daniel verfasserin aut Herfarth, Klaus verfasserin aut von Deimling, Andreas verfasserin aut Krieg, Sandro verfasserin aut Wick, Antje verfasserin aut Wick, Wolfgang verfasserin aut Grosu, Anca verfasserin aut Debus, Jürgen verfasserin aut Sahm, Felix verfasserin aut Ricklefs, Franz verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 11. Apr. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:11 month:04 https://dx.doi.org/10.1186/s12885-024-12170-4 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 11 04 |
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10.1186/s12885-024-12170-4 doi (DE-627)SPR055491243 (SPR)s12885-024-12170-4-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Deng, Maximilian Y. verfasserin aut Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 da Silva, Amanda Salviano verfasserin aut Göller, Pauline Carlotta verfasserin aut König, Laila verfasserin aut Schäfer, Henning verfasserin aut Maire, Cecile verfasserin aut Lentz-Hommertgen, Adriane verfasserin aut Held, Thomas verfasserin aut Regnery, Sebastian verfasserin aut Eichkorn, Tanja verfasserin aut Stritzke, Florian verfasserin aut Bauer, Lukas verfasserin aut Schnell, Daniel verfasserin aut Herfarth, Klaus verfasserin aut von Deimling, Andreas verfasserin aut Krieg, Sandro verfasserin aut Wick, Antje verfasserin aut Wick, Wolfgang verfasserin aut Grosu, Anca verfasserin aut Debus, Jürgen verfasserin aut Sahm, Felix verfasserin aut Ricklefs, Franz verfasserin aut Enthalten in BMC cancer BioMed Central, 2001 24(2024), 1 vom: 11. Apr. (DE-627)326643710 (DE-600)2041352-X 1471-2407 nnns volume:24 year:2024 number:1 day:11 month:04 https://dx.doi.org/10.1186/s12885-024-12170-4 X:VERLAG 0 kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2031 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2061 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2190 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 11 04 |
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Enthalten in BMC cancer 24(2024), 1 vom: 11. Apr. volume:24 year:2024 number:1 day:11 month:04 |
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Enthalten in BMC cancer 24(2024), 1 vom: 11. Apr. volume:24 year:2024 number:1 day:11 month:04 |
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Radiotherapy Liquid biopsy Extracellular vesicles Meningioma. |
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Deng, Maximilian Y. @@aut@@ da Silva, Amanda Salviano @@aut@@ Göller, Pauline Carlotta @@aut@@ König, Laila @@aut@@ Schäfer, Henning @@aut@@ Maire, Cecile @@aut@@ Lentz-Hommertgen, Adriane @@aut@@ Held, Thomas @@aut@@ Regnery, Sebastian @@aut@@ Eichkorn, Tanja @@aut@@ Stritzke, Florian @@aut@@ Bauer, Lukas @@aut@@ Schnell, Daniel @@aut@@ Herfarth, Klaus @@aut@@ von Deimling, Andreas @@aut@@ Krieg, Sandro @@aut@@ Wick, Antje @@aut@@ Wick, Wolfgang @@aut@@ Grosu, Anca @@aut@@ Debus, Jürgen @@aut@@ Sahm, Felix @@aut@@ Ricklefs, Franz @@aut@@ |
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Deng, Maximilian Y. ddc 610 bkl 44.00 misc Radiotherapy misc Liquid biopsy misc Extracellular vesicles misc Meningioma. Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) |
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610 VZ 44.00 bkl Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) Radiotherapy (dpeaa)DE-He213 Liquid biopsy (dpeaa)DE-He213 Extracellular vesicles (dpeaa)DE-He213 Meningioma. (dpeaa)DE-He213 |
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Deng, Maximilian Y. da Silva, Amanda Salviano Göller, Pauline Carlotta König, Laila Schäfer, Henning Maire, Cecile Lentz-Hommertgen, Adriane Held, Thomas Regnery, Sebastian Eichkorn, Tanja Stritzke, Florian Bauer, Lukas Schnell, Daniel Herfarth, Klaus von Deimling, Andreas Krieg, Sandro Wick, Antje Wick, Wolfgang Grosu, Anca Debus, Jürgen Sahm, Felix Ricklefs, Franz |
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plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (aro 2023-05/ag-nro-07) |
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Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) |
abstract |
Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. © The Author(s) 2024 |
abstractGer |
Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. © The Author(s) 2024 |
abstract_unstemmed |
Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. DNA methylation profiling of plasma EVs in meningioma patients may enable molecular risk stratification, facilitating a molecularly-guided target volume delineation and adjusted dose prescription during RT treatment planning. © The Author(s) 2024 |
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Plasma extracellular vesicles in meningioma patients following radiotherapy as liquid biopsy- a prospective explorative biomarker study (ARO 2023-05/AG-NRO-07) |
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da Silva, Amanda Salviano Göller, Pauline Carlotta König, Laila Schäfer, Henning Maire, Cecile Lentz-Hommertgen, Adriane Held, Thomas Regnery, Sebastian Eichkorn, Tanja Stritzke, Florian Bauer, Lukas Schnell, Daniel Herfarth, Klaus von Deimling, Andreas Krieg, Sandro Wick, Antje Wick, Wolfgang Grosu, Anca Debus, Jürgen Sahm, Felix Ricklefs, Franz |
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Biopsies are often omitted in light of potential postoperative neurological deficits, resulting in a lack of histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles in the bloodstream will be investigated in patients with macroscopic meningiomas to identify a biomarker for molecular risk stratification and disease monitoring. Methods In total, 60 patients with meningiomas and an indication of radiotherapy (RT) and macroscopic tumor on the planning MRI will be enrolled. Blood samples will be obtained before the start, during, and after radiotherapy, as well as during clinical follow-up every 6 months. Extracellular vesicles will be isolated from the blood samples, quantified and correlated with the clinical treatment response or progression. Further, nanopore sequencing-based DNA methylation profiles of plasma EV-DNA will be generated for methylation-based meningioma classification. Discussion This study will explore the dynamic of plasma EVs in meningioma patients under/after radiotherapy, with the objective of identifying potential biomarkers of (early) tumor progression. 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