Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff

Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Eme...
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Autor*in:	Sampson, FC [verfasserIn] Hughes, J [verfasserIn] Long, J [verfasserIn] Buykx, P [verfasserIn] Goodacre, SW [verfasserIn] Snooks, H [verfasserIn] Edwards, A [verfasserIn] Evans, Bridie [verfasserIn] Jones, Jenna [verfasserIn] Moore, Chris [verfasserIn] Johnston, Sasha [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	2024

Schlagwörter:	Take home naloxone Drug overdose prevention Qualitative research Emergency services Feasibility study Patient perspectives

Anmerkung:	© The Author(s) 2024

Übergeordnetes Werk:	Enthalten in: BMC emergency medicine - BioMed Central, 2001, 24(2024), 1 vom: 29. Apr.
Übergeordnetes Werk:	volume:24 ; year:2024 ; number:1 ; day:29 ; month:04

Links:	Volltext

DOI / URN:	10.1186/s12873-024-00987-y

Katalog-ID:	SPR055671527

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245	1	0	\|a Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
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520			\|a Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits.
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allfields	10.1186/s12873-024-00987-y doi (DE-627)SPR055671527 (SPR)s12873-024-00987-y-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Sampson, FC verfasserin aut Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213 Hughes, J verfasserin aut Long, J verfasserin aut Buykx, P verfasserin aut Goodacre, SW verfasserin aut Snooks, H verfasserin aut Edwards, A verfasserin aut Evans, Bridie verfasserin aut Jones, Jenna verfasserin aut Moore, Chris verfasserin aut Johnston, Sasha verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Apr. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:04 https://dx.doi.org/10.1186/s12873-024-00987-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 04
spelling	10.1186/s12873-024-00987-y doi (DE-627)SPR055671527 (SPR)s12873-024-00987-y-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Sampson, FC verfasserin aut Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213 Hughes, J verfasserin aut Long, J verfasserin aut Buykx, P verfasserin aut Goodacre, SW verfasserin aut Snooks, H verfasserin aut Edwards, A verfasserin aut Evans, Bridie verfasserin aut Jones, Jenna verfasserin aut Moore, Chris verfasserin aut Johnston, Sasha verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Apr. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:04 https://dx.doi.org/10.1186/s12873-024-00987-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 04
allfields_unstemmed	10.1186/s12873-024-00987-y doi (DE-627)SPR055671527 (SPR)s12873-024-00987-y-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Sampson, FC verfasserin aut Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213 Hughes, J verfasserin aut Long, J verfasserin aut Buykx, P verfasserin aut Goodacre, SW verfasserin aut Snooks, H verfasserin aut Edwards, A verfasserin aut Evans, Bridie verfasserin aut Jones, Jenna verfasserin aut Moore, Chris verfasserin aut Johnston, Sasha verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Apr. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:04 https://dx.doi.org/10.1186/s12873-024-00987-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 04
allfieldsGer	10.1186/s12873-024-00987-y doi (DE-627)SPR055671527 (SPR)s12873-024-00987-y-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Sampson, FC verfasserin aut Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213 Hughes, J verfasserin aut Long, J verfasserin aut Buykx, P verfasserin aut Goodacre, SW verfasserin aut Snooks, H verfasserin aut Edwards, A verfasserin aut Evans, Bridie verfasserin aut Jones, Jenna verfasserin aut Moore, Chris verfasserin aut Johnston, Sasha verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Apr. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:04 https://dx.doi.org/10.1186/s12873-024-00987-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 04
allfieldsSound	10.1186/s12873-024-00987-y doi (DE-627)SPR055671527 (SPR)s12873-024-00987-y-e DE-627 ger DE-627 rakwb eng 610 VZ 44.00 bkl Sampson, FC verfasserin aut Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213 Hughes, J verfasserin aut Long, J verfasserin aut Buykx, P verfasserin aut Goodacre, SW verfasserin aut Snooks, H verfasserin aut Edwards, A verfasserin aut Evans, Bridie verfasserin aut Jones, Jenna verfasserin aut Moore, Chris verfasserin aut Johnston, Sasha verfasserin aut Enthalten in BMC emergency medicine BioMed Central, 2001 24(2024), 1 vom: 29. Apr. (DE-627)33101873X (DE-600)2050431-7 1471-227X nnns volume:24 year:2024 number:1 day:29 month:04 https://dx.doi.org/10.1186/s12873-024-00987-y X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 44.00 VZ AR 24 2024 1 29 04
language	English
source	Enthalten in BMC emergency medicine 24(2024), 1 vom: 29. Apr. volume:24 year:2024 number:1 day:29 month:04
sourceStr	Enthalten in BMC emergency medicine 24(2024), 1 vom: 29. Apr. volume:24 year:2024 number:1 day:29 month:04
format_phy_str_mv	Article
institution	findex.gbv.de
topic_facet	Take home naloxone Drug overdose prevention Qualitative research Emergency services Feasibility study Patient perspectives
dewey-raw	610
isfreeaccess_bool	true
container_title	BMC emergency medicine
authorswithroles_txt_mv	Sampson, FC @@aut@@ Hughes, J @@aut@@ Long, J @@aut@@ Buykx, P @@aut@@ Goodacre, SW @@aut@@ Snooks, H @@aut@@ Edwards, A @@aut@@ Evans, Bridie @@aut@@ Jones, Jenna @@aut@@ Moore, Chris @@aut@@ Johnston, Sasha @@aut@@
publishDateDaySort_date	2024-04-29T00:00:00Z
hierarchy_top_id	33101873X
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language_de	englisch
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All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. 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author	Sampson, FC
spellingShingle	Sampson, FC ddc 610 bkl 44.00 misc Take home naloxone misc Drug overdose prevention misc Qualitative research misc Emergency services misc Feasibility study misc Patient perspectives Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
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topic_title	610 VZ 44.00 bkl Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff Take home naloxone (dpeaa)DE-He213 Drug overdose prevention (dpeaa)DE-He213 Qualitative research (dpeaa)DE-He213 Emergency services (dpeaa)DE-He213 Feasibility study (dpeaa)DE-He213 Patient perspectives (dpeaa)DE-He213
topic	ddc 610 bkl 44.00 misc Take home naloxone misc Drug overdose prevention misc Qualitative research misc Emergency services misc Feasibility study misc Patient perspectives
topic_unstemmed	ddc 610 bkl 44.00 misc Take home naloxone misc Drug overdose prevention misc Qualitative research misc Emergency services misc Feasibility study misc Patient perspectives
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title	Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
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title_full	Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
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title_sort	is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? findings from a uk qualitative study exploring perspectives of people who use opioids and emergency services staff
title_auth	Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
abstract	Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. © The Author(s) 2024
abstractGer	Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. © The Author(s) 2024
abstract_unstemmed	Objective Distribution of take-home naloxone (THN) by emergency services may increase access to THN and reduce deaths and morbidity from opioid overdose. As part of a feasibility study for a randomised controlled trial (RCT) of distribution of THN kits and education within ambulance services and Emergency Departments (EDs), we used qualitative methods to explore key stakeholders’ perceptions of feasibility and acceptability of delivering the trial. Methods We undertook semi-structured interviews and focus groups with 26 people who use opioids and with 20 paramedics and ED staff from two intervention sites between 2019 and 2021. Interviews and focus groups were recorded, transcribed verbatim and analysed using Framework Analysis. Results People using opioids reported high awareness of overdose management, including personal experience of THN use. Staff perceived emergency service provision of THN as a low-cost, low-risk intervention with potential to reduce mortality, morbidity and health service use. Staff understood the trial aims and considered it compatible with their work. All participants supported widening access to THN but reported limited trial recruitment opportunities partly due to difficulties in consenting patients during overdose. Procedural problems, restrictive recruitment protocols, limited staff buy-in and patients already owning THN limited trial recruitment. Determining trial effectiveness was challenging due to high levels of alternative community provision of THN. Conclusions Distribution of THN in emergency settings was considered feasible and acceptable for stakeholders but an RCT to establish the effectiveness of THN delivery is unlikely to generate further useful evidence due to difficulties in recruiting patients and assessing benefits. © The Author(s) 2024
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title_short	Is a randomised controlled trial of take home naloxone distributed in emergency settings likely to be feasible and acceptable? Findings from a UK qualitative study exploring perspectives of people who use opioids and emergency services staff
url	https://dx.doi.org/10.1186/s12873-024-00987-y
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author2	Hughes, J Long, J Buykx, P Goodacre, SW Snooks, H Edwards, A Evans, Bridie Jones, Jenna Moore, Chris Johnston, Sasha
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