Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes
Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible asso...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Nasser, Mai A. [verfasserIn] Refky, Basel [verfasserIn] Abdeen, Hanaa M. [verfasserIn] Neamatallah, Mustafa [verfasserIn] Nada, Hoda Ahmed [verfasserIn] Abd Elghaffar, Mahmoud Adel [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
2024 |
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| Anmerkung: |
© The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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| Übergeordnetes Werk: |
Enthalten in: Indian Journal of Gynecologic Oncology - Springer India, 2015, 22(2024), 2 vom: 01. Mai |
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| Übergeordnetes Werk: |
volume:22 ; year:2024 ; number:2 ; day:01 ; month:05 |
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| DOI / URN: |
10.1007/s40944-024-00853-6 |
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SPR055708560 |
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| 520 | |a Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. | ||
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| 700 | 1 | |a Nada, Hoda Ahmed |e verfasserin |4 aut | |
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10.1007/s40944-024-00853-6 doi (DE-627)SPR055708560 (SPR)s40944-024-00853-6-e DE-627 ger DE-627 rakwb eng Nasser, Mai A. verfasserin (orcid)0000-0002-8265-1354 aut Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Refky, Basel verfasserin aut Abdeen, Hanaa M. verfasserin aut Neamatallah, Mustafa verfasserin aut Nada, Hoda Ahmed verfasserin aut Abd Elghaffar, Mahmoud Adel verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology Springer India, 2015 22(2024), 2 vom: 01. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:22 year:2024 number:2 day:01 month:05 https://dx.doi.org/10.1007/s40944-024-00853-6 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 22 2024 2 01 05 |
| spelling |
10.1007/s40944-024-00853-6 doi (DE-627)SPR055708560 (SPR)s40944-024-00853-6-e DE-627 ger DE-627 rakwb eng Nasser, Mai A. verfasserin (orcid)0000-0002-8265-1354 aut Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Refky, Basel verfasserin aut Abdeen, Hanaa M. verfasserin aut Neamatallah, Mustafa verfasserin aut Nada, Hoda Ahmed verfasserin aut Abd Elghaffar, Mahmoud Adel verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology Springer India, 2015 22(2024), 2 vom: 01. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:22 year:2024 number:2 day:01 month:05 https://dx.doi.org/10.1007/s40944-024-00853-6 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 22 2024 2 01 05 |
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10.1007/s40944-024-00853-6 doi (DE-627)SPR055708560 (SPR)s40944-024-00853-6-e DE-627 ger DE-627 rakwb eng Nasser, Mai A. verfasserin (orcid)0000-0002-8265-1354 aut Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Refky, Basel verfasserin aut Abdeen, Hanaa M. verfasserin aut Neamatallah, Mustafa verfasserin aut Nada, Hoda Ahmed verfasserin aut Abd Elghaffar, Mahmoud Adel verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology Springer India, 2015 22(2024), 2 vom: 01. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:22 year:2024 number:2 day:01 month:05 https://dx.doi.org/10.1007/s40944-024-00853-6 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 22 2024 2 01 05 |
| allfieldsGer |
10.1007/s40944-024-00853-6 doi (DE-627)SPR055708560 (SPR)s40944-024-00853-6-e DE-627 ger DE-627 rakwb eng Nasser, Mai A. verfasserin (orcid)0000-0002-8265-1354 aut Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Refky, Basel verfasserin aut Abdeen, Hanaa M. verfasserin aut Neamatallah, Mustafa verfasserin aut Nada, Hoda Ahmed verfasserin aut Abd Elghaffar, Mahmoud Adel verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology Springer India, 2015 22(2024), 2 vom: 01. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:22 year:2024 number:2 day:01 month:05 https://dx.doi.org/10.1007/s40944-024-00853-6 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 22 2024 2 01 05 |
| allfieldsSound |
10.1007/s40944-024-00853-6 doi (DE-627)SPR055708560 (SPR)s40944-024-00853-6-e DE-627 ger DE-627 rakwb eng Nasser, Mai A. verfasserin (orcid)0000-0002-8265-1354 aut Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 Refky, Basel verfasserin aut Abdeen, Hanaa M. verfasserin aut Neamatallah, Mustafa verfasserin aut Nada, Hoda Ahmed verfasserin aut Abd Elghaffar, Mahmoud Adel verfasserin aut Enthalten in Indian Journal of Gynecologic Oncology Springer India, 2015 22(2024), 2 vom: 01. Mai (DE-627)827030576 (DE-600)2823586-1 2363-8400 nnns volume:22 year:2024 number:2 day:01 month:05 https://dx.doi.org/10.1007/s40944-024-00853-6 X:SPRINGER Resolving-System lizenzpflichtig Volltext SYSFLAG_0 GBV_SPRINGER GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_152 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_250 GBV_ILN_281 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 22 2024 2 01 05 |
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Enthalten in Indian Journal of Gynecologic Oncology 22(2024), 2 vom: 01. Mai volume:22 year:2024 number:2 day:01 month:05 |
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Enthalten in Indian Journal of Gynecologic Oncology 22(2024), 2 vom: 01. Mai volume:22 year:2024 number:2 day:01 month:05 |
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Nasser, Mai A. @@aut@@ Refky, Basel @@aut@@ Abdeen, Hanaa M. @@aut@@ Neamatallah, Mustafa @@aut@@ Nada, Hoda Ahmed @@aut@@ Abd Elghaffar, Mahmoud Adel @@aut@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">SPR055708560</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240608064722.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240502s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1007/s40944-024-00853-6</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR055708560</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s40944-024-00853-6-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Nasser, Mai A.</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(orcid)0000-0002-8265-1354</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. 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Nasser, Mai A. |
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Nasser, Mai A. misc Nuclear division cycle 80 misc mRNA expression misc Ovarian cancer misc NUF2 misc Biomarker Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes |
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Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes Nuclear division cycle 80 (dpeaa)DE-He213 mRNA expression (dpeaa)DE-He213 Ovarian cancer (dpeaa)DE-He213 NUF2 (dpeaa)DE-He213 Biomarker (dpeaa)DE-He213 |
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misc Nuclear division cycle 80 misc mRNA expression misc Ovarian cancer misc NUF2 misc Biomarker |
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Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes |
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Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes |
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Nasser, Mai A. |
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Indian Journal of Gynecologic Oncology |
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Nasser, Mai A. Refky, Basel Abdeen, Hanaa M. Neamatallah, Mustafa Nada, Hoda Ahmed Abd Elghaffar, Mahmoud Adel |
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Nasser, Mai A. |
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expression of nuclear division cycle 80 complex genes in ovarian cancer and correlation with the clinicopathological features and survival outcomes |
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Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes |
| abstract |
Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstractGer |
Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
| abstract_unstemmed |
Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. Correlations of the genes’ expression with the patients’ clinicopathological data were reviewed. Effect of the genes’ expression on survival outcomes was assessed using Kaplan–Meier plotter. Logistic regression analysis was used to identify predictors of higher tumor stages among OC patients. Results All four genes were significantly overexpressed in OC tissues compared to adjacent non-cancerous ovarian tissues. NDC80, SPC24, and SPC25 demonstrated significant diagnostic values. Combinations of NDC80 + SPC24, NUF2 + SPC24, and SPC24 + SPC25 showed a diagnostic advantage over single-gene analysis. NDC80 and NUF2 were associated with late tumor stages. NUF2 was associated with bilateral ovarian masses. SPC24 was related to negative PR status. The mRNA expression of NDC80, NUF2, and SPC25 was positively correlated. NUF2 overexpression and mutated p53 were significant predictors of higher tumor stages. NDC80, NUF2, and SPC25 predicted poor overall survival. NDC80 and NUF2 predicted poor progression-free survival. Conclusion Overexpression of NDC80 complex genes is involved in OC pathogenesis. The genes may serve as potential biomarkers for OC diagnosis and prognosis. © The Author(s) under exclusive licence to Association of Gynecologic Oncologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. |
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Expression of Nuclear Division Cycle 80 Complex Genes in Ovarian Cancer and Correlation with the Clinicopathological Features and Survival Outcomes |
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Refky, Basel Abdeen, Hanaa M. Neamatallah, Mustafa Nada, Hoda Ahmed Abd Elghaffar, Mahmoud Adel |
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Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Purpose Aberrant expression of the nuclear division cycle 80 (NDC80) complex has been implicated in various cancers but remains understudied in ovarian cancer (OC). This study aimed to evaluate the mRNA expression of NDC80 complex genes (NDC80, NUF2, SPC24, and SPC25) in OC and explore possible associations with the clinicopathological features of OC patients. Methods NDC80, NUF2, SPC24, and SPC25 mRNA expression levels were evaluated in 40 OC tissue specimens and 40 adjacent non-cancerous ovarian tissue specimens by real-time quantitative PCR. 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| score |
7.399805 |