Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people
Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previ...
Ausführliche Beschreibung
Autor*in: |
Poisson, Johanne [verfasserIn] El-Sissy, Carine [verfasserIn] Serret-Larmande, Arnaud [verfasserIn] Smith, Nikaïa [verfasserIn] Lebraud, Morgane [verfasserIn] Augy, Jean-Loup [verfasserIn] Conti, Catherine [verfasserIn] Gonnin, Cécile [verfasserIn] Planquette, Benjamin [verfasserIn] Arlet, Jean-Benoît [verfasserIn] Hermann, Bertrand [verfasserIn] Charbit, Bruno [verfasserIn] Pastre, Jean [verfasserIn] Devaux, Floriane [verfasserIn] Ladavière, Cyrielle [verfasserIn] Lim, Lydie [verfasserIn] Ober, Pauline [verfasserIn] Cannovas, Johanna [verfasserIn] Biard, Lucie [verfasserIn] Gulczynski, Marie-Christelle [verfasserIn] Blumenthal, Noémie [verfasserIn] Péré, Hélène [verfasserIn] Knosp, Camille [verfasserIn] Gey, Alain [verfasserIn] Benhamouda, Nadine [verfasserIn] Murris, Juliette [verfasserIn] Veyer, David [verfasserIn] Tartour, Eric [verfasserIn] Diehl, Jean-Luc [verfasserIn] Duffy, Darragh [verfasserIn] Paillaud, Elena [verfasserIn] Granier, Clémence [verfasserIn] |
---|
Format: |
E-Artikel |
---|---|
Sprache: |
Englisch |
Erschienen: |
2024 |
---|
Schlagwörter: |
---|
Anmerkung: |
© The Author(s) 2024 |
---|
Übergeordnetes Werk: |
Enthalten in: Immunity & ageing - BioMed Central, 2004, 21(2024), 1 vom: 07. Mai |
---|---|
Übergeordnetes Werk: |
volume:21 ; year:2024 ; number:1 ; day:07 ; month:05 |
Links: |
---|
DOI / URN: |
10.1186/s12979-024-00430-7 |
---|
Katalog-ID: |
SPR055775462 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | SPR055775462 | ||
003 | DE-627 | ||
005 | 20240508064725.0 | ||
007 | cr uuu---uuuuu | ||
008 | 240508s2024 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1186/s12979-024-00430-7 |2 doi | |
035 | |a (DE-627)SPR055775462 | ||
035 | |a (SPR)s12979-024-00430-7-e | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
082 | 0 | 4 | |a 610 |q VZ |
100 | 1 | |a Poisson, Johanne |e verfasserin |4 aut | |
245 | 1 | 0 | |a Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
264 | 1 | |c 2024 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a Computermedien |b c |2 rdamedia | ||
338 | |a Online-Ressource |b cr |2 rdacarrier | ||
500 | |a © The Author(s) 2024 | ||
520 | |a Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. | ||
650 | 4 | |a Immunosenescence |7 (dpeaa)DE-He213 | |
650 | 4 | |a Inflammaging |7 (dpeaa)DE-He213 | |
650 | 4 | |a Immune-ageing |7 (dpeaa)DE-He213 | |
650 | 4 | |a COVID-19 |7 (dpeaa)DE-He213 | |
650 | 4 | |a Geriatrics |7 (dpeaa)DE-He213 | |
650 | 4 | |a Infections |7 (dpeaa)DE-He213 | |
650 | 4 | |a Senescence-associated secretory phenotype |7 (dpeaa)DE-He213 | |
650 | 4 | |a CD8-positive T-lymphocytes |7 (dpeaa)DE-He213 | |
650 | 4 | |a GMCSF |7 (dpeaa)DE-He213 | |
650 | 4 | |a CXCL10 |7 (dpeaa)DE-He213 | |
650 | 4 | |a TSCM |7 (dpeaa)DE-He213 | |
700 | 1 | |a El-Sissy, Carine |e verfasserin |4 aut | |
700 | 1 | |a Serret-Larmande, Arnaud |e verfasserin |4 aut | |
700 | 1 | |a Smith, Nikaïa |e verfasserin |4 aut | |
700 | 1 | |a Lebraud, Morgane |e verfasserin |4 aut | |
700 | 1 | |a Augy, Jean-Loup |e verfasserin |4 aut | |
700 | 1 | |a Conti, Catherine |e verfasserin |4 aut | |
700 | 1 | |a Gonnin, Cécile |e verfasserin |4 aut | |
700 | 1 | |a Planquette, Benjamin |e verfasserin |4 aut | |
700 | 1 | |a Arlet, Jean-Benoît |e verfasserin |4 aut | |
700 | 1 | |a Hermann, Bertrand |e verfasserin |4 aut | |
700 | 1 | |a Charbit, Bruno |e verfasserin |4 aut | |
700 | 1 | |a Pastre, Jean |e verfasserin |4 aut | |
700 | 1 | |a Devaux, Floriane |e verfasserin |4 aut | |
700 | 1 | |a Ladavière, Cyrielle |e verfasserin |4 aut | |
700 | 1 | |a Lim, Lydie |e verfasserin |4 aut | |
700 | 1 | |a Ober, Pauline |e verfasserin |4 aut | |
700 | 1 | |a Cannovas, Johanna |e verfasserin |4 aut | |
700 | 1 | |a Biard, Lucie |e verfasserin |4 aut | |
700 | 1 | |a Gulczynski, Marie-Christelle |e verfasserin |4 aut | |
700 | 1 | |a Blumenthal, Noémie |e verfasserin |4 aut | |
700 | 1 | |a Péré, Hélène |e verfasserin |4 aut | |
700 | 1 | |a Knosp, Camille |e verfasserin |4 aut | |
700 | 1 | |a Gey, Alain |e verfasserin |4 aut | |
700 | 1 | |a Benhamouda, Nadine |e verfasserin |4 aut | |
700 | 1 | |a Murris, Juliette |e verfasserin |4 aut | |
700 | 1 | |a Veyer, David |e verfasserin |4 aut | |
700 | 1 | |a Tartour, Eric |e verfasserin |4 aut | |
700 | 1 | |a Diehl, Jean-Luc |e verfasserin |4 aut | |
700 | 1 | |a Duffy, Darragh |e verfasserin |4 aut | |
700 | 1 | |a Paillaud, Elena |e verfasserin |4 aut | |
700 | 1 | |a Granier, Clémence |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Immunity & ageing |d BioMed Central, 2004 |g 21(2024), 1 vom: 07. Mai |w (DE-627)473203588 |w (DE-600)2168941-6 |x 1742-4933 |7 nnns |
773 | 1 | 8 | |g volume:21 |g year:2024 |g number:1 |g day:07 |g month:05 |
856 | 4 | 0 | |u https://dx.doi.org/10.1186/s12979-024-00430-7 |m X:SPRINGER |x Resolving-System |z kostenfrei |3 Volltext |
912 | |a SYSFLAG_0 | ||
912 | |a GBV_SPRINGER | ||
912 | |a SSG-OLC-PHA | ||
912 | |a GBV_ILN_11 | ||
912 | |a GBV_ILN_20 | ||
912 | |a GBV_ILN_22 | ||
912 | |a GBV_ILN_23 | ||
912 | |a GBV_ILN_24 | ||
912 | |a GBV_ILN_31 | ||
912 | |a GBV_ILN_39 | ||
912 | |a GBV_ILN_40 | ||
912 | |a GBV_ILN_60 | ||
912 | |a GBV_ILN_62 | ||
912 | |a GBV_ILN_63 | ||
912 | |a GBV_ILN_65 | ||
912 | |a GBV_ILN_69 | ||
912 | |a GBV_ILN_73 | ||
912 | |a GBV_ILN_74 | ||
912 | |a GBV_ILN_95 | ||
912 | |a GBV_ILN_105 | ||
912 | |a GBV_ILN_110 | ||
912 | |a GBV_ILN_151 | ||
912 | |a GBV_ILN_161 | ||
912 | |a GBV_ILN_170 | ||
912 | |a GBV_ILN_206 | ||
912 | |a GBV_ILN_213 | ||
912 | |a GBV_ILN_230 | ||
912 | |a GBV_ILN_285 | ||
912 | |a GBV_ILN_293 | ||
912 | |a GBV_ILN_602 | ||
912 | |a GBV_ILN_2003 | ||
912 | |a GBV_ILN_2005 | ||
912 | |a GBV_ILN_2009 | ||
912 | |a GBV_ILN_2011 | ||
912 | |a GBV_ILN_2014 | ||
912 | |a GBV_ILN_2055 | ||
912 | |a GBV_ILN_2111 | ||
912 | |a GBV_ILN_4012 | ||
912 | |a GBV_ILN_4037 | ||
912 | |a GBV_ILN_4112 | ||
912 | |a GBV_ILN_4125 | ||
912 | |a GBV_ILN_4126 | ||
912 | |a GBV_ILN_4249 | ||
912 | |a GBV_ILN_4305 | ||
912 | |a GBV_ILN_4306 | ||
912 | |a GBV_ILN_4307 | ||
912 | |a GBV_ILN_4313 | ||
912 | |a GBV_ILN_4322 | ||
912 | |a GBV_ILN_4323 | ||
912 | |a GBV_ILN_4324 | ||
912 | |a GBV_ILN_4325 | ||
912 | |a GBV_ILN_4338 | ||
912 | |a GBV_ILN_4367 | ||
912 | |a GBV_ILN_4700 | ||
951 | |a AR | ||
952 | |d 21 |j 2024 |e 1 |b 07 |c 05 |
author_variant |
j p jp c e s ces a s l asl n s ns m l ml j l a jla c c cc c g cg b p bp j b a jba b h bh b c bc j p jp f d fd c l cl l l ll p o po j c jc l b lb m c g mcg n b nb h p hp c k ck a g ag n b nb j m jm d v dv e t et j l d jld d d dd e p ep c g cg |
---|---|
matchkey_str |
article:17424933:2024----::nraelvlogcfncc1adoc8eoytmclcutrmresfmuoeecn |
hierarchy_sort_str |
2024 |
publishDate |
2024 |
allfields |
10.1186/s12979-024-00430-7 doi (DE-627)SPR055775462 (SPR)s12979-024-00430-7-e DE-627 ger DE-627 rakwb eng 610 VZ Poisson, Johanne verfasserin aut Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 El-Sissy, Carine verfasserin aut Serret-Larmande, Arnaud verfasserin aut Smith, Nikaïa verfasserin aut Lebraud, Morgane verfasserin aut Augy, Jean-Loup verfasserin aut Conti, Catherine verfasserin aut Gonnin, Cécile verfasserin aut Planquette, Benjamin verfasserin aut Arlet, Jean-Benoît verfasserin aut Hermann, Bertrand verfasserin aut Charbit, Bruno verfasserin aut Pastre, Jean verfasserin aut Devaux, Floriane verfasserin aut Ladavière, Cyrielle verfasserin aut Lim, Lydie verfasserin aut Ober, Pauline verfasserin aut Cannovas, Johanna verfasserin aut Biard, Lucie verfasserin aut Gulczynski, Marie-Christelle verfasserin aut Blumenthal, Noémie verfasserin aut Péré, Hélène verfasserin aut Knosp, Camille verfasserin aut Gey, Alain verfasserin aut Benhamouda, Nadine verfasserin aut Murris, Juliette verfasserin aut Veyer, David verfasserin aut Tartour, Eric verfasserin aut Diehl, Jean-Luc verfasserin aut Duffy, Darragh verfasserin aut Paillaud, Elena verfasserin aut Granier, Clémence verfasserin aut Enthalten in Immunity & ageing BioMed Central, 2004 21(2024), 1 vom: 07. Mai (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:21 year:2024 number:1 day:07 month:05 https://dx.doi.org/10.1186/s12979-024-00430-7 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 07 05 |
spelling |
10.1186/s12979-024-00430-7 doi (DE-627)SPR055775462 (SPR)s12979-024-00430-7-e DE-627 ger DE-627 rakwb eng 610 VZ Poisson, Johanne verfasserin aut Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 El-Sissy, Carine verfasserin aut Serret-Larmande, Arnaud verfasserin aut Smith, Nikaïa verfasserin aut Lebraud, Morgane verfasserin aut Augy, Jean-Loup verfasserin aut Conti, Catherine verfasserin aut Gonnin, Cécile verfasserin aut Planquette, Benjamin verfasserin aut Arlet, Jean-Benoît verfasserin aut Hermann, Bertrand verfasserin aut Charbit, Bruno verfasserin aut Pastre, Jean verfasserin aut Devaux, Floriane verfasserin aut Ladavière, Cyrielle verfasserin aut Lim, Lydie verfasserin aut Ober, Pauline verfasserin aut Cannovas, Johanna verfasserin aut Biard, Lucie verfasserin aut Gulczynski, Marie-Christelle verfasserin aut Blumenthal, Noémie verfasserin aut Péré, Hélène verfasserin aut Knosp, Camille verfasserin aut Gey, Alain verfasserin aut Benhamouda, Nadine verfasserin aut Murris, Juliette verfasserin aut Veyer, David verfasserin aut Tartour, Eric verfasserin aut Diehl, Jean-Luc verfasserin aut Duffy, Darragh verfasserin aut Paillaud, Elena verfasserin aut Granier, Clémence verfasserin aut Enthalten in Immunity & ageing BioMed Central, 2004 21(2024), 1 vom: 07. Mai (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:21 year:2024 number:1 day:07 month:05 https://dx.doi.org/10.1186/s12979-024-00430-7 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 07 05 |
allfields_unstemmed |
10.1186/s12979-024-00430-7 doi (DE-627)SPR055775462 (SPR)s12979-024-00430-7-e DE-627 ger DE-627 rakwb eng 610 VZ Poisson, Johanne verfasserin aut Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 El-Sissy, Carine verfasserin aut Serret-Larmande, Arnaud verfasserin aut Smith, Nikaïa verfasserin aut Lebraud, Morgane verfasserin aut Augy, Jean-Loup verfasserin aut Conti, Catherine verfasserin aut Gonnin, Cécile verfasserin aut Planquette, Benjamin verfasserin aut Arlet, Jean-Benoît verfasserin aut Hermann, Bertrand verfasserin aut Charbit, Bruno verfasserin aut Pastre, Jean verfasserin aut Devaux, Floriane verfasserin aut Ladavière, Cyrielle verfasserin aut Lim, Lydie verfasserin aut Ober, Pauline verfasserin aut Cannovas, Johanna verfasserin aut Biard, Lucie verfasserin aut Gulczynski, Marie-Christelle verfasserin aut Blumenthal, Noémie verfasserin aut Péré, Hélène verfasserin aut Knosp, Camille verfasserin aut Gey, Alain verfasserin aut Benhamouda, Nadine verfasserin aut Murris, Juliette verfasserin aut Veyer, David verfasserin aut Tartour, Eric verfasserin aut Diehl, Jean-Luc verfasserin aut Duffy, Darragh verfasserin aut Paillaud, Elena verfasserin aut Granier, Clémence verfasserin aut Enthalten in Immunity & ageing BioMed Central, 2004 21(2024), 1 vom: 07. Mai (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:21 year:2024 number:1 day:07 month:05 https://dx.doi.org/10.1186/s12979-024-00430-7 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 07 05 |
allfieldsGer |
10.1186/s12979-024-00430-7 doi (DE-627)SPR055775462 (SPR)s12979-024-00430-7-e DE-627 ger DE-627 rakwb eng 610 VZ Poisson, Johanne verfasserin aut Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 El-Sissy, Carine verfasserin aut Serret-Larmande, Arnaud verfasserin aut Smith, Nikaïa verfasserin aut Lebraud, Morgane verfasserin aut Augy, Jean-Loup verfasserin aut Conti, Catherine verfasserin aut Gonnin, Cécile verfasserin aut Planquette, Benjamin verfasserin aut Arlet, Jean-Benoît verfasserin aut Hermann, Bertrand verfasserin aut Charbit, Bruno verfasserin aut Pastre, Jean verfasserin aut Devaux, Floriane verfasserin aut Ladavière, Cyrielle verfasserin aut Lim, Lydie verfasserin aut Ober, Pauline verfasserin aut Cannovas, Johanna verfasserin aut Biard, Lucie verfasserin aut Gulczynski, Marie-Christelle verfasserin aut Blumenthal, Noémie verfasserin aut Péré, Hélène verfasserin aut Knosp, Camille verfasserin aut Gey, Alain verfasserin aut Benhamouda, Nadine verfasserin aut Murris, Juliette verfasserin aut Veyer, David verfasserin aut Tartour, Eric verfasserin aut Diehl, Jean-Luc verfasserin aut Duffy, Darragh verfasserin aut Paillaud, Elena verfasserin aut Granier, Clémence verfasserin aut Enthalten in Immunity & ageing BioMed Central, 2004 21(2024), 1 vom: 07. Mai (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:21 year:2024 number:1 day:07 month:05 https://dx.doi.org/10.1186/s12979-024-00430-7 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 07 05 |
allfieldsSound |
10.1186/s12979-024-00430-7 doi (DE-627)SPR055775462 (SPR)s12979-024-00430-7-e DE-627 ger DE-627 rakwb eng 610 VZ Poisson, Johanne verfasserin aut Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people 2024 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier © The Author(s) 2024 Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 El-Sissy, Carine verfasserin aut Serret-Larmande, Arnaud verfasserin aut Smith, Nikaïa verfasserin aut Lebraud, Morgane verfasserin aut Augy, Jean-Loup verfasserin aut Conti, Catherine verfasserin aut Gonnin, Cécile verfasserin aut Planquette, Benjamin verfasserin aut Arlet, Jean-Benoît verfasserin aut Hermann, Bertrand verfasserin aut Charbit, Bruno verfasserin aut Pastre, Jean verfasserin aut Devaux, Floriane verfasserin aut Ladavière, Cyrielle verfasserin aut Lim, Lydie verfasserin aut Ober, Pauline verfasserin aut Cannovas, Johanna verfasserin aut Biard, Lucie verfasserin aut Gulczynski, Marie-Christelle verfasserin aut Blumenthal, Noémie verfasserin aut Péré, Hélène verfasserin aut Knosp, Camille verfasserin aut Gey, Alain verfasserin aut Benhamouda, Nadine verfasserin aut Murris, Juliette verfasserin aut Veyer, David verfasserin aut Tartour, Eric verfasserin aut Diehl, Jean-Luc verfasserin aut Duffy, Darragh verfasserin aut Paillaud, Elena verfasserin aut Granier, Clémence verfasserin aut Enthalten in Immunity & ageing BioMed Central, 2004 21(2024), 1 vom: 07. Mai (DE-627)473203588 (DE-600)2168941-6 1742-4933 nnns volume:21 year:2024 number:1 day:07 month:05 https://dx.doi.org/10.1186/s12979-024-00430-7 X:SPRINGER Resolving-System kostenfrei Volltext SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 AR 21 2024 1 07 05 |
language |
English |
source |
Enthalten in Immunity & ageing 21(2024), 1 vom: 07. Mai volume:21 year:2024 number:1 day:07 month:05 |
sourceStr |
Enthalten in Immunity & ageing 21(2024), 1 vom: 07. Mai volume:21 year:2024 number:1 day:07 month:05 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
Immunosenescence Inflammaging Immune-ageing COVID-19 Geriatrics Infections Senescence-associated secretory phenotype CD8-positive T-lymphocytes GMCSF CXCL10 TSCM |
dewey-raw |
610 |
isfreeaccess_bool |
true |
container_title |
Immunity & ageing |
authorswithroles_txt_mv |
Poisson, Johanne @@aut@@ El-Sissy, Carine @@aut@@ Serret-Larmande, Arnaud @@aut@@ Smith, Nikaïa @@aut@@ Lebraud, Morgane @@aut@@ Augy, Jean-Loup @@aut@@ Conti, Catherine @@aut@@ Gonnin, Cécile @@aut@@ Planquette, Benjamin @@aut@@ Arlet, Jean-Benoît @@aut@@ Hermann, Bertrand @@aut@@ Charbit, Bruno @@aut@@ Pastre, Jean @@aut@@ Devaux, Floriane @@aut@@ Ladavière, Cyrielle @@aut@@ Lim, Lydie @@aut@@ Ober, Pauline @@aut@@ Cannovas, Johanna @@aut@@ Biard, Lucie @@aut@@ Gulczynski, Marie-Christelle @@aut@@ Blumenthal, Noémie @@aut@@ Péré, Hélène @@aut@@ Knosp, Camille @@aut@@ Gey, Alain @@aut@@ Benhamouda, Nadine @@aut@@ Murris, Juliette @@aut@@ Veyer, David @@aut@@ Tartour, Eric @@aut@@ Diehl, Jean-Luc @@aut@@ Duffy, Darragh @@aut@@ Paillaud, Elena @@aut@@ Granier, Clémence @@aut@@ |
publishDateDaySort_date |
2024-05-07T00:00:00Z |
hierarchy_top_id |
473203588 |
dewey-sort |
3610 |
id |
SPR055775462 |
language_de |
englisch |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR055775462</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240508064725.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240508s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12979-024-00430-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR055775462</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12979-024-00430-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Poisson, Johanne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunosenescence</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammaging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune-ageing</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Geriatrics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infections</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Senescence-associated secretory phenotype</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CD8-positive T-lymphocytes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GMCSF</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CXCL10</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TSCM</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">El-Sissy, Carine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Serret-Larmande, Arnaud</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smith, Nikaïa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lebraud, Morgane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Augy, Jean-Loup</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Conti, Catherine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gonnin, Cécile</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Planquette, Benjamin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arlet, Jean-Benoît</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hermann, Bertrand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Charbit, Bruno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastre, Jean</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Devaux, Floriane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ladavière, Cyrielle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lim, Lydie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ober, Pauline</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cannovas, Johanna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Biard, Lucie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gulczynski, Marie-Christelle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Blumenthal, Noémie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Péré, Hélène</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Knosp, Camille</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gey, Alain</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benhamouda, Nadine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Murris, Juliette</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Veyer, David</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tartour, Eric</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Diehl, Jean-Luc</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Duffy, Darragh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Paillaud, Elena</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Granier, Clémence</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Immunity & ageing</subfield><subfield code="d">BioMed Central, 2004</subfield><subfield code="g">21(2024), 1 vom: 07. Mai</subfield><subfield code="w">(DE-627)473203588</subfield><subfield code="w">(DE-600)2168941-6</subfield><subfield code="x">1742-4933</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:21</subfield><subfield code="g">year:2024</subfield><subfield code="g">number:1</subfield><subfield code="g">day:07</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s12979-024-00430-7</subfield><subfield code="m">X:SPRINGER</subfield><subfield code="x">Resolving-System</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_0</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">21</subfield><subfield code="j">2024</subfield><subfield code="e">1</subfield><subfield code="b">07</subfield><subfield code="c">05</subfield></datafield></record></collection>
|
author |
Poisson, Johanne |
spellingShingle |
Poisson, Johanne ddc 610 misc Immunosenescence misc Inflammaging misc Immune-ageing misc COVID-19 misc Geriatrics misc Infections misc Senescence-associated secretory phenotype misc CD8-positive T-lymphocytes misc GMCSF misc CXCL10 misc TSCM Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
authorStr |
Poisson, Johanne |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)473203588 |
format |
electronic Article |
dewey-ones |
610 - Medicine & health |
delete_txt_mv |
keep |
author_role |
aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut aut |
collection |
springer |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1742-4933 |
topic_title |
610 VZ Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people Immunosenescence (dpeaa)DE-He213 Inflammaging (dpeaa)DE-He213 Immune-ageing (dpeaa)DE-He213 COVID-19 (dpeaa)DE-He213 Geriatrics (dpeaa)DE-He213 Infections (dpeaa)DE-He213 Senescence-associated secretory phenotype (dpeaa)DE-He213 CD8-positive T-lymphocytes (dpeaa)DE-He213 GMCSF (dpeaa)DE-He213 CXCL10 (dpeaa)DE-He213 TSCM (dpeaa)DE-He213 |
topic |
ddc 610 misc Immunosenescence misc Inflammaging misc Immune-ageing misc COVID-19 misc Geriatrics misc Infections misc Senescence-associated secretory phenotype misc CD8-positive T-lymphocytes misc GMCSF misc CXCL10 misc TSCM |
topic_unstemmed |
ddc 610 misc Immunosenescence misc Inflammaging misc Immune-ageing misc COVID-19 misc Geriatrics misc Infections misc Senescence-associated secretory phenotype misc CD8-positive T-lymphocytes misc GMCSF misc CXCL10 misc TSCM |
topic_browse |
ddc 610 misc Immunosenescence misc Inflammaging misc Immune-ageing misc COVID-19 misc Geriatrics misc Infections misc Senescence-associated secretory phenotype misc CD8-positive T-lymphocytes misc GMCSF misc CXCL10 misc TSCM |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
cr |
hierarchy_parent_title |
Immunity & ageing |
hierarchy_parent_id |
473203588 |
dewey-tens |
610 - Medicine & health |
hierarchy_top_title |
Immunity & ageing |
isfreeaccess_txt |
true |
familylinks_str_mv |
(DE-627)473203588 (DE-600)2168941-6 |
title |
Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
ctrlnum |
(DE-627)SPR055775462 (SPR)s12979-024-00430-7-e |
title_full |
Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
author_sort |
Poisson, Johanne |
journal |
Immunity & ageing |
journalStr |
Immunity & ageing |
lang_code |
eng |
isOA_bool |
true |
dewey-hundreds |
600 - Technology |
recordtype |
marc |
publishDateSort |
2024 |
contenttype_str_mv |
txt |
author_browse |
Poisson, Johanne El-Sissy, Carine Serret-Larmande, Arnaud Smith, Nikaïa Lebraud, Morgane Augy, Jean-Loup Conti, Catherine Gonnin, Cécile Planquette, Benjamin Arlet, Jean-Benoît Hermann, Bertrand Charbit, Bruno Pastre, Jean Devaux, Floriane Ladavière, Cyrielle Lim, Lydie Ober, Pauline Cannovas, Johanna Biard, Lucie Gulczynski, Marie-Christelle Blumenthal, Noémie Péré, Hélène Knosp, Camille Gey, Alain Benhamouda, Nadine Murris, Juliette Veyer, David Tartour, Eric Diehl, Jean-Luc Duffy, Darragh Paillaud, Elena Granier, Clémence |
container_volume |
21 |
class |
610 VZ |
format_se |
Elektronische Aufsätze |
author-letter |
Poisson, Johanne |
doi_str_mv |
10.1186/s12979-024-00430-7 |
dewey-full |
610 |
author2-role |
verfasserin |
title_sort |
increased levels of gm-csf and cxcl10 and low $ cd8^{+} $ memory stem t cell count are markers of immunosenescence and severe covid-19 in older people |
title_auth |
Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
abstract |
Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. © The Author(s) 2024 |
abstractGer |
Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. © The Author(s) 2024 |
abstract_unstemmed |
Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care. © The Author(s) 2024 |
collection_details |
SYSFLAG_0 GBV_SPRINGER SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_602 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2009 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2055 GBV_ILN_2111 GBV_ILN_4012 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4249 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4700 |
container_issue |
1 |
title_short |
Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people |
url |
https://dx.doi.org/10.1186/s12979-024-00430-7 |
remote_bool |
true |
author2 |
El-Sissy, Carine Serret-Larmande, Arnaud Smith, Nikaïa Lebraud, Morgane Augy, Jean-Loup Conti, Catherine Gonnin, Cécile Planquette, Benjamin Arlet, Jean-Benoît Hermann, Bertrand Charbit, Bruno Pastre, Jean Devaux, Floriane Ladavière, Cyrielle Lim, Lydie Ober, Pauline Cannovas, Johanna Biard, Lucie Gulczynski, Marie-Christelle Blumenthal, Noémie Péré, Hélène Knosp, Camille Gey, Alain Benhamouda, Nadine Murris, Juliette Veyer, David Tartour, Eric Diehl, Jean-Luc Duffy, Darragh Paillaud, Elena Granier, Clémence |
author2Str |
El-Sissy, Carine Serret-Larmande, Arnaud Smith, Nikaïa Lebraud, Morgane Augy, Jean-Loup Conti, Catherine Gonnin, Cécile Planquette, Benjamin Arlet, Jean-Benoît Hermann, Bertrand Charbit, Bruno Pastre, Jean Devaux, Floriane Ladavière, Cyrielle Lim, Lydie Ober, Pauline Cannovas, Johanna Biard, Lucie Gulczynski, Marie-Christelle Blumenthal, Noémie Péré, Hélène Knosp, Camille Gey, Alain Benhamouda, Nadine Murris, Juliette Veyer, David Tartour, Eric Diehl, Jean-Luc Duffy, Darragh Paillaud, Elena Granier, Clémence |
ppnlink |
473203588 |
mediatype_str_mv |
c |
isOA_txt |
true |
hochschulschrift_bool |
false |
doi_str |
10.1186/s12979-024-00430-7 |
up_date |
2024-07-03T17:55:39.591Z |
_version_ |
1803581484793069568 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000naa a22002652 4500</leader><controlfield tag="001">SPR055775462</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20240508064725.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">240508s2024 xx |||||o 00| ||eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1186/s12979-024-00430-7</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)SPR055775462</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(SPR)s12979-024-00430-7-e</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="082" ind1="0" ind2="4"><subfield code="a">610</subfield><subfield code="q">VZ</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Poisson, Johanne</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Increased levels of GM-CSF and CXCL10 and low $ CD8^{+} $ memory stem T Cell count are markers of immunosenescence and severe COVID-19 in older people</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">2024</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">© The Author(s) 2024</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background Ageing leads to altered immune responses, resulting in higher susceptibility to certain infections in the elderly. Immune ageing is a heterogeneous process also associated with inflammaging, a low-grade chronic inflammation. Altered cytotoxic T cell responses and cytokine storm have previously been described in severe COVID-19 cases, however the parameters responsible for such immune response failures are not well known. The aim of our study was to characterize $ CD8^{+} $ T cells and cytokines associated with ageing, in a cohort of patients aged over 70 years stratified by COVID-19 severity. Results One hundred and four patients were included in the study. We found that, in older people, COVID-19 severity was associated with (i) higher level of GM-CSF, CXCL10 (IP-10), VEGF, IL-1β, CCL2 (MCP-1) and the neutrophil to lymphocyte ratio (NLR), (ii) increased terminally differentiated $ CD8^{+} $T cells, and (ii) decreased early precursors $ CD8^{+} $ T stem cell-like memory cells (TSCM) and $ CD27^{+} $$ CD28^{+} $. The cytokines mentioned above were found at higher concentrations in the COVID-$ 19^{+} $ older cohort compared to a younger cohort in which they were not associated with disease severity. Conclusions Our results highlight the particular importance of the myeloid lineage in COVID-19 severity among older people. As GM-CSF and CXCL10 were not associated with COVID-19 severity in younger patients, they may represent disease severity specific markers of ageing and should be considered in older people care.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immunosenescence</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Inflammaging</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Immune-ageing</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">COVID-19</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Geriatrics</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Infections</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Senescence-associated secretory phenotype</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CD8-positive T-lymphocytes</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">GMCSF</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CXCL10</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">TSCM</subfield><subfield code="7">(dpeaa)DE-He213</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">El-Sissy, Carine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Serret-Larmande, Arnaud</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Smith, Nikaïa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lebraud, Morgane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Augy, Jean-Loup</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Conti, Catherine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gonnin, Cécile</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Planquette, Benjamin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Arlet, Jean-Benoît</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hermann, Bertrand</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Charbit, Bruno</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Pastre, Jean</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Devaux, Floriane</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ladavière, Cyrielle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Lim, Lydie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ober, Pauline</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Cannovas, Johanna</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Biard, Lucie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gulczynski, Marie-Christelle</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Blumenthal, Noémie</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Péré, Hélène</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Knosp, Camille</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Gey, Alain</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Benhamouda, Nadine</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Murris, Juliette</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Veyer, David</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tartour, Eric</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Diehl, Jean-Luc</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Duffy, Darragh</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Paillaud, Elena</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Granier, Clémence</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">Enthalten in</subfield><subfield code="t">Immunity & ageing</subfield><subfield code="d">BioMed Central, 2004</subfield><subfield code="g">21(2024), 1 vom: 07. Mai</subfield><subfield code="w">(DE-627)473203588</subfield><subfield code="w">(DE-600)2168941-6</subfield><subfield code="x">1742-4933</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:21</subfield><subfield code="g">year:2024</subfield><subfield code="g">number:1</subfield><subfield code="g">day:07</subfield><subfield code="g">month:05</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://dx.doi.org/10.1186/s12979-024-00430-7</subfield><subfield code="m">X:SPRINGER</subfield><subfield code="x">Resolving-System</subfield><subfield code="z">kostenfrei</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SYSFLAG_0</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_SPRINGER</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">SSG-OLC-PHA</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_11</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_20</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_22</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_23</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_24</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_39</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_40</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_60</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_62</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_63</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_65</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_69</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_73</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_74</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_95</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_105</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_110</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_151</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_161</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_170</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_206</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_213</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_230</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_285</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_293</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_602</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2003</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2005</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2009</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2055</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2111</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4012</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4112</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4125</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4126</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4249</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4305</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4306</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4307</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4313</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4322</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4323</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4324</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4325</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4338</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4367</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_4700</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">21</subfield><subfield code="j">2024</subfield><subfield code="e">1</subfield><subfield code="b">07</subfield><subfield code="c">05</subfield></datafield></record></collection>
|
score |
7.3984547 |